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Comparison of Oral Sulfate Solution and Polyethylene Glycol Plus Ascorbic Acid on the Efficacy of Bowel Preparation
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Ji Hyung Nam, Seok Bo Hong, Yun Jeong Lim, Seongju Lee, Hyoun Woo Kang, Jae Hak Kim, Jin Ho Lee
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Clin Endosc 2020;53(5):568-574. Published online April 24, 2020
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DOI: https://doi.org/10.5946/ce.2019.209
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 Abstract
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- Background
/Aims: The quality of bowel preparation is one of the quality indicators for colonoscopy. The aim of this study was to compare the efficacy of oral sulfate solution (OSS) and polyethylene glycol plus ascorbic acid (PEG-AA) for bowel preparation.
Methods
The study involved 167 patients who underwent diagnostic colonoscopies. Inadequate bowel preparation was defined as any score of ≤1 in each colon section based on the Boston Bowel Preparation Scale. Multivariate logistic regression was used to compare the efficacy of OSS and PEG-AA. Subgroup analyses were performed based on patient characteristics.
Results
Overall, 106 (63.5%) patients received OSS, and 61 (36.5%) patients received PEG-AA. The rate of inadequate bowel preparation was 12.3% in patients receiving OSS and 32.8% in patients receiving PEG-AA (p=0.001). OSS (odds ratio [OR] = 0.26; p=0.003) and morning examination (OR=0.11; p=0.038) were significantly associated with efficient bowel preparation. The efficacy of OSS compared with PEG-AA was only significant in patients ≥50 years of age vs. <50 years of age (OR=0.13; p=0.001 vs. OR=0.96; p=0.959) and female vs. male patients (OR=0.06; p=0.002 vs. OR=0.58; p=0.339).
Conclusions
OSS was significantly more efficient for bowel preparation than PEG-AA, especially in patients ≥50 years of age and female patients. Morning examination led to a good quality of bowel preparation, irrespective of the preparation regimen.
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Citations
Citations to this article as recorded by  - Efficacy of Oral Sulfate Tablet and 2 L-Polyethylene Glycol with Ascorbic Acid for Bowel Preparation: A Prospective Randomized KASID Multicenter Trial
Yunho Jung, Hyun Gun Kim, Dong-Hoon Yang, Hyoun Woo Kang, Jae Jun Park, Dong Hoon Baek, Jaeyoung Chun, Tae-Geun Gweon, Hyeon Jeong Goong, Min Seob Kwak, Hyun Jung Lee, Soo-Kyung Park, Jong Hoon Lee
Journal of Korean Medical Science.2024;[Epub] CrossRef - Observation of the application effect of low-volume polyethylene glycol electrolyte lavage solution (PEG-ELS) combined with ascorbic acid tablets in bowel preparation for colonoscopy in hospitalized patients
Le-Can Wu, En-Dian Zheng, Hao-Yue Sun, Xi-Zhou Lin, Ju-Yi Pan, Xiao-Xiao Lin
Frontiers in Oncology.2023;[Epub] CrossRef - Comparison of the efficacy and safety of an oral sulfate solution and 3-L polyethylene glycol on bowel preparation before colonoscopy: a phase III multicenter randomized controlled trial
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Gastrointestinal Endoscopy.2023; 98(6): 977. CrossRef - Randomized trial of oral sulfate solution versus polyethylene glycol–ascorbic acid for bowel cleansing in elderly people
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Journal of Gastroenterology and Hepatology.2022; 37(2): 319. CrossRef - Comparison of 2 L Polyethylene Glycol Plus Ascorbic Acid and 4 L Polyethylene Glycol in Elderly Patients Aged 60–79: A Prospective Randomized Study
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Digestive Diseases and Sciences.2022; 67(10): 4841. CrossRef - Oral sulfate solution benefits polyp and adenoma detection during colonoscopy: Meta‐analysis of randomized controlled trials
Cheng Chen, Mengyang Shi, Zhongli Liao, Weiqing Chen, Yongzhong Wu, Xu Tian
Digestive Endoscopy.2022; 34(6): 1121. CrossRef - Efficacy, safety and tolerability of oral sulphate tablet for bowel preparation in patients with inflammatory bowel disease: A multicentre randomized controlled study
Kyeong Ok Kim, Eun Young Kim, Yoo Jin Lee, Hyun Seok Lee, Eun Soo Kim, Yun Jin Chung, Byung Ik Jang, Sung Kook Kim, Chang Heon Yang
Journal of Crohn's and Colitis.2022; 16(11): 1706. CrossRef - How to Choose the Optimal Bowel Preparation Regimen for Colonoscopy
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The Ewha Medical Journal.2021; 44(4): 122. CrossRef - Oral Sulfate Solution is as Effective as 2 L Polyethylene Glycol Plus Ascorbic Acid
Sung Hyun Shin, Kwang An Kwon
Clinical Endoscopy.2020; 53(5): 503. CrossRef
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