-
Immunohistochemical Expression of Epithelial-Mesenchymal Transition Markers in Early Gastric Cancer: Cancer Tissue versus Noncancer Tissue
-
Hee Jae Jung, Su Jin Hong, Shin Hee Kim
-
Clin Endosc 2019;52(5):464-471. Published online May 22, 2019
-
DOI: https://doi.org/10.5946/ce.2018.181
-
-
 Abstract
 PDF PubReader ePub
- Background
/Aims: Epithelial-mesenchymal transition (EMT) is a developmental process, wherein the epithelial cells show reduced intercellular adhesions and acquire migratory fibroblastic properties. EMT is associated with downregulation in epithelial marker expression, abnormal translocation of E-cadherin, and upregulation in mesenchymal marker expression. Here, we investigated the immunohistochemical (IHC) expression of EMT markers in early gastric cancer (EGC) between cancer and noncancer tissues.
Methods
Tissue samples were prospectively obtained from 19 patients with EGC that underwent endoscopic submucosal dissection (ESD). We compared the expression level of transforming growth factor (TGF)-β, vascular endothelial growth factor (VEGF), E-cadherin, α-smooth muscle actin (α-SMA), and vimentin between cancer and noncancer tissues using IHC. Among the 19 patients, 15 patients had follow-up biopsy at 3 months after ESD for EGC.
Results
Cancer tissues presented higher values of EMT mesenchymal markers (α-SMA/vimentin/TGF-β/VEGF) than the noncancerous tissues (p<0.05) that were significantly low after ESD (p<0.05). No significant correlation was reported for tumor location and initial Helicobacter pylori infection.
Conclusions
The mesenchymal expression of EMT markers was higher in the cancerous tissues than in the noncancer tissues.
-
Citations
Citations to this article as recorded by  - Gastric Carcinoma with low ROR alpha, low E- Cadherin and High LAPTM4B Immunohistochemical Profile; is associated with unfavorable prognosis in Egyptian patients
Shereen Nagib El Mashad, Mona Abd El Halim Kandil, Taysseer Abd El-Hamid Talab, Abd El Naby Saied Abd El Naby, Mervat Mahmoud Sultan, Ahmed Sohaib, Aiat Shaban Hemida
Journal of Immunoassay and Immunochemistry.2024; 45(1): 50. CrossRef - Hematological, histomorphological, and immunohistochemical diagnosis of bilateral testicular Sertoli cell tumor in a Mongrel dog: a case history
Samson Eneojo Abalaka, Zakariya Audu
Comparative Clinical Pathology.2024; 33(4): 511. CrossRef - MiR-522-3p Targets Transcription Factor 4 to Overcome Cisplatin Resistance of Gastric Cells
Guofeng Ma, Wen Xue, Jie Ni, Ran Tao, Xiangya Ding
Journal of Oncology.2022; 2022: 1. CrossRef - Investigating Helicobacter pylori-related pyloric hypomotility: functional, histological, and molecular alterations
Aya Aly Ashraf, Sarah Mahmoud Gamal, Hend Ashour, Basma Emad Aboulhoda, Laila Ahmed Rashed, Inas Anas Harb, Gaber Hassan Abdelfattah, Eman Ahmed El-Seidi, Heba Mohamed Shawky
American Journal of Physiology-Gastrointestinal and Liver Physiology.2021; 321(5): G461. CrossRef
-
5,990
View
-
162
Download
-
4
Web of Science
-
4
Crossref
|
KSGE
