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Correlation of Endoscopic Findings of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma with Recurrence after Complete Remission
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Chang Min Lee, Dong Ho Lee, Byung Kyu Ahn, Jae Jin Hwang, Hyuk Yoon, Young Soo Park, Cheol Min Shin, Nayoung Kim
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Clin Endosc 2017;50(1):51-57. Published online March 24, 2016
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DOI: https://doi.org/10.5946/ce.2016.015
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Abstract
PDFPubReaderePub
- Background
/Aims: In gastric mucosa-associated lymphoid tissue (MALT) lymphoma, the clinical significance of various endoscopic findings has not yet been determined. This study aimed to compare the time to complete remission (CR) and relapse-free survival (RFS) in gastric MALT lymphoma based on endoscopic findings.
Methods In this single-center retrospective cohort study, the medical records of 122 consecutive adult patients with gastric MALT lymphoma were collected over a period of 12 years. CR was defined by the absence of macroscopic or microscopic features of lymphoma on two subsequent follow-ups. Relapse was clinically defined by a positive endoscopic biopsy after CR.
Results The median time to CR did not differ significantly between treatment methods. However, it was significantly longer in the group with polypoid endoscopic appearance than in the groups with diffuse infiltration or ulceration (7.83, 3.43, and 3.10 months, respectively; p=0.003). Six patients relapsed after CR. Kaplan-Meier analysis showed that RFS differed significantly between groups based on Ann Arbor staging, treatment methods, and initial endoscopic findings.
Conclusions In gastric MALT lymphoma, the endoscopically defined polypoid type was characterized by a longer duration to CR, with a higher likelihood of recurrence, compared to the endoscopically defined diffuse infiltration or ulceration types.
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Citations
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- A Case of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma with Special Endoscopic Morphology
Xin Sun, Yanbo Zhen, Pan Pan, Liang Liu Journal of Digestive Endoscopy.2024;[Epub] CrossRef - Characteristic endoscopic findings of gastrointestinal malignant lymphomas other than mucosa-associated lymphoid tissue lymphoma
T Kanno, T Katano, T Shimura, R Nishigaki, Y Kojima, M Sasaki, Y Okuda, N Sugimura, S Fukusada, Y Mizuno, H Iwasaki, H Nishie, M Tanaka, K Ozeki, E Kubota, S Tanida, H Kataoka Acta Gastro Enterologica Belgica.2022; 85(3): 477. CrossRef - Diagnosis and Treatment for Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
Shotaro Nakamura, Mariko Hojo Journal of Clinical Medicine.2022; 12(1): 120. CrossRef - Normal gastrointestinal tract inflammatory cells and review of select benign hematolymphoid proliferations
Jennifer Y. Ju, Edward B. Stelow, Elizabeth L. Courville Seminars in Diagnostic Pathology.2021; 38(4): 6. CrossRef - Optimal Initial Workup in Patients With Superficial Primary Gastric MALT Lymphoma
Hee Kyong Na, Sung Hyun Won, Jeong Hoon Lee, Ga Hee Kim, Kee Wook Jung, Ji Yong Ahn, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung Journal of Clinical Gastroenterology.2021; 55(9): 785. CrossRef - Endoscopic features and clinical outcomes of colorectal mucosa-associated lymphoid tissue lymphoma
Min Kyung Jeon, Hoonsub So, Jooryung Huh, Hee Sang Hwang, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Kee Don Choi, Byong Duk Ye, Seung-Jae Myung, Suk-Kyun Yang, Jeong-Sik Byeon Gastrointestinal Endoscopy.2018; 87(2): 529. CrossRef - Endoscopic Findings of Gastric Extranodal Marginal Zone B-Cell Mucosa-Associated Lymphoid Tissue Lymphoma
Sang Kil Lee Clinical Endoscopy.2017; 50(1): 1. CrossRef
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Low Grade Gastric Mucosa-associated Lymphoid Tissue Lymphoma: Clinicopathological Factors Associated with Helicobacter pylori Eradication and Tumor Regression
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Yoon Jin Choi, Dong Ho Lee, Ji Yeon Kim, Ji Eun Kwon, Jae Yeon Kim, Hyun Jin Jo, Cheol Min Shin, Hyun Young Kim, Young Soo Park, Nayoung Kim, Hyun Chae Jung, In Sung Song
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Clin Endosc 2011;44(2):101-108. Published online December 31, 2011
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DOI: https://doi.org/10.5946/ce.2011.44.2.101
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Abstract
PDFPubReaderePub
- Background/Aims
Eradication of Helicobacter pylori is widely accepted as initial therapy for low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, approximately 20% of patients with this disease are not responsive to H. pylori eradication therapy. The aim of this study was to assess remission and relapse rates of low-grade gastric MALT lymphoma after H. pylori eradication and identify the clinical factors that affect remission. MethodsThirty-nine patients diagnosed with gastric MALT lymphoma (May 2003 to May 2010) were retrospectively analyzed. ResultsOf the 39 patients, 30 (77%) had a H. pylori infection. There were 35/39 (90%) patients with stage I. Among stage I, 25 patients with the infection underwent eradication therapy and 22/25 (88%) achieved remission. The total regression rate with eradication only in stage I was 24/28 (86%). The median time to remission was 98 days (range, 22 to 397 days). Age, tumor location, invasion depth, H. pylori burden, and severity of mononuclear leukocyte and neutrophil infiltration were not related to remission. However, patients with less neutrophil infiltration were more likely to achieve a successful first H. pylori eradication (p=0.049). ConclusionsThe results show that the rate of low-grade gastric MALT lymphoma regression (86%) with H. pylori eradication alone was higher than that in Western studies (77.8%) and that neutrophil infiltration was inversely related to success of the first H. pylori eradication procedure.
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Citations
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- Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma: An up-to-date meta-analysis
Fabian Fellipe Bueno Lemos, Caroline Tianeze de Castro, Mariana Santos Calmon, Marcel Silva Luz, Samuel Luca Rocha Pinheiro, Clara Faria Souza Mendes dos Santos, Gabriel Lima Correa Santos, Hanna Santos Marques, Henrique Affonso Delgado, Kádima Nayara Tei World Journal of Gastroenterology.2023; 29(14): 2202. CrossRef - Efficacy of eradication therapy in Helicobacter pylori‐negative gastric mucosa‐associated lymphoid tissue lymphoma: A meta‐analysis
Kyoungwon Jung, Do Hoon Kim, Hyun Il Seo, Eun Jeong Gong, Chang Seok Bang Helicobacter.2021;[Epub] CrossRef - Clinical efficacy of the modified Helicobacter pylori eradication therapy for Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphoma: a meta analysis
Ya-Lin Xie, Chun-Yan He, Si-Qi Wei, Wen-Ju Guan, Zheng Jiang Chinese Medical Journal.2020; 133(11): 1337. CrossRef - Clinical Efficacy of Radiotherapy inHelicobacter pyloriNegative or Unresponsive to Eradication Therapy Primary Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
Byung Sam Park, Si Hyung Lee The Korean Journal of Gastroenterology.2019; 73(1): 19. CrossRef - Endoscopic features aiding the diagnosis of gastric mucosa-associated lymphoid tissue lymphoma
Byung Sam Park, Si Hyung Lee Yeungnam University Journal of Medicine.2019; 36(2): 85. CrossRef - Bone marrow involvement is not associated with the clinical outcomes of gastric mucosa-associated lymphoid tissue lymphoma
Eun Jeong Gong, Ji Yong Ahn, Hwoon-Yong Jung, Kyoungwon Jung, Charles J. Cho, Hee Kyong Na, Kee Wook Jung, Do Hoon Kim, Jeong Hoon Lee, Kee Don Choi, Ho June Song, Gin Hyug Lee, Jin-Ho Kim, Dok Hyun Yoon Scandinavian Journal of Gastroenterology.2016; 51(8): 942. CrossRef - Helicobacter pyloriEradication Therapy Is Effective as the Initial Treatment for Patients withH. pylori-Negative and Disseminated Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
Eun Jeong Gong, Ji Yong Ahn, Hwoon-Yong Jung, Hyungchul Park, Young Bo Ko, Hee Kyong Na, Kee Wook Jung, Do Hoon Kim, Jeong Hoon Lee, Kee Don Choi, Ho June Song, Gin Hyug Lee, Jin-Ho Kim Gut and Liver.2016; 10(5): 706. CrossRef - Antisecretory medication is associated with decreased Helicobacter pylori detection in gastric marginal zone lymphoma
Kurt B. Schaberg, Mark F. Evans, Rebecca Wilcox, Michael R. Lewis Annals of Diagnostic Pathology.2015; 19(6): 397. CrossRef - A Polypoid Mucosa-Associated Lymphoid Tissue Lymphoma of the Stomach Treated with Endoscopic Polypectomy
Shin Young Min, Jun Haeng Lee, Poong-Lyul Rhee Clinical Endoscopy.2013; 46(6): 647. CrossRef
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Dual Therapy Trial Using Esomeprazole and Amoxicillin as Third-line Rescue Therapy for Helicobacter pylori Infection
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Hyun Kyung Park, Dong Ho Lee, Seungchul Suh, Pyoung Ju Seo, Nayoung Kim, Sook-Hyang Jeong, Jin-Wook Kim, Jin-Hyeok Hwang, Young Soo Park, Sang Hyub Lee, Cheol Min Shin
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Clin Endosc 2011;44(1):33-37. Published online September 30, 2011
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DOI: https://doi.org/10.5946/ce.2011.44.1.33
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Abstract
PDFPubReaderePub
- Background/Aims
The purpose of this study was to evaluate the efficacy and tolerability of dual therapy consisting of esomeprazole and amoxicillin as a rescue therapy for Helicobacter pylori infection. MethodsFrom December 2009 to August 2010, 21 patients who experienced two consecutive eradication failures were included. They received esomeprazole (40 mg, b.i.d.) and amoxicillin (1,000 mg, b.i.d.) for 14 days as a third eradication regimen. Compliance and side effects were determined from an interview. H. pylori status was evaluated using the 13C urea breath test at least 6 weeks after treatment. ResultsThe mean age of the patients was 59 years and included 52% males. Indications for treatment were functional dyspepsia (61.9%), peptic ulcer disease (28.6%), and gastric adenoma (9.5%). H. pylori was eradicated in 14 of 21 (66.7%) patients. Minor side effects were reported in three of the 21 patients (14.3%). These side effects consisted mainly of nausea and epigastric discomfort. ConclusionsA 2-week course of dual therapy failed to show satisfactory results in third-line H. pylori eradication, but it was very safe and tolerable. Therefore, dual therapy constitutes an encouraging empirical strategy for the elderly and infirm patients with multiple previous eradication failures.
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Citations
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- Dual therapy for Helicobacter pylori infection
Miao Duan, Jing Liu, Xiuli Zuo Chinese Medical Journal.2023;[Epub] CrossRef -
Helicobacter pylori Antimicrobial Susceptibility Testing-Guided Salvage Therapy in the USA: A Real Life Experience
Bei Tan, Jyh-Chin Yang, Carol L. Young, Shrinivas Bishu, Stephanie Y. Owyang, Mohamad El-Zaatari, Min Zhang, Helmut Grasberger, Jia-ming Qian, John Y. Kao Digestive Diseases and Sciences.2018; 63(2): 437. CrossRef - Treatment of Helicobacter pylori Infection in Korea: A Systematic Review and Meta-analysis
Sang Wook Lee, Hyun Jung Kim, Jae Gyu Kim Journal of Korean Medical Science.2015; 30(8): 1001. CrossRef
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