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Rifampin-induced Pseudomembranous Colitis with Rectosigmoid Sparing
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Sun Young Yim, Ja Seol Koo, Ye Ji Kim, Sang Jung Park, Jin Nam Kim, Sung Woo Jung, Hyung Joon Yim, Sang Woo Lee, Jai Hyun Choi, Chang Duck Kim
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Clin Endosc 2011;44(2):137-139. Published online December 31, 2011
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DOI: https://doi.org/10.5946/ce.2011.44.2.137
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Abstract
PDFPubReaderePub
Pseudomembranous colitis (PMC) is known to be associated with antibiotic treatment, but is not commonly related to antitubercular (anti-TB) agent, rifampin. PMC is frequently localized to rectum and sigmoid colon, which can be diagnosed with sigmoidoscopy. We report a case of rifampin-induced PMC with rectosigmoid sparing in a pulmonary tuberculosis patient. An 81-year-old man using anti-TB agents was admitted with a 30-day history of severe diarrhea and general weakness. On colonoscopy, nonspecific findings such as mucosal edema and erosion were found in sigmoid colon, whereas multiple yellowish plaques were confined to cecal mucosa only. Biopsy specimen of the cecum was compatible with PMC. Metronidazole was started orally, and the anti-TB medications excluding rifampin were readministerred. His symptoms remarkably improved within a few days without recurrence. Awareness of rectosigmoid sparing PMC in patients who develop diarrhea during anti-TB treatment should encourage early total colonoscopy.
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Shadi Hamdeh, Dejan Micic, Stephen Hanauer Clinical Gastroenterology and Hepatology.2021; 19(9): 1759. CrossRef - Incidence and Clinical Outcomes of Clostridium difficile Infection after Treatment with Tuberculosis Medication
Yu Mi Lee, Kyu Chan Huh, Soon Man Yoon, Byung Ik Jang, Jeong Eun Shin, Hoon Sup Koo, Yunho Jung, Sae Hee Kim, Hee Seok Moon, Seung Woo Lee Gut and Liver.2016; 10(2): 250. CrossRef - A case of pseudomembranous colitis associated with antituberculosis therapy in a patient with tuberculous meningitis
Mi Jin Kim, Hye Won Jeong, Young Rak Choi Journal of Biomedical Research.2014; 15(1): 44. CrossRef - Emergence of Clostridium difficile infection in tuberculosis patients due to a highly rifampicin-resistant PCR ribotype 046 clone in Poland
P. Obuch-Woszczatyński, G. Dubiel, C. Harmanus, E. Kuijper, U. Duda, D. Wultańska, A. Belkum, H. Pituch European Journal of Clinical Microbiology & Infectious Diseases.2013; 32(8): 1027. CrossRef
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