A 66-year-old woman with a 40-mm laterally spreading tumor of the rectum was referred for endoscopic resection. Before the endoscopic resection, we observed the lesion with an EC-L590ZW endoscope with the LASEREO system (FUJIFILM Co., Tokyo, Japan), with white light (Fig. 1A) and with Linked Color Imaging (LCI) (Fig. 1B). The lesion was clearly seen as a bright reddish area on LCI. Compared with the white light image, the LCI image makes the lesion more easily recognizable, thanks to the striking color contrast between the neoplastic mucosa and the normal mucosa. The lesion was diagnosed as an adenoma on the basis of the magnified BLI images. Successful en bloc endoscopic submucosal dissection was performed for the lesion, and the diagnosis of high-grade adenoma with negative resection margins was confirmed histopathologically (Fig. 1C).

NBI is the most widely used system among several available image enhanced endoscopy systems. NBI modifies the center wavelength and bandwidth of an endoscope’s light into narrow-band illumination at 415±30 nm within the hemoglobin absorption band, thereby facilitating a clearer visualization of vascular structures [4]. However, this technique has limitations such as dark imaging of distant lesions because of narrow-band illumination. BLI was developed to compensate for these inherent limitations of NBI. BLI uses narrow-band laser light combined with white light. This combination results in a bright image of the digestive mucosa, enabling the detailed visualization of both the microstructure and the microvasculature [5]. However, BLI still is not able to obtain sufficient brightness for distant lesions. The newly developed LCI system (FUJIFILM Co.) creates clear and bright endoscopic images by using short-wavelength narrow-band laser light combined with white laser light on the basis of BLI technology. This system can obtain bright endoscopic images even at a distant view because LCI has more intense white light than the short-wavelength narrow-band laser light. Short-wavelength narrow-band laser light enhances the vessels on the mucosal surface and the patterns of the mucosa, which means that BLI enables a clearer visualization of microvascular structures than does LCI. In contrast, LCI enhances differences in hue, in the red region of the spectrum, through digital processing (Fig. 2). This makes red areas appear redder and white areas appear whiter. Thus, it is easier to recognize a slight difference in color of the mucosa. Therefore, LCI may facilitate the detection of flat colorectal neoplasms without magnification. After the detection of lesions, BLI images are easily produced with a push of a button for use in qualitative diagnosis. Further studies are needed to confirm the utility of LCI.