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Endoscopic Characteristics of Rugal Hyperplasia and Related Acid Condition in Helicobacter pylori-Infected Stomach
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Byung Chul Kim, Mi Ae Song, Sung Ho Kwon
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Clin Endosc 2021;54(1):73-84. Published online December 15, 2020
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DOI: https://doi.org/10.5946/ce.2020.020
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 Abstract
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- Background
/Aims: Rugal hyperplastic gastritis (RHG) is associated with Lauren’s diffuse-type gastric cancer (GC) and the accompanying active inflammation is linked to gastric hypoacidity. We tried to establish the steps for identifying high-risk GC patients.
Methods
We included 196 patients with confirmed Helicobacter pylori infection by rapid urease test during screening endoscopy for health check-up from January 2016 to September 2016; all patients underwent blood tests for pepsinogen I and II and fasting serum gastrin. We compared RHG findings with various other endoscopic mucosal images. We also evaluated the relationships between RHG and other mucosal aspects for a given acid status based on serological markers.
Results
Hypoacid and ultra-low-acid (67%) statuses were dominant, with only 18% hyperacid patients. RHG with high acid was related to a less atrophic body type (p=0.001), and RHG with ultra-low acid was associated with body xanthoma (p=0.029) and increased serum gastrin level (p=0.038). However, RHG’s influence on gastric acidity was only seen in closed-type endoscopic atrophic border (EAB), not in open type (p=0.001).
Conclusions
The majority of RHG patients had hypoacid status. RHG frequency showed no difference between closed and opentype EAB, but gastric acidity was influenced by RHG only in closed-type EAB.
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Citations
Citations to this article as recorded by  - Differential Diagnosis of Thickened Gastric Wall between Hypertrophic Gastritis and Borrmann Type 4 Advanced Gastric Cancer
Jun-young Seo, Do Hoon Kim, Ji Yong Ahn, Kee Don Choi, Hwa Jung Kim, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Gut and Liver.2024; 18(6): 961. CrossRef - Cancer risk stratification system and classification of gastritis: Perspectives
Sergey M Kotelevets, Sergey A Chekh, Sergey Z Chukov
World Journal of Meta-Analysis.2023; 11(1): 18. CrossRef - Risk factors for early gastric cancer: focus on Helicobacter pylori gastritis
Hee Seok Moon
Journal of the Korean Medical Association.2022; 65(5): 259. CrossRef - Giant Rugae in Helicobacter pylori-Infected Stomachs
Sun-Young Lee
Clinical Endoscopy.2021; 54(1): 1. CrossRef
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