The two cases of women in their mid-40s who experienced Takotsubo syndrome (TTS) in the setting of esophagogastroduodenoscopy (EGD), reported by Yu et al. [1] in the January issue of Clinical Endoscopy, are interesting because the patients were premenopausal, had midventricular TTS, were under conscious sedation, and did not appear to be under stress during the procedure. The first patient initially had hypertension and tachycardia, which was followed by hypotension and bradycardia, suggesting vagotonia, a feature characteristic of the later presentation of TTS [2,3]. The other patient developed hypotension and tachycardia “1 minute after the insertion of the EGD scope [1].” One wonders whether TTS in the setting of EGD is mediated by intense vagotonia, characterized by hypotension and/or bradycardia [2,3]. with tachycardia and/or hypertension being mediated by a reflex counterbalancing intense activation of the autonomic sympathetic nervous system, and the effects of the drugs administered to manage the hypotension and/or bradycardia.

The authors refer to five cases that have been reported worldwide to be associated with gastrointestinal endoscopy [1], and state that “previous reports indicated one case of EGD in a postmenopausal woman with sedation, three cases of colonoscopy (COL), and one case of simultaneous EGD and COL in a postmenopausal woman [1,4-6].” I was able to access the paper describing the patient with both EGD and COL, who had TTS complicated by ventricular fibrillation, but I could not access the other two papers the authors are referring to [5,6]. I would appreciate comments by the authors on the remaining four patients with TTS, including the circumstances under which they experienced TTS, their ages and sex, whether they were postmenopausal, had hypotension and/or bradycardia, and the type of TTS they developed (apical, midventricular, basal, or segmental).