Recent advances in optical molecular imaging allow identification of morphologic and biochemical changes in tissues associated with gastrointestinal (GI) premalignant lesions earlier and in real-time. This focused review series introduces high-resolution imaging modalities that are being evaluated preclinically and clinically for the detection of early GI cancers, especially Barrett esophagus and esophageal adenocarcinoma. Although narrow band imaging, autofluorescence imaging, and chromoendoscopy are currently applied for this purpose in the clinic, further adoptions of probe-based confocal laser endomicroscopy, high-resolution microendoscopy, optical coherence tomography, and metabolomic imaging, as well as imaging mass spectrometry, will lead to detection at the earliest and will guide predictions of the clinical course in the near future in a manner that is beyond current advancements in optical imaging. In this review article, the readers will be introduced to sufficient information regarding this matter with which to enjoy this new era of high technology and to confront science in the field of molecular medical imaging.

Citations

Citations to this article as recorded by  

• Fluorescence imaging-guided surgery: current status and future directions
  Zia Ullah, Shubham Roy, Saz Muhammad, Chen Yu, Haiyan Huang, Dongxiang Chen, Haodong Long, Xiulan Yang, Xuelian Du, Bing Guo
  Biomaterials Science.2024; 12(15): 3765.     CrossRef
• Pivotal Role of Peptides in Gastric Carcinoma: Diagnosis and Therapy
  Sajjad Ahmadpour, Fatemeh Khodadust, Ahmad Hormati, Karim Eivaziatashbeik
  International Journal of Peptide Research and Therapeutics.2021; 27(1): 503.     CrossRef
• High-resolution proteomics and metabolomics in thyroid cancer: Deciphering novel biomarkers
  Diana Navas-Carrillo, José Manuel Rodriguez, Silvia Montoro-García, Esteban Orenes-Piñero
  Critical Reviews in Clinical Laboratory Sciences.2017; 54(7-8): 446.     CrossRef
• hERG1 behaves as biomarker of progression to adenocarcinoma in Barrett's esophagus and can be exploited for a novel endoscopic surveillance
  Elena Lastraioli, Tiziano Lottini, Jessica Iorio, Giancarlo Freschi, Marilena Fazi, Claudia Duranti, Laura Carraresi, Luca Messerini, Antonio Taddei, Maria Novella Ringressi, Marianna Salemme, Vincenzo Villanacci, Carla Vindigni, Anna Tomezzoli, Roberta L
  Oncotarget.2016; 7(37): 59535.     CrossRef
• Imaging Mass Spectrometry in Papillary Thyroid Carcinoma for the Identification and Validation of Biomarker Proteins
  Kyueng-Whan Min, Joo-Young Bang, Kwang Pyo Kim, Wan-Seop Kim, Sang Hwa Lee, Selina Rahman Shanta, Jeong Hwa Lee, Ji Hye Hong, So Dug Lim, Young-Bum Yoo, Chan-Hyun Na
  Journal of Korean Medical Science.2014; 29(7): 934.     CrossRef
• Molecular Imaging for Theranostics in Gastroenterology: One Stone to Kill Two Birds
  Kwang Hyun Ko, Chang-Il Kown, Jong Min Park, Hoo Geun Lee, Na Young Han, Ki Baik Hahm
  Clinical Endoscopy.2014; 47(5): 383.     CrossRef

Imaging mass spectrometry (IMS) is currently receiving large attention from the mass spectrometric community, although its use is not yet well known in the clinic. As matrix-assisted laser desorption/ionization time-of-flight (MALDI)-IMS can show the biomolecular changes in cells as well as tissues, it can be an ideal tool for biomedical diagnostics as well as the molecular diagnosis of clinical specimens, especially aimed at the prompt detection of premalignant lesions much earlier before overt mass formation, or for obtaining histologic clues from endoscopic biopsy. Besides its use for pathologic diagnosis, MALDI-IMS is also a powerful tool for the detection and localization of drugs, proteins, and lipids in tissue. Measurement of parameters that define and control the implications, challenges, and opportunities associated with the application of IMS to biomedical tissue studies might be feasible through a deep understanding of mass spectrometry. In this focused review series, new insights into the molecular processes relevant to IMS as well as other field applications are introduced.

Citations

Citations to this article as recorded by  

• Oncoproteomics: Trials and tribulations
  Li Zhou, Qifu Li, Jiandong Wang, Canhua Huang, Edouard C. Nice
  PROTEOMICS – Clinical Applications.2016; 10(4): 516.     CrossRef
• Identifying Diffuse Axonal Injury by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight
  Guanheng Ren, Donghua Zou, Ping Huang, Zhengdong Li, Yu Shao, Kaifei Deng, Yijiu Chen, Ningguo Liu
  American Journal of Forensic Medicine & Pathology.2016; 37(4): 279.     CrossRef
• Surface-Assisted Laser Desorption/Ionization of Trinitrotoluene on Porous Silicon under Ambient Conditions
  Yury Kuzishchin, Igor Martynov, Dmitriy Dovzhenko, Gennadii Kotkovskii, Alexander Chistyakov
  The Journal of Physical Chemistry C.2015; 119(11): 6382.     CrossRef
• Imaging Mass Spectrometry in Papillary Thyroid Carcinoma for the Identification and Validation of Biomarker Proteins
  Kyueng-Whan Min, Joo-Young Bang, Kwang Pyo Kim, Wan-Seop Kim, Sang Hwa Lee, Selina Rahman Shanta, Jeong Hwa Lee, Ji Hye Hong, So Dug Lim, Young-Bum Yoo, Chan-Hyun Na
  Journal of Korean Medical Science.2014; 29(7): 934.     CrossRef
• Recent Advances in Molecular Imaging of Premalignant Gastrointestinal Lesions and Future Application for Early Detection of Barrett Esophagus
  Kwang Hyun Ko, Na Young Han, Chang Il Kwon, Hoo Keun Lee, Jong Min Park, Eun Hee Kim, Ki Baik Hahm
  Clinical Endoscopy.2014; 47(1): 7.     CrossRef
• Molecular Imaging for Theranostics in Gastroenterology: One Stone to Kill Two Birds
  Kwang Hyun Ko, Chang-Il Kown, Jong Min Park, Hoo Geun Lee, Na Young Han, Ki Baik Hahm
  Clinical Endoscopy.2014; 47(5): 383.     CrossRef
• Predictive proteomic biomarkers for inflammatory bowel disease-associated cancer: Where are we now in the era of the next generation proteomics?
  Jong-Min Park
  World Journal of Gastroenterology.2014; 20(37): 13466.     CrossRef