Clinical Endoscopy

Gyriform duodenal mucosa as a manifestation of light chain deposition disease: Fumiya Masakado, Sho Yamazawa, Mariko Tanaka, Aya Shinozaki-Ushiku, Daisuke Ohki, Tetsuo Ushiku; Clin Endosc 2026;59(1):142-143. Published online August 4, 2025; DOI: https://doi.org/10.5946/ce.2025.142

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Recent advancement in endoscopic diagnosis for risk stratification of gastric cancer: Takuma Hiramatsu, Naomi Kakushima, Hikaru Kuribara, Ryohei Miyata, Hideki Nakagawa, Hiroyuki Hisada, Dai Kubota, Yuko Miura, Hiroya Mizutani, Daisuke Ohki, Chihiro Takeuchi, Seiichi Yakabi, Yosuke Tsuji, Nobutake Yamamichi, Mitsuhiro Fujishiro; Clin Endosc 2025;58(6):787-796. Published online July 10, 2025; DOI: https://doi.org/10.5946/ce.2024.355

Abstract PDF PubReader ePub: Approximately 90% of cases of gastric cancer (GC) are caused by Helicobacter pylori infection, and screening esophagogastroduodenoscopy is effective for secondary prevention of GC. Endoscopic findings of the stomach due to H. pylori infection vary widely, and the risk of GC varies according to each finding. GC risk is evaluated by combining endoscopic and histopathological findings. In the operative link on gastritis assessment and operative link on gastric intestinal metaplasia assessment staging, GC risk is determined by histopathological evaluation. In the endoscopic grading of gastric intestinal metaplasia, Kyoto classification, and modified Kyoto classification, the risk is considered based on endoscopic findings. However, evaluating endoscopic findings is challenging because the evaluation varies depending on the skill of the endoscopist. Similarly, histopathological findings can be assessed differently by different pathologists. Histopathological evaluation by biopsy carries a risk of bleeding; thus, simpler and less-invasive risk stratification methods are desirable. Artificial intelligence for risk stratification, which has the potential for improved accuracy and consistency, has been developed for endoscopic and histopathological evaluations. Appropriate GC risk stratification would benefit the economy and patients, and further evaluation of surveillance intervals tailored to individual risks is warranted.

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Clinical meaning of sarcopenia in patients undergoing endoscopic treatment: Hiroyuki Hisada, Yosuke Tsuji, Hikaru Kuribara, Ryohei Miyata, Kaori Oshio, Satoru Mizutani, Hideki Nakagawa, Rina Cho, Nobuyuki Sakuma, Yuko Miura, Hiroya Mizutani, Daisuke Ohki, Seiichi Yakabi, Yu Takahashi, Yoshiki Sakaguchi, Naomi Kakushima, Nobutake Yamamichi, Mitsuhiro Fujishiro; Clin Endosc 2024;57(4):446-453. Published online March 22, 2024; DOI: https://doi.org/10.5946/ce.2023.193

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With increasing global life expectancy, the significance of geriatric assessment parameters has increased. Sarcopenia is a crucial assessment parameter and is defined as the age-related loss of muscle mass and strength. Sarcopenia is widely acknowledged as a risk factor for postoperative complications in diverse advanced malignancies and has a detrimental effect on the long-term prognosis. While most studies have primarily concentrated on the correlation between sarcopenia and advanced cancer, more recent investigations have focused on the relationship between sarcopenia and early-stage cancer. Endoscopic submucosal dissection (ESD), which is less invasive than surgical intervention, is extensively employed in the management of early-stage cancer, although it is associated with complications such as bleeding and perforation. In recent years, several reports have revealed the adverse consequences of sarcopenia in patients with early-stage cancer undergoing ESD. This literature review briefly summarizes the recent studies on the association between sarcopenia and ESD.

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Correlation between sarcopenia and esophageal stenosis following endoscopic submucosal dissection and construction of a postoperative stenosis risk model
Kai-Zhe Yang, Lu Chen, Li Xu, Bin-Xiang Xu, Ming-Yue Li, Zhi Wang, Qin Lu
World Journal of Gastroenterology.2026;[Epub] CrossRef
Sarcopenia in the era of aging populations: its clinical implications for peptic ulcer bleeding
Hiroyuki Hisada, Yosuke Tsuji, Mitsuhiro Fujishiro
Clinical Endoscopy.2025; 58(3): 401. CrossRef
Clinical Significance of Sarcopenia in Elderly Patients Undergoing Endoscopic Submucosal Dissection: A Systematic Review and Meta-analysis
Yuanhao Su, Yongke Wu, Cheng Li, Yiyuan Zhao, Yunhao Li, Xing Jin, Zhidong Wang
Digestive Diseases and Sciences.2024; 69(8): 2970. CrossRef

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Recent Development of Techniques and Devices in Colorectal Endoscopic Submucosal Dissection: Hiroya Mizutani, Satoshi Ono, Daisuke Ohki, Chihiro Takeuchi, Seiichi Yakabi, Yosuke Kataoka, Itaru Saito, Yoshiki Sakaguchi, Chihiro Minatsuki, Yosuke Tsuji, Keiko Niimi, Shinya Kodashima, Nobutake Yamamichi, Mitsuhiro Fujishiro, Kazuhiko Koike; Clin Endosc 2017;50(6):562-568. Published online November 30, 2017; DOI: https://doi.org/10.5946/ce.2017.108

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Colorectal endoscopic submucosal dissection (ESD) is now a well-established endoscopic treatment for early-stage colorectal neoplasms, especially in Asian countries, including Japan. Despite the spread of colorectal ESD, there are still situations in which achieving successful submucosal dissection is difficult. Various novel techniques and devices have been developed to overcome these difficulties, and past reports have shown that some of these strategies can be applied to colorectal ESD. We review several recent developments in the field. The techniques reviewed include the pocket creation method and traction methods and the devices reviewed include the overtube with balloon and electrosurgical knives with water-jet function. These improved techniques and devices can facilitate safer, more reliable ESDs and expand its applicability and acceptability all over the world.

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The Current Landscape of Endoscopic Submucosal Training in the United States
Mike T. Wei, Shai Friedland, Joo Ha Hwang
Current Gastroenterology Reports.2025;[Epub] CrossRef
A new technique for ureteral reconstruction using a colonic mucosa graft in a beagle model
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Cureus.2024;[Epub] CrossRef
Endoscopic techniques for management of large colorectal polyps, strictures and leaks
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Surgery Open Science.2024; 20: 156. CrossRef
Endoscopic Submucosal Dissection of Superficial Colorectal Neoplasms at “Challenging Sites” Using a Double-Balloon Endoluminal Interventional Platform: A Single-Center Study
Gianluca Andrisani, Francesco Maria Di Matteo
Diagnostics.2023; 13(19): 3154. CrossRef
Traction-assisted endoscopic submucosal dissection reduces procedure time and risk of serious adverse events: a systematic review and meta-analysis
Chawin Lopimpisuth, Malorie Simons, Venkata S. Akshintala, Klaorat Prasongdee, Julie Nanavati, Saowanee Ngamruengphong
Surgical Endoscopy.2022; 36(3): 1775. CrossRef
Snare devices with thinner loop wire may provide higher performance for cold snare polypectomy in an experimental model
Satoshi Ono, Kyohei Maejima, Shun Ito, Shosuke Hosaka, Kiyotaka Umeki, Shin-ichiro Sato, Kota Akamine, Daichi Asai, Mitsuhiro Fujishiro
Endoscopy International Open.2022; 10(05): E664. CrossRef
The usefulness of a double-balloon endolumenal interventional platform for colorectal endoscopic submucosal dissection by non-expert endoscopists in a porcine model (with video)
Hiroki Yamashita, Hiroaki Ikematsu, Tatsuro Murano, Naoki Aoyama, Yuki Kano, Tomohiro Mitsui, Hironori Sunakawa, Kensuke Shinmura, Kenji Takashima, Keiichiro Nakajo, Tomohiro Kadota, Yusuke Yoda, Tomonori Yano
Surgical Endoscopy.2022; 36(10): 7818. CrossRef
Long-Term Outcomes of Endoscopic Submucosal Dissection for Colorectal Epithelial Neoplasms: A Systematic Review
Toshihiro Nishizawa, Takashi Ueda, Hirotoshi Ebinuma, Osamu Toyoshima, Hidekazu Suzuki
Cancers.2022; 15(1): 239. CrossRef
A Clip-with-Line Traction Suture Method for Closing Mucosal Defects after Endoscopic Submucosal Dissection
Chong Wang, Yiting Wang, Yuanyuan Li, Sheng Zeng, Youxiang Chen, Guohua Li, Konstantinos Triantafyllou
Gastroenterology Research and Practice.2021; 2021: 1. CrossRef
Effectiveness of S-O Clip-Assisted Colorectal Endoscopic Submucosal Dissection
Haruka Fujinami, Akira Teramoto, Saeko Takahashi, Takayuki Ando, Shinya Kajiura, Ichiro Yasuda
Journal of Clinical Medicine.2021; 11(1): 141. CrossRef
Efficacy and suitable indication of colorectal endoscopic submucosal dissection using a balloon‐assisted endoscope
Yuichiro Kuroki, Kunio Asonuma, Natsumi Uehara, Toshiyuki Endo, Reika Suzuki, Yorimasa Yamamoto, Masatsugu Nagahama
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Task Deconstruction of Colonic Endoscopic Submucosal Dissection (cESD): An Expert Consensus
Karen J. Dickinson, Brian J. Dunkin, John J. Nguyen‐Lee, Aman B. Ali, Stephanie Zajac
World Journal of Surgery.2020; 44(7): 2401. CrossRef
Review on colorectal endoscopic submucosal dissection focusing on the technical aspect
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Surgical Endoscopy.2020; 34(9): 3766. CrossRef
A Novel Technique of Endoscopic Papillectomy with Hybrid Endoscopic Submucosal Dissection for Ampullary Tumors: A Proof-of-Concept Study (with Video)
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Cost Analysis of Endoscopic Submucosal Dissection for the Treatment of Colorectal Lesions in China
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