Korean Journal of Gastrointestinal Endoscopy 2010;41(1): 56-60.
Tumor Necrosis Factor-Ձ Monoclonal Antibody (Infliximab)으로 치료한 회장 말단부의 단순 궤양
이석종ㆍ정우철ㆍ이강문ㆍ오유석ㆍ김은정ㆍ최강현ㆍ백창렬
가톨릭대학교 의과대학 내과학교실
A Case of Simple Ulcer of the Terminal Ileum Successfully Treated by Monoclonal Antibody to Tumor Necrosis Factor-Ձ (Infliximab)
Seok Jong Lee, M.D., Woo Chul Chung, M.D., Kang Moon Lee, M.D., You Suk Oh, M.D., Eun Jung Kim, M.D., Kang Hyun Choi, M.D. and Chang Nyol Paik, M.D.
Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea
Abstract
Nonspecific and idiopathic ulcer of the small bowel or colon is a rare condition, and it is the so called "simple ulcer" when the patients do not have systemic symptoms of Behcet's syndrome. Differentiation of simple ulcer from intestinal Behcet's disease according to the endoscopic and pathologic findings is often impossible and the clinical course of the 2 maladies is similar. A 51-year-old man presented with low abdominal pain, and colonoscopy revealed a huge deep ulceration with an entero-enteric fistula in the terminal ileum. He was diagnosed with simple ulcer without the constitutional symptoms of Behcet's syndrome. He was refractory to conventional therapy with corticosteroids and antibiotics, and so he required surgical resection. Monoclonal antibody against tumor necrosis factor-Ձ (Infliximab) was administered at 0, 2 and 6 weeks. His symptoms were relieved after the therapy and the ulceration had completely resolved after 1 year. He was entirely asymptomatic at the 36 month follow up. (Korean J Gastrointest Endosc 2010;41:56-60)
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