Clinical Endoscopy

Masahiro Okada

5 Articles

Underwater Endoscopic Mucosal Resection without Submucosal Injection Facilitates En bloc Resection of Colon Adenomas Extending into a Diverticulum: Yoshikazu Hayashi, Masahiro Okada, Takaaki Morikawa, Tatsuma Nomura, Hisashi Fukuda, Takahito Takezawa, Alan Kawarai Lefor, Hironori Yamamoto; Clin Endosc 2021;54(3):436-440. Published online November 6, 2020; DOI: https://doi.org/10.5946/ce.2020.168

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Superficial colonic neoplasms sometimes extend into a diverticulum. Conventional endoscopic mucosal resection of these lesions is considered challenging because colonic diverticula do not have a muscularis propria and are deeply inverted. Even if the solution is carefully injected below the mucosa at the bottom of the diverticulum, the mucosa is rarely elevated from the diverticular orifice, and it is usually just narrowed. Although endoscopic submucosal dissection or full-thickness resection with an over-the-scope clip device enables the complete resection of these lesions, it is still challenging, time consuming and expensive. Underwater endoscopic mucosal resection without submucosal injection (UEMR) is an innovative technique enabling en bloc resection of superficial colon lesions. We report three patients with colon adenomas extending into a diverticulum treated with successful UEMR. UEMR enabled rapid and safe en bloc resection of colon lesions extending into a diverticulum.

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Underwater endoscopic mucosal resection for colorectal lesions: Can it be an “Underwater” revolution?
Yoji Takeuchi, Satoki Shichijo, Noriya Uedo, Ryu Ishihara
DEN Open.2022;[Epub] CrossRef

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Double-Balloon Endoscopy-Assisted Balloon Dilation of Strictures Secondary to Small-Intestinal Lymphoma: Shogo Magome, Hirotsugu Sakamoto, Satoshi Shinozaki, Masahiro Okada, Tomonori Yano, Keijiro Sunada, Alan Kawarai Lefor, Hironori Yamamoto; Clin Endosc 2020;53(1):101-105. Published online July 10, 2019; DOI: https://doi.org/10.5946/ce.2019.015

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Endoscopic Diagnosis of Small Bowel Tumor
Tomonori Yano, Hironori Yamamoto
Cancers.2024; 16(9): 1704. CrossRef
Primary Gastrointestinal Follicular Lymphoma Presenting With Bowel Stenosis
Hiroto Suzuki, Yasuhiko Hamada, Kyosuke Tanaka, Noriyuki Horiki, Hayato Nakagawa
Cureus.2022;[Epub] CrossRef
Small bowel lymphoma: clinical update and challenges for the gastroenterologist
Priya Oka, Reena Sidhu
Current Opinion in Gastroenterology.2022; 38(3): 270. CrossRef

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Blue Laser Imaging with a Small-Caliber Endoscope Facilitates Detection of Early Gastric Cancer: Haruo Takahashi, Yoshimasa Miura, Hiroyuki Osawa, Takahito Takezawa, Yuji Ino, Masahiro Okada, Alan Kawarai Lefor, Hironori Yamamoto; Clin Endosc 2019;52(3):273-277. Published online August 14, 2018; DOI: https://doi.org/10.5946/ce.2018.100

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Conventional endoscopy often misses early gastric cancers with minimal red discoloration because they cannot be distinguished from inflamed mucosa. We treated a patient with a small early gastric cancer that was difficult to diagnose using conventional endoscopy. Conventional endoscopy using a small-caliber endoscope showed only subtle red discoloration of the gastric mucosa. However, blue laser imaging showed a clearly discolored area measuring 10 mm in diameter around the red lesion, which was distinct from the surrounding inflamed mucosa. Irregular vessels on the tumor surface (suspicious for early gastric cancer) were observed even with small-caliber endoscopy. Biopsy revealed a well-moderately differentiated tubular adenocarcinoma, and endoscopic submucosal dissection was performed. Histopathological examination of the specimen confirmed well-moderately differentiated adenocarcinoma localized to the mucosa with slight depression compared to the surrounding mucosa, consistent with the endoscopic findings. This small early gastric cancer became clearly visible with blue laser imaging using small-caliber endoscopy.

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Diagnostic performance of blue laser imaging for early detection of gastric cancer: A systematic review and meta-analysis
Mohammed Rifat Shaik, Andrew Canakis, Nishat Anjum Shaik, Shivanand Bomman, Dushyant Singh Dahiya, Emily Gorman, Mohammad Bilal, Saurabh Chandan
Indian Journal of Gastroenterology.2024; 43(5): 976. CrossRef
Improved detection of early gastric cancer with linked color imaging using an ultrathin endoscope: a video-based analysis
Tsevelnorov Khurelbaatar, Yoshimasa Miura, Hiroyuki Osawa, Yuji Ino, Takahito Takezawa, Chihiro Iwashita, Yoshie Nomoto, Masato Tsunoda, Takashi Ueno, Haruo Takahashi, Manabu Nagayama, Hisashi Fukuda, Alan Kawarai Lefor, Hironori Yamamoto
Endoscopy International Open.2022; 10(05): E644. CrossRef
Current status of the gastric cancer screening program in Korea
Young-Il Kim, Il Ju Choi
Journal of the Korean Medical Association.2022; 65(5): 250. CrossRef
Current Evidence for a Paradigm Shift in Gastric Cancer Prevention From Endoscopic Screening toHelicobacter pyloriEradication in Korea
Young-Il Kim, Il Ju Choi
Journal of Gastric Cancer.2022; 22(3): 169. CrossRef
Clinical Features of False-Negative Early Gastric Cancers: A Retrospective Study of Endoscopic Submucosal Dissection Cases
Kohei Oka, Naoto Iwai, Takashi Okuda, Tasuku Hara, Yutaka Inada, Toshifumi Tsuji, Toshiyuki Komaki, Junichi Sakagami, Yuji Naito, Keizo Kagawa, Yoshito Itoh, Fabiana Zingone
Gastroenterology Research and Practice.2021; 2021: 1. CrossRef
Appropriate Color Enhancement Settings for Blue Laser Imaging Facilitates the Diagnosis of Early Gastric Cancer with High Color Contrast
Yuji Hiraoka, Yoshimasa Miura, Hiroyuki Osawa, Yoshie Nomoto, Haruo Takahashi, Masato Tsunoda, Manabu Nagayama, Takashi Ueno, Alan Kawarai Lefor, Hironori Yamamoto
Journal of Gastric Cancer.2021; 21(2): 142. CrossRef
Linked Color Imaging and Blue Laser Imaging for Upper Gastrointestinal Screening
Hiroyuki Osawa, Yoshimasa Miura, Takahito Takezawa, Yuji Ino, Tsevelnorov Khurelbaatar, Yuichi Sagara, Alan Kawarai Lefor, Hironori Yamamoto
Clinical Endoscopy.2018; 51(6): 513. CrossRef

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Laser Imaging Facilitates Early Detection of Synchronous Adenocarcinomas in Patients with Barrett’s Esophagus: Chihiro Iwashita, Yoshimasa Miura, Hiroyuki Osawa, Takahito Takezawa, Yuji Ino, Masahiro Okada, Alan K. Lefor, Hironori Yamamoto; Clin Endosc 2017;50(1):81-86. Published online May 9, 2016; DOI: https://doi.org/10.5946/ce.2016.027

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Barrett’s adenocarcinoma may occur in multiple sites, and recurrence and metachronous lesions are the major problems with endoscopic resection. Therefore, early detection of such lesions is ideal to achieve complete resection and obtain improved survival rates with minimally invasive treatment. Laser imaging systems allow multiple modalities of endoscopic imaging by using white light laser, flexible spectral imaging color enhancement (FICE), blue laser imaging (BLI), and linked color imaging even at a distant view. However, the usefulness of these modalities has not been sufficiently reported regarding Barrett’s adenocarcinoma. Here, we report on a patient with three synchronous lesions followed by one metachronous lesion in a long segment with changes of Barrett’s esophagus, all diagnosed with this new laser endoscopic imaging system and enhanced by using FICE and/or BLI with high contrast compared with the surrounding mucosa. Laser endoscopic imaging may facilitate the detection of malignancies in patients with early Barrett’s adenocarcinoma.

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Validation of simplified classification of magnifying endoscopy for diagnosis of Barrett's dysplasia with blue laser imaging
Tzu‐Haw Chen, Ro‐Ting Lin, Wen‐Lun Wang, Ching‐Tai Lee, Cheng‐Hao Tseng, Wen‐Hung Hsu, Wei‐Chen Tai, Hsiu‐Po Wang, Chi‐Yang Chang
Advances in Digestive Medicine.2022; 9(1): 10. CrossRef
Opciones terapéuticas en el tratamiento del cáncer precoz de la unión esofagogástrica
Félix Junquera, Sonia Fernández-Ananín, Carmen Balagué
Cirugía Española.2019; 97(8): 438. CrossRef
Blue Laser Imaging with a Small-Caliber Endoscope Facilitates Detection of Early Gastric Cancer
Haruo Takahashi, Yoshimasa Miura, Hiroyuki Osawa, Takahito Takezawa, Yuji Ino, Masahiro Okada, Alan Kawarai Lefor, Hironori Yamamoto
Clinical Endoscopy.2019; 52(3): 273. CrossRef
Therapeutic Options for Early Cancer of the Esophagogastric Junction
Félix Junquera, Sonia Fernández-Ananín, Carmen Balagué
Cirugía Española (English Edition).2019; 97(8): 438. CrossRef
How to get the most out of costly Barrett’s oesophagus surveillance
Barbara Braden, Evonne Jones-Morris
Digestive and Liver Disease.2018; 50(9): 871. CrossRef
Linked Color Imaging and Blue Laser Imaging for Upper Gastrointestinal Screening
Hiroyuki Osawa, Yoshimasa Miura, Takahito Takezawa, Yuji Ino, Tsevelnorov Khurelbaatar, Yuichi Sagara, Alan Kawarai Lefor, Hironori Yamamoto
Clinical Endoscopy.2018; 51(6): 513. CrossRef
Image assessment of Barrett’s esophagus using the simplified narrow band imaging classification
Masayuki Kato, Kenichi Goda, Yuichi Shimizu, Akira Dobashi, Masakazu Takahashi, Masahiro Ikegami, Tadakazu Shimoda, Mototsugu Kato, Prateek Sharma
Journal of Gastroenterology.2017; 52(4): 466. CrossRef
Animal experimental studies using small intestine endoscope
Jin-Hua Liu, Dan-Yang Liu, Li Wang, Li-Ping Han, Zhe-Yu Qi, Hai-Jun Ren, Yan Feng, Feng-Ming Luan, Liang-Tian Mi, Shu-Mei Shan
World Journal of Gastroenterology.2017; 23(20): 3684. CrossRef

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Laterally Spreading Tumor of the Rectum Delineated with Linked Color Imaging Technology: Masahiro Okada, Hirotsugu Sakamoto, Takahito Takezawa, Yoshikazu Hayashi, Keijiro Sunada, Alan K. Lefor, Hironori Yamamoto; Clin Endosc 2016;49(2):207-208. Published online February 12, 2016; DOI: https://doi.org/10.5946/ce.2015.077

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Practical utility of linked color imaging in colonoscopy: Updated literature review
Fumiaki Ishibashi, Sho Suzuki
Digestive Endoscopy.2024;[Epub] CrossRef
The Past, Present and Future of Imaging Enhanced Endoscopy in Colon Tumor
Kyueng-Whan Min, One-Zoong Kim
Journal of Digestive Cancer Research.2024; 12(2): 90. CrossRef
Linked color imaging and upper gastrointestinal neoplasia
Shoko Ono, Masaki Inoue, Masayuki Higashino, Shuhei Hayasaka, Shugo Tanaka, Hiroki Egami, Naoya Sakamoto
Digestive Endoscopy.2024;[Epub] CrossRef
Linked color imaging improves the diagnostic accuracy of eosinophilic esophagitis
Yasuhiko Abe, Yu Sasaki, Makoto Yagi, Naoko Mizumoto, Yusuke Onozato, Takashi Kon, Masakuni Shoji, Kazuhiro Sakuta, Takayuki Sakai, Matsuki Umehara, Minami Ito, Shuhei Nakamura, Hidemoto Tsuchida, Yoshiyuki Ueno
DEN Open.2023;[Epub] CrossRef
Improvement of detection sensitivity of upper gastrointestinal epithelial neoplasia in linked color imaging based on data of eye tracking
Masayuki Higashino, Shoko Ono, Shogo Matsumoto, Marina Kubo, Naohiro Yasuura, Shuhei Hayasaka, Ikko Tanaka, Yoshihiko Shimoda, Yusuke Nishimura, Masayoshi Ono, Keiko Yamamoto, Yuji Ono, Naoya Sakamoto
Journal of Gastroenterology and Hepatology.2023; 38(5): 710. CrossRef
Efficacy of image-enhanced endoscopy for colorectal adenoma detection: A multicenter, randomized trial
Zhi-Peng Qi, En-Pan Xu, Dong-Li He, Yan Wang, Bai-Sheng Chen, Xue-Si Dong, Qiang Shi, Shi-Lun Cai, Qi Guo, Ni Li, Xing Li, Hai-Yan Huang, Bing Li, Di Sun, Jian-Guang Xu, Zhang-Han Chen, Ayimukedisi Yalikong, Jin-Yi Liu, Zhen-Tao Lv, Jian-Min Xu, Ping-Hong
World Journal of Gastrointestinal Oncology.2023; 15(5): 878. CrossRef
Using the string‐clip method to retrieve the resected specimen allowed a clear observation of the colon and detection of a new lesion
Xinghua Ma, Kazumasa Kawashima, Yutaka Saito
Digestive Endoscopy.2022;[Epub] CrossRef
Linked color imaging improves identification of early gastric cancer lesions by expert and non-expert endoscopists
Kiki Fockens, Jeroen de Groof, Joost van der Putten, Tsevelnorov Khurelbaatar, Hisashi Fukuda, Takahito Takezawa, Yoshimasa Miura, Hiroyuki Osawa, Hironori Yamamoto, Jacques Bergman
Surgical Endoscopy.2022; 36(11): 8316. CrossRef
Diagnostic accuracy of linked colour imaging versus white light imaging for early gastric cancers: a prospective, multicentre, randomized controlled trial study
Min Min, Xiaotian Sun, Jianying Bai, Qinsheng Zhang, Xiaocui Yang, Qiang Guo, Rong Wang, Bangmao Wang, Zhiwu Lv, Jie Pan, Chunmeng Jiang, Duanmin Hu, Bing Nong, Enqiang Linghu, Yan Liu
Annals of Medicine.2022; 54(1): 3305. CrossRef
A case of Cronkhite–Canada syndrome with repeated linked color imaging observation of the subepithelial capillary network in the colon
Yayoi Matsumoto, Fumikazu Koyama, Kohei Morita, Hiroyuki Kuge, Shinsaku Obara, Yosuke Iwasa, Takeshi Takei, Tomomi Sadamitsu, Chiho Ohbayashi, Masayuki Sho
Clinical Journal of Gastroenterology.2022; 15(5): 934. CrossRef
Linked color imaging improves visibility of colorectal serrated lesion by high color contrast to surrounding mucosa
Takashi Murakami, Eiji Kamba, Kei Nomura, Taro Kurosawa, Keiichi Haga, Hirofumi Fukushima, Tsutomu Takeda, Tomoyoshi Shibuya, Takashi Yao, Akihito Nagahara
Digestive Endoscopy.2022; 34(7): 1422. CrossRef
Using texture and colour enhancement imaging to evaluate gastrointestinal diseases in clinical practice: a review
Mitsushige Sugimoto, Yohei Koyama, Takao Itoi, Takashi Kawai
Annals of Medicine.2022; 54(1): 3314. CrossRef
Gastric intestinal metaplasia assessment between linked color imaging based on endoscopy and pathology
Guanpo Zhang, Jin Zheng, Linfu Zheng, Shentong Yu, Chuanshen Jiang, Wulian Lin, Dazhou Li, Lijuan Qu, Wen Wang
Scandinavian Journal of Gastroenterology.2021; 56(1): 103. CrossRef
Optical effect of spraying l-menthol on gastric intestinal metaplasia visualized by linked color imaging
Shoko Ono, Yoshihiko Shimoda, Ikko Tanaka, Sayoko Kinowaki, Masaki Inoue, Masayoshi Ono, Keiko Yamamoto, Yuichi Shimizu, Naoya Sakamoto
European Journal of Gastroenterology & Hepatology.2021; 33(3): 358. CrossRef
Linked colour imaging versus white‐light colonoscopy for the detection of flat colorectal lesions: A randomized controlled trial
Takahiro Kudo, Akira Horiuchi, Reiko Kyodo, Ichitaro Horiuchi, Nobuyasu Arai, Masashi Kajiyama, Naoki Tanaka
Colorectal Disease.2021; 23(6): 1414. CrossRef
Application of linked color imaging in the diagnosis of early gastrointestinal neoplasms and precancerous lesions: a review
Shanshan Wang, Lei Shen, Hesheng Luo
Therapeutic Advances in Gastroenterology.2021;[Epub] CrossRef
Linked-color Imaging May Help Improve the Visibility of Superficial Barrett's Esophageal Adenocarcinoma by Increasing the Color Difference
Masahiro Saito, Tomoyuki Koike, Yuki Ohara, Kenichiro Nakagawa, Takeshi Kanno, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune
Internal Medicine.2021; 60(21): 3351. CrossRef
Colon polyp detection using linked color imaging compared to white light imaging: Systematic review and meta‐analysis
Satoshi Shinozaki, Yasutoshi Kobayashi, Yoshikazu Hayashi, Hirotsugu Sakamoto, Keijiro Sunada, Alan Kawarai Lefor, Hironori Yamamoto
Digestive Endoscopy.2020; 32(6): 874. CrossRef
Significance of Linked Color Imaging for Predicting the Risk of Clinical Relapse in Ulcerative Colitis
Shuji Kanmura, Akihito Tanaka, Kazuki Yutsudou, Kosuke Kuwazuru, Fukiko Komaki, Yuga Komaki, Hiromichi Iwaya, Shiho Arima, Fumisato Sasaki, Shiroh Tanoue, Shinichi Hashimoto, Akio Ido
Gastroenterology Research and Practice.2020; 2020: 1. CrossRef
Linked color imaging can enhance recognition of early gastric cancer by high color contrast to surrounding gastric intestinal metaplasia
Hisashi Fukuda, Yoshimasa Miura, Hiroyuki Osawa, Takahito Takezawa, Yuji Ino, Masahiro Okada, Tsevelnorov Khurelbaatar, Alan Kawarai Lefor, Hironori Yamamoto
Journal of Gastroenterology.2019; 54(5): 396. CrossRef
Advanced Treatment and Imaging in Colonoscopy: The Pocket-Creation Method for Complete Resection and Linked Color Imaging for Better Detection of Early Neoplastic Lesions by Colonoscopy
Hironori Yamamoto, Satoshi Shinozaki, Yoshikazu Hayashi, Yoshimasa Miura, Tsevelnorov Khurelbaatar, Hiroyuki Osawa, Alan Kawarai Lefor
Clinical Endoscopy.2019; 52(2): 107. CrossRef
Objective evaluation of the visibility of colorectal lesions using eye tracking
Kana Kumahara, Hiroaki Ikematsu, Kensuke Shinmura, Tatsuro Murano, Atsushi Inaba, Kei Okumura, Keiichiro Nishihara, Hironori Sunakawa, Yasuaki Furue, Renma Ito, Daiki Sato, Tatsunori Minamide, Naoki Okamoto, Yoichi Yamamoto, Masayuki Suyama, Kenji Takashi
Digestive Endoscopy.2019; 31(5): 552. CrossRef
Blue Laser Imaging with a Small-Caliber Endoscope Facilitates Detection of Early Gastric Cancer
Haruo Takahashi, Yoshimasa Miura, Hiroyuki Osawa, Takahito Takezawa, Yuji Ino, Masahiro Okada, Alan Kawarai Lefor, Hironori Yamamoto
Clinical Endoscopy.2019; 52(3): 273. CrossRef
Linked color imaging for the detection of early gastrointestinal neoplasms
Satoshi Shinozaki, Hiroyuki Osawa, Yoshikazu Hayashi, Alan Kawarai Lefor, Hironori Yamamoto
Therapeutic Advances in Gastroenterology.2019;[Epub] CrossRef
Evaluation of the impact of linked color imaging for improving the visibility of colonic polyp
Yasuyoshi Tanaka, Takuya Inoue, Kazuki Kakimoto, Kei Nakazawa, Hideki Tawa, Yuki Hirata, Toshihiko Okada, Sadaharu Nouda, Ken Kawakami, Toshihisa Takeuchi, Yutaro Egashira, Kazuhide Higuchi
Oncology Letters.2019;[Epub] CrossRef
Linked color imaging improves detection of minimal change esophagitis in non-erosive reflux esophagitis patients
Pei Deng, Min Min, Tenghui Dong, Yiliang Bi, Airong Tang, Yan Liu
Endoscopy International Open.2018; 06(10): E1177. CrossRef
Linked color imaging enhances gastric cancer in gastric intestinal metaplasia
Shoko Ono, Satoshi Abiko, Mototsugu Kato
Digestive Endoscopy.2017; 29(2): 230. CrossRef
Flexible Gastro-intestinal Endoscopy — Clinical Challenges and Technical Achievements
Niehls Kurniawan, Martin Keuchel
Computational and Structural Biotechnology Journal.2017; 15: 168. CrossRef
Comparison of linked color imaging and white-light colonoscopy for detection of colorectal polyps: a multicenter, randomized, crossover trial
Min Min, Pei Deng, Wenhua Zhang, Xiaomin Sun, Yan Liu, Bing Nong
Gastrointestinal Endoscopy.2017; 86(4): 724. CrossRef
Linked colour imaging benefits the endoscopic diagnosis of distal gastric diseases
Xiaotian Sun, Yiliang Bi, Tenghui Dong, Min Min, Wei Shen, Yang Xu, Yan Liu
Scientific Reports.2017;[Epub] CrossRef
Image-enhanced endoscopy: How far do we need to go?
Hazem Hammad, Tonya Kaltenbach, Roy Soetikno
Gastrointestinal Endoscopy.2017; 86(4): 698. CrossRef
Objective Endoscopic Analysis with Linked Color Imaging regarding Gastric Mucosal Atrophy: A Pilot Study
Kazuhiro Mizukami, Ryo Ogawa, Kazuhisa Okamoto, Mitsutaka Shuto, Kensuke Fukuda, Akira Sonoda, Osamu Matsunari, Yuka Hirashita, Tadayoshi Okimoto, Masaaki Kodama, Kazunari Murakami
Gastroenterology Research and Practice.2017; 2017: 1. CrossRef
3) Progress in Endoscopy
Hironori Yamamoto
Nihon Naika Gakkai Zasshi.2017; 106(9): 1796. CrossRef
Endoscopic Submucosal Dissection of a Rectal Neuroendocrine Tumor Using Linked Color Imaging Technique
Xiao-Tian Sun, Min Min, Yi-Liang Bi, Yang Xu, Yan Liu
Chinese Medical Journal.2017; 130(9): 1127. CrossRef
Linked color imaging application for improving the endoscopic diagnosis accuracy: a pilot study
Xiaotian Sun, Tenghui Dong, Yiliang Bi, Min Min, Wei Shen, Yang Xu, Yan Liu
Scientific Reports.2016;[Epub] CrossRef
Linked color imaging technology facilitates early detection of flat gastric cancers
Hisashi Fukuda, Yoshimasa Miura, Yoshikazu Hayashi, Takahito Takezawa, Yuji Ino, Masahiro Okada, Hiroyuki Osawa, Alan K. Lefor, Hironori Yamamoto
Clinical Journal of Gastroenterology.2015; 8(6): 385. CrossRef

9,243 View
156 Download
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