Cronkhite-Canada syndrome (CCS) is a rare nonfamilial polyposis syndrome characterized by epithelial disturbances both in the gastrointestinal tract and in the epidermis. The pathologic finding of the polyp is usually a hamartomatous polyp of the juvenile type; however, the possibility of serrated adenoma associated malignant neoplasm was reported in some Japanese cases. Up till now in South Korea, 13 CCS cases have been reported, but there was no case accompanied by the colon cancer. We report the first case of CCS associated with malignant colon polyp and serrated adenoma in Korea. A 72-year-old male patient who complained of diarrhea and weight loss was presented with both hands and feet nail dystrophy, hyperpigmentation, and alopecia. Endoscopic examination showed numerous hamartomatous polyps from the stomach to the colon. The pathologic results confirmed colon cancer and serrated adenoma. Helicobacter pylori eradication and prednisolone was used. Thus, the authors report this case along with a literature review.

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• Differential Diagnoses and Management Approaches for Gastric Polyposis
  Masaya Iwamuro, Seiji Kawano, Motoyuki Otsuka
  Gastroenterology Insights.2024; 15(1): 122.     CrossRef
• Cronkhite-Canada Syndrome Presenting with life-threatening protein-losing enteropathy: a case report
  Tolga Olmez
  Medical Science Pulse.2023; 16(4): 1.     CrossRef
• Estimated Prevalence of Cronkhite-Canada Syndrome, Chronic Enteropathy Associated With SLCO2A1 Gene, and Intestinal Behçet’s Disease in Japan in 2017: A Nationwide Survey
  Mari S. Oba, Yoshitaka Murakami, Yuji Nishiwaki, Keiko Asakura, Satoko Ohfuji, Wakaba Fukushima, Yosikazu Nakamura, Yasuo Suzuki
  Journal of Epidemiology.2021; 31(2): 139.     CrossRef
• Gewichtsverlust, Diarrhöen und dystrophe Veränderungen der Fingernägel bei einem 80-jährigen Patienten
  Manuel Strohmeier
  Der Internist.2021; 62(1): 100.     CrossRef
• Successful surgical treatment of Cronkhite-Canada Syndrome with bilateral flail chest: a case report
  Guang-chao Lv, Zhi-hong Li, Zong-sheng Duan, Chun-bo Niu, Ming-he Li, Kai-zhong Wang, Jin-dong Jiang
  BMC Surgery.2020;[Epub]     CrossRef
• Cronkhite–Canada syndrome: from clinical features to treatment
  Ze-Yu Wu, Li-Xuan Sang, Bing Chang
  Gastroenterology Report.2020; 8(5): 333.     CrossRef
• Case of Cronkhite Canada Syndrome - A Non-Inherited Gastrointestinal Polyposis Syndrome
  Arun Solanki, Rajesh Bhurkunde
  Journal of Evolution of Medical and Dental Sciences.2019; 8(40): 3046.     CrossRef
• Cronkhite-Canada Syndrome Showing Good Early Response to Steroid Treatment
  Woohee Cho, Kwangwoo Nam, Ki Bae Bang, Hyun Deok Shin, Jeong Eun Shin
  The Korean Journal of Gastroenterology.2018; 71(4): 239.     CrossRef
• Cronkhite-Canada Syndrome Associated with Metastatic Colon Cancer
  Shirin Haghighi, Sima Noorali, Amir Houshang Mohammad Alizadeh
  Case Reports in Gastroenterology.2018; 12(1): 109.     CrossRef
• Compound traditional serrated adenoma and sessile serrated adenoma
  Carlos A Rubio, Åsa Edvardsson, Jan Björk, Anne Tuomisto, Timo Väisänen, Markus Mäkinen
  Journal of Clinical Pathology.2016; 69(8): 745.     CrossRef
• Cronkhite-Canada Syndrome: an unusual finding of gastro-intestinal adenomatous polyps in a syndrome characterized by hamartomatous polyps
  Christopher M. Flannery, John A. Lunn
  Gastroenterology Report.2015; 3(3): 254.     CrossRef
• Cases Report the Cronkhite-Canada Syndrome
  Yi Qun Yu, Peter James Whorwell, Lin Heng Wang, Jun Xiang Li, Qing Chang, Jie Meng
  Medicine.2015; 94(52): e2356.     CrossRef
• Cronkhite–Canada syndrome six decades on: the many faces of an enigmatic disease
  Tomas Slavik, Elizabeth Anne Montgomery
  Journal of Clinical Pathology.2014; 67(10): 891.     CrossRef
• A Case of Cronkhite-Canada Syndrome Showing Spontaneous Remission
  Dong-Uk Kang, Dong-Hoon Yang, Yunsik Choi, Ji-Beom Kim, Ho-Su Lee, Hyo Jeong Lee, Sang Hyoung Park, Kee Wook Jung, Kyung-Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Jin-Ho Kim
  Intestinal Research.2013; 11(4): 317.     CrossRef