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Raman Spectroscopy for the Endoscopic Diagnosis of Esophageal, Gastric, and Colonic Diseases
Neel Sharma, Nobuyoshi Takeshita, Khek Yu Ho
Clin Endosc 2016;49(5):404-407.   Published online September 22, 2016
DOI: https://doi.org/10.5946/ce.2016.100
AbstractAbstract PDFPubReaderePub
Globally white-light endoscopy with biopsy sampling is the gold standard diagnostic modality for esophageal, gastric, and colonic pathologies. However, there is overwhelming evidence to highlight the deficiencies of an approach based predominantly on eyeball visualization. Biopsy sampling is also problematic due in part to excessive sampling and hence attendant cost. Various innovations are currently taking place in the endoscopic domain to aid operators in diagnosis forming. These include narrow band imaging which aims to enhance the surface anatomy and vasculature, and confocal laser endomicroscopy which provides real time histological information. However, both of these tools are limited by the skill of the operator and the extensive learning curve associated with their use. There is a gap therefore for a new form of technology that relies solely on an objective measure of disease and reduces the need for biopsy sampling. Raman spectroscopy (RS) is a potential platform that aims to satisfy these criteria. It enables a fingerprint capture of tissue in relation to the protein, DNA, and lipid content. This focused review highlights the strong potential for the use of RS during endoscopic gastroenterological examination.

Citations

Citations to this article as recorded by  
  • Biomedical applications, perspectives and tag design concepts in the cell – silent Raman window
    Martha Z. Vardaki, Vasilis G. Gregoriou, Christos L. Chochos
    RSC Chemical Biology.2024; 5(4): 273.     CrossRef
  • Label-Free Optical Technologies to Enhance Noninvasive Endoscopic Imaging of Early-Stage Cancers
    Shuang Chang, Halina Krzyzanowska, Audrey K. Bowden
    Annual Review of Analytical Chemistry .2024; 17(1): 289.     CrossRef
  • Raman fiber-optic probe for rapid diagnosis of gastric and esophageal tumors with machine learning analysis or similarity assessments: a comparative study
    Shiyan Fang, Pei Xu, Siyi Wu, Zhou Chen, Junqing Yang, Haibo Xiao, Fangbao Ding, Shuchun Li, Jin Sun, Zirui He, Jian Ye, Linley Li Lin
    Analytical and Bioanalytical Chemistry.2024; 416(29): 6759.     CrossRef
  • Raman spectroscopy in the diagnosis of malignant biliary stricture: A feasibility study
    Peter Slodička, Přemysl Falt, Václav Ranc, Vincent Dansou Zoundjiekpon, Ondřej Urban
    Hepatobiliary & Pancreatic Diseases International.2024;[Epub]     CrossRef
  • Comparing Raman Spectroscopy-Based Artificial Intelligence to High-Definition White Light Endoscopy for Endoscopic Diagnosis of Gastric Neoplasia: A Feasibility Proof-of-Concept Study
    Tse Kiat Soong, Guo Wei Kim, Daryl Kai Ann Chia, Jimmy Bok Yan So, Jonathan Wei Jie Lee, Asim Shabbbir, Jeffrey Huey Yew Lum, Gwyneth Shook Ting Soon, Khek Yu Ho
    Diagnostics.2024; 14(24): 2839.     CrossRef
  • Toward a New Era of SERS and TERS at the Nanometer Scale: From Fundamentals to Innovative Applications
    Tamitake Itoh, Marek Procházka, Zhen-Chao Dong, Wei Ji, Yuko S. Yamamoto, Yao Zhang, Yukihiro Ozaki
    Chemical Reviews.2023; 123(4): 1552.     CrossRef
  • Performance assessment of probe-based Raman spectroscopy systems for biomedical analysis
    Sean Fitzgerald, Eric Marple, Anita Mahadevan-Jansen
    Biomedical Optics Express.2023; 14(7): 3597.     CrossRef
  • Raman opportunities in the field of pathological calcifications
    Ivan T. Lucas, Dominique Bazin, Michel Daudon
    Comptes Rendus. Chimie.2022; 25(S1): 83.     CrossRef
  • Mevastatin in colon cancer by spectroscopic and microscopic methods – Raman imaging and AFM studies
    K. Beton, P. Wysocki, B. Brozek-Pluska
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.2022; 270: 120726.     CrossRef
  • In Vitro Detection of Biochemical Effect in Human CaCo-2 Cell Line after Exposure to a Low Concentration of a Deltamethrin-Based Pesticide
    Giuseppe Perna, Vito Capozzi, Maria Lasalvia
    Chemosensors.2022; 10(11): 438.     CrossRef
  • Advances in optical gastrointestinal endoscopy: a technical review
    Yubo Tang, Sharmila Anandasabapathy, Rebecca Richards‐Kortum
    Molecular Oncology.2021; 15(10): 2580.     CrossRef
  • Label-free detection of human enteric nerve system using Raman spectroscopy: A pilot study for diagnosis of Hirschsprung disease
    Katsuhiro Ogawa, Yusuke Oshima, Tsuyoshi Etoh, Yushi Kaisyakuji, Manabu Tojigamori, Yasuharu Ohno, Norio Shiraishi, Masafumi Inomata
    Journal of Pediatric Surgery.2021; 56(7): 1150.     CrossRef
  • Non-invasive diagnosis of colorectal cancer by Raman spectroscopy: Recent developments in liquid biopsy and endoscopy approaches
    Hemanth Noothalapati, Keita Iwasaki, Tatsuyuki Yamamoto
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.2021; 258: 119818.     CrossRef
  • From Raman to SESORRS: moving deeper into cancer detection and treatment monitoring
    Sian Sloan-Dennison, Stacey Laing, Duncan Graham, Karen Faulds
    Chemical Communications.2021; 57(93): 12436.     CrossRef
  • Present and Future of Surface-Enhanced Raman Scattering
    Judith Langer, Dorleta Jimenez de Aberasturi, Javier Aizpurua, Ramon A. Alvarez-Puebla, Baptiste Auguié, Jeremy J. Baumberg, Guillermo C. Bazan, Steven E. J. Bell, Anja Boisen, Alexandre G. Brolo, Jaebum Choo, Dana Cialla-May, Volker Deckert, Laura Fabris
    ACS Nano.2020; 14(1): 28.     CrossRef
  • Implementation of a classification strategy of Raman data collected in different clinical conditions: application to the diagnosis of chronic lymphocytic leukemia
    M. Féré, C. Gobinet, L. H. Liu, A. Beljebbar, V. Untereiner, D. Gheldof, M. Chollat, J. Klossa, B. Chatelain, O. Piot
    Analytical and Bioanalytical Chemistry.2020; 412(4): 949.     CrossRef
  • Virtual spectral histopathology of colon cancer - biomedical applications of Raman spectroscopy and imaging
    Beata Brozek-Pluska, Adam Dziki, Halina Abramczyk
    Journal of Molecular Liquids.2020; 303: 112676.     CrossRef
  • BPC 157 Rescued NSAID-cytotoxicity Via Stabilizing Intestinal Permeability and Enhancing Cytoprotection
    Jong M. Park, Ho J. Lee, Predrag Sikiric, Ki B. Hahm
    Current Pharmaceutical Design.2020; 26(25): 2971.     CrossRef
  • Challenges to diagnostic standardization of Barrett's esophagus in Asia
    Yu Sen Alex Soh, Yeong Yeh Lee, Takuji Gotoda, Prateek Sharma, Khek‐Yu Ho
    Digestive Endoscopy.2019; 31(6): 609.     CrossRef
  • Biochemical Changes in Human Cells Exposed to Low Concentrations of Gold Nanoparticles Detected by Raman Microspectroscopy
    Maria Lasalvia, Giuseppe Perna, Vito Capozzi
    Sensors.2019; 19(10): 2418.     CrossRef
  • Intelligent magnetic manipulation for gastrointestinal ultrasound
    Joseph C. Norton, Piotr R. Slawinski, Holly S. Lay, James W. Martin, Benjamin F. Cox, Gerard Cummins, Marc P.Y. Desmulliez, Richard E. Clutton, Keith L. Obstein, Sandy Cochran, Pietro Valdastri
    Science Robotics.2019;[Epub]     CrossRef
  • Analysis of Human Colon by Raman Spectroscopy and Imaging-Elucidation of Biochemical Changes in Carcinogenesis
    Beata Brozek-Pluska, Jacek Musial, Radzislaw Kordek, Halina Abramczyk
    International Journal of Molecular Sciences.2019; 20(14): 3398.     CrossRef
  • Raman spectroscopic analysis of cataract lens: A compendious review
    Chia-Chi Huang, Wenlung Chen
    Applied Spectroscopy Reviews.2018; 53(9): 689.     CrossRef
  • Histochemical analysis of human breast tissue samples by IR and Raman spectroscopies. Protocols discussion
    Beata Brozek-Pluska, Monika Kopec, Jakub Surmacki, Halina Abramczyk
    Infrared Physics & Technology.2018; 93: 247.     CrossRef
  • Potential Application of Raman Spectroscopy for Real-time Diagnosis and Classification of Colorectal Cancer
    Ryuichi SEKINE, Sumito SATO, Jun-ichi TANAKA, Hirotada KAGOSHIMA, Takeshi AOKI, Masahiko MURAKAMI
    The Showa University Journal of Medical Sciences.2018; 30(3): 381.     CrossRef
  • Linked colour imaging benefits the endoscopic diagnosis of distal gastric diseases
    Xiaotian Sun, Yiliang Bi, Tenghui Dong, Min Min, Wei Shen, Yang Xu, Yan Liu
    Scientific Reports.2017;[Epub]     CrossRef
  • Endoscopic imaging using surface-enhanced Raman scattering
    Yong-il Kim, Sinyoung Jeong, Bong-Hyun Jun, Yun-Sang Lee, Yoon-Sik Lee, Dae Hong Jeong, Dong Soo Lee
    European Journal of Nanomedicine.2017;[Epub]     CrossRef
  • 9,008 View
  • 219 Download
  • 30 Web of Science
  • 27 Crossref
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Endoscopic Closure for Full-Thickness Gastrointestinal Defects: Available Applications and Emerging Innovations
Nobuyoshi Takeshita, Khek Yu Ho
Clin Endosc 2016;49(5):438-443.   Published online August 30, 2016
DOI: https://doi.org/10.5946/ce.2016.104
AbstractAbstract PDFPubReaderePub
Full-thickness gastrointestinal defects such as perforation, anastomotic leak, and fistula are severe conditions caused by various types of pathologies. They are more likely to require intensive care and a long hospital stay and have high rates of morbidity and mortality. After intentional full-thickness opening of hollow organs for natural orifice transluminal endoscopic surgery, safe and secure closure is urgently required. The currently available advanced endoscopic closing techniques have a major role in the treatment of full-thickness gastrointestinal defects. Appropriate usage of these techniques requires taking into account their advantages and limitations during practical application. We reviewed the available endoscopic modalities, including endoscopic clips, stents, vacuum-assisted closure, gap filling, and suturing devices, discussed their advantages and limitations when treating full-thickness gastrointestinal defects, and explored emerging innovations, including a novel endoluminal surgical platform for versatile suturing and a cell-laden scaffold for effective gap filling. Although these emerging technologies still require further pre-clinical and clinical trials to assess their feasibility and efficacy, the available modalities may be replaced and refined by these new techniques in the near future.

Citations

Citations to this article as recorded by  
  • Advances in minimally invasive surgical techniques for the management of enterocutaneous fistula: a systematic review of clinical and postoperative outcomes
    Jorge Eduardo Maldonado Lopez, Alfonso Joan Massé Ponce, Andrea Yissel Franco Sánchez, Dario Javier Caguate Miranda, Ronny Ricardo Olalla Alava, Alexander David Silva, José Daniel Nuñez Moreno, Katherine Sandoval Hernández
    International Journal of Research in Medical Sciences.2025;[Epub]     CrossRef
  • Injectable nanoengineered adhesive hydrogel for treating enterocutaneous fistulas
    Natan Roberto de Barros, Ankit Gangrade, Ahmad Rashad, RunRun Chen, Fatemeh Zehtabi, Menekse Ermis, Natashya Falcone, Reihaneh Haghniaz, Safoora Khosravi, Alejandro Gomez, Shuyi Huang, Marvin Mecwan, Danial Khorsandi, Junmin Lee, Yangzhi Zhu, Bingbing Li,
    Acta Biomaterialia.2024; 173: 231.     CrossRef
  • What Is New with Cervical Perforations? A Clinical Review Article
    Hope Conrad, Praveen Sridhar
    Thoracic Surgery Clinics.2024; 34(4): 321.     CrossRef
  • Successful Endoscopic Vacuum-Assisted Closure Therapy for Esophageal Perforation: A Case Report
    Jung Huh, Jinsun Yang, Seung Joo Kang, Hyoun Woo Kang, Hyeon Jong Moon, Su Hwan Kim, Bokyung Kim, Ji Won Kim, Kook Lae Lee, Yong Won Seong, Kwang Woo Kim
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2024; 24(2): 187.     CrossRef
  • Novel external reinforcement device for gastrointestinal anastomosis in an experimental study
    Hiro Hasegawa, Nobuyoshi Takeshita, Woogi Hyon, Suong-Hyu Hyon, Masaaki Ito
    BMC Surgery.2023;[Epub]     CrossRef
  • Colon Sparing Endoscopic Full-Thickness Resection for Advanced Colorectal Lesions: Is It Time for Global Adoption?
    Zhong-Wei Wu, Chao-Hui Ding, Yao-Dong Song, Zong-Chao Cui, Xiu-Qian Bi, Bo Cheng
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • The Etiology, Diagnosis, and Management of Esophageal Perforation
    Puja Gaur Khaitan, Amber Famiglietti, Thomas J. Watson
    Journal of Gastrointestinal Surgery.2022; 26(12): 2606.     CrossRef
  • Advanced Endoscopic Tools
    Eleanor C. Fung
    Digestive Disease Interventions.2021; 05(02): 194.     CrossRef
  • Repair of upper-GI fistulas and anastomotic leakage by the use of endoluminal vacuum-assisted closure
    Andrew Watson, Tobias Zuchelli
    VideoGIE.2019; 4(1): 40.     CrossRef
  • Effect of poly(3-hydroxyalkanoates) as natural polymers on mesenchymal stem cells
    Vera Voinova, Garina Bonartseva, Anton Bonartsev
    World J Stem Cells.2019; 11(10): 764.     CrossRef
  • Endoscopic Closure of Gastrointestinal Fistulae and Leaks
    Jaehoon Cho, Ara B. Sahakian
    Gastrointestinal Endoscopy Clinics of North America.2018; 28(2): 233.     CrossRef
  • Non-visible colovesical fistula located by cystoscopy and successfully managed with the novel Padlock® device for endoscopic closure
    Benito Velayos, L. Del Olmo, L. Merino, M. Valsero, J. M. González
    International Journal of Colorectal Disease.2018; 33(6): 827.     CrossRef
  • Poly(3-hydroxybutyrate) and Human Microbiota (Review)
    A. P. Bonartsev, V. V. Voinova, G. A. Bonartseva
    Applied Biochemistry and Microbiology.2018; 54(6): 547.     CrossRef
  • Hepatocolic fistula managed with a novel Padlock® device for endoscopic closure
    Benito Velayos Jiménez, Lourdes Del Olmo Martínez, Carmen Alonso Martín, Javier Trueba Arguiñarena, José Manuel González Hernández
    Revista Española de Enfermedades Digestivas.2017;[Epub]     CrossRef
  • Anastomotic leaks in gastrointestinal surgery and their prevention
    Tomasz Banasiewicz, Adam Dziki, Paweł Lampe, Zbigniew Lorenc, Marek Szczepkowski, Jacek Zieliński, Grzegorz Wallner
    Polish Journal of Surgery.2017; 89(2): 49.     CrossRef
  • 10,077 View
  • 195 Download
  • 12 Web of Science
  • 15 Crossref
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