-
Epidemiology of early esophageal adenocarcinoma
-
Thuy-Van P. Hang, Zachary Spiritos, Anthony M. Gamboa, Zhengjia Chen, Seth Force, Vaishali Patel, Saurabh Chawla, Steven Keilin, Nabil F. Saba, Bassel El-Rayes, Qiang Cai, Field F. Willingham
-
Clin Endosc 2022;55(3):372-380. Published online February 11, 2022
-
DOI: https://doi.org/10.5946/ce.2021.152
-
-
 Abstract
 PDF PubReader ePub
- Background
/Aims: Endoscopic resection has become the preferred treatment approach for select early esophageal adenocarcinoma (EAC); however, the epidemiology of early stage disease has not been well defined.
Methods
Surveillance Epidemiology and End Results (SEER) data were analyzed to determine age-adjusted incidence rates among major epithelial carcinomas, including EAC, from 1973 to 2017. The percent change in incidence over time was compared according to tumor subtype. Early T-stage, node-negative EAC without metastasis was examined from 2004 to 2017 when precise T-stage data were available.
Results
The percent change in annual incidence from 1973 to 2017 was 767% for EAC. Joinpoint analysis showed that the average annual percent change in EAC from 1973 to 2017 was 5.11% (95% confidence interval, 4.66%–5.56%). The annual percent change appeared to plateau between 2004 and 2017; however, early EAC decreased from 2010 to 2017, with an annual percent change of -5.78%.
Conclusions
There has been a 7-fold increase in the incidence of EAC, which was significantly greater than that of the other major epithelial malignancies examined. More recently, the incidence of early EAC has been decreasing. Approximately one in five patients has node negative, potentially resectable early stage disease.
-
Citations
Citations to this article as recorded by  - Histology Shift in Esophageal Cancer Between Biopsies and Resections After Neoadjuvant Therapy: A Pilot Study
Tieying Hou, Zhaohai Yang, Qingzhao Zhang, Xuchen Zhang, Xiaoyan Liao, Jingmei Lin
International Journal of Surgical Pathology.2024; 32(5): 920. CrossRef - Concise Commentary: It’s All Downhill from Here—How Diagnostic and Therapeutic Advances May Decrease the Incidence Rates of Gastroesophageal Junction and Esophageal Adenocarcinoma
Anthony Gamboa, Rishi Naik
Digestive Diseases and Sciences.2024; 69(1): 254. CrossRef - Descriptive Epidemiology of Early-Onset Gastrointestinal Cancers in Iran, 2014-2018
Mohammad Sadra Gholami Chahkand, Fatemeh Esmaeilpour Moallem, Fatemeh Ghasemi-Kebria, Reza Malekzadeh, Gholamreza Roshandel, Mohammad Taher
Middle East Journal of Digestive Diseases.2024; 16(1): 28. CrossRef - A Systematic Review and Meta-analysis of the Relationship between Statin Intake
and Esophageal Cancer
Armin Khaghani, Karamali Kasiri, Saeid Heidari-Soureshjani, Catherine M.T. Sherwin, Hossein Mardani-Nafchi
Anti-Cancer Agents in Medicinal Chemistry.2024; 24(14): 1029. CrossRef - Long-term outcomes of endoscopic submucosal dissection for early esophageal adenocarcinoma in the Eastern population: a comprehensive analysis
Xiao-han Jiang, Qing Liu, Min Fu, Cheng-fan Wang, Rui-han Zou, Li Liu, Min Wang
Journal of Gastrointestinal Surgery.2024;[Epub] CrossRef - Inhibition of Insulin-like Growth Factor 1 Receptor/Insulin Receptor Signaling by Small-Molecule Inhibitor BMS-754807 Leads to Improved Survival in Experimental Esophageal Adenocarcinoma
Md Sazzad Hassan, Chloe Johnson, Saisantosh Ponna, Dimitri Scofield, Niranjan Awasthi, Urs von Holzen
Cancers.2024; 16(18): 3175. CrossRef - Epidemiologie der Adenokarzinome des Ösophagus und des ösophagogastralen Übergangs
Sabine Luttmann, Andrea Eberle, Joachim Hübner
Die Onkologie.2023; 29(6): 470. CrossRef - Evaluation of Esophageal Dysphagia in Elderly Patients
Khanh Hoang Nicholas Le, Eric E. Low, Rena Yadlapati
Current Gastroenterology Reports.2023; 25(7): 146. CrossRef - Molecular Biology and Clinical Management of Esophageal Adenocarcinoma
Shulin Li, Sanne Johanna Maria Hoefnagel, Kausilia Krishnawatie Krishnadath
Cancers.2023; 15(22): 5410. CrossRef - Progress in Clinical Management of Esophago-Jejunal Anastomotic Fistula with Total Gastrectomy for Adenocarcinoma of the Esophagogastric Junction
天伟 赖
Advances in Clinical Medicine.2023; 13(11): 17210. CrossRef - Cranberry Proanthocyanidins Mitigate Reflux-Induced Transporter Dysregulation in an Esophageal Adenocarcinoma Model
Yun Zhang, Katherine M. Weh, Bridget A. Tripp, Jennifer L. Clarke, Connor L. Howard, Shruthi Sunilkumar, Amy B. Howell, Laura A. Kresty
Pharmaceuticals.2023; 16(12): 1697. CrossRef - Lessons learned in clinical epidemiology of esophageal adenocarcinoma
Hye Kyung Jung
Clinical Endoscopy.2022; 55(3): 365. CrossRef
-
5,707
View
-
279
Download
-
7
Web of Science
-
12
Crossref
|
KSGE
