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Mi Ae Song 1 Article
Endoscopic Characteristics of Rugal Hyperplasia and Related Acid Condition in Helicobacter pylori-Infected Stomach
Byung Chul Kim, Mi Ae Song, Sung Ho Kwon
Clin Endosc 2021;54(1):73-84.   Published online December 15, 2020
AbstractAbstract PDFPubReaderePub
/Aims: Rugal hyperplastic gastritis (RHG) is associated with Lauren’s diffuse-type gastric cancer (GC) and the accompanying active inflammation is linked to gastric hypoacidity. We tried to establish the steps for identifying high-risk GC patients.
We included 196 patients with confirmed Helicobacter pylori infection by rapid urease test during screening endoscopy for health check-up from January 2016 to September 2016; all patients underwent blood tests for pepsinogen I and II and fasting serum gastrin. We compared RHG findings with various other endoscopic mucosal images. We also evaluated the relationships between RHG and other mucosal aspects for a given acid status based on serological markers.
Hypoacid and ultra-low-acid (67%) statuses were dominant, with only 18% hyperacid patients. RHG with high acid was related to a less atrophic body type (p=0.001), and RHG with ultra-low acid was associated with body xanthoma (p=0.029) and increased serum gastrin level (p=0.038). However, RHG’s influence on gastric acidity was only seen in closed-type endoscopic atrophic border (EAB), not in open type (p=0.001).
The majority of RHG patients had hypoacid status. RHG frequency showed no difference between closed and opentype EAB, but gastric acidity was influenced by RHG only in closed-type EAB.


Citations to this article as recorded by  
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  • Risk factors for early gastric cancer: focus on Helicobacter pylori gastritis
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    Journal of the Korean Medical Association.2022; 65(5): 259.     CrossRef
  • Giant Rugae in Helicobacter pylori-Infected Stomachs
    Sun-Young Lee
    Clinical Endoscopy.2021; 54(1): 1.     CrossRef
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