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The brief history of photodynamic therapy (PDT) research has been focused on photosensitizers (PSs) and light delivery was introduced recently. The appropriate PSs were developed from the first generation PS Photofrin (QLT) to the second (chlorins or bacteriochlorins derivatives) and third (conjugated PSs on carrier) generations PSs to overcome undesired disadvantages, and to increase selective tumor accumulation and excellent targeting. For the synthesis of new chlorin PSs chlorophyll a is isolated from natural plants or algae, and converted to methyl pheophorbide a (MPa) as an important starting material for further synthesis. MPa has various active functional groups easily modified for the preparation of different kinds of PSs, such as methyl pyropheophorbide a, purpurin-18, purpurinimide, and chlorin e6 derivatives. Combination therapy, such as chemotherapy and photothermal therapy with PDT, is shortly described here. Advanced light delivery system is shown to establish successful clinical applications of PDT. Phtodynamic efficiency of the PSs with light delivery was investigated in vitro and/or in vivo.

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Photodynamic therapy (PDT) is a light based therapy used to ablate tumors. As practiced in oncology a photosensitizing agent is applied and then activated by a specific wavelength and energy of light. This light energy in the presence of oxygen will lead to the creation of the photodynamic reaction which is cyto and vasculo toxic. This paper will review the mechanisms of action of PDT and how they may be manipulated to improve clinical outcome in cancer patients.

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• Melanoma-targeted photodynamic therapy based on hypericin-loaded multifunctional P123-spermine/folate micelles
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• Specific Antibodies to the Fragments of Meningococcal IgA1 Protease during the Formation of Immunity to Bacterial Infections
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• An insight into photodynamic therapy towards treating major dermatological conditions
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• Efficacy of Antimicrobial Photodynamic Therapy Mediated by Photosensitizers Conjugated with Inorganic Nanoparticles: Systematic Review and Meta-Analysis
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• Oxygen-supplied electrotherapy for enhanced photodynamic synergistic therapy overcomes hypoxia tumor microenvironment
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• The Therapeutic Efficacy of Punica granatum and Its Bioactive Constituents with Special Reference to Photodynamic Therapy
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• Possible Mechanisms of Resistance Development to Photodynamic Therapy (PDT) In Vulvar Cancer Cells
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• Construction of photo-induced zinc-doped carbon dots based on drug-resistant bactericides and their application for local treatment
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• Accumulation Dynamics of a Photosensitizer Liposomal Borated Chlorine e6 in Various Morphological Types of Experimental Tumors
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• Analysis and Data-Based Modeling of the Photochemical Reaction Dynamics of the Induced Singlet Oxygen in Light Therapies
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• The effect of indocyanine green-mediated photodynamic therapy in healing of experimentally induced oral mucosal traumatic ulcer in rat
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• The Impact of Photosensitizer Selection on Bactericidal Efficacy Of PDT against Cariogenic Biofilms: A Systematic Review and Meta-Analysis
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• Influence of two photodynamic therapy sessions and different photosensitizers on the bond strength of glass-fiber posts in different regions of intraradicular dentin
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• Push–pull effect to improve the electronic and optical properties of [7] circulene
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• Recent progress in sono-photodynamic cancer therapy: From developed new sensitizers to nanotechnology-based efficacy-enhancing strategies
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• Laser Photobiomodulation (PBM)—A Possible New Frontier for the Treatment of Oral Cancer: A Review of In Vitro and In Vivo Studies
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• Optically activatable photosynthetic bacteria-based highly tumor specific immunotheranostics
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• Cholesterol-rich nanoemulsion (LDE) as a novel drug delivery system to diagnose, delineate, and treat human glioblastoma
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• Impact of riboflavin mediated photodynamic disinfection around fixed orthodontic system infected with oral bacteria
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• Photodynamic Therapy of Sarcoma M-1 in Rats with Photosensitizer Photoran E6
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• Considerations and Technical Pitfalls in the Employment of the MTT Assay to Evaluate Photosensitizers for Photodynamic Therapy
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• Strategies for Cancer Treatment Based on Photonic Nanomedicine
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• Comparison of the Photodynamic Action of Porphyrin, Chlorin, and Isobacteriochlorin Derivatives toward a Melanotic Cell Line
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This paper reviews the use of photodynamic therapy (PDT) in patients with Barrett's esophagus and esophageal carcinoma. We describe the history of PDT, mechanics, photosensitizers for PDT in patients with esophageal disease. Finally, we discuss its utility and limitations in this setting.

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The most common form in bile duct cancers is a highly desmoplastic cancer with a growth pattern characterized by periductal extension and infiltration. The prognosis of bile duct cancers, especially hilar cholangiocarcinoma, is limited by tumor spread along the biliary tree leading to refractory obstructive cholestasis, cholangitis, and liver failure. Although biliary endoprosthesis improves occlusion rates and reduces the number of therapeutic interventions, median survival time is not ameliorated. Photodynamic therapy (PDT) is a local photochemical tumor treatment that consists of a photosensitizing agent in combination with laser irradiation of a distinct wavelength. Tumor ablation with PDT combined with biliary stenting reduces cholestasis and significantly improves median survival time in selected patients with bile duct cancers.

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Capsule endoscopy (CE) is considered as a noninvasive and reliable diagnostic tool of examining the entire small bowel. CE has been performed frequently at many medical centers in South Korea; however, there is no evidence-based CE guideline for adequate diagnostic approaches. To provide accurate information and suggest correct testing approaches for small bowel disease, the guideline on CE was developed by the Korean Gut Image Study Group, a part of the Korean Society of Gastrointestinal Endoscopy. Operation teams for developing the guideline were organized into four areas: obscure gastrointestinal bleeding, small bowel preparation, Crohn's disease, and small bowel tumor. A total of 20 key questions were selected. In preparing this guideline, MEDLINE, Cochrane library, KMbase, KISS, and KoreaMed literature searches were performed. After writing a draft of the guideline, opinions from various experts were reflected before approving the final document. The guideline should be regarded as recommendations only to gastroenterologists in providing care to their patients. These are not absolute rules and should not be construed as establishing a legal standard of care. Although further revision may be necessary as new data appear, this guideline is expected to play a role for adequate diagnostic approaches of various small bowel diseases.

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Intra-abdominal tuberculous lymphadenitis can mimic a variety of other abdominal disorders such as pancreatic cancer, metastatic lymph nodes, or lymphoma, which can make a proper diagnosis difficult. A correct diagnosis of intra-abdominal tuberculous lymphadenitis can lead to appropriate management. Endoscopic ultrasonography (EUS)-guided needle biopsy may be the procedure of choice for tissue acquisition when onsite cytopathology examination is unavailable because it is essential to obtain sufficient material suitable for the examination using an ancillary method, such as flow cytometry, molecular diagnosis, cytogenetics, or microbiological culture. We report a case of intra-abdominal tuberculous lymphadenitis diagnosed using an EUS-guided, 22-gauge histology new needle biopsy without an onsite cytopathology examination.

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• Coeliac lymph node abscess: A case report of a rare manifestation of extrapulmonary tuberculosis
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• Gastric Tuberculosis Presenting as a Subepithelial Mass: A Rare Cause of Gastrointestinal Bleeding
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• Ultrasonography in the Assessment of Lymph Node Disease
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Pyogenic granuloma is a benign inflammatory vascular lesion, mainly found in the skin and oral mucosa. A few cases of pyogenic granuloma in the gastrointestinal tract have been reported, and the esophagus was the main site in these cases. These patients were diagnosed with pyogenic granuloma after they underwent upper endoscopy and biopsy. Endoscopic resection is a favorable treatment option for esophageal pyogenic granuloma. Recently, we observed characteristic endosonographic findings in two cases with esophageal pyogenic granuloma, which were then treated successfully by endoscopic resection.

Citations

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• Esophageal pyogenic granuloma resected by polypectomy using a detachable snare
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  Ji Han Yu, Kyung-Jin Seo, Young-Seok Cho
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• Morphological Changes in a Pyogenic Granuloma of the Esophagus Observed over Three Years
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Cowden's disease, also known as a kind of phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome, is an uncommon autosomal dominant inherited complex disorder with various hamartomatous growths of multiple organs involving all three germ cell layers. It usually manifests with polyps throughout the gastrointestinal tract, ranging anywhere from 30% to 85%, and more common extra intestinal findings. Mucocutaneous lesions like facial trichilemmomas, acral keratoses, papillomatous papules and macrocephaly, and malignancies including breast, thyroid and endometrial carcinoma are the hallmark of the disease. Here we report on familial Cowden's diseases case of a 52-year-old male proband with mucocutaneous lesions and mutation on the PTEN gene obtained by extrapolating from gastrointestinal polyposis as a starter and his daughter who developed thyroid cancer.

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• Cowden Syndrome: A Case Series Highlighting Cutaneous and Systemic Diversity
  Marcus S Rossi, Jessica P Sejo, Allison Kirchner, Maria Tsoukas
  Cureus.2024;[Epub]     CrossRef
• Cowden Syndrome: A Review
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• Colorectal polyposis as a clue to the diagnosis of Cowden syndrome: Report of two cases and literature review
  Giovanni Innella, Sara Miccoli, Dora Colussi, Laura Maria Pradella, Laura Benedetta Amato, Roberta Zuntini, Nunzio Cosimo Mario Salfi, Guido Collina, Francesco Ferrara, Luigi Ricciardiello, Daniela Turchetti
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The most common cause of esophagorespiratory fistulas (ERFs) is associated with malignancy. The use of self-expandable metal stents is effective for the treatment of malignant ERFs, but benign ERF is rare, which is why its optimal treatment is not defined yet. There have been few reports describing benign esophagopleural fistula and its treatments in South Korea. Here, we report a rare case of spontaneous esophagopleural fistula, which was successfully treated by endoscopic placement of a membrane covered metal stent.

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• Delayed esophagopleural fistula after endoscopic injection sclerotherapy for esophageal varices
  Mingliang Sui, Weibing Tang, Changjiang Wu, Jinhu Yang, Huiping Liu, Chaofa Huang, Xianzhu Hu, Damei Xia, Yadi Yang
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• Unusual Presentation of an Esophagopleural Fistula in a Patient With Severe Esophagitis: Blunt Trauma or Iatrogenic?
  Yanting Wang, Oscar A. Rivas Chicas, Anupam Basu
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  Indian Journal of Thoracic and Cardiovascular Surgery.2015; 31(4): 316.     CrossRef
• Treatment of Esophagopleural Fistulas Using Covered Retrievable Expandable Metallic Stents
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The endoscopic insertion of the self-expandable metal stent (SEMS) in benign biliary stricture has become an alternative to surgery. Fracture or migration of SEMS can occur rarely as complications. We report a case of fracture of SEMS during endoscopic retrieval in patients with chronic pancreatitis. In this case, broken stent was successfully removed with endoscopic ballooning of bile duct and with a snare device.

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• Plastic biliary stent fracture: A rare complication of percutaneous biliary drain placement
  Kurren A. Mehta, Paul S. Jowell, Joshua P. Spaete
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• Successful endoscopic removal of a fully covered self-expandable metallic stent that fractured above a benign distal bile duct stricture
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Development of biliary casts is very unusual, especially in patients who have not undergone liver transplantation. Variable causes of biliary cast formation in nonliver transplantation patients have been suggested. However, stasis of bile flow and/or gallbladder hypocontractility is known to eventually result in the promotion of biliary sludge and subsequent cast formation. Here we present one case of biliary cast syndrome, which developed in a nonliver transplant patient who had biliary sludge for a long period of time, providing evidence that long-standing biliary sludge may lead to cast formation.

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• Intensive Care Unit–Related Cholangiopathy-Induced Biliary Cast Syndrome Without Liver Transplantation: A Rare Entity
  Fnu Vikash, Sindhu Vikash, Sammy Ho, Donald Kotler, Sunny Patel
  ACG Case Reports Journal.2024; 11(2): e01269.     CrossRef
• A Case of Biliary Cast Syndrome with Cholangiocarcinoma-like Lesion in a Patient with No History of Liver Transplantation
  Sa-Hong Jo, Ho-Cheol Choi, Sung-Eun Park, Jin-Il Moon, Jung-Ho Won, Jae-Boem Na, Yang-Won Kim, Won-Jeong Yang, Byeong-Ju Koo, Jae-Kyeong Ahn, Seong-Je Kim
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Brunner's gland adenoma is a rare benign proliferative lesion developing most commonly in the posterior wall of the duodenum. It is usually small in size and asymptomatic. Depending on its size or location, however, the clinical manifestations of this tumor may be variable from nonspecific symptoms to gastrointestinal bleeding or obstruction. Brunner's gland adenoma in the proximal jejunum is extremely rare. We report a very rare case of giant Brunner's gland adenoma developing in the proximal jejunum which presented as iron deficiency anemia and mimicked intussusceptions on radiologic studies.

Citations

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• Brunner’s gland hamartomas: Not always benign
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• A Case Of Huge Brunner's Gland Adenoma With Acute Bleeding Treated By Endoscopic Resection
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• Successful Endoscopic Resection of Large Pedunculated Brunner's Gland Hamartoma Causing Gastrointestinal Bleeding Arising from the Pylorus
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A secondary aortoenteric fistula (AEF) is a direct communication between the gastrointestinal tract and the aorta in a patient who has undergone major surgery on the aorta, often an aorta graft operation. We experienced a patient who had undergone graft interposition for abdominal aortic aneurysm and was admitted due to three episodes of hematemesis and following hamatochezia. Gastroscopy, colonoscopy, and radioactive iodine scan failed to identify the bleeding site in the patient. He was diagnosed with AEF by double balloon enteroscopy and recovered after surgical intervention.

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• Aortic Bulge: A Possible Predictive Sign of Impending Aortoenteric Fistula
  Patrick Kennedy, Sandra Monteiro, Gordon Yip, Fernando Gastaldo
  Canadian Association of Radiologists Journal.2019; 70(2): 204.     CrossRef
• Editor's Choice – Management of Secondary Aorto-enteric and Other Abdominal Arterio-enteric Fistulas: A Review and Pooled Data Analysis
  S.K. Kakkos, C.D. Bicknell, I.A. Tsolakis, D. Bergqvist
  European Journal of Vascular and Endovascular Surgery.2016; 52(6): 770.     CrossRef