Melanocytic Nevus on the Rectal Mucosa Removed Using Endoscopic Submucosal Dissection

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Abstract

INTRODUCTION

The annual occurrence of malignant melanoma has been dramatically increasing over the past few decades, and the exposure to ultraviolet light is assumed to be a major risk factor [1]. Other risk factors including the high number of typical melanocytic nevi, presence of atypical nevi, personal history of melanoma, and several genetic factors including increased frequency of CDKN2A mutations have been reported [2-4]. Additionally, familial atypical multiple mole and melanoma syndrome are reportedly related with a higher incidence of malignant melanoma [5].

Typical melanocytic nevi occur at photo-exposed areas, where the risk of cutaneous melanoma greatly increases, and they are generally round with a uniform color and a diameter of 5 mm or less [6]. Melanocytic nevi are infrequently pigmented to the mucosa, and several cases of melanocytic nevus at the rectal mucosa have been reported [2-4]. However, there are no prior reports of the malignant transformation of rectal melanocytic nevus or its treatment. Like melanocytic nevus of the skin, rectal melanocytic nevus has the potential to transform to malignant melanoma. Thus, endoscopic resection of rectal melanocytic nevus might be an alternative treatment option. Here, we report the first detailed case report of rectal melanocytic nevi resected using endoscopic submucosal dissection (ESD).

CASE REPORT

A 70-year-old male without a medical history of remarkable illness visited our hospital for screening colonoscopy. The patient had no previous experience of colonoscopy and successfully underwent propofol-based conscious sedation. During the procedure, a 1.0×0.8 cm hyperpigmented and slightly elevated lesion was observed at the far distal rectum near from dentate line (Fig. 1). A tiny piece of tissue was taken from the lesion, and the acquired specimen was tested under H&E staining and immunohistochemical staining for tumor proliferation using the Ki-67 labeling index. The Ki-67 labeling index was less than 1%, and the results of the hematoxylin-eosin-stain identified it as a melanocytic nevus (Fig. 2). Although there have been no previous written reports of the transformation of melanocytic nevus at the rectum to malignant melanoma, a large melanocytic nevus might have the potential for malignant transformation. The patient was recommended periodic colonoscopy or endoscopic resection, and he decided to receive therapeutic endoscopic resection after 10 months of colonoscopic examinations.

Fig. 1.

Endoscopic finding of rectal melanocytic nevus. A 1.0×0.8 cm hyperpigmented and slightly

Fig. 2.

Histopathological findings of endoscopic biopsy tissue. (A) The sample is composed of many melanocytes and brown pigmentation without malignant cells (H&E stain, ×40). (B) The Ki-67 labeling index of the specimen is <1% (×200).

The hyperpigmented lesion at the rectum showed no change in size, and under midazolam- and propofol injection-based sedation, standard ESD was performed (Fig. 3). During the procedure, the patient was stable without major complications. The acquired specimen was fixed in 4% formalin and sent to the pathology department. The lesion was 0.7×0.7 cm, and hematoxylin-eosin staining and S-100 using immunohistochemical staining revealed many melanocytes and positivity for S-100 stain. Therefore, the resected specimen was finally diagnosed as a melanocytic nevus with no malignant cells (Fig. 4).

Fig. 3.

Endoscopic submucosal dissection of melanocytic nevus of the rectum. (A) A rectal melanocytic nevus is visible on the far-distal rectum. (B) A submucosal injection is performed using epinephrine-indigo carmine-saline solution. (C) A mucosal incision around the lesion is made using a needle knife. (D, E) The submucosal dissection is performed using an insulated-tip knife. (F) The rectal melanocytic nevus is completely removed without major complications.

Fig. 4.

Histopathological findings of the resected specimen. (A) The gross findings of the specimen indicate that the lesion is 0.7×0.7 cm. (B) The nevus involves the submucosa of the anorectal junction (H&E stain, ×12.5). (C) The resected lesion is composed of many melanocytes without malignant cells. Almost all of the cells include brown pigmentation (H&E stain, ×400). (D) The lesion is positive for S-100 (×100).

DISCUSSION

Melanocytic nevus has the potential for malignant transformation, and if malignant melanoma is developed on the colon or rectum, severe adverse effects such as diarrhea, rectal bleeding, constipation, and obstruction may occur [3]. However, in many cases, such side effects may not be clear, making it difficult to diagnose malignant melanoma in the lower gastrointestinal tract [7]. Up to 1% of total melanoma cases are the anorectal type, the prognosis of which is known to be generally poor [8,9]. Considering the potential risk for malignant transformation, if melanocytic nevus is found on the rectum, a biopsy should be taken to confirm the presence of malignant cells. Furthermore, either colonoscopic surveillance or resection should be considered despite a benign pathologic examination. However, there has been no case report of the malignant transformation of rectal melanocytic nevus, and the incidence of malignant transformation of rectal melanocytic nevus remains unknown. Therefore, endoscopic resection using ESD may be preferred if regular surveillance colonoscopy is unavailable or if the patients are younger or want to remove the lesion. To our knowledge, this is the first case in which ESD was used to provide therapeutic resection of rectal melanocytic nevus. However, a treatment consensus should be established by future case reports and long-term follow-up data of endoscopic resection of rectal melanocytic nevus.

In conclusion, rectal melanocytic nevus may have the potential for malignant transformation; therefore, periodic monitoring via colonoscopy should be performed. However, colonoscopic surveillance requires patients to complete a cumbersome bowel preparation process and may increase their anxiety of malignant transformation during the long-term follow-up period. In such cases, removal of the rectal melanocytic nevus can be considered a definite treatment option, and endoscopic procedures including ESD can be safe and feasible alternatives.

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