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Review
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A practical approach for small bowel bleeding
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Sung Eun Kim, Hyun Jin Kim, Myeongseok Koh, Min Cheol Kim, Joon Sung Kim, Ji Hyung Nam, Young Kwan Cho, A Reum Choe, The Research Group for Capsule Endoscopy and Enteroscopy of the Korean Society of Gastrointestinal Endoscopy
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Clin Endosc 2023;56(3):283-289. Published online May 11, 2023
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DOI: https://doi.org/10.5946/ce.2022.302
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Abstract
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- Gastrointestinal (GI) bleeding is one of the most common conditions among patients visiting emergency departments in Korea. GI bleeding is divided into upper and lower GI bleeding, according to the bleeding site. GI bleeding is also divided into overt and occult GI bleeding based on bleeding characteristics. In addition, obscure GI bleeding refers to recurrent or persistent GI bleeding from a source that cannot be identified after esophagogastroduodenoscopy or colonoscopy. The small intestine is the largest part of the alimentary tract. It extends from the pylorus to the cecum. The small intestine is difficult to access owing to its long length. Moreover, it is not fixed to the abdominal cavity. When hemorrhage occurs in the small intestine, the source cannot be found in many cases because of the characteristics of the small intestine. In practice, small-intestinal bleeding accounts for most of the obscure GI bleeding. Therefore, in this review, we introduce and describe systemic approaches and examination methods, including video capsule endoscopy and balloon enteroscopy, that can be performed in patients with suspected small bowel bleeding in clinical practice.
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Citations
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- Effect of Different Types of Antithrombotic Agents on Clinical Outcomes in Patients With Small Bowel Bleeding Who Underwent Balloon‐Assisted Enteroscopy: A KASID Multicenter Study
Jihye Park, Jin Su Kim, Joo Hye Song, Kwangwoo Nam, Seong‐Eun Kim, Eui Sun Jeong, Jae Hyun Kim, Seong Ran Jeon
Journal of Gastroenterology and Hepatology.2025; 40(2): 456. CrossRef - Do all antithrombotic agents have a similar impact on small bowel bleeding?
Chung Hyun Tae, Ki-Nam Shim
Clinical Endoscopy.2025; 58(1): 80. CrossRef - Balloon-assisted enteroscopy in the management of adult small-bowel intussusception: a comparative analysis of with and without double-balloon enteroscopy
Won Shik Kim, Beom Jae Lee, Moon Kyung Joo, Seung Han Kim, Jong-Jae Park
Surgical Endoscopy.2025; 39(3): 2044. CrossRef - Manejo da hemorragia digestiva baixa na emergência: abordagem cirúrgica
Carla Azevedo Zaibak, Sara Monteiro Barbosa, Nathalia Machado De Lima, Jordane Lula Cruz, Angela Maria Pereira Costa, Maria Eduarda da Silva Borges, Mariana Vasconcellos De Oliveira, Danyelly Rodrigues Machado
Cuadernos de Educación y Desarrollo.2024;[Epub] CrossRef - Case 19: A 65-Year-Old Man With Melena and Hematochezia
Hajin Lee, Younghee Choe, Jung Heo, Gwkang Hui Park, Su Young Lee, Young Wook Cho, Hyo Suk Kim
Journal of Korean Medical Science.2024;[Epub] CrossRef - Aortoduodenal fistula bleeding caused by an aortic stent graft
Seunghyun Hong, Gwang Ha Kim
Clinical Endoscopy.2024; 57(3): 407. CrossRef - Diagnostic Yield and Outcomes of Small Bowel Capsule Endoscopy in Patients with Small Bowel Bleeding Receiving Antithrombotics
Nikos Viazis, Dimitris Christodoulou, Vasilis Papastergiou, Konstantinos Mousourakis, Dimitra Kozompoli, Giannis Stasinos, Konstantina Dimopoulou, Periklis Apostolopoulos, Fotios Fousekis, Christos Liatsos, Nikolaos Kyriakos, Theodoros Argyropoulos, Georg
Diagnostics.2024; 14(13): 1361. CrossRef - Difficult Small Bowel Bleeding in Surgical View
Jung Min Bae
Journal of Acute Care Surgery.2024; 14(2): 41. CrossRef - Jejunal Dieulafoy’s lesion resembling subepithelial mass resulting in profound gastrointestinal hemorrhage
Thanaboon Chaemsupaphan, Tanawat Geeratragool, Napat Angkathunyakul, Arissa Phothisirisakulwong, Monthira Maneerattanaporn
Clinical Endoscopy.2024; 57(4): 552. CrossRef
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Original Article
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Efficacy and Safety of Etomidate in Comparison with Propofol or Midazolam as Sedative for Upper Gastrointestinal Endoscopy
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Jae Hyun Kim, Sanghwan Byun, Youn Jung Choi, Hye Jung Kwon, Kyoungwon Jung, Sung Eun Kim, Moo In Park, Won Moon, Seun Ja Park
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Clin Endosc 2020;53(5):555-561. Published online March 31, 2020
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DOI: https://doi.org/10.5946/ce.2019.210
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Abstract
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- Background
/Aims: In this study, we compared the efficacy and safety of etomidate with those of propofol or midazolam for the maintenance of sedation during endoscopy.
Methods
The study enrolled patients who underwent sedative endoscopy in our hospital and divided them into three groups. Patients in each group were administered midazolam as induction therapy and were subsequently administered either midazolam (M + M group), propofol (M + P group), or etomidate (M + E group) as maintenance medication. The primary outcome was overall cardiovascular and respiratory adverse events.
Results
In total, 105 patients who underwent sedative endoscopic examination were enrolled. The outcomes related to the procedure and sedation were not significantly different among the groups. Overall cardiovascular and respiratory adverse events were observed in 9 patients (25.7%) in the M + M group, 8 patients (23.5%) in the M + P group, and 10 patients (27.8%) in the M + E group. The logistic regression analysis revealed that etomidate use was not an independent risk factor for overall cardiovascular and respiratory adverse events.
Conclusions
The outcomes following the use of etomidate for maintenance after induction with midazolam for sedation in upper gastrointestinal endoscopy were not inferior to those following midazolam or propofol use from the perspectives of safety and efficacy.
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Citations
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- Comparison of ciprofol–alfentanil and propofol–alfentanil sedation during bidirectional endoscopy: A prospective, double-blind, randomised, controlled trial
Jiqiang Zhang, Ruijuan Liu, Ruirui Bi, Xia Li, Mengjun Xu, Lijuan Li, Yuxi su, Wenjun Yan
Digestive and Liver Disease.2024; 56(4): 663. CrossRef - Effects of Earmuffs and Eye Masks on Propofol Sedation during Spinal Anesthesia for Orthopedic Surgery: A Randomized Controlled Trial
Jin-Woo Park, Sung Il Bae, Jungyul Ryu, Seung Hyun Chung, Sang-Hwan Do
Journal of Clinical Medicine.2023; 12(3): 899. CrossRef - Effect of intravenous anesthesia by etomidate in combination with propofol on gastrointestinal endoscopy
Bo CHEN, Ke ZHANG, Mingshuai YU
Minerva Surgery.2023;[Epub] CrossRef - New sedatives and analgesic drugs for gastrointestinal endoscopic procedures
Jae Min Lee, Yehyun Park, Jin Myung Park, Hong Jun Park, Jun Yong Bae, Seung Young Seo, Jee Hyun Lee, Hyung Ku Chon, Jun-Won Chung, Hyun Ho Choi, Jun Kyu Lee, Byung-Wook Kim
Clinical Endoscopy.2022; 55(5): 581. CrossRef - Drugs used for sedation in gastrointestinal endoscopy
Jun Kyu Lee
Journal of the Korean Medical Association.2022; 65(11): 735. CrossRef - Comparative Safety Profiles of Sedatives Commonly Used in Clinical Practice: A 10-Year Nationwide Pharmacovigilance Study in Korea
Yeo-Jin Choi, Seung-Won Yang, Won-Gun Kwack, Jun-Kyu Lee, Tae-Hee Lee, Jae-Yong Jang, Eun-Kyoung Chung
Pharmaceuticals.2021; 14(8): 783. CrossRef - Physical and Chemical Compatibility of Etomidate and Propofol Injectable Emulsions
Chunling Wang, Shengnan Wang, Cuishuan Wu, Li Lei, Dong-Xin Wang, Qiang Zhang
Pharmacology.2021; 106(11-12): 644. CrossRef
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Case Report
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Ascending Colon Cancer with Pathologically Confirmed Tumor Thrombosis of Superior Mesenteric Vein: A Case Report
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Sung Eun Kim, Sang Jin Lee, Jun Young Cha, Sang Won Yi, Tae Sun Kim, Il Leon Cho, Jae Young Kwak, Kwang Hoon Oh
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Clin Endosc 2019;52(5):506-509. Published online April 17, 2019
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DOI: https://doi.org/10.5946/ce.2018.135
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Abstract
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- Colon cancer is very rarely accompanied by tumor thrombosis of the superior mesenteric vein (SMV). A 46-year-old patient had been diagnosed with SMV tumor thrombosis related to colon cancer without hepatic metastasis and underwent right hemicolectomy with SMV tumor thrombectomy. Tumor thrombosis was pathologically confirmed as metastatic colon cancer. There has been no recurrence for 12 months with 12 cycles of adjuvant-chemotherapy.
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Citations
Citations to this article as recorded by

- Superior mesenteric vein tumour thrombus in a patient with caecal adenocarcinoma: a rare and important finding
Janki Trivedi, Heinrich Bouwer, Tom Sutherland
BJR|case reports.2021; 7(2): 20200147. CrossRef - Isolated Malignant Portal Vein Thrombus in Colon Carcinoma: A Rare Finding on 18F-FDG PET/CECT
Tarun Kumar Jain, Ajay Yadav, Hemant Malhotra, Nitin Khunteta, Guman Singh
Journal of Nuclear Medicine Technology.2021; 49(2): 190. CrossRef - Ascending colon cancer accompanied by tumor thrombosis in the superior mesenteric vein: A case report
Yoshiaki Fujii, Kenji Kobayashi, Sho Kimura, Shuhei Uehara, Shuji Takiguchi
International Journal of Surgery Case Reports.2020; 73: 239. CrossRef - Treatment of tumor thrombus in the superior mesenteric vein due to advanced colon cancer with complete surgical resection and chemotherapy: a case report
Yoshitsugu Yanagida, Takahiro Amano, Ryuji Akai, Akira Toyoshima, Jotaro Kobayashi, Takuya Hashimoto, Eiji Sunami, Toshio Kumasaka, Shin Sasaki
Surgical Case Reports.2020;[Epub] CrossRef
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Original Article
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Effect of Sending Educational Video Clips via Smartphone Mobile Messenger on Bowel Preparation before Colonoscopy
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Sung Chan Jeon, Jae Hyun Kim, Sun Jung Kim, Hye Jung Kwon, Youn Jung Choi, Kyoungwon Jung, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park
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Clin Endosc 2019;52(1):53-58. Published online August 29, 2018
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DOI: https://doi.org/10.5946/ce.2018.072
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Abstract
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- Background
/Aim: We aimed to evaluate the efficacy of sending educational video clips via smartphone mobile messenger (SMM) on enhancing bowel preparation before colonoscopy.
Methods
This was a prospective, endoscopist-blinded, randomized controlled study. Patients in the SMM group received two video clips sent via SMM that explained the diet and regimen for bowel preparation, whereas those in the control group did not receive any video clips. We compared the quality of bowel preparation between the two groups, which was assessed by an endoscopist using the Ottawa scale.
Results
Between August and November 2014, 140 patients in the SMM group and 141 patients in the control group underwent colonoscopic examination. The total Ottawa score of the SMM group was significantly lower than that of the control group (5.47±1.74 vs. 5.97±1.78, p=0.018). These results were particularly prominent in the younger age group; the total Ottawa score of patents in the SMM group aged <40 years was significantly lower than that of patients in the control group aged <40 years (5.10±1.55 vs. 6.22±2.33, p=0.034).
Conclusions
We demonstrated that sending educational video clips via SMM could result in better bowel preparation, especially in the younger age group.
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Citations
Citations to this article as recorded by

- Evaluation of the effect of reinforced education on the satisfaction of patients undergoing colonoscopy: A randomized controlled trial
Negin Farid, Shakila Sharifian, Raziyeh Ghafouri, Antonio Brillantino
PLOS ONE.2024; 19(1): e0296126. CrossRef - Can an educational video improve the adequacy of bowel preparation for patients undergoing their first colonoscopy? Results of the EBOPS RCT
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Tanawat Pattarapuntakul, Thanyaporn Kanchanasuwan, Apichat Kaewdech, Thanawin Wong, Nisa Netinatsunton, Nalerdon Chalermsuksant, Pimsiri Sripongpun
Frontiers in Medicine.2024;[Epub] CrossRef - Edukacinio 3D virtualiosios realybės vaizdo metodo įtaka ruošiant žarnyną kolonoskopijai: pirmieji rezultatai
Edvinas Kildušis, Gintautas Brimas
Lietuvos chirurgija.2024; 23(2): 108. CrossRef - Online patient endoscopy education platform improves outpatient bowel preparation quality: Retrospective observational study
Yuming Ding, Ann Vandeleur, Gonzalo Chinchilla, Kimberley Littlemore, Ruth Hodgson, Tony Rahman
Endoscopy International Open.2024; 12(11): E1326. CrossRef - Effectiveness of bowel preparation innovative technology instructions (BPITIs) on clinical outcomes among patients undergoing colonoscopy: a systematic review and meta-analysis
Parichat Wonggom, Siwanon Rattanakanokchai, Orathai Suebkinorn
Scientific Reports.2023;[Epub] CrossRef - Impact of WeChat guidance on bowel preparation for colonoscopy: a quasi-experiment study
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Annals of Medicine.2023;[Epub] CrossRef - An Interactive Video Educational Tool Does Not Improve the Quality of Bowel Preparation for Colonoscopy: A Randomized Controlled Study
Ted B. Walker, Tricia A. Hengehold, Kevin Garza, Benjamin D. Rogers, Dayna Early
Digestive Diseases and Sciences.2022; 67(6): 2347. CrossRef - Comparison of 2 L Polyethylene Glycol Plus Ascorbic Acid and 4 L Polyethylene Glycol in Elderly Patients Aged 60–79: A Prospective Randomized Study
Sung Hoon Jung, Chul-Hyun Lim, Tae-Geun Gweon, Jinsu Kim, Jung Hwan Oh, Kyu-Tae Yoon, Jee Young An, Jeong‑Seon Ji, Hwang Choi
Digestive Diseases and Sciences.2022; 67(10): 4841. CrossRef - Patient education by smartphones for bowel preparation before colonoscopy
Peng Li, Xueqian He, Xufang Yang, Jing Du, Weiquan Wu, Jiangfeng Tu
Journal of Gastroenterology and Hepatology.2022; 37(7): 1349. CrossRef - Los efectos de la educación perfeccionada, realizada por enfermeros en la calidad de la preparación intestinal para colonoscopia
Gamze Arslanca, Mahmure Aygün
Revista Latino-Americana de Enfermagem.2022;[Epub] CrossRef - Effect of nurse-performed enhanced patient education on colonoscopy bowel preparation quality
Gamze Arslanca, Mahmure Aygün
Revista Latino-Americana de Enfermagem.2022;[Epub] CrossRef - Os efeitos da educação aprimorada, realizada por enfermeiros na qualidade do preparo intestinal para colonoscopia
Gamze Arslanca, Mahmure Aygün
Revista Latino-Americana de Enfermagem.2022;[Epub] CrossRef - Comparison of Two Types of 1-L Polyethylene Glycol-ascorbic Acid as Colonoscopic Bowel Preparation: A Prospective Randomized Study
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Clinical and Experimental Emergency Medicine.2021; 8(1): 48. CrossRef - Quality Improvement of Bowel Preparation for Screening Colonoscopies: A Study of Hospital Team Resource Management in Taiwan
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Edvinas Kildušis, Gintautas Brimas
Lietuvos chirurgija.2021; 20(3-4): 135. CrossRef - Telephonic Nurse Guidance for Colonoscopy: A Clinical Trial
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Review
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Borrmann Type 4 Advanced Gastric Cancer: Focus on the Development of Scirrhous Gastric Cancer
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Kyoungwon Jung, Moo In Park, Sung Eun Kim, Seun Ja Park
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Clin Endosc 2016;49(4):336-345. Published online July 25, 2016
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DOI: https://doi.org/10.5946/ce.2016.057
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Abstract
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- Early diagnosis of Borrmann type 4 advanced gastric cancer (AGC) is very important for improving the prognosis of AGC patients. Because there is no definite mass in most cases of Borrmann type 4 AGC, its accurate diagnosis via endoscopy requires an understanding of its pathogenesis and developmental process. Moreover, many people confuse linitis plastica (LP) type gastric cancer (GC), scirrhous GC, and Borrmann type 4 AGC. To distinguish each of these cancers, knowledge of their endoscopic and pathological differences is necessary, especially for LP type GCs in the developmental stage. In conclusion, diagnosis of pre-stage or latent LP type GC before progression to typical LP type GC requires the detection of IIc-like lesions in the fundic gland area. It is also crucial to identify any abnormalities such as sclerosis of the gastric wall and hypertrophy of the mucosal folds during endoscopy.
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