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Michael Albosta 1 Article
Radiation Proctitis and Management Strategies
Dushyant Singh Dahiya, Asim Kichloo, Faiz Tuma, Michael Albosta, Farah Wani
Clin Endosc 2022;55(1):22-32.   Published online November 18, 2021
DOI: https://doi.org/10.5946/ce.2020.288
AbstractAbstract PDFPubReaderePub
Radiotherapy (RT) is a treatment modality that uses high-energy rays or radioactive agents to generate ionizing radiation against rapidly dividing cells. The main objective of using radiation in cancer therapy is to impair or halt the division of the tumor cells. Over the past few decades, advancements in technology, the introduction of newer methods of RT, and a better understanding of the pathophysiology of cancers have enabled physicians to deliver doses of radiation that match the exact dimensions of the tumor for greater efficacy, with minimal exposure of the surrounding tissues. However, RT has numerous complications, the most common being radiation proctitis (RP). It is characterized by damage to the rectal epithelium by secondary ionizing radiation. Based on the onset of signs and symptoms, post-radiotherapy RP can be classified as acute or chronic, each with varying levels of severity and complication rates. The treatment options available for RP are limited, with most of the data on treatment available from case reports or small studies. Here, we describe the types of RT used in modern-day medicine and radiation-mediated tissue injury. We have primarily focused on the classification, epidemiology, pathogenesis, clinical features, treatment strategies, complications, and prognosis of RP.

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  • Management of gastrointestinal bleed in the intensive care setting, an updated literature review
    Vignesh K Nagesh, Sai Priyanka Pulipaka, Ruchi Bhuju, Emelyn Martinez, Shruthi Badam, Gomathy Aarthy Nageswaran, Hadrian Hoang-Vu Tran, Daniel Elias, Charlene Mansour, Jaber Musalli, Sanket Bhattarai, Lokeash Subramani Shobana, Tannishtha Sethi, Ritvik Se
    World Journal of Critical Care Medicine.2025;[Epub]     CrossRef
  • Delta-radiomics analysis based on magnetic resonance imaging to identify radiation proctitis in patients with cervical cancer after radiotherapy
    Jing Xue, Menghan Wu, Jing Zhang, Jiayang Yang, Guannan Lv, Baojun Qu, Yanping Zhang, Xia Yan, Jianbo Song
    Frontiers in Oncology.2025;[Epub]     CrossRef
  • A novel antioxidant and anti-inflammatory carboxymethylcellulose/chitosan hydrogel loaded with cannabidiol promotes the healing of radiation-combined wound skin injury in the 60Co γ-irradiated mice
    Wei Zhou, Long Zhu, Xiaoran Zu, Yaolei Ma, Pan Shen, Yangyi Hu, Pengfei Zhang, Zhexin Ni, Ningning Wang, Dezhi Sun, Zhijie Bai, Xiang Gao, Chaoji Huangfu, Yue Gao
    Phytomedicine.2025; 142: 156790.     CrossRef
  • Concurrent rectal perforation and obstruction following neoadjuvant chemoradiation for locally advanced rectal cancer: A case report
    Tahmineh Tahouri, Sahand Hedayati Omami, Maryam Hosseini, Ehsanollah Rahimi-Movaghar
    International Journal of Surgery Case Reports.2024; 116: 109337.     CrossRef
  • Endoscopic resection of residual rectal neoplasia after definitive chemoradiotherapy for rectal cancer
    Robert Klimkowski, Jakub Krzyzkowiak, Nastazja Dagny Pilonis, Krzysztof Bujko, Michal F. Kaminski
    Best Practice & Research Clinical Gastroenterology.2024; 68: 101896.     CrossRef
  • Radiation injuries of organs and tissues: mechanisms of occurrence, methods of prevention and treatment: A review
    Daiana A. Balaeva, Denis S. Romanov, Oxana P. Trofimova, Zarina Z. Gadzhibabaeva, Yury Yu. Gorchak, Garia A. Gariaev
    Journal of Modern Oncology.2024; 25(4): 504.     CrossRef
  • Interventions for Managing Late Gastrointestinal Symptoms Following Pelvic Radiotherapy: a Systematic Review and Meta-analysis
    H. Berntsson, A. Thien, D. Hind, L. Stewart, M. Mahzabin, W.S. Tung, M. Bradburn, M. Kurien
    Clinical Oncology.2024; 36(5): 318.     CrossRef
  • Intestinal microecological transplantation for a patient with chronic radiation enteritis: A case report
    Lin Wang, Yan Li, Yu-Jing Zhang, Li-Hua Peng
    World Journal of Gastroenterology.2024; 30(19): 2603.     CrossRef
  • Intrarectal formalin treatment for haemorrhagic radiation‐induced proctopathy: efficacy and safety
    Darina Kohoutova, Ana Wilson, Caroline Gee, Ramy Elhusseiny, Linda Wanders, David Cunningham
    Colorectal Disease.2024; 26(5): 932.     CrossRef
  • Emodin ameliorates acute radiation proctitis in mice by regulating AKT/MAPK/NF-κB/VEGF pathways
    Jinsheng Gao, Yousong Li, Jiaohua Chen, Wen Feng, Jianchen Bu, Zixuan Lu, Jiandong Wang
    International Immunopharmacology.2024; 132: 111945.     CrossRef
  • Protocolo diagnóstico de la rectitis (proctitis)
    C. Iniesta Cavero, L. Menchén-Viso
    Medicine - Programa de Formación Médica Continuada Acreditado.2024; 14(8): 468.     CrossRef
  • Feel the Burn: RFA for Chronic Radiation Proctitis
    Gabriele De Sena, Federico Maria Mongardini, Danilo Porpora, Maria Mauro, Davide Bentivoglio, Davide Centore, Luigi Brusciano, Claudio Gambardella, Augusto Lauro, Ludovico Docimo, Vincenzo Napolitano
    Digestive Diseases and Sciences.2024; 69(9): 3147.     CrossRef
  • Pelvic Radiation Therapy Increases Risk of Pouch Failure in Patients with Inflammatory Bowel Disease and Ileal Pouch
    Karthik Gnanapandithan, Laura G. Stuessel, Bo Shen, Fadi H. Mourad, Zhongwei Peng, Francis A. Farraye, Jana G. Hashash
    Digestive Diseases and Sciences.2024; 69(9): 3392.     CrossRef
  • Acute toxicity patterns and their management after moderate and ultra- hypofractionated radiotherapy for prostate cancer: A prospective cohort study
    F. Sinzabakira, L. Incrocci, K. de Vries, M.E.M.C. Christianen, M. Franckena, F.E. Froklage, H. Westerveld, W.D. Heemsbergen
    Clinical and Translational Radiation Oncology.2024; 48: 100842.     CrossRef
  • Prevention and management of radiotherapy-related toxicities in gynecological malignancies. Position paper on behalf of AIRO (Italian Association of Radiotherapy and Clinical Oncology)
    Elisabetta Perrucci, Gabriella Macchia, Annamaria Cerrotta, Angela Damiana Andrulli, Rosa Autorino, Amelia Barcellini, Maura Campitelli, Giulia Corrao, Sara Costantini, Vitaliana De Sanctis, Jacopo Di Muzio, Valeria Epifani, Patrizia Ferrazza, Andrei Fodo
    La radiologia medica.2024; 129(9): 1329.     CrossRef
  • Radiation-Induced Intestinal Injury: Molecular Mechanisms and Therapeutic Status
    Dandan Gao, Heng Zhang, Wanjun Sun, Huaqing Wang, Hui Wang
    DNA and Cell Biology.2024; 43(11): 537.     CrossRef
  • Preventive efficacy of hydrocortisone enema for radiation proctitis in rectal cancer patients undergoing short-course radiotherapy: a phase II randomized placebo-controlled clinical trial
    Mohammad Mohammadianpanah, Maryam Tazang, Nam Phong Nguyen, Niloofar Ahmadloo, Shapour Omidvari, Ahmad Mosalaei, Mansour Ansari, Hamid Nasrollahi, Behnam Kadkhodaei, Nezhat Khanjani, Seyed Vahid Hosseini
    Annals of Coloproctology.2024; 40(5): 506.     CrossRef
  • Utility of Endoscopic Full-Thickness Resection for Refractory Rectal Bleeding in Chronic Radiation Proctitis
    Benjamin I. Richter, Yazan Abboud, Ben Flikshteyn, Kaveh Hajifathalian
    ACG Case Reports Journal.2024; 11(11): e01556.     CrossRef
  • Navigating the Complexities of Radiation Injuries: Therapeutic Principles and Reconstructive Strategies
    Andreea Grosu-Bularda, Flavia-Francesca Lita, Florin-Vlad Hodea, Eliza-Maria Bordeanu-Diaconescu, Andrei Cretu, Catalina-Stefania Dumitru, Stefan Cacior, Bogdan-Mihai Marinescu, Ioan Lascar, Cristian-Sorin Hariga
    Journal of Personalized Medicine.2024; 14(11): 1100.     CrossRef
  • Management of radiation-induced proctitis using submucosal endoscopic injections of autologous adipose-derived stromal vascular fraction: a case report
    A. V. Smirnov, V. I. Sychev, S. M. Kuznetsova, V. A. Kalsin, V. S. Vasilyev, Yu. V. Ivanov, V. R. Stankevich, D. V. Sazonov, F. G. Zabozlaev, M. A. Konoplyannikov, V. P. Baklaushev, A. V. Troitsky
    Stem Cell Research & Therapy.2024;[Epub]     CrossRef
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    Journal für Gastroenterologische und Hepatologische Erkrankungen.2024; 22(4): 108.     CrossRef
  • ARGONOPLASMIC COAGULATION IN THE TREATMENT OF CHRONIC RADIATION PROCTITIS COMPLICATED BY BLEEDING
    V. A. Koltsov, I. M. Musinov, I. R. Alieva
    Bulletin of Pirogov National Medical & Surgical Center.2024; 19(4): 58.     CrossRef
  • Administration of modified Gegen Qinlian decoction for hemorrhagic chronic radiation proctitis: A case report and review of literature
    Shao-Yong Liu, Liu-Ling Hu, Shi-Jun Wang, Zhong-Li Liao
    World Journal of Clinical Cases.2023; 11(5): 1129.     CrossRef
  • A Retrospective Single-Arm Cohort Study in a Single Center of Radiofrequency Ablation in Treatment of Chronic Radiation Proctitis
    Chien-En Tang, Kung-Chuan Cheng, Kuen-Lin Wu, Hong-Hwa Chen, Ko-Chao Lee
    Life.2023; 13(2): 566.     CrossRef
  • Survivorship in Early-Stage Rectal Cancer Patients Who Have Received Combined Modality Therapy
    Saboor E. Randhawa, Laura Tenner
    Clinical Colorectal Cancer.2023; 22(4): 375.     CrossRef
  • A Systematic Review of Population-Based Studies of Chronic Bowel Symptoms in Cancer Survivors following Pelvic Radiotherapy
    Adam Biran, Iakov Bolnykh, Ben Rimmer, Anthony Cunliffe, Lisa Durrant, John Hancock, Helen Ludlow, Ian Pedley, Colin Rees, Linda Sharp
    Cancers.2023; 15(16): 4037.     CrossRef
  • The effectiveness of hyperbaric oxygen therapy for managing radiation-induced proctitis – results of a 10-year retrospective cohort study
    António Moreira Monteiro, Diogo Alpuim Costa, Virgínia Mareco, Carla Espiney Amaro
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Chinese clinical practice guidelines for the prevention and treatment of radiation‐induced rectal injury
    Hui Zhang, Zhen Zhang, Shuanghu Yuan
    Precision Radiation Oncology.2023; 7(4): 237.     CrossRef
  • Progress in multidisciplinary treatment of hemorrhagic radiation proctitis
    Qiulian Li, Guangjie Liao
    Annals of Oncology Research and Therapy.2022; 2(1): 10.     CrossRef
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