Clinical Endoscopy

Review

Role of artificial intelligence in diagnosing Barrett’s esophagus-related neoplasia: Michael Meinikheim, Helmut Messmann, Alanna Ebigbo; Clin Endosc 2023;56(1):14-22. Published online January 17, 2023; DOI: https://doi.org/10.5946/ce.2022.247

Barrett’s esophagus is associated with an increased risk of adenocarcinoma. Thorough screening during endoscopic surveillance is crucial to improve patient prognosis. Detecting and characterizing dysplastic or neoplastic Barrett’s esophagus during routine endoscopy are challenging, even for expert endoscopists. Artificial intelligence-based clinical decision support systems have been developed to provide additional assistance to physicians performing diagnostic and therapeutic gastrointestinal endoscopy. In this article, we review the current role of artificial intelligence in the management of Barrett’s esophagus and elaborate on potential artificial intelligence in the future.

Citations

Citations to this article as recorded by

Artificial intelligence in functional gastrointestinal disorders: From precision diagnosis to preventive healthcare
Yi-Nan Yan, Jing-Qi Zeng, Xia Ding
Artificial Intelligence in Gastroenterology.2026;[Epub] CrossRef
Update on the management of Barrett’s neoplasia
Sharmila Subramaniam, Elisabetta Mastrorocco, Mohan Ramchandani, Pradeep Bhandari
Frontline Gastroenterology.2026; 17(e1): e23. CrossRef
Evaluating ChatGPT‐5 for Detection of Barrett's Esophagus and Grading of Esophagitis: A Multiclass Endoscopic Image Analysis
Hamza R. Khan, Ibraheem Mirza, Owais M. Aftab, Yash Shah, Ahmed H. Al‐Khazraji
JGH Open.2026;[Epub] CrossRef
Artificial intelligence for computer assistance in endoscopic procedures and training
Pablo Achurra, Domingo Mery, Arnoldo Riquelme, Chaya Shwaartz
Global Surgical Education - Journal of the Association for Surgical Education.2025;[Epub] CrossRef
Telemedizin und KI-gestützte Diagnostik im Alltag der Viszeralmedizin
Matthias Grade, Verena Uslar
Die Chirurgie.2025; 96(1): 23. CrossRef
The current state of artificial intelligence in robotic esophageal surgery
Constantine M. Poulos, Ryan Cassidy, Eamon Khatibifar, Erik Holzwanger, Lana Schumacher
Mini-invasive Surgery.2025;[Epub] CrossRef
Artificial Intelligence Applications in Image-Based Diagnosis of Early Esophageal and Gastric Neoplasms
Alanna Ebigbo, Helmut Messmann, Sung Hak Lee
Gastroenterology.2025; 169(3): 396. CrossRef
Future of image enhanced endoscopy of esophageal adenocarcinoma
Kerem Parlar, Mert Cakir, Ozlem Ozer, Prateek Sharma
Clinical Endoscopy.2025; 58(4): 503. CrossRef
Endoskopische Therapie von Barrett-Neoplasien und Magenfrühkarzinomen
Florian Berreth, Jan Peveling-Oberhag, Jörg G. Albert
best practice onkologie.2024; 19(1-2): 28. CrossRef
The Role of Screening and Early Detection in Upper Gastrointestinal Cancers
Jin Woo Yoo, Monika Laszkowska, Robin B. Mendelsohn
Hematology/Oncology Clinics of North America.2024; 38(3): 693. CrossRef
Artificial intelligence in gastroenterology: where are we and where are we going?
Laurence B Lovat
Gastrointestinal Nursing.2024; 22(Sup3): S6. CrossRef
As how artificial intelligence is revolutionizing endoscopy
Jean-Francois Rey
Clinical Endoscopy.2024; 57(3): 302. CrossRef
Screening and Diagnostic Advances of Artificial Intelligence in Endoscopy
Muhammed Yaman Swied, Mulham Alom, Obada Daaboul, Abdul Swied
Innovations in Digital Health, Diagnostics, and Biomarkers.2024; 4(2024): 31. CrossRef
Endoscopic Artificial Intelligence for Image Analysis in Gastrointestinal Neoplasms
Ryosuke Kikuchi, Kazuaki Okamoto, Tsuyoshi Ozawa, Junichi Shibata, Soichiro Ishihara, Tomohiro Tada
Digestion.2024; 105(6): 419. CrossRef
Edge Artificial Intelligence Device in Real-Time Endoscopy for Classification of Gastric Neoplasms: Development and Validation Study
Eun Jeong Gong, Chang Seok Bang, Jae Jun Lee
Biomimetics.2024; 9(12): 783. CrossRef
Endoskopische Therapie von Barrett-Neoplasien und Magenfrühkarzinomen
Florian Berreth, Jan Peveling-Oberhag, Jörg G. Albert
Die Gastroenterologie.2023; 18(3): 186. CrossRef

8,185 View
329 Download
12 Web of Science
16 Crossref

Original Article

Endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma: long-term follow-up in a Western center: Andreas Probst, Alanna Ebigbo, Stefan Eser, Carola Fleischmann, Tina Schaller, Bruno Märkl, Stefan Schiele, Bernd Geissler, Gernot Müller, Helmut Messmann; Clin Endosc 2023;56(1):55-64. Published online January 13, 2023; DOI: https://doi.org/10.5946/ce.2022.093

Abstract PDF

Background
/Aims: Endoscopic submucosal dissection (ESD) has been established as a treatment modality for superficial esophageal squamous cell carcinoma (ESCC). Long-term follow-up data are lacking in Western countries. The aim of this study was to analyze long-term survival in a Western center.
Methods
Patients undergoing ESD for ESCC were included. The analysis was performed retrospectively using a prospectively collected database.
Results
R0 resection rate was 96.7% (59/61 lesions in 58 patients). Twenty-seven patients (46.6%) fulfilled the curative resection criteria (M1/M2) (group A), 11 patients (19.0%) had M3 lesions without lymphovascular invasion (LVI) (group B), and 20 patients (34.5%) had lesions with submucosal invasion or LVI (group C). Additional treatment was recommended after non-curative resection. It was not performed in 20/31 patients (64.5%), mainly because of comorbidities (75%). Twenty-nine out of 58 (50.0%) patients died during a mean follow-up of 3.7 years. Death was related to ESCC in 17.2% (5/29) of patients. The disease-specific survival rate after curative resection was 100%. Overall survival rates after 5 years were 61.5%, 63.6% and 28.1% for groups A, B, and C, respectively. The overall survival was significantly worse after non-curative resection (p=0.038).
Conclusions
Non-curative resection is frequent after ESD for ESCC in Western patients. The long-term prognosis is limited and mainly determined by comorbidity. Early diagnosis and pre-interventional assessments need to be improved.

Citations

Citations to this article as recorded by

Outcomes of endoscopic submucosal dissection for superficial esophageal squamous neoplasms: a multicenter North American experience
Rishi Subrahmanyan, Hiroyuki Aihara, Anand Kumar, Alexander Schlachterman, Shai Friedland, Joo Ha Hwang, Mohamed Othman, Salmaan Jawaid, Lorenzo Ferri, Christopher Teshima, Jeffrey Mosko, Robert Bechara, Jason Samarasena, Dennis Yang, Michael Ujiki, Yutak
Gastrointestinal Endoscopy.2026; 104(1): 21. CrossRef
Endoscopic submucosal dissection in early esophageal neoplasia: Celebrating efficacy, confronting heterogeneity, and refining surveillance for high-risk patients
Shi-Qiong Zhou, Qing-Hua Ke
World Journal of Clinical Oncology.2026;[Epub] CrossRef
Long-Term Outcomes of Endoscopic Submucosal Dissection for Esophageal Squamous High-Grade Dysplasia and Early Squamous Cell Carcinoma in the West: Absolute vs Outside Criteria
Sunil Gupta, Francesco Vito Mandarino, Brian Lam, Julia Gauci, Clarence Kerrison, Duncan McLeod, Eric Lee, Nicholas Burgess, Michael J. Bourke
Clinical Gastroenterology and Hepatology.2026;[Epub] CrossRef
Endoscopic resection of early esophageal neoplasia in patients with esophageal varices: a systematic review
Charlotte N. Frederiks, Laura S. Boer, Bas Gloudemans, Lorenza Alvarez Herrero, Jacques J.G.H.M. Bergman, Roos E. Pouw, Bas L.A.M. Weusten
Endoscopy.2025; 57(07): 769. CrossRef
Non-Curative Endoscopic Submucosal Dissection: Current Concepts, Pitfalls and Future Perspectives
João Santos-Antunes
Journal of Clinical Medicine.2025; 14(7): 2488. CrossRef
Feasibility and predictors of same-day discharge following endoscopic submucosal dissection for early esophageal cancer
Yu-ping Yuan, Chi-chao Wang, Yuan-liang Zheng
BMC Gastroenterology.2025;[Epub] CrossRef
Navigating the Treatment Landscape for Widespread Superficial Esophageal Squamous Cell Neoplasia
Moon Won Lee, Gwang Ha Kim
Gut and Liver.2025; 19(3): 305. CrossRef
Endoscopic submucosal dissection in the West: tips and tricks for successful resection
Roberta Maselli
Gastrointestinal Endoscopy.2025; 102(4): 488. CrossRef
Endoscopic submucosal dissection for early gastrointestinal malignancies: Current state and future perspectives
Sandip Pal, Gourab Bhaduri
World Journal of Gastrointestinal Endoscopy.2025;[Epub] CrossRef
Endoscopic submucosal dissection for early esophageal squamous cell carcinoma: long-term results from a Western cohort
Ilse N. Beaufort, Charlotte N. Frederiks, Anouk Overwater, Lodewijk A.A. Brosens, Arjun D. Koch, Roos E. Pouw, Jacques J.G.H.M. Bergman, Bas L.A.M. Weusten
Endoscopy.2024; 56(05): 325. CrossRef
Long-Term Outcomes of Esophageal Squamous Neoplasia with Muscularis Mucosa Involvement after Endoscopic Submucosal Dissection
Chen-Huan Yu, Yueh-Hung Chou, Tze-Yu Shieh, Chao-Yu Liu, Jiann-Ming Wu, Chen-Hsi Hsieh, Tzong-Hsi Lee, Chen-Shuan Chung
Biomedicines.2024; 12(8): 1660. CrossRef
Endoscopic Submucosal Dissection for Esophageal Cancer: Current and Future
Yuki Okubo, Ryu Ishihara
Life.2023; 13(4): 892. CrossRef

8,644 View
177 Download
11 Web of Science
12 Crossref

Review

Methods that Assist Traction during Endoscopic Submucosal Dissection of Superficial Gastrointestinal Cancers: A Systematic Literature Review: Georgios Tziatzios, Alanna Ebigbo, Stefan Karl Gölder, Andreas Probst, Helmut Messmann; Clin Endosc 2020;53(3):286-301. Published online January 9, 2020; DOI: https://doi.org/10.5946/ce.2019.147

Abstract PDF Supplementary Material

Endoscopic submucosal dissection (ESD) is a well-established method for the treatment of early-stage gastrointestinal neoplasms. Adequate submucosal exposure is one of the most significant factors related to an effective and safe dissection. The aim of this systematic review was to evaluate the effcacy and safety of various methods that assist traction during ESD of precancerous and earlystage neoplastic lesions of the gastrointestinal tract. We performed an electronic search of the MEDLINE and the Cochrane Controlled Trials Register databases for relevant studies published up to May 2019. Trials exclusively recruiting patients undergoing ESD for superficial gastrointestinal cancer were considered eligible for inclusion. Thirty-three articles including 3,134 patients met the inclusion criteria. The studies evaluated different approaches for widening the endoscopic view, including magnetic anchor-guided ESD (3 studies), use of a second endoscope (5 studies), clip-involving technique (21 studies), and miscellaneous methods (4 studies). Among them, only 6 were randomized controlled trials evaluating different approaches. Overall, the implementation of methods that assist traction during ESD significantly improved the operating time and R0 resection rate and decreased the rate of complications (bleeding and perforation). Interventions that assist traction seem effcacious in improving tissue traction, thus facilitating ESD performance.

Citations

Citations to this article as recorded by

“Umbrella-shaped pulley traction” assisted endoscopic submucosal dissection of colonic lesions – a modified external traction technique
Rui Xie, Ru Feng, Xiaozhong Yang, Honggang Wang, Weijie Dai
Endoscopy.2026; 58(S 01): E26. CrossRef
Endoscopic Submucosal Dissection for Early Gastric Cancer: Current Standard Indication and Management
Moon Won Lee
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2026; 26(1): 15. CrossRef
Reducing hyperkalemia in hemodialysis: a nurse-led quality improvement project using the clinical translation model
Yanhua Jiang, Chunhua Sun, Xuan Shen, Binbin Chen, Yifan Jin, Rongrong Pan, Qing Yu, Yili Zhang
JBI Evidence Implementation.2026;[Epub] CrossRef
Third-Space Endoscopy in Gastrointestinal Disease: Techniques, Outcomes, and Future Directions: A Narrative Review
Esma Z. Kizilaslan, Mousa Ayoub, Oscar Cahyadi, Peter Ewald, Alanna Ebigbo
Visceral Medicine.2026; : 1. CrossRef
Prospective, randomized controlled study evaluating a double-balloon interventional endoscopic platform for colorectal endoscopic submucosal dissection (with video)
Sergey V. Kantsevoy, Angela Palmer, Deborah Hockett, April Vilches
Gastrointestinal Endoscopy.2025; 101(1): 149. CrossRef
Response
Sergey V. Kantsevoy, Angela Palmer, Deborah Hockett, April Vilches
Gastrointestinal Endoscopy.2025; 101(1): 230. CrossRef
Giant gastric leiomyoma excision using endoscopic submucosal dissection with dental floss clip traction technique: a case report
Jiwen Deng, Zhaohui Liu, Dayong Sun
Journal of International Medical Research.2025;[Epub] CrossRef
Magnetic anchors with line-guided endoscopic full-thickness resection for gastric submucosal tumors
Xueyan Zhang, Hongli Wang, Chen He, Zhenghan Xiao, Yanshun Zhang, Bo Qu
European Journal of Medical Research.2025;[Epub] CrossRef
Efficacy and safety of multi-loop traction device-assisted colorectal endoscopic submucosal dissection: Multicenter randomized clinical trial
Mamoru Ito, Yuko Miura, Yasuhiko Mizuguchi, Hiroto Furuhashi, Yosuke Tsuji, Hiroyuki Takamaru, Naoto Tamai, Mitsuhiro Fujishiro, Yutaka Saito, Kazuki Sumiyama
Endoscopy International Open.2025;[Epub] CrossRef
Endoscopic Submucosal Dissection with Rubber Bands and Clips Compared to Conventional Endoscopic Submucosal Dissection: A Systematic Review and Meta-Analysis
Abdelaziz A. Awad, Hazem Abosheaishaa, Malak A. Hassan, Mohamed Mahmoud Marey, Ahmed Bahnasy, Rashad G. Mohamed, Menna A. Keshk, Yousef Radwan Alnomani, Manar A. Balouz, Ahmed Abdelgayed M Hussein, Fatma S. Mohamed, Mohammed A. Alaeb, Mohamed S. Sharaf, O
Digestive Diseases and Sciences.2025; 70(8): 2823. CrossRef
The efficacy and safety of endoscopic submucosal resection in periappendiceal lesions: a systematic review and meta-analysis
Hazem Abosheaishaa, Abdellatif Ismail, Mohanad Awadalla, Shaikhoon Mohammed, Monzer Abdalla, Ayman Elawad, Chukwunonso Ezeani, Jenson Phung, Mohamed Abdallah, Neil Nero, Amit Bhatt, Madhusudhan Sanaka, Mohammad Bilal
European Journal of Gastroenterology & Hepatology.2025; 37(12): 1350. CrossRef
Orthodontic rubber band combined with through-the-scope twin clip-assisted endoscopic intermuscular dissection for large laterally spreading tumors in the distal rectum
Kunming Lv, Xiangdong Wang, Yifan Xu, Yaoqian Yuan, Enqiang Linghu, Qianqian Chen
Endoscopy.2025; 57(S 01): E1010. CrossRef
The Impact of Traction Methods on Endoscopic Submucosal Dissection Efficacy for Gastric Neoplasia: A Systematic Review and Meta-analysis
Chengu Niu, Jing Zhang, Saarwaani Vallabhajosyula, Bryan E-Xin, Mahesh Napel, Patrick I. Okolo
Journal of Gastrointestinal Cancer.2024; 55(1): 129. CrossRef
Facilitating endoscopic full‐thickness resection for gastric submucosal tumors with a novel snare traction method (with video)
Lei Gu, Xiaotong Wang, Miao Ouyang, Fujun Li, Yu Wu, Xiaowei Liu
Journal of Gastroenterology and Hepatology.2024; 39(3): 535. CrossRef
Endoscopic Resection of Malignancies in the Upper GI Tract: A Clinical Algorithm
Ulrike Walburga Denzer
Visceral Medicine.2024; 40(3): 116. CrossRef
Efficacy, safety, and impact on procedural outcomes of local anesthesia in endoscopic submucosal dissection: a systematic review and meta-analysis
Hazem Abosheaishaa, Abdelmalek Abdelghany, Abdallfatah Abdallfatah, Doha Mohamed, Ammar Ayman Bahbah, Islam Mohamed, Khaled Elfert, Ahmed E. Salem, Azizullah Beran, Ahmad Madkour, Mohammad Al-Haddad
Baylor University Medical Center Proceedings.2024; 37(6): 963. CrossRef
Building the Toolbox of Devices to Optimize a Practice in Submucosal Endoscopy
Rahil H. Shah, Sunil Amin
Gastrointestinal Endoscopy Clinics of North America.2023; 33(1): 15. CrossRef
Error-Correcting Mean-Teacher: Corrections instead of consistency-targets applied to semi-supervised medical image segmentation
Robert Mendel, David Rauber, Luis A. de Souza, João P. Papa, Christoph Palm
Computers in Biology and Medicine.2023; 154: 106585. CrossRef
Endoscopic submucosal dissection techniques and technology: European Society of Gastrointestinal Endoscopy (ESGE) Technical Review
Diogo Libânio, Pedro Pimentel-Nunes, Barbara Bastiaansen, Raf Bisschops, Michael J. Bourke, Pierre H. Deprez, Gianluca Esposito, Arnaud Lemmers, Philippe Leclercq, Roberta Maselli, Helmut Messmann, Oliver Pech, Mathieu Pioche, Michael Vieth, Bas L.A.M. We
Endoscopy.2023; 55(04): 361. CrossRef
Multi-loop traction device facilitates gastric endoscopic submucosal dissection: ex vivo pilot study and an inaugural clinical experience
Hiroaki Matsui, Naoto Tamai, Toshiki Futakuchi, Shunsuke Kamba, Akira Dobashi, Kazuki Sumiyama
BMC Gastroenterology.2022;[Epub] CrossRef
Novel Colorectal Endoscopic Submucosal Dissection With Double-Endoscope and Snare-Based Traction
Chu-Kuang Chou, Kun-Feng Tsai, Cheng-Hao Tseng, Ching-Tai Lee, Kuo-Hsin Yang, Min-Chi Chang, Chao-Wen Hsu
Diseases of the Colon & Rectum.2022; 65(7): 936. CrossRef
Novel articulating through-the-scope traction device
Cem Simsek, Christopher C. Thompson, Khaled J. Alkhateeb, Sebastian A. Jofre, Hiroyuki Aihara
VideoGIE.2022; 7(10): 353. CrossRef
“String-to-ring” traction technique for endoscopic submocosal dissection in the treatment of rectal tumors
A. A. Mitrakov, S. S. Pirogov, N. N. Mitrakova, S. V. Gamayunov, M. V. Timoshchenko, R. A. Gagaev
Experimental and Clinical Gastroenterology.2022; (5): 97. CrossRef
Combination of endoscopic submucosal dissection techniques, a practical solution for difficult cases
Dong-Hoon Yang
Clinical Endoscopy.2022; 55(5): 626. CrossRef
A novel training model to simulate thread traction in colorectal endoscopic submucosal dissection – a video vignette
Shih‐Feng Huang, Chao‐Wen Hsu
Colorectal Disease.2021; 23(4): 1012. CrossRef
Endoscopic diagnosis and treatment of gastric dysplasia and early cancer: Current evidence and what the future may hold
Edward Young, Hamish Philpott, Rajvinder Singh
World Journal of Gastroenterology.2021; 27(31): 5126. CrossRef
Double-endoscope assisted endoscopic submucosal dissection for treating tumors in rectum and distal colon by expert endoscopists: a feasibility study
A. Ebigbo, G. Tziatzios, S. K. Gölder, A. Probst, H. Messmann
Techniques in Coloproctology.2020; 24(12): 1293. CrossRef

11,837 View
319 Download
22 Web of Science
27 Crossref

First
Prev
Page of 1
Next
Last

Search