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Remimazolam, a novel drug, for safe and effective endoscopic sedation
Jae Min Lee, Yehyun Park, Dong Won Ahn, Jun Kyu Lee, Kwang Hyuck Lee
Received February 7, 2024  Accepted May 8, 2024  Published online January 14, 2025  
DOI: https://doi.org/10.5946/ce.2024.026    [Epub ahead of print]
AbstractAbstract PDFPubReaderePub
Remimazolam is a novel benzodiazepine with unique pharmacokinetic and pharmacodynamic properties, making it an ideal candidate for sedation during endoscopic procedures. Distinguished by its rapid onset and short duration of action, remimazolam offers a safer and more efficient alternative to traditional sedatives, such as midazolam and propofol, with fewer side effects, such as hypotension, bradycardia, and respiratory depression. This article reviews the characteristics of remimazolam and its practical advantages, including ease of use, quick recovery time, and minimal residual sedation, emphasizing its potential to improve patient safety and procedural efficiency in clinical endoscopy settings.
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Flattened oval brown objects extracted from the bile duct
Jae Min Lee
Clin Endosc 2024;57(4):555-557.   Published online July 23, 2024
DOI: https://doi.org/10.5946/ce.2024.104
PDFPubReaderePub
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Reviews
New sedatives and analgesic drugs for gastrointestinal endoscopic procedures
Jae Min Lee, Yehyun Park, Jin Myung Park, Hong Jun Park, Jun Yong Bae, Seung Young Seo, Jee Hyun Lee, Hyung Ku Chon, Jun-Won Chung, Hyun Ho Choi, Jun Kyu Lee, Byung-Wook Kim, Endoscopic Sedation Committee of the Korean Society of Gastrointestinal Endoscopy
Clin Endosc 2022;55(5):581-587.   Published online August 29, 2022
DOI: https://doi.org/10.5946/ce.2021.283
AbstractAbstract PDFPubReaderePub
Procedural sedation has become increasingly common in endoscopy. Sedatives and analgesics induce anxiolysis and amnesia. In addition, an appropriate level of sedation is necessary for safe procedures including therapeutic endoscopy. Midazolam and propofol are the most commonly used drugs in sedative endoscopy. In recent years, the need to ascertain the safety and effectiveness of sedation has increased in practice. Therefore, new sedatives and analgesic drugs for optimal sedative endoscopy, have recently emerged. This article reviews the characteristics of sedatives and analgesics, and describes their clinical use in gastrointestinal endoscopy.

Citations

Citations to this article as recorded by  
  • Comparative effects of ciprofol and propofol on perioperative outcomes: a systematic review and meta-analysis of randomized controlled trials
    Jiazheng Qi, Lingjing Zhang, Fanhua Meng, Xiaoyu Yang, Baoxuan Chen, Lingqi Gao, Xu Zhao, Mengqiang Luo
    Brazilian Journal of Anesthesiology (English Edition).2025; 75(2): 844578.     CrossRef
  • Clinical Practice Guideline for Percutaneous Endoscopic Gastrostomy
    Chung Hyun Tae, Ju Yup Lee, Moon Kyung Joo, Chan Hyuk Park, Eun Jeong Gong, Cheol Min Shin, Hyun Lim, Hyuk Soon Choi, Miyoung Choi, Sang Hoon Kim, Chul-Hyun Lim, Jeong-Sik Byeon, Ki-Nam Shim, Geun Am Song, Moon Sung Lee, Jong-Jae Park, Oh Young Lee
    Gut and Liver.2024; 18(1): 10.     CrossRef
  • Assessing wound complications in gastroscopy with Streptomyces protease enzyme combined with Shutai
    Qihui Chen, Hangfei Li, Lijuan Zhou, Zhanbo Yang
    International Wound Journal.2024;[Epub]     CrossRef
  • Characterization of Pediatric Rectal Absorption, Drug Disposition, and Sedation Level for Midazolam Gel Using Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling
    Jinying Zhu, Sufeng Zhou, Lu Wang, Yuqing Zhao, Jie Wang, Tangping Zhao, Tongtong Li, Feng Shao
    Molecular Pharmaceutics.2024; 21(5): 2187.     CrossRef
  • Development of a predictive model for hypoxia due to sedatives in gastrointestinal endoscopy: a prospective clinical study in Korea
    Jung Wan Choe, Jong Jin Hyun, Seong-Jin Son, Seung-Hak Lee
    Clinical Endoscopy.2024; 57(4): 476.     CrossRef
  • Optimal Surveillance of Metachronous Gastric Lesion after Endoscopic Resection of Early Gastric Cancer
    Dong Chan Joo, Gwang Ha Kim
    Gut and Liver.2024; 18(5): 781.     CrossRef
  • Clinical practice guidelines for percutaneous endoscopic gastrostomy
    Chung Hyun Tae, Ju Yup Lee, Moon Kyung Joo, Chan Hyuk Park, Eun Jeong Gong, Cheol Min Shin, Hyun Lim, Hyuk Soon Choi, Miyoung Choi, Sang Hoon Kim, Chul-Hyun Lim, Jeong-Sik Byeon, Ki-Nam Shim, Geun Am Song, Moon Sung Lee, Jong-Jae Park, Oh Young Lee
    Clinical Endoscopy.2023; 56(4): 391.     CrossRef
  • Quality of recovery and pre-existing impaired cognition in patients undergoing advanced GI endoscopic procedures with patient-controlled sedation: a prospective observational cohort study
    Sara Lyckner, Michelle S. Chew, Andreas Nilsson
    iGIE.2023; 2(3): 292.     CrossRef
  • Clinical Practice Guideline for Percutaneous Endoscopic Gastrostomy
    Chung Hyun Tae, Ju Yup Lee, Moon Kyung Joo, Chan Hyuk Park, Eun Jeong Gong, Cheol Min Shin, Hyun Lim, Hyuk Soon Choi, Miyoung Choi, Sang Hoon Kim, Chul-Hyun Lim, Jeong-Sik Byeon, Ki-Nam Shim, Geun Am Song, Moon Sung Lee, Jong-Jae Park, Oh Young Lee
    The Korean Journal of Gastroenterology.2023; 82(3): 107.     CrossRef
  • Drugs used for sedation in gastrointestinal endoscopy
    Jun Kyu Lee
    Journal of the Korean Medical Association.2022; 65(11): 735.     CrossRef
  • 5,783 View
  • 339 Download
  • 11 Web of Science
  • 10 Crossref
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2021 Korean Society of Gastrointestinal Endoscopy Clinical Practice Guidelines for Endoscopic Sedation
Hong Jun Park, Byung-Wook Kim, Jun Kyu Lee, Yehyun Park, Jin Myung Park, Jun Yong Bae, Seung Young Seo, Jae Min Lee, Jee Hyun Lee, Hyung Ku Chon, Jun-Won Chung, Hyun Ho Choi, Myung Ha Kim, Dong Ah Park, Jae Hung Jung, Joo Young Cho, Endoscopic Sedation Committee of Korean Society of Gastrointestinal Endoscopy
Clin Endosc 2022;55(2):167-182.   Published online February 22, 2022
DOI: https://doi.org/10.5946/ce.2021.282
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Sedation can resolve anxiety and fear in patients undergoing endoscopy. The use of sedatives has increased in Korea. Appropriate sedation is a state in which the patient feels subjectively comfortable while maintaining the airway reflex for stable spontaneous breathing. The patient should maintain a state of consciousness to the extent that he or she can cooperate with the needs of the medical staff. Despite its benefits, endoscopic sedation has been associated with cardiopulmonary complications. Cardiopulmonary complications are usually temporary. Most patients recover without sequelae. However, they may progress to serious complications, such as cardiovascular collapse. Therefore, it is essential to screen high-risk patients before sedation and reduce complications by meticulous monitoring. Additionally, physicians should be familiar with the management of emergencies. The first Korean clinical practice guideline for endoscopic sedation was developed based on previous worldwide guidelines for endoscopic sedation using an adaptation process. The guideline consists of nine recommendations based on a critical review of currently available data and expert consensus when the guideline was drafted. These guidelines should provide clinicians, nurses, medical school students, and policy makers with information on how to perform endoscopic sedation with minimal risk.

Citations

Citations to this article as recorded by  
  • Using Clinical-based Discharge Criteria to Discharge Patients After Endoscopy Procedures Under Drug-induced Intravenous Sedation in the Outpatient Care Unit: An Observational Study
    Liangyu Fang, Lina Chen, Bingbing Wu, Yinchuan Xu, Laijuan Chen
    Journal of PeriAnesthesia Nursing.2024; 39(5): 859.     CrossRef
  • Development and Effectiveness Evaluation of 360-Degree Virtual Reality-Based Educational Intervention for Adult Patients Undergoing Colonoscopy
    Minju Gwag, Jaeyong Yoo
    Healthcare.2024; 12(14): 1448.     CrossRef
  • Development of a predictive model for hypoxia due to sedatives in gastrointestinal endoscopy: a prospective clinical study in Korea
    Jung Wan Choe, Jong Jin Hyun, Seong-Jin Son, Seung-Hak Lee
    Clinical Endoscopy.2024; 57(4): 476.     CrossRef
  • Comparison of Synergistic Sedation with Midazolam and Propofol Versus Midazolam and Pethidine in Colonoscopies: A Prospective, Randomized Controlled Study
    Jae Woong Lim, Min Jae Kim, Gang Han Lee, Dae Sol Kim, Sang Hyuk Jung, Yu Yeon Kim, Jin Won Kim, Yohan Lee, Hyun Soo Kim, Seon Young Park, Dong Hyun Kim
    Chonnam Medical Journal.2024; 60(3): 192.     CrossRef
  • Nasal mask versus conventional oxygen supply for endoscopy under intravenous sedation: protocol for a systematic review and meta-analysis
    Wentao Ji, Yu Deng, Min Zheng, Xiaoting Zhang, Jun Lu, Jinhai Liu, Bo Li, Lulong Bo
    BMJ Open.2024; 14(12): e092868.     CrossRef
  • Experience of organizing outpatient anesthetic care at Endoscopy centre of Multidisciplinary city clinic
    O. V. Makarov, S. A. Osipov, E. P. Rodionov, A. A. Malyshev, I. Yu. Korzheva, L. M. Avramenko, Z. Z. Loseva, I. V. Balykov, L. A. Baichorova, E. I. Alikhanova, A. V. Vlasenko, E. A. Evdokimov, V. I. Makovey, V. V. Erofeev
    Medical alphabet.2023; (6): 50.     CrossRef
  • Anesthesia care provider sedation versus conscious sedation for endoscopic ultrasound–guided tissue acquisition: a retrospective cohort study
    Sneha Shaha, Yinglin Gao, Jiahao Peng, Kendrick Che, John J. Kim, Wasseem Skef
    Clinical Endoscopy.2023; 56(5): 658.     CrossRef
  • Current status of the gastric cancer screening program in Korea
    Young-Il Kim, Il Ju Choi
    Journal of the Korean Medical Association.2022; 65(5): 250.     CrossRef
  • In pursuit of the right plan for airway management in gastrointestinal endoscopic procedures…the battle half won?
    Upender Gowd, Sukhminder Jit Singh Bajwa, Madhuri Kurdi, Gaurav Sindwani
    Indian Journal of Anaesthesia.2022; 66(10): 683.     CrossRef
  • Drugs used for sedation in gastrointestinal endoscopy
    Jun Kyu Lee
    Journal of the Korean Medical Association.2022; 65(11): 735.     CrossRef
  • 7,111 View
  • 614 Download
  • 9 Web of Science
  • 10 Crossref
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Clinical Practice Guidelines for the Endoscopic Management of Peripancreatic Fluid Collections
Chi Hyuk Oh, Jun Kyu Lee, Tae Jun Song, Jin-Seok Park, Jae Min Lee, Jun Hyuk Son, Dong Kee Jang, Miyoung Choi, Jeong-Sik Byeon, In Seok Lee, Soo Teik Lee, Ho Soon Choi, Ho Gak Kim, Hoon Jai Chun, Chan Guk Park, Joo Young Cho
Clin Endosc 2021;54(4):505-521.   Published online July 27, 2021
DOI: https://doi.org/10.5946/ce.2021.185
AbstractAbstract PDFPubReaderePub
Endoscopic ultrasonography-guided intervention has gradually become a standard treatment for peripancreatic fluid collections (PFCs). However, it is difficult to popularize the procedure in Korea because of restrictions on insurance claims regarding the use of endoscopic accessories, as well as the lack of standardized Korean clinical practice guidelines. The Korean Society of Gastrointestinal Endoscopy (KSGE) appointed a Task Force to develope medical guidelines by referring to the manual for clinical practice guidelines development prepared by the National Evidence-Based Healthcare Collaborating Agency. Previous studies on PFCs were searched, and certain studies were selected with the help of experts. Then, a set of key questions was selected, and treatment guidelines were systematically reviewed. Answers to these questions and recommendations were selected via peer review. This guideline discusses endoscopic management of PFCs and makes recommendations on Indications for the procedure, pre-procedural preparations, optimal approach for drainage, procedural considerations (e.g., types of stent, advantages and disadvantages of plastic and metal stents, and accessories), adverse events of endoscopic intervention, and procedural quality issues. This guideline was reviewed by external experts and suggests best practices recommended based on the evidence available at the time of preparation. This will be revised as necessary to address advances and changes in technology and evidence obtained in clinical practice and future studies.

Citations

Citations to this article as recorded by  
  • Benign biliary stricture caused by transduodenal lumen-apposing metal stent placement for pancreatic acute necrotic collection
    Shuhei Shintani, Takuya Okamoto, Kosuke Hiroe, Hidenori Kimura, Hiroto Inoue, Atsushi Nishida, Osamu Inatomi
    International Journal of Gastrointestinal Intervention.2025; 14(1): 24.     CrossRef
  • Pancreatic Pseudocyst after Fully Covered Self-expandable Metallic Stent Placement
    Mitsuhito Koizumi, Sho Ishikawa, Kaori Marui, Masahito Kokubu, Yusuke Okujima, Yuki Numata, Yoshiki Imamura, Teru Kumagi, Yoichi Hiasa
    Internal Medicine.2024; 63(21): 2943.     CrossRef
  • Neutrophil Gelatinase-Associated Lipocalin for the Differentiation of Mucinous Pancreatic Cystic Lesions
    Miruna Patricia Olar, Maria Iacobescu, Sorana D. Bolboacă, Cristina Pojoga, Ofelia Moșteanu, Radu Seicean, Ioana Rusu, Oana Banc, Cristina Adela Iuga, Andrada Seicean
    International Journal of Molecular Sciences.2024; 25(6): 3224.     CrossRef
  • Comparative outcome of single versus two double-pigtail stents for endoscopic drainage of pancreatic fluid collections with minimal necrosis: a retrospective analysis
    S Giri, S Bhrugumalla, S Gangadhar, S Angadi
    Acta Gastro Enterologica Belgica.2024; 87(1): 1.     CrossRef
  • Use of an endoscopic powered debridement device for treatment of post-surgical fatty pancreatic necrosis
    Judy Daboul, Shiab Mussad, Anna Cecilia Amaral, Waleed K. Hussain, Peter J. Lee, Samuel Han
    Clinical Endoscopy.2024; 57(3): 412.     CrossRef
  • Single double pigtail plastic stent (DPT) is equally effective to two double pigtail plastic stents for endoscopic ultrasonography-guided drainage of "symptomatic peripancreatic fluid collection with 30 % or less necrotic debris"
    Hemanta Kumar Nayak, Shubham Gupta, Manas Kumar Panigrahi, Abhijeet Rai, Saswati Kar, Mansi Chaudhary, Ajay Ghosh, Taraprasad Tripathy, Bramhadatta Pattnaik, Subash Chandra Samal
    Pancreatology.2024; 24(7): 1211.     CrossRef
  • Advances in self-expandable metal stents for endoscopic ultrasound-guided interventions
    Dong Kee Jang, Dong Wook Lee, Seong-Hun Kim, Kwang Bum Cho, Sundeep Lakhtakia
    Clinical Endoscopy.2024; 57(5): 588.     CrossRef
  • Drainage for fluid collections post pancreatic surgery and acute pancreatitis: similar but different?
    Yousuke Nakai, Saburo Matsubara, Tsuyoshi Mukai, Tsuyoshi Hamada, Takashi Sasaki, Hirotoshi Ishiwatari, Susumu Hijioka, Hideyuki Shiomi, Mamoru Takenaka, Takuji Iwashita, Atsuhiro Masuda, Tomotaka Saito, Hiroyuki Isayama, Ichiro Yasuda
    Clinical Endoscopy.2024; 57(6): 735.     CrossRef
  • Endoscopic ultrasound-guided drainage for local complications related to pancreatitis
    Hyung Ku Chon, Seong-Hun Kim
    International Journal of Gastrointestinal Intervention.2023; 12(1): 7.     CrossRef
  • A preferable modality for the differentiation of peripancreatic fluid collections: Endoscopic ultrasound
    Ning Xu, Longsong Li, Danqi Zhao, Zixin Wang, Xueting Wang, Runzi Wang, Yanbo Zeng, Lei Zhang, Ning Zhong, Ying Lv, Enqiang Linghu, Ningli Chai
    Endoscopic Ultrasound.2022; 11(4): 291.     CrossRef
  • Disconnected pancreatic duct syndrome in acute pancreatitis
    A.V. Fedorov, V.N. Ektov, M.A. Khodorkovsky
    Khirurgiya. Zhurnal im. N.I. Pirogova.2022; (8): 83.     CrossRef
  • Single balloon enteroscopy-guided endoscopic retrograde pancreatography for the treatment of a symptomatic pancreatic pseudocyst complicated by pancreaticojejunostomy stricture: A case report
    Eunae Cho, Chang-Hwan Park, Seo Yeon Cho
    Medicine.2022; 101(43): e31293.     CrossRef
  • 6,822 View
  • 267 Download
  • 13 Web of Science
  • 12 Crossref
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Clinical and Technical Guideline for Endoscopic Ultrasound (EUS)-Guided Tissue Acquisition of Pancreatic Solid Tumor: Korean Society of Gastrointestinal Endoscopy (KSGE)
Moon Jae Chung, Se Woo Park, Seong-Hun Kim, Chang Min Cho, Jun-Ho Choi, Eun Kwang Choi, Tae Hoon Lee, Eunae Cho, Jun Kyu Lee, Tae Jun Song, Jae Min Lee, Jun Hyuk Son, Jin Suk Park, Chi Hyuk Oh, Dong-Ah Park, Jeong-Sik Byeon, Soo Teik Lee, Ho Gak Kim, Hoon Jai Chun, Ho Soon Choi, Chan Guk Park, Joo Young Cho
Clin Endosc 2021;54(2):161-181.   Published online March 24, 2021
DOI: https://doi.org/10.5946/ce.2021.069
AbstractAbstract PDFPubReaderePub
Endoscopic ultrasound (EUS)-guided tissue acquisition of pancreatic solid tumor requires a strict recommendation for its proper use in clinical practice because of its technical difficulty and invasiveness. The Korean Society of Gastrointestinal Endoscopy (KSGE) appointed a Task Force to draft clinical practice guidelines for EUS-guided tissue acquisition of pancreatic solid tumor. The strength of recommendation and the level of evidence for each statement were graded according to the Minds Handbook for Clinical Practice Guideline Development 2014. The committee, comprising a development panel of 16 endosonographers and an expert on guideline development methodology, developed 12 evidence-based recommendations in 8 categories intended to help physicians make evidence-based clinical judgments with regard to the diagnosis of pancreatic solid tumor. This clinical practice guideline discusses EUS-guided sampling in pancreatic solid tumor and makes recommendations on circumstances that warrant its use, technical issues related to maximizing the diagnostic yield (e.g., needle type, needle diameter, adequate number of needle passes, sample obtaining techniques, and methods of specimen processing), adverse events of EUS-guided tissue acquisition, and learning-related issues. This guideline was reviewed by external experts and suggests best practices recommended based on the evidence available at the time of preparation. This guideline may not be applicable for all clinical situations and should be interpreted in light of specific situations and the availability of resources. It will be revised as necessary to cover progress and changes in technology and evidence from clinical practice.

Citations

Citations to this article as recorded by  
  • Role of Endoscopic Ultrasound in the Management of Pancreatic Cancer
    Balaji Musunuri, Shiran Shetty
    Indian Journal of Surgical Oncology.2024; 15(S2): 269.     CrossRef
  • Endoscopic Ultrasound (EUS) guided biopsy of healthy pig pancreas: Towards the histological diagnosis of chronic pancreatitis.
    Julio Iglesias-García, Yessica Domínguez-Novoa, Héctor Lazare-Iglesias, Antonio González-Cantalapiedra, Ihab Abdulkader-Nallib, Óscar Varela-López, José Lariño-Noia, Enrique Domínguez-Muñoz
    Revista Española de Enfermedades Digestivas.2024;[Epub]     CrossRef
  • Endoscopic ultrasound-guided tissue acquisition for personalized treatment in pancreatic adenocarcinoma
    Sang Myung Woo
    Clinical Endoscopy.2023; 56(2): 183.     CrossRef
  • Pancreatic duct lavage cytology combined with a cell-block method for patients with possible pancreatic ductal adenocarcinomas, including pancreatic carcinoma in situ
    Hiroaki Kusunose, Shinsuke Koshita, Yoshihide Kanno, Takahisa Ogawa, Toshitaka Sakai, Keisuke Yonamine, Kazuaki Miyamoto, Fumisato Kozakai, Hideyuki Anan, Kazuki Endo, Haruka Okano, Masaya Oikawa, Takashi Tsuchiya, Takashi Sawai, Yutaka Noda, Kei Ito
    Clinical Endoscopy.2023; 56(3): 353.     CrossRef
  • Anesthesia care provider sedation versus conscious sedation for endoscopic ultrasound–guided tissue acquisition: a retrospective cohort study
    Sneha Shaha, Yinglin Gao, Jiahao Peng, Kendrick Che, John J. Kim, Wasseem Skef
    Clinical Endoscopy.2023; 56(5): 658.     CrossRef
  • Endoscopic ultrasound-guided tissue acquisition and gene panel testing for pancreatic cancer
    Kentaro SUDO, Emiri KITA, Akiko TSUJIMOTO, Kazuyoshi NAKAMURA, Akiko ODAKA, Makiko ITAMI, Sana YOKOI, Hiroshi ISHII
    Suizo.2022; 37(1): 8.     CrossRef
  • Impact of rapid on-site evaluation on diagnostic accuracy of EUS-guided fine-needle aspiration of solid pancreatic lesions: experience from a single center
    Irem Guvendir, Itir Ebru Zemheri, Kamil Ozdil
    BMC Gastroenterology.2022;[Epub]     CrossRef
  • Endoscopic Ultrasound Guided Fine Needle Aspiration and Biopsy for Pancreatic Disease
    Kwang Hyuck Lee
    The Korean Journal of Pancreas and Biliary Tract.2021; 26(4): 241.     CrossRef
  • 9,045 View
  • 309 Download
  • 5 Web of Science
  • 8 Crossref
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Original Articles
Feasibility of Wearable Display Glasses for Medical Students in the Endoscopy Room
Kang Won Lee, Hyuk Soon Choi, Hoon Jai Chun, Jae Min Lee, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Soon Ho Um, Hong Sik Lee
Clin Endosc 2021;54(5):694-700.   Published online March 15, 2021
DOI: https://doi.org/10.5946/ce.2020.246
AbstractAbstract PDFPubReaderePub
Background
/Aims: Several attempts have been made to incorporate smart glasses in the medical field. We applied wearable display glasses to show the position of an observer during endoscopy and compared students’ responses between the conventional and new methods.
Methods
We surveyed 28 medical students regarding the use of wearable display devices. The students used wearable display glasses to observe an endoscopic procedure and answered the prepared questionnaire. Their collected responses were analyzed for statistical correlations between each variable.
Results
The survey of medical students revealed disadvantages including dizziness (dissatisfied and very dissatisfied: 21.5%) and eye fatigue (25% dissatisfied) and advantages including concentration (satisfied and very satisfied: 57.2%) and securing patient rights (71.4%). The students showed more positive than negative reviews regarding the new devices (32.1% vs. 21.5%).
Conclusions
We investigated the advantages and disadvantages of viewing the endoscope image with new wearable display glasses compared to the conventional method using the survey to record user experience. The results revealed relatively positive responses from the medical students in the survey. If the new device compensates for some shortcomings, its use in the endoscopy room will be feasible.

Citations

Citations to this article as recorded by  
  • A remote clinical clerkship program for severe COVID-19 in ICU using smart glasses: questionnaire survey
    Nobuyuki Nosaka, Hideo Yamanouch, Kazuki Takada, Kenji Wakabayashi
    Journal of the Japanese Society of Intensive Care Medicine.2023; 30(4): 261.     CrossRef
  • Smart Glasses to Facilitate Ultrasound Guided Peripheral Intravenous Access in the Simulation Setting for Thai Emergency Medical Service Providers
    Kamonwon Ienghong, Lap Woon Cheung, Pornpawit Wongwan, Korakot Apiratwarakul
    Journal of Multidisciplinary Healthcare.2023; Volume 16: 2201.     CrossRef
  • 4,462 View
  • 105 Download
  • 1 Web of Science
  • 2 Crossref
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Novel Ablation Therapy Using Endoscopic Irreversible Electroporation in the Bile Duct: A Pilot Animal Study
Kang Won Lee, Jae Min Lee, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Soon Ho Um, Hong Sik Lee, Hoon Jai Chun, Chang Duck Kim, Chi Hyuk Oh, Hong Bae Kim
Clin Endosc 2021;54(3):413-419.   Published online October 20, 2020
DOI: https://doi.org/10.5946/ce.2020.126
AbstractAbstract PDFPubReaderePub
Background
/Aims: Irreversible electroporation (IRE) is a relatively new ablation method. However, the application of IRE ablation in the treatment of biliary disease has not been attempted. A minimally invasive approach using endoscopic retrograde cholangiopancreatography (ERCP) can be a novel therapeutic modality for IRE ablation. In this study, we aimed to investigate the feasibility of endoscopic IRE for the biliary tract using an animal model.
Methods
A new catheter-type electrode was developed for endoscopic IRE ablation of the biliary tract. We performed ERCP and endoscopic IRE ablations in the normal common bile duct of Yorkshire pigs. The experimental setting of IRE was 500 V/cm (50 pulses, 100-µs length). The animals were sacrificed after 24 hr, and the ablated bile duct was examined.
Results
Well-demarcated focal color changes were observed on the mucosa of the common bile duct. The depth of change after IRE was confined to the mucosal and submucosal layers. Apoptotic changes in the bile duct were observed only around the IRE ablation area. Immunohistochemistry assay showed cell death in the bile duct along the electrode.
Conclusions
Endoscopic IRE ablation using ERCP was successfully performed in the common bile duct. It can be a potential option for the treatment of biliary tumors.

Citations

Citations to this article as recorded by  
  • Balloon‐assisted laser application for endoscopic treatment of biliary stricture
    Seonghee Lim, Van Gia Truong, Seok Jeong, Jiho Lee, Byeong‐il Lee, Hyun Wook Kang
    Lasers in Surgery and Medicine.2023; 55(10): 912.     CrossRef
  • Biliary complications and efficacy after ablation of peribiliary tumors using irreversible electroporation (IRE) or radiofrequency ablation (RFA)
    Somrach Thamtorawat, Rujira Patanawanitkul, Satit Rojwatcharapibarn, Walailak Chaiyasoot, Trongtum Tongdee, Jirawadee Yodying, Sukrit Sorotpinya
    International Journal of Hyperthermia.2022; 39(1): 751.     CrossRef
  • Large Animal Models in Pancreas and Biliary Disease
    Seok Jeong, Jin-Seok Park, Don Haeng Lee
    The Korean Journal of Gastroenterology.2021; 77(3): 99.     CrossRef
  • Comparison of four endoluminal radiofrequency ablation devices and four power generators in an ex vivo bovine liver model
    Stephan Rheinheimer, Anna Jacobsen, Philipp Mayer, Hans-Ulrich Kauczor, Andreas Mahnken
    World Academy of Sciences Journal.2021;[Epub]     CrossRef
  • 5,922 View
  • 180 Download
  • 3 Web of Science
  • 4 Crossref
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Case Report
Primary Gastric Small Cell Carcinoma (Presenting as Linitis Plastica) Diagnosed Using Endoscopic Ultrasound-Guided Biopsy: A Case Report
Ra Ri Cha, Jin Kyu Cho, Wan Soo Kim, Jin Joo Kim, Jae Min Lee, Sang Soo Lee, Hyun Jin Kim
Clin Endosc 2019;52(3):278-282.   Published online October 5, 2018
DOI: https://doi.org/10.5946/ce.2018.114
AbstractAbstract PDFPubReaderePub
Small cell carcinomas are the most aggressive, highly malignant neuroendocrine tumors; among these, gastric small cell carcinoma (GSCC) is extremely rare. Here we report a case of a patient with primary GSCC, presenting as linitis plastic, who was diagnosed using endoscopic ultrasound (EUS)-guided biopsy. With undiagnosed linitis plastica, an 80-year-old woman was referred to our institution. Abdominal computed tomography revealed irregular wall thickening extending from the gastric body to the antrum. Endoscopy suspected to have Borrmann type IV advanced gastric cancer. EUS of the stomach showed diffuse submucosal thickening of the gastric wall, mainly the antrum. EUS-guided bite-on-bite biopsy confirmed the diagnosis of GSCC. In general, GSCC is difficult to diagnose and careful examination is necessary to determine the therapeutic strategy; however, EUS is particularly helpful in the differential diagnosis of a lesion presenting as linitis plastica.

Citations

Citations to this article as recorded by  
  • An online tool for survival prediction of extrapulmonary small cell carcinoma with random forest
    Xin Zhang
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Gastric linitis plastica due to signet-ring cell carcinoma with Krukenberg tumors diagnosed by endoscopic ultrasound-guided fine-needle aspiration
    Takeshi Okamoto, Hidekazu Suzuki, Katsuyuki Fukuda
    Clinical Journal of Gastroenterology.2021; 14(4): 994.     CrossRef
  • A case report of advanced gastric small cell carcinoma with neoadjuvant chemotherapy followed by radical total gastrectomy
    Bing Wang, Nanlin Jiao, Lianghui Shi
    Asian Journal of Surgery.2020; 43(12): 1205.     CrossRef
  • 7,938 View
  • 161 Download
  • 3 Web of Science
  • 3 Crossref
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Original Articles
Is There a Change in Patient Preference for a Female Colonoscopist during the Last Decade in Korea?
Jung Min Lee, Eun Sun Kim, Hoon Jai Chun, In Kyung Yoo, Jae Min Lee, Seung Han Kim, Hyuk Soon Choi, Bora Keum, Yeon Seok Seo, Hong Sik Lee, Yoon Tae Jeen, Jong-Jae Park, Sang Woo Lee, Soon Ho Um, Chang Duck Kim
Clin Endosc 2018;51(1):72-79.   Published online October 10, 2017
DOI: https://doi.org/10.5946/ce.2017.057
AbstractAbstract PDFPubReaderePub
Background
/Aims: Patients may feel embarrassed during colonoscopy. Our study aimed to assess changes in patient preference, over the past decade, for the sex of their colonoscopist.
Methods
Prospective studies were performed at a single health center from July to September 2008, and from July to September 2016. Subjects included colonoscopy patients (2008: 354, 2016: 304) who were asked to complete a questionnaire before colonoscopy.
Results
In 2016, 69 patients (24.9%) expressed a sex preference, compared with 46 patients (14.6%) in 2008. By 2016, female patient preference for a female colonoscopist had significantly increased to 95% (odds ratio [OR], 2.678; 95% confidence interval [CI], 1.418– 5.057; P=0.002). In multivariate analysis, patient sex (OR, 4.404; P=0.000), patient age (OR, 0.977; 95% CI, 0.961–0.992; P=0.004), and year of procedure (OR, 1.674; 95% CI, 1.028–2.752) were statistically significant factors in sex preference. Between 2008 and 2016, female patients preferred a female colonoscopist because of embarrassment. Male patients also preferred a male colonoscopist, and the primary reason shifted from expertise to patient embarrassment (2008: 29%, 2016: 63%).
Conclusions
Patients have an increased gender preference for the colonoscopist because of embarrassment. Taking this into account can increase patient satisfaction during colonoscopy.

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    Kyeongmin Lee, Haejoo Seo, Sunho Choe, Seung-Yong Jeong, Ji Won Park, Mina Suh, Aesun Shin, Kui Son Choi, Filipe Prazeres
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Job Stress and Job Satisfaction among Health-Care Workers of Endoscopy Units in Korea
Seung-Joo Nam, Hoon Jai Chun, Jeong Seop Moon, Sung Chul Park, Young-Jae Hwang, In Kyung Yoo, Jae Min Lee, Seung Han Kim, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yoon Tae Jeen, Hong Sik Lee, Chang Duck Kim
Clin Endosc 2016;49(3):266-272.   Published online February 22, 2016
DOI: https://doi.org/10.5946/ce.2015.085
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background
/Aims: The management of job-related stress among health-care workers is critical for the improvement of healthcare services; however, there is no existing research on endoscopy unit workers as a team. Korea has a unique health-care system for endoscopy unit workers. In this study, we aimed to estimate job stress and job satisfaction among health-care providers in endoscopy units in Korea.
Methods
We performed a cross-sectional survey of health-care providers in the endoscopy units of three university-affiliated hospitals in Korea. We analyzed the job stress levels by using the Korean occupational stress scale, contributing factors, and job satisfaction.
Results
Fifty-nine workers completed the self-administered questionnaires. The job stress scores for the endoscopy unit workers (46.39±7.81) were relatively lower compared to those of the national sample of Korean workers (51.23±8.83). Job stress differed across job positions, with nurses showing significantly higher levels of stress (48.92±7.97) compared to doctors (42.59±6.37). Job stress and job satisfaction were negatively correlated with each other (R2 =0.340, p<0.001).
Conclusions
An endoscopy unit is composed of a heterogeneous group of health-care professionals (i.e., nurses, fellows, and professors), and job stress and job satisfaction significantly differ according to job positions. Job demand, insufficient job control, and job insecurity are the most important stressors in the endoscopy unit.

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  • Suriyeli Sığınmacı Kamplarının Bulunduğu İlçelerde Çalışan Sağlık Personelinin İş Stres Seviyesi: Şanlıurfa Örneği
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Case Report
Ectopic Opening of the Common Bile Duct into the Duodenal Bulb Accompanied with Cholangitis and Gallbladder Cancer: A Report of Two Cases
Jae Min Lee, Hong Jun Kim, Chang Yoon Ha, Hyun Ju Min, Hyunjin Kim, Tae Hyo Kim, Woon Tae Jung, Ok Jae Lee
Clin Endosc 2015;48(3):260-264.   Published online May 29, 2015
DOI: https://doi.org/10.5946/ce.2015.48.3.260
AbstractAbstract PDFPubReaderePub

An ectopic opening of the common bile duct (CBD) into the duodenal bulb is a very rare congenital anomaly of the biliary system, which may cause recurrent duodenal ulcer or biliary diseases such as choledocholithiasis and cholangitis. Endoscopic retrograde cholangiopancreatography (ERCP) plays a major role in the diagnosis of this anomaly. We report two such cases: one in a 61-year-old man and the other in a 57-year-old man. In the first case, this anomaly caused acute cholangitis with multiple CBD stones, which were successfully treated by ERCP. In the second case, abdominal computed tomography showed pneumobilia, which was further evaluated using ERCP. Besides, this patient was diagnosed with an ectopic opening of the CBD associated with gallbladder cancer. We report these unusual cases and review the relevant medical literature.

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    Korean Journal of Pancreas and Biliary Tract.2016; 21(2): 112.     CrossRef
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