-
Expression of MUC5AC and Trefoil Peptide 1 (TFF1) in the Subtypes of Intestinal Metaplasia
-
Joo-Yong Song, Byung-Wook Kim, Ah-Won Lee, Kyo-Young Lee, In-Sik Chung, Bo-In Lee, Hwang Choi, Jeong-Seon Ji, Hiun-Suk Chae, Kyu-Yong Choi
-
Clin Endosc 2012;45(2):151-154. Published online June 30, 2012
-
DOI: https://doi.org/10.5946/ce.2012.45.2.151
-
-
 Abstract
 PDF PubReader ePub
- Background/Aims
Alterations of the expression pattern of mucins and trefoil peptides have been described in gastric adenocarcinomas and in their precursor lesions. The aim of this study was to determine the progression patterns of intestinal metaplasia (IM) subtypes by analyzing the expression patterns of TFF1 and MUC5AC in different subtypes of IM of the stomach. MethodsEndoscopic gastric biopsies of the antrum and body were obtained from patients with dyspepsia and endoscopic IM. Alcian blue/periodic acid-Schiff staining and the high iron diamine technique were used to classify the subtypes of IM. Immunoreactivity for MUC5AC and TFF1 was estimated in different types of IM. ResultsIM was detected in 128 samples from 80 patients; type I was found in 48 samples, type II was found in 37 samples, and type III was found in 43 samples. There was a gradual decrease in MUC5AC and TFF1 expression during the progression of IM from type I to type III via the type II intermediate. ConclusionsThis downregulation of MUC5AC and TFF1 expression may challenge the sequential progression of IM from type I to type III via the type II intermediate, and it might be associated with gastric carcinogenesis.
-
Citations
Citations to this article as recorded by  - Early Immune Remodeling Steers Clinical Response to First-Line Chemoimmunotherapy in Advanced Gastric Cancer
Minae An, Arnav Mehta, Byung Hoon Min, You Jeong Heo, Samuel J. Wright, Milan Parikh, Lynn Bi, Hyuk Lee, Tae Jun Kim, Song-Yi Lee, Jeonghyeon Moon, Ryan J. Park, Matthew R. Strickland, Woong-Yang Park, Won Ki Kang, Kyoung-Mee Kim, Seung Tae Kim, Samuel J.
Cancer Discovery.2024; 14(5): 766. CrossRef - Expression of Trefoil Factor 1 (TFF1) in Cancer: A Tissue Microarray Study Involving 18,878 Tumors
Florian Lutz, Soo-Young Han, Seyma Büyücek, Katharina Möller, Florian Viehweger, Ria Schlichter, Anne Menz, Andreas M. Luebke, Ahmed Abdulwahab Bawahab, Viktor Reiswich, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Sören Weidemann, Maximilian Lennartz
Diagnostics.2024; 14(19): 2157. CrossRef - RNA Sequencing of Early-Stage Gastric Adenocarcinoma Reveals Multiple Activated Pathways and Novel Long Non-Coding RNAs in Patient Tissue Samples
Sadegh Fattahi, Novin Nikbakhsh, Hassan Taheri , Mohammad Ranaee, Haleh Akhavan-Niaki
Reports of Biochemistry and Molecular Biology.2021; 9(4): 478. CrossRef - Helicobacter pylori Infection and the Patterns of Gastric Mucin Expression in Children
Ana-Maria Teodora Domșa, Raluca Lupușoru, Dan Gheban, Alexandra Buruiană-Simic, Bogdan Alexandru Gheban, Camelia Lazăr, Cristina Maria Borzan
Journal of Clinical Medicine.2020; 9(12): 4030. CrossRef - Helicobacter pylori and cytokine gene variants as predictors of premalignant gastric lesions
Anca Negovan, Mihaela Iancu, Emőke Fülöp, Claudia Bănescu
World Journal of Gastroenterology.2019; 25(30): 4105. CrossRef - Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer
Ivonne Lozano-Pope, Arnika Sharma, Michael Matthias, Kelly S. Doran, Marygorret Obonyo
BMC Cancer.2017;[Epub] CrossRef - The changes in MUC5AC expression in gastric cancer before and after Helicobacter pylori eradication
Ding Shi, Xin-min Qiu, Xing-jun Yan
Clinics and Research in Hepatology and Gastroenterology.2014; 38(2): 235. CrossRef - Pathophysiology and Epidemiology of Intestinal Metaplasia
Joon Sung Kim, Byung-Wook Kim
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2013; 13(2): 73. CrossRef
-
6,011
View
-
46
Download
-
8
Crossref
|
KSGE
