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Michelle Kang Kim 3 Articles
The Role of Endoscopy in Small Bowel Neuroendocrine Tumors
Ji Yoon Yoon, Nikhil A. Kumta, Michelle Kang Kim
Clin Endosc 2021;54(6):818-824.   Published online April 1, 2021
DOI: https://doi.org/10.5946/ce.2020.296
AbstractAbstract PDFPubReaderePub
Small bowel neuroendocrine tumors (NETs) represent approximately one-third of NETs of the gastrointestinal tract, and their incidence is increasing. When determining if endoscopic resection is appropriate, endoscopic ultrasound is used to assess the lesion size and depth of invasion for duodenal NETs. A number of techniques, including endoscopic mucosal resection (EMR), band-assisted EMR (band-EMR), endoscopic submucosal dissection (ESD), and over-the-scope clip-assisted endoscopic full-thickness resection (EFTR), have been studied; however, the best technique for endoscopic resection remains unclear. The vast majority of currently available data are retrospective, and prospective studies with longer follow-up times are required. For jejunal and ileal NETs, endoscopic techniques such as video capsule endoscopy (VCE) and balloon enteroscopy (BE) assist in diagnosis. This includes localization of the primary NET in metastatic disease where initial workup has been negative, and the identification of multifocal disease, which may change management and prognostication.

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  • Small Bowel Neuroendocrine Neoplasms—A Review
    Sai Swarupa Vulasala, Mayur Virarkar, Dheeraj Gopireddy, Rebecca Waters, Ahmad Alkhasawneh, Ziad Awad, Jessica Maxwell, Nisha Ramani, Sindhu Kumar, Nirmal Onteddu, Ajaykumar C. Morani
    Journal of Computer Assisted Tomography.2024; 48(4): 563.     CrossRef
  • Performance of capsule endoscopy for the detection of small intestinal neuroendocrine tumors in familial carcinoid: a prospective single-site study
    Derek Tang, Ramona Lim, Louis Korman, Joanne Forbes, Kristen Ellsbury, Sungyoung Auh, Apurva Trivedi, Clara C. Chen, Marybeth Hughes, Stephen Wank
    Gastrointestinal Endoscopy.2024; 99(2): 227.     CrossRef
  • Multimodal management of foregut neuroendocrine neoplasms
    Yichan Zhou, James Weiquan Li, Noriya Uedo
    Best Practice & Research Clinical Gastroenterology.2024; 68: 101889.     CrossRef
  • Improvements and future perspective in diagnostic tools for neuroendocrine neoplasms
    Sara Massironi, Marianna Franchina, Davide Ippolito, Federica Elisei, Olga Falco, Cesare Maino, Fabio Pagni, Alessandra Elvevi, Luca Guerra, Pietro Invernizzi
    Expert Review of Endocrinology & Metabolism.2024; 19(4): 349.     CrossRef
  • Quantitative characterization of duodenal gastrinoma autofluorescence using multiphoton microscopy
    Thomas G. Knapp, Suzann Duan, Juanita L. Merchant, Travis W. Sawyer
    Lasers in Surgery and Medicine.2023; 55(2): 208.     CrossRef
  • Ileal Neuroendocrine Tumors Detected During Screening or Diagnostic Colonoscopy — Case Series and Comparison of Tumor Characteristics
    Kaden R. Narayani, Raj I. Narayani
    Journal of Gastrointestinal Cancer.2023; 54(4): 1374.     CrossRef
  • Imaging of Small-Bowel Neuroendocrine Neoplasms: AJR Expert Panel Narrative Review
    Patrick J. Navin, Eric C. Ehman, Jason B. Liu, Thorvardur R. Halfdanarson, Akshya Gupta, Andrea Laghi, Don C. Yoo, Laura R. Carucci, Wolfgang Schima, Shannon P. Sheedy
    American Journal of Roentgenology.2023; 221(3): 289.     CrossRef
  • Magnifying Endoscopy with Narrow-Band Imaging for Duodenal Neuroendocrine Tumors
    Gwang Ha Kim, Kiyoun Yi, Dong Chan Joo, Moon Won Lee, Hye Kyung Jeon, Bong Eun Lee
    Journal of Clinical Medicine.2023; 12(9): 3106.     CrossRef
  • Long-term outcomes of endoscopic resection for duodenal neuroendocrine tumors
    Kiyoun Yi, Gwang Ha Kim, Su Jin Kim, Cheol Woong Choi, Moon Won Lee, Bong Eun Lee, Geun Am Song
    Scientific Reports.2023;[Epub]     CrossRef
  • Endoscopic full-thickness resection of well-differentiated T2 neuroendocrine tumors in the duodenal bulb: a case series
    Sarah Dwyer, Shaffer Mok
    VideoGIE.2022; 7(5): 196.     CrossRef
  • State of the Art in Endoscopic Therapy for the Management of Gastroenteropancreatic Neuroendocrine Tumors
    Apostolis Papaefthymiou, Faidon-Marios Laskaratos, Apostolos Koffas, Anastasios Manolakis, Paraskevas Gkolfakis, Sergio Coda, Mikael Sodergren, Noriko Suzuki, Christos Toumpanakis
    Current Treatment Options in Oncology.2022; 23(7): 1014.     CrossRef
  • The utility of near infrared autofluorescence imaging for detecting small bowel carcinoid tumors in comparison to DOTATATE PET: A pilot study
    Eren Berber, Onuralp Ergun, Seyma Avci, Gizem Isiktas, Mohammed Osman, Paresh Mahajan
    Journal of Surgical Oncology.2022; 126(7): 1199.     CrossRef
  • Gastroenteropancreatic Neuroendocrine Tumors
    Conrad J. Fernandes, Galen Leung, Jennifer R. Eads, Bryson W. Katona
    Gastroenterology Clinics of North America.2022; 51(3): 625.     CrossRef
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  • 286 Download
  • 13 Web of Science
  • 13 Crossref
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Is Endoscopic Ultrasound-Fine Needle Aspiration for Ki67 Aspirational Enough?
Yakira David, Michelle Kang Kim
Clin Endosc 2020;53(2):111-113.   Published online March 11, 2020
DOI: https://doi.org/10.5946/ce.2020.045
PDFPubReaderePub

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  • Double Ki-67 and synaptophysin labeling in pancreatic neuroendocrine tumor biopsies
    Bokyung Ahn, Jin Kying Jung, HaeSung Jung, Yeon-Mi Ryu, Yeon Wook Kim, Tae Jun Song, Do Hyun Park, Dae wook Hwang, HyungJun Cho, Sang-Yeob Kim, Seung-Mo Hong
    Pancreatology.2022; 22(3): 427.     CrossRef
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  • 72 Download
  • 1 Web of Science
  • 1 Crossref
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Diagnosis of Pancreatic Neuroendocrine Tumors
Dong Wook Lee, Michelle Kang Kim, Ho Gak Kim
Clin Endosc 2017;50(6):537-545.   Published online November 30, 2017
DOI: https://doi.org/10.5946/ce.2017.131
AbstractAbstract PDFPubReaderePub
Pancreatic neuroendocrine tumors (PNETs) are relatively rare; however, the incidence has increased over the last few decades. They are classified as functional or non-functional tumors according to the presence of associated clinical symptoms. The majority are non-functional tumors. For classification and staging, the World Health Organization 2010 classification system is the most commonly accepted. Chromogranin A is the most sensitive marker but has insufficient specificity. In general, PNETs are hypervascular tumors, and multiphasic contrast-enhanced computed tomography is considered the first choice for imaging study. Multiphasic magnetic resonance imaging can detect PNETs smaller than 2 cm and small liver metastasis compared with other modalities. Somatostatin receptor scintigraphy is often used in cases where functional PNETs are suspected. Positron emission tomography (PET) scan with 18F-fluorodeoxyglucose cannot visualize PNETs, but PET with 68-Ga DOTATATE can. Endoscopic ultrasonography can characterize smaller PNETs using contrast and confirm histology through fine needle aspiration or biopsy. In this article, we review the characteristics of grading systems and diagnostic modalities commonly used for PNETs.

Citations

Citations to this article as recorded by  
  • Diagnostic Anatomic Imaging for Neuroendocrine Neoplasms: Maximizing Strengths and Mitigating Weaknesses
    Mina Hesami, Michael Blake, Mark A. Anderson, Luigi Asmundo, Aoife Kilcoyne, Zahra Najmi, Peter D. Caravan, Ciprian Catana, Cynthia Czawlytko, Shadi Abdar Esfahani, Avinash R. Kambadakone, Anthony Samir, Shaunagh McDermott, Liran Domachevsky, Stephan Ursp
    Journal of Computer Assisted Tomography.2024; 48(4): 521.     CrossRef
  • Safety and efficacy of endoscopic ultrasound‐guided radiofrequency ablation for pancreatic neuroendocrine neoplasms: Systematic review and meta‐analysis
    Tawfik Khoury, Wisam Sbeit, Pietro Fusaroli, Davide Campana, Nicole Brighi, Bertrand Napoleon, Andrea Lisotti
    Digestive Endoscopy.2024; 36(4): 395.     CrossRef
  • Imaging Update for Hereditary Abdominopelvic Neuroendocrine Neoplasms
    Hanna R. Ferreira Dalla Pria, Kedar G. Sharbidre, Mayur Virarkar, Sanaz Javadi, Hrishabh Bhosale, Jessica Maxwell, Chandana Lall, Ajaykumar C. Morani
    Journal of Computer Assisted Tomography.2024; 48(4): 533.     CrossRef
  • Endoscopic ultrasonography-based intratumoral and peritumoral machine learning radiomics analyses for distinguishing insulinomas from non-functional pancreatic neuroendocrine tumors
    Shuangyang Mo, Cheng Huang, Yingwei Wang, Huaying Zhao, Wenhong Wu, Haixing Jiang, Shanyu Qin
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Diagnostic Management of Gastroenteropancreatic Neuroendocrine Neoplasms: Technique Optimization and Tips and Tricks for Radiologists
    Fabio Pellegrino, Vincenza Granata, Roberta Fusco, Francesca Grassi, Salvatore Tafuto, Luca Perrucci, Giulia Tralli, Mariano Scaglione
    Tomography.2023; 9(1): 217.     CrossRef
  • All you need to know about gastrinoma today | Gastrinoma and Zollinger‐Ellison syndrome: A thorough update
    Odysseas Chatzipanagiotou, Dimitrios Schizas, Michail Vailas, Marina Tsoli, Panagiotis Sakarellos, Maria Sotiropoulou, Alexandros Papalambros, Evangellos Felekouras
    Journal of Neuroendocrinology.2023;[Epub]     CrossRef
  • Surgical management of pancreatic neuroendocrine neoplasms
    Piero Alberti, David Martin, Georgios Gemenetzis, Rowan Parks
    Laparoscopic, Endoscopic and Robotic Surgery.2023; 6(3): 83.     CrossRef
  • An integrative view on glucagon function and putative role in the progression of pancreatic neuroendocrine tumours (pNETs) and hepatocellular carcinomas (HCC)
    Bárbara Ferreira, Adrián Heredia, Jacinta Serpa
    Molecular and Cellular Endocrinology.2023; 578: 112063.     CrossRef
  • Pancreatic Neuroendocrine Tumor (Pan-NET) Presented by Abdominal Pain: A Case Report and Literature Review
    Matteo Regolo, Nicolas Cardaci, Clara Salmeri, Alfredo Laudani, Michele Colaci, Massimo Ippolito, Fabio Motta, Salvatore Magrì, Stefanie Parisi, Alfredo Gaetano Torcitto, Lorenzo Malatino
    Journal of Clinical Medicine.2023; 12(20): 6617.     CrossRef
  • A review of functional pancreatic neuroendocrine tumors: Exploring the molecular pathogenesis, diagnosis and treatment
    Yasir Alshareefy, Sinead Cummins, Adele Mazzoleni, Vidushi Sharma, Saibaba Guggilapu, Amanda Weng Yee Leong, Andrew Awuah Wireko
    Medicine.2023; 102(46): e36094.     CrossRef
  • Endoscopic radiofrequency ablation under the control of ultrasonography as a new method of treatment of neuroendocrine pancreatic tumors and analgesia option for locally advanced forms of pancreatic cancer. First experience in Russia
    V. V. Lozovaya, O. A. Malikhova, A. S. Vodoleev, O. A. Gusarova, A. O. Tumanyan, A. G. Malikhov
    Surgery and Oncology.2023; 13(3): 11.     CrossRef
  • C1QA and COMP: plasma-based biomarkers for early diagnosis of pancreatic neuroendocrine tumors
    Priya Kumari Gorai, Prahalad Singh Bharti, Shashi Kumar, Girish H. Rajacharya, Sabyasachi Bandyopadhyay, Sujoy Pal, Renu Dhingra, Rakesh Kumar, Fredrik Nikolajeff, Saroj Kumar, Neerja Rani
    Scientific Reports.2023;[Epub]     CrossRef
  • Racial disparities in operative management of localized, non-functional pancreatic neuroendocrine tumors in surgically fit patients
    Katherine E. Bingmer, Jonathan J. Hue, Kavin Sugumar, John B. Ammori, Luke D. Rothermel, Jordan M. Winter, Jeffrey M. Hardacre, Lee M. Ocuin
    HPB.2022; 24(2): 217.     CrossRef
  • Facility type and size-stratified analysis of management patterns and outcomes of patients with localized non-functional pancreatic neuroendocrine tumors
    Jonathan J. Hue, Kavin Sugumar, John B. Ammori, Luke D. Rothermel, Jeffrey M. Hardacre, Jordan M. Winter, Lee M. Ocuin
    HPB.2022; 24(4): 498.     CrossRef
  • Current and New Challenges in the Management of Pancreatic Neuroendocrine Tumors: The Role of miRNA-Based Approaches as New Reliable Biomarkers
    Andrei Havasi, Daniel Sur, Simona Sorana Cainap, Cristian-Virgil Lungulescu, Laura-Ioana Gavrilas, Calin Cainap, Catalin Vlad, Ovidiu Balacescu
    International Journal of Molecular Sciences.2022; 23(3): 1109.     CrossRef
  • Unilateral pseudouveitis revealing a pancreatic neuroendocrine carcinoma: A case report
    Faten Cherchir, Ines Naceur, Ahmed Anas Haouari, Tayssir Ben Achour, Hajer Ben Mansour, Khadija Bellil, Fatma Said, Mohamed Habib Houman
    Clinical Case Reports.2022;[Epub]     CrossRef
  • Nonfunctional pancreatic neuroendocrine tumours misdiagnosed as autoimmune pancreatitis: A case report and review of literature
    Zi-Qi Lin, Xin Li, Yan Yang, Yi Wang, Xiao-Ying Zhang, Xiao-Xin Zhang, Jia Guo
    World Journal of Clinical Cases.2022; 10(15): 4886.     CrossRef
  • Assessing the Role of Operative Intervention in Elderly Patients With Nonfunctional Pancreatic Neuroendocrine Neoplasms
    Jonathan J. Hue, Kavin Sugumar, Amr Mohamed, J. Eva Selfridge, David Bajor, Jeffrey M. Hardacre, John B. Ammori, Luke D. Rothermel, Jordan M. Winter, Lee M. Ocuin
    Pancreas.2022; 51(4): 380.     CrossRef
  • Endoscopic ultrasound radiofrequency ablation of pancreatic insulinoma in elderly patients: Three case reports
    Gemma Rossi, Maria Chiara Petrone, Gabriele Capurso, Stefano Partelli, Massimo Falconi, Paolo Giorgio Arcidiacono
    World Journal of Clinical Cases.2022; 10(19): 6514.     CrossRef
  • A Curious Peripancreatic Mass: A Case of an Exophytic Pancreatic Neuroendocrine Tumor
    Bohyun Kim, Younghoon Kim
    Korean Journal of Abdominal Radiology.2022; 6(1): 57.     CrossRef
  • Prognostic and Predictive Biomarkers for Pancreatic Neuroendocrine Tumors
    Wenzel M. Hackeng, Hussein A. Assi, Florine H.M. Westerbeke, Lodewijk A.A. Brosens, Christopher M. Heaphy
    Surgical Pathology Clinics.2022; 15(3): 541.     CrossRef
  • Pancreatic adenocarcinoma and pancreatic high-grade neuroendocrine carcinoma: two sides of the moon
    Anna La Salvia, Irene Persano, Elena Parlagreco, Alessandro Audisio, Massimiliano Cani, Maria Pia Brizzi
    Medical Oncology.2022;[Epub]     CrossRef
  • Application of spectral CT combined with perfusion scan in diagnosis of pancreatic neuroendocrine tumors
    Yamin Wan, Hui Hao, Yunjin Chen, Yifan Zhang, Qingmei Yue, Zhizhen Li
    Insights into Imaging.2022;[Epub]     CrossRef
  • Endoscopic ultrasound-guided radiofrequency ablation of premalignant pancreatic-cystic neoplasms and neuroendocrine tumors: prospective study
    Fadi Younis, Dana Ben-Ami Shor, Nir Lubezky, Ravit Geva, Esther Osher, Oren Shibolet, Adam Phillips, Erez Scapa
    European Journal of Gastroenterology & Hepatology.2022; 34(11): 1111.     CrossRef
  • EUS-guided radiofrequency ablation of pancreatic/peripancreatic tumors and oligometastatic disease: an observational prospective multicenter study
    Mariana Figueiredo Ferreira, Rodrigo Garces-Duran, Pierre Eisendrath, Jacques Devière, Pierre Deprez, Laurent Monino, Jean-Luc Van Laethem, Ivan Borbath
    Endoscopy International Open.2022; 10(10): E1380.     CrossRef
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    Phoenix D. Bell, Aatur D. Singhi
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