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Alteration in gut microbiota after colonoscopy: proposed mechanisms and the role of probiotic interventions
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Hyeong Ho Jo, Moon Young Lee, Se Eun Ha, Dong Han Yeom, Yong Sung Kim
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Clin Endosc 2025;58(1):25-39. Published online September 2, 2024
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DOI: https://doi.org/10.5946/ce.2024.147
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Abstract
PDFPubReaderePub
- Colonoscopy, a widely used procedure for diagnosing and treating colonic diseases, induces transient gastrointestinal symptoms and alterations in the gut microbiota. This review comprehensively examines the evidence on alterations in the gut microbiota following colonoscopy and their possible mechanisms. Factors such as rapid colonic evacuation, increased osmolality, and mucus thinning caused by bowel preparation and exposure to oxygen during the procedure contribute to these alterations. Typically, the alterations revert to the baseline within a short time. However, their long-term implications remain unclear, necessitating further investigation. Split-dose bowel preparation and CO2 insufflation during the procedure result in fewer alterations in the gut microbiota. Probiotic administration immediately after colonoscopy shows promise in reducing alterations and gastrointestinal symptoms. However, the widespread use of probiotics remains controversial due to the transient nature of both the symptoms and gut microbial alterations following a colonoscopy. Probiotics may offer greater benefits to individuals with preexisting gastrointestinal symptoms. Thus, probiotic administration may be a viable option for selected patients.
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- Efficacy of Fecal Microbial Transplantation for Improving Symptoms of Irritable Bowel Syndrome - A Pilot Study for Voluntary Participants in Korea
Jung Won Lee, Nayoung Kim The Korean Journal of Gastroenterology.2024; 84(4): 168. CrossRef
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Value of Fecal Calprotectin Measurement During the Initial Period of Therapeutic Anti-Tubercular Trial
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Hyeong Ho Jo, Eun Young Kim, Jin Tae Jung, Joong Goo Kwon, Eun Soo Kim, Hyun Seok Lee, Yoo Jin Lee, Kyeong Ok Kim, Byung Ik Jang, the Crohn’s and Colitis Association in Daegu-Gyeongbuk
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Clin Endosc 2022;55(2):256-262. Published online November 5, 2021
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DOI: https://doi.org/10.5946/ce.2021.061
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Abstract
PDFPubReaderePub
- Background
/Aims: The diagnosis of intestinal tuberculosis (ITB) is often challenging. Therapeutic anti-tubercular trial (TATT) is sometimes used for the diagnosis of ITB. We aimed to evaluate the changing pattern of fecal calprotectin (FC) levels during TATT in patients with ITB.
Methods A retrospective review was performed on the data of 39 patients who underwent TATT between September 2015 and November 2018 in five university hospitals in Daegu, South Korea. The analysis was performed for 33 patients with serial FC measurement reports.
Results The mean age of the participants was 48.8 years. The final diagnosis of ITB was confirmed in 30 patients based on complete mucosal healing on follow-up colonoscopy performed after 2 months of TATT. Before starting TATT, the mean FC level of the ITB patients was 170.2 μg/g (range, 11.5-646.5). It dropped to 25.4 μg/g (range, 11.5-75.3) and then 23.3 μg/g (range, 11.5-172.2) after one and two months of TATT, respectively. The difference in mean FC before and one month after TATT was statistically significant (p<0.001), and FC levels decreased to below 100 μg/g in all patients after one month of TATT.
Conclusions All ITB patients showed FC decline after only 1 month of TATT, and this finding correlated with complete mucosal healing in the follow-up colonoscopy after 2 months of TATT.
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Citations
Citations to this article as recorded by
- Primary Gastric Tuberculosis in an Immunocompetent Patient: The Truth Lying beneath the Surface
Fábio Pereira Correia, Luísa Martins Figueiredo, Luís Carvalho Lourenço, Sofia Santos, Rita Theias Manso, David Horta GE - Portuguese Journal of Gastroenterology.2024; 31(3): 191. CrossRef - New diagnostic strategies to distinguish Crohn's disease and gastrointestinal tuberculosis
Himanshu Narang, Saurabh Kedia, Vineet Ahuja Current Opinion in Infectious Diseases.2024; 37(5): 392. CrossRef - Evidence-based approach to diagnosis and management of abdominal tuberculosis
Daya Krishna Jha, Mythili Menon Pathiyil, Vishal Sharma Indian Journal of Gastroenterology.2023; 42(1): 17. CrossRef - Fecal Calprotectin as a Surrogate Marker for Mucosal Healing After Initiating the Therapeutic Anti-Tubercular Trial
Satimai Aniwan Clinical Endoscopy.2022; 55(2): 210. CrossRef
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Endoscopic Management of Anastomotic Strictures after Liver Transplantation
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Dong Wook Lee, Hyeong Ho Jo, Juveria Abdullah, Michel Kahaleh
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Clin Endosc 2016;49(5):457-461. Published online September 30, 2016
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DOI: https://doi.org/10.5946/ce.2016.130
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Abstract
PDFPubReaderePub
- Endoscopic treatment of biliary strictures involving plastic stent placement has been used widely. The use of self-expandable metal stents (SEMSs) has been described for anastomotic strictures following liver transplantation (LT). This review aimed to assess and compare the efficacy of plastic stents with SEMS in LT patients. Information was retrieved regarding technical success, stricture resolution, the number of endoscopic retrograde cholangiography procedures, follow-up, immediate, and late complications. Eight studies involving plastic stents had a stricture resolution rate of 84.5%, with the rates ranging from 63% to 100%. These rates are comparable with the stricture resolution rate of 75% determined from six studies that involved 236 patients who received metal stents and the rates ranged from 53% to 81%. The observed success rate for metal stents used to manage post-LT anastomotic biliary strictures was below the reported rate for multiple plastic stents. Hence, the currently available metal stents should not be offered for the management of post-LT anastomotic biliary strictures.
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Citations
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- Less is more: The use of single biodegradable stenting to treat biliary anastomotic strictures in pediatric liver transplantation
Jesús Quintero Bernabeu, Javier Juamperez Goñi, Maria Mercadal Hally, Cristina Padrós Fornieles, Mauricio Larrarte King, José Andrés Molino Gahete, Anna Coma Muñoz, Iratxe Diez Miranda, Mercedes Pérez Lafuente, Ramon Charco Torra, Ernest Hidalgo Llompart Liver Transplantation.2024;[Epub] CrossRef - Long-Term Results of Endoscopic Metal Stenting for Biliary Anastomotic Stricture after Liver Transplantation
Aymeric Becq, Alexis Laurent, Quentin De Roux, Cristiano Cremone, Hugo Rotkopf, Yann Le Baleur, Farida Mesli, Christophe Duvoux, Aurélien Amiot, Charlotte Gagniere, Nicolas Mongardon, Julien Calderaro, Daniele Sommacale, Alain Luciani, Iradj Sobhani Journal of Clinical Medicine.2023; 12(4): 1453. CrossRef - Endoskopisches Management von Gallengangskomplikationen nach Leberchirurgie
Martha M. Kirstein, Torsten Voigtländer Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie.2022; 147(04): 398. CrossRef - Intraductal fully covered self-expanding metal stents in the management of post-liver transplant anastomotic strictures: a UK wide experience
Wafaa Ahmed, Dave Kyle, Amardeep Khanna, John Devlin, David Reffitt, Zeino Zeino, George Webster, Simon Phillpotts, Robert Gordon, Gareth Corbett, William Gelson, Manu Nayar, Haider Khan, Matthew Cramp, Jonathan Potts, Waleed Fateen, Hamish Miller, Bharat Therapeutic Advances in Gastroenterology.2022;[Epub] CrossRef - Incidents and risk factors of biliary complications after orthotropic liver transplantation
Samir Zeair, Robert Stasiuk, Labib Zair, Marta Wawrzynowicz-Syczewska, Anita Rybicka, Elżbieta Grochans, Arkadiusz Kazimierczak Medicine.2021; 100(34): e26994. CrossRef - Biliary complications in recipients of living donor liver transplantation: A single-centre study
Reginia Nabil Guirguis, Ehab Hasan Nashaat, Azza Emam Yassin, Wesam Ahmed Ibrahim, Shereen A Saleh, Mohamed Bahaa, Mahmoud El-Meteini, Mohamed Fathy, Hany Mansour Dabbous, Iman Fawzy Montasser, Manar Salah, Ghada Abdelrahman Mohamed World Journal of Hepatology.2021; 13(12): 2081. CrossRef - Management of Post-Transplant Anastomotic Stricture Using Self-Expandable Metal Stent
Dong Wook Lee, Kazuo Hara Clinical Endoscopy.2020; 53(3): 261. CrossRef - A unique type of fully covered metal stent for the management of post liver transplant biliary anastomotic strictures
Ben Warner, Phillip Harrison, Muhammad Farman, John Devlin, David Reffitt, Yasser El-Sherif, Shirin E. Khorsandi, Andreas Prachalias, Miriam Cortes Cerisuelo, Krish Menon, Wayel Jassem, Parthi Srinivasan, Hector Vilca-Melendez, Michael Heneghan, Nigel Hea BMC Gastroenterology.2020;[Epub] CrossRef - The first experience with the fully-covered self-expandable nitinol stents in the management of anastomotic biliary strictures after orthotopic liver transplantation
A. V. Shabunin, I. Yu. Korzheva, G. M. Chechenin, S. S. Lebedev, P. A. Drozdov, O. S. Zhuravel, S. A. Astapovich Almanac of Clinical Medicine.2020; 48(3): 171. CrossRef - Endoscopic Management of Biliary Issues in the Liver Transplant Patient
James F. Crismale, Jawad Ahmad Gastrointestinal Endoscopy Clinics of North America.2019; 29(2): 237. CrossRef - Endoscopic management of anastomotic stricture after living-donor liver transplantation
Dong Wook Lee, Jimin Han The Korean Journal of Internal Medicine.2019; 34(2): 261. CrossRef - Efficacy of Nasobiliary Tubes and Biliary Stents in Management of Patients with Bile Leak after Liver Transplantation: A Systematic Review
Ali Raza, Anam Omer, Sara Iqbal, Vineet Gudsoorkar, Pramoda Koduru, Kumar Krishnan Clinical Endoscopy.2019; 52(2): 159. CrossRef - Endoscopic management of biliary strictures post-liver transplantation
Ahmed Akhter, Patrick Pfau, Mark Benson, Anurag Soni, Deepak Gopal World Journal of Meta-Analysis.2019; 7(4): 120. CrossRef - Liver transplant–related anastomotic biliary strictures: a novel, rapid, safe, radiation-sparing, and cost-effective management approach
Monique T. Barakat, Robert J. Huang, Nirav C. Thosani, Abhishek Choudhary, Mohit Girotra, Subhas Banerjee Gastrointestinal Endoscopy.2018; 87(2): 501. CrossRef - Long‐term outcomes of early compared to late onset choledochocholedochal anastomotic strictures after orthotopic liver transplantation
Sanjaya K. Satapathy, Imran Sheikh, Bilal Ali, Fazal Yahya, Mehmet Kocak, Laxmi Babu Parsa, James D. Eason, Jason M. Vanatta, Satheesh P. Nair Clinical Transplantation.2017;[Epub] CrossRef - Challenges of Endoscopic Management of Pancreaticobiliary Complications in Surgically Altered Gastrointestinal Anatomy
Tin Moe Wai, Eun Young Kim Clinical Endoscopy.2016; 49(6): 502. CrossRef
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