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6 "Takashi Toyonaga"
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Management of esophageal neoplasms by endoscopic submucosal dissection: experience over 100 consecutive procedures
Josué Aliaga Ramos, Yoshinori Morita, Takashi Toyonaga, Danilo Carvalho, Moises Salgado Pedrosa, Vitor N. Arantes
Clin Endosc 2023;56(5):613-622.   Published online May 17, 2023
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReaderePub
/Aims: Endoscopic submucosal dissection (ESD) is currently considered the first-line treatment for the eradication of superficial neoplasms of the esophagus in Eastern countries. However, in the West, particularly in Latin America, the experience with esophageal ESD is still limited because of the high technical complexity required for its execution. This study aimed to present the results of the clinical application of ESD to manage superficial esophageal neoplasms in a Latin American center in over 100 consecutive cases.
This retrospective study included consecutive patients who underwent endoscopic ESD for superficial esophageal neoplasms between 2009 and 2022. The following clinical outcomes were assessed: en bloc, complete, and curative resection rates, local recurrence, adverse events, and procedure-related mortality.
Esophageal ESD was performed mainly for squamous cell carcinoma (66.6%), high-grade intraepithelial neoplasia (17.1%), and adenocarcinoma (11.4%). En bloc and complete resection rates were 96.2% and 81.0%, respectively. The curative resection rate was 64.8%. Adverse events occurred in six cases (5.7%). Endoscopic follow-up was performed for an average period of 29.7 months.
ESD performed by trained operators is feasible, safe, and clinically effective for managing superficial neoplastic lesions of the esophagus in Latin America.
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Feasibility and safety of endoscopic submucosal dissection for lesions in proximity to a colonic diverticulum
Nobuaki Ikezawa, Takashi Toyonaga, Shinwa Tanaka, Tetsuya Yoshizaki, Toshitatsu Takao, Hirofumi Abe, Hiroya Sakaguchi, Kazunori Tsuda, Satoshi Urakami, Tatsuya Nakai, Taku Harada, Kou Miura, Takahisa Yamasaki, Stuart Kostalas, Yoshinori Morita, Yuzo Kodama
Clin Endosc 2022;55(3):417-425.   Published online May 12, 2022
AbstractAbstract PDFSupplementary MaterialPubReaderePub
/Aims: Endoscopic submucosal dissection (ESD) for diverticulum-associated colorectal lesions is generally contraindicated because of the high risk of perforation. Several studies on patients with such lesions treated with ESD have been reported recently. However, the feasibility and safety of ESD for lesions in proximity to a colonic diverticulum (D-ESD) have not been fully clarified. The aim of this study was to evaluate the feasibility and safety of D-ESD.
D-ESD was defined as ESD for lesions within approximately 3 mm of a diverticulum. Twenty-six consecutive patients who underwent D-ESD were included. Two strategic approaches were used depending on whether submucosal dissection of the diverticulum-related part was required (strategy B) or not (strategy A). Treatment outcomes and adverse events associated with each strategy were analyzed.
The en bloc resection rate was 96.2%. The rates of R0 and curative resection in strategies A and B were 80.8%, 73.1%, 84.6%, and 70.6%, respectively. Two cases of intraoperative perforation and one case of delayed perforation occurred. The delayed perforation case required emergency surgery, but the other cases were managed conservatively.
D-ESD may be a feasible treatment option. However, it should be performed in a high-volume center by expert hands because it requires highly skilled endoscopic techniques.


Citations to this article as recorded by  
  • Endoscopic submucosal dissection for diverticulum using combination of countertraction and circumferential-inversion method
    Hiroshi Takayama, Yoshinori Morita, Toshitatsu Takao, Douglas Motomura, Madoka Takao, Takashi Toyonaga, Yuzo Kodama
    Endoscopy.2024; 56(S 01): E91.     CrossRef
  • Traction-assisted endoscopic submucosal dissection for resection of ileocecal valve neoplasia: a French retrospective multicenter case series
    Clara Yzet, Timothée Wallenhorst, Jérémie Jacques, Mariana Figueiredo Ferreira, Jérôme Rivory, Florian Rostain, Louis-Jean Masgnaux, Jean Grimaldi, Romain Legros, Pierre Lafeuille, Jérémie Albouys, Fabien Subtil, Marion Schaefer, Mathieu Pioche
    Endoscopy.2024;[Epub]     CrossRef
  • The role of cap-assisted endoscopy and its future implications
    Sol Kim, Bo-In Lee
    Clinical Endoscopy.2024; 57(3): 293.     CrossRef
  • Successful planned piecemeal endoscopic resection using gel immersion and an over-the-scope clip for a lesion extensively extended into the colonic diverticulum
    Tomoaki Tashima, Takahiro Muramatsu, Tomonori Kawasaki, Tsubasa Ishikawa, Shomei Ryozawa
    VideoGIE.2023; 8(4): 167.     CrossRef
  • Future therapeutic implications of new molecular mechanism of colorectal cancer
    Sen Lu, Cheng-You Jia, Jian-She Yang
    World Journal of Gastroenterology.2023; 29(16): 2359.     CrossRef
  • Iatrogenic colorectal perforation caused by a clip
    Hirotaka Oura, Yasuki Hatayama, Erika Nomura, Harutoshi Sugiyama, Daisuke Murakami, Makoto Arai, Takayoshi Nishino
    Endoscopy.2023; 55(S 01): E1091.     CrossRef
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  • 6 Crossref
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Clinical Impact of Different Reconstruction Methods on Remnant Gastric Cancer at the Anastomotic Site after Distal Gastrectomy
Kei Matsumoto, Shinwa Tanaka, Takashi Toyonaga, Nobuaki Ikezawa, Mari Nishio, Masanao Uraoka, Tomoatsu Yoshihara, Hiroya Sakaguchi, Hirofumi Abe, Tetsuya Yoshizaki, Madoka Takao, Toshitatsu Takao, Yoshinori Morita, Hiroshi Yokozaki, Yuzo Kodama
Clin Endosc 2022;55(1):86-94.   Published online August 13, 2021
AbstractAbstract PDFSupplementary MaterialPubReaderePub
/Aims: The anastomotic site after distal gastrectomy is the area most affected by duodenogastric reflux. Different reconstruction methods may affect the lesion characteristics and treatment outcomes of remnant gastric cancers at the anastomotic site. We retrospectively investigated the clinicopathologic and endoscopic submucosal dissection outcomes of remnant gastric cancers at the anastomotic site.
We recruited 34 consecutive patients who underwent endoscopic submucosal dissection for remnant gastric cancer at the anastomotic site after distal gastrectomy. Clinicopathology and treatment outcomes were compared between the Billroth II and non-Billroth II groups.
The tumor size in the Billroth II group was significantly larger than that in the non-Billroth II group (22 vs. 19 mm; p=0.048). More severe gastritis was detected endoscopically in the Billroth II group (2 vs. 1.33; p=0.0075). Moreover, operation time was longer (238 vs. 121 min; p=0.004) and the frequency of bleeding episodes was higher (7.5 vs. 3.1; p=0.014) in the Billroth II group.
Compared to remnant gastric cancers in non-Billroth II patients, those in the Billroth II group had larger lesions with a background of severe remnant gastritis. Endoscopic submucosal dissection for remnant gastric cancers in Billroth II patients involved longer operative times and more frequent bleeding episodes than that in patients without Billroth II.
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Efficacy of the Envelope Method in Applying Polyglycolic Acid Sheets to Post-Endoscopic Submucosal Dissection Ulcers in Living Pigs
Hiroya Sakaguchi, Toshitatsu Takao, Yoshitaka Takegawa, Yuki Koga, Kazunori Yamanaka, Masataka Sagata, Shinwa Tanaka, Yoshinori Morita, Takashi Toyonaga, Yuzo Kodama
Clin Endosc 2021;54(1):64-72.   Published online July 16, 2020
AbstractAbstract PDFSupplementary MaterialPubReaderePub
/Aims: Application of polyglycolic acid (PGA) sheets using fibrin glue in post-endoscopic submucosal dissection (ESD) ulcers to prevent bleeding has been reported to be difficult with the conventional delivery method because of gravity. This study assessed the usefulness of the envelope-based delivery system with and against gravity in living pigs.
PGA sheets were applied on post-ESD ulcers with and against gravity six times each using the conventional and envelope methods, respectively. The PGA sheet delivery time and the endoscopic and histological findings of the treated ulcer floors were compared.
With gravity, the median PGA sheet application time was 1.00 (0.68–1.30) min/cm2 and 0.32 (0.18–0.52) min/cm2 with the conventional and envelope techniques (p=0.002), respectively, and against gravity, it was 1.20 (1.13–1.63) min/cm2 and 0.50 (0.39–0.58) min/cm2 (p=0.002), respectively. Against gravity, the endoscopic and histological findings revealed that the conventional group had insufficient fixation of the PGA sheets, but the envelope groups had sufficient fixation. The results with gravity were similar between the groups.
The envelope method makes it possible to deliver PGA sheets to the stomach quickly and cover ulcers appropriately both with and against gravity in living pigs.


Citations to this article as recorded by  
  • Endoscopic sealing hemostasis with polyglycolic acid sheet and fibrin glue as a novel endoscopic hemostatic technique: a report of three cases
    Kai Korekawa, Atsushi Kunimitsu
    Clinical Journal of Gastroenterology.2024;[Epub]     CrossRef
  • Clinical Impact of Different Reconstruction Methods on Remnant Gastric Cancer at the Anastomotic Site after Distal Gastrectomy
    Kei Matsumoto, Shinwa Tanaka, Takashi Toyonaga, Nobuaki Ikezawa, Mari Nishio, Masanao Uraoka, Tomoatsu Yoshihara, Hiroya Sakaguchi, Hirofumi Abe, Tetsuya Yoshizaki, Madoka Takao, Toshitatsu Takao, Yoshinori Morita, Hiroshi Yokozaki, Yuzo Kodama
    Clinical Endoscopy.2022; 55(1): 86.     CrossRef
  • The importance of pH adjustment for preventing fibrin glue dissolution in the stomach: an in vitro study
    Yoshitaka Takegawa, Toshitatsu Takao, Hiroya Sakaguchi, Tatsuya Nakai, Kazuhiro Takeo, Yoshinori Morita, Takashi Toyonaga, Yuzo Kodama
    Scientific Reports.2022;[Epub]     CrossRef
  • A Novel Self-Assembled Gel for Gastric Endoscopic Submucosal Dissection-Induced Ulcer: A Preclinical Study in a Porcine Model
    Meng Li, Haifeng Jin, Changpei Shi, Bin Lyu, Xiao Ying, Yuan Shi
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • 4,997 View
  • 119 Download
  • 5 Web of Science
  • 4 Crossref
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Reasons for Diagnostic Failure in Forty-Five Consecutive Mucosal Cutting Biopsy Examinations of Gastric Subepithelial Tumors
Yoshiko Nakano, Toshitatsu Takao, Yoshinori Morita, Shinwa Tanaka, Takashi Toyonaga, Eiji Umegaki, Yuzo Kodama
Clin Endosc 2020;53(5):575-582.   Published online February 14, 2020
AbstractAbstract PDFPubReaderePub
/Aims: Mucosal cutting biopsy (MCB) is useful for the histopathological diagnosis of gastric subepithelial tumors (SETs). However, there is little information on cases in which MCB did not establish a diagnosis. In the current study, we aimed to investigate the characteristics of cases in which MCB was unsuccessful.
Cases in which MCB was used to histopathologically diagnose gastric SETs at Kobe University Hospital between August 2012 and October 2018 were retrospectively reviewed.
Forty-five cases in which MCB was used to diagnose 43 gastric SETs in 43 patients were analyzed. The median tumor size was 20 mm (range, 8–50 mm). Pathological examinations resulted in definitive and suspected diagnoses and no diagnosis in 29 (gastrointestinal stromal tumor: n=17, leiomyoma: n=7, aberrant pancreas: n=3, others: n=2), 6, and 10 cases, respectively. Failure to expose the tumor according to retrospective examinations of endoscopic images was significantly associated with no diagnosis. Other possible explanations included a less elevated tumor, biopsy of the surrounding field instead of the tumor due to the mobility, and poor endoscope maneuverability due to the tumor being close to the cardia.
Clear exposure of gastric SETs during MCB may improve the diagnostic rate of such examinations.


Citations to this article as recorded by  
  • Technical outcomes and postprocedural courses of mucosal incision‐assisted biopsy for possible gastric gastrointestinal stromal tumors: A series of 48 cases (with video)
    Eriko Koizumi, Osamu Goto, Shun Nakagome, Tsugumi Habu, Yumiko Ishikawa, Kumiko Kirita, Hiroto Noda, Kazutoshi Higuchi, Takeshi Onda, Teppei Akimoto, Jun Omori, Naohiko Akimoto, Katsuhiko Iwakiri
    DEN Open.2024;[Epub]     CrossRef
  • Utility and advantage of the unroofing technique for gastrointestinal subepithelial tumors: A multicenter retrospective cohort study
    Masashi Yamamoto, Tsutomu Nishida, Ryotaro Uema, Takashi Kanesaka, Hiroyuki Ogawa, Shinji Kitamura, Hideki Iijima, Kengo Nagai, Shusaku Tsutsui, Masato Komori, Katsumi Yamamoto, Yoshiki Tsujii, Yoshito Hayashi, Tetsuo Takehara
    DEN Open.2024;[Epub]     CrossRef
  • Systematic Endoscopic Approach for Diagnosing Gastric Subepithelial Tumors
    Gwang Ha Kim
    Gut and Liver.2022; 16(1): 19.     CrossRef
  • The Diagnosis of Small Gastrointestinal Subepithelial Lesions by Endoscopic Ultrasound-Guided Fine Needle Aspiration and Biopsy
    Masanari Sekine, Takeharu Asano, Hirosato Mashima
    Diagnostics.2022; 12(4): 810.     CrossRef
  • Advancements in the Diagnosis of Gastric Subepithelial Tumors
    Osamu Goto, Mitsuru Kaise, Katsuhiko Iwakiri
    Gut and Liver.2022; 16(3): 321.     CrossRef
  • Mucosal Incision-Assisted Endoscopic Biopsy as an Alternative to Endoscopic Ultrasound-Guided Fine-Needle Aspiration/Biopsy for Gastric Subepithelial Tumor
    Cheol Woong Choi, Joo Ha Hwang
    Clinical Endoscopy.2020; 53(5): 505.     CrossRef
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  • 6 Web of Science
  • 6 Crossref
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Focused Review Series: Globalization and Universalization of ESD
Principles of Quality Controlled Endoscopic Submucosal Dissection with Appropriate Dissection Level and High Quality Resected Specimen
Takashi Toyonaga, Eisei Nishino, Mariko Man-i, James E. East, Takeshi Azuma
Clin Endosc 2012;45(4):362-374.   Published online November 30, 2012
AbstractAbstract PDFPubReaderePub

Endoscopic submucosal dissection (ESD) has enabled en bloc resection of early stage gastrointestinal tumors with negligible risk of lymph node metastasis, regardless of tumor size, location, and shape. However, ESD is a relatively difficult technique compared with conventional endoscopic mucosal resection, requiring a longer procedure time and potentially causing more complications. For safe and reproducible procedure of ESD, the appropriate dissection of the ramified vascular network in the level of middle submucosal layer is required to reach the avascular stratum just above the muscle layer. The horizontal approach to maintain the appropriate depth for dissection beneath the vascular network enables treatment of difficult cases with large vessels and severe fibrosis. The most important aspect of ESD is the precise evaluation of curability. This approach can also secure the quality of the resected specimen with enough depth of the submucosal layer.


Citations to this article as recorded by  
  • The role of advanced endoscopy in appendiceal polyp management and outcomes
    Carla F. Justiniano, Ilker Ozgur, David Liska, Michael A. Valente, Scott R. Steele, Emre Gorgun
    Surgical Endoscopy.2024; 38(4): 2267.     CrossRef
  • Is there a best choice of equipment for colorectal endoscopic submucosal dissection?
    Francesco Cocomazzi, Sonia Carparelli, Nunzia Labarile, Antonio Capogreco, Marco Gentile, Roberta Maselli, Jahnvi Dhar, Jayanta Samanta, Alessandro Repici, Cesare Hassan, Francesco Perri, Antonio Facciorusso
    Expert Review of Medical Devices.2024; : 1.     CrossRef
  • Assessment and Techniques for Endoscopic Closure
    Ragavan Siddharthan, Peter Marcello
    Clinics in Colon and Rectal Surgery.2023;[Epub]     CrossRef
  • Utility of a novel self‐assembling peptide for bleeding from the specimen side during gastric endoscopic submucosal dissection
    Ayaka Takasu, Aya Iwao, Xiaoyan Tang
    Digestive Endoscopy.2023;[Epub]     CrossRef
  • Efficacy and Safety of a Novel Hemostatic Peptide Solution During Endoscopic Submucosal Dissection: A Multicenter Randomized Controlled Trial
    Toshio Uraoka, Noriya Uedo, Tsuneo Oyama, Yutaka Saito, Naohisa Yahagi, Ai Fujimoto, Yoshiro Kawahara, Katsuhiro Mabe, Takuto Hikichi, Yorimasa Yamamoto, Hisao Tajiri
    American Journal of Gastroenterology.2023; 118(2): 276.     CrossRef
  • Safe and Efficient Procedures and Training System for Endoscopic Submucosal Dissection
    Yu Kamitani, Kouichi Nonaka, Yoshitsugu Misumi, Hajime Isomoto
    Journal of Clinical Medicine.2023; 12(11): 3692.     CrossRef
  • Red dichromatic imaging improves visibility of bleeding during gastric endoscopic submucosal dissection
    Kohei Oka, Naoto Iwai, Takashi Okuda, Toshifumi Tsuji, Hiroaki Sakai, Chie Hattori, Masashi Taniguchi, Tasuku Hara, Toshiyuki Komaki, Junichi Sakagami, Keizo Kagawa, Osamu Dohi, Yoshito Itoh
    Scientific Reports.2023;[Epub]     CrossRef
  • Endoscopic full-thickness resection versus endoscopic submucosal dissection for challenging colorectal lesions: a randomized trial
    Gianluca Andrisani, Cesare Hassan, Margherita Pizzicannella, Francesco Pugliese, Massimiliano Mutignani, Chiara Campanale, Giorgio Valerii, Carmelo Barbera, Giulio Antonelli, Francesco Maria Di Matteo
    Gastrointestinal Endoscopy.2023; 98(6): 987.     CrossRef
  • Endoscopic Submucosal Dissection of Superficial Colorectal Neoplasms at “Challenging Sites” Using a Double-Balloon Endoluminal Interventional Platform: A Single-Center Study
    Gianluca Andrisani, Francesco Maria Di Matteo
    Diagnostics.2023; 13(19): 3154.     CrossRef
  • Clinical usefulness of red dichromatic imaging in hemostatic treatment during endoscopic submucosal dissection: First report from a multicenter, open‐label, randomized controlled trial
    Ai Fujimoto, Yutaka Saito, Seiichiro Abe, Syu Hoteya, Kosuke Nomura, Hiroshi Yasuda, Yasumasa Matsuo, Toshio Uraoka, Shiko Kuribayashi, Yosuke Tsuji, Daisuke Ohki, Tadateru Maehata, Motohiko Kato, Naohisa Yahagi
    Digestive Endoscopy.2022; 34(2): 379.     CrossRef
  • A Steep Early Learning Curve for Endoscopic Submucosal Dissection in the Live Porcine Model
    Ricardo Küttner-Magalhães, Mário Dinis-Ribeiro, Marco J. Bruno, Ricardo Marcos-Pinto, Carla Rolanda, Arjun D. Koch
    Digestive Diseases.2022; 40(6): 816.     CrossRef
  • Evaluation of the visibility of bleeding points using red dichromatic imaging in endoscopic hemostasis for acute GI bleeding (with video)
    Yuichiro Hirai, Ai Fujimoto, Naomi Matsutani, Soichiro Murakami, Yuki Nakajima, Ryoichi Miyanaga, Yoshihiro Nakazato, Kazuyo Watanabe, Masahiro Kikuchi, Naohisa Yahagi
    Gastrointestinal Endoscopy.2022; 95(4): 692.     CrossRef
  • Risk factors of major intraoperative bleeding and postoperative bleeding associated with endoscopic submucosal dissection for gastric neoplasms
    Shanshan Xu, Ningli Chai, Xiaowei Tang, Enqiang Linghu, Shasha Wang
    Chinese Medical Journal.2022; 135(3): 309.     CrossRef
  • Colon Polypectomy with Endoscopic Submucosal Dissection and Endoscopic Full-Thickness Resection
    Maham Hayat, Nabeel Azeem, Mohammad Bilal
    Gastrointestinal Endoscopy Clinics of North America.2022; 32(2): 277.     CrossRef
  • Thickness of colorectal submucosal (SM) layer in resected specimens: Is more better?
    Alanna Ebigbo
    Endoscopy International Open.2022; 10(06): E727.     CrossRef
  • Clinical benefit of tunnel endoscopic submucosal dissection for esophageal squamous cancer: a multicenter, randomized controlled trial
    Xiaotong Fan, Qi Wu, Rui Li, Weifeng Chen, Huaping Xie, Xin Zhao, Shaohua Zhu, Caixia Fan, Jianyi Li, Mei Liu, Zhiguo Liu, Ying Han
    Gastrointestinal Endoscopy.2022; 96(3): 436.     CrossRef
  • From advanced diagnosis to advanced resection in early neoplastic colorectal lesions: Never-ending and trending topics in the 2020s
    Francesco Auriemma, Sandro Sferrazza, Mario Bianchetti, Maria Flavia Savarese, Laura Lamonaca, Danilo Paduano, Nicole Piazza, Enrica Giuffrida, Lupe Sanchez Mete, Alessandra Tucci, Sebastian Manuel Milluzzo, Chiara Iannelli, Alessandro Repici, Benedetto M
    World Journal of Gastrointestinal Surgery.2022; 14(7): 632.     CrossRef
  • Superficial neoplasia involving the Ileocecal valve: Clinical outcomes of endoscopic submucosal dissection
    Gianluca Andrisani, Takehide Fukuchi, Giulio Antonelli, Jun Hamanaka, Cesare Hassan, Guido Costamagna, Shin Maeda, Francesco Maria Di Matteo, Kingo Hirasawa
    Digestive and Liver Disease.2021; 53(7): 889.     CrossRef
  • Prioritizing an oncologic approach to endoscopic resection of pedunculated colorectal polyps
    Douglas K. Rex, Mauro Risio, Cesare Hassan
    Gastrointestinal Endoscopy.2021; 94(1): 155.     CrossRef
  • How to Perform a High-Quality Endoscopic Submucosal Dissection
    Yutaka Saito, Seiichiro Abe, Haruhiro Inoue, Hisao Tajiri
    Gastroenterology.2021; 161(2): 405.     CrossRef
  • Recent Advance in the Management of Dysplasia in the Ulcerative Colitis
    Dong-Hoon Yang
    Journal of Digestive Cancer Reports.2021; 9(2): 50.     CrossRef
  • Factors associated with pyrexia after gastric endoscopic submucosal dissection
    Yuta Tahata, Yohei Horikawa, Sayaka Sato, Saki Fushimi, Haruka Hatakeyama
    Progress of Digestive Endoscopy.2021; 99(1): 22.     CrossRef
  • Hemorrhage control during gastric endoscopic submucosal dissection: Techniques using uncovered knives
    Yohei Horikawa, Saki Fushimi, Sayaka Sato
    JGH Open.2020; 4(1): 4.     CrossRef
  • Review on colorectal endoscopic submucosal dissection focusing on the technical aspect
    Tak Lit Derek Fung, Chi Woo Samuel Chow, Pak Tat Chan, Kam Hung Kwok
    Surgical Endoscopy.2020; 34(9): 3766.     CrossRef
  • Novel strategy using pocket creation method to reduce intraoperative bleeding in gastric endoscopic submucosal dissection
    Nobuaki Ikezawa, Shinwa Tanaka, Takashi Toyonaga
    Digestive Endoscopy.2020;[Epub]     CrossRef
  • Feasibility of gastric endoscopic submucosal dissection without using proton pump inhibitor injection: a propensity score analysis
    Saki Fushimi, Yohei Horikawa, Hiroya Mizutamari, Nobuya Mimori, Yuhei Kato, Sayaka Sato
    Journal of Rural Medicine.2020; 15(3): 85.     CrossRef
  • Efficacy of a new image-enhancement technique for achieving hemostasis in endoscopic submucosal dissection
    Tadateru Maehata, Ai Fujimoto, Toshio Uraoka, Motohiko Kato, Joichiro Horii, Motoki Sasaki, Yoshiyuki Kiguchi, Teppei Akimoto, Atsushi Nakayama, Yasutoshi Ochiai, Osamu Goto, Toshihiro Nishizawa, Naohisa Yahagi
    Gastrointestinal Endoscopy.2020; 92(3): 667.     CrossRef
  • Haemostasis treatment using dual red imaging during endoscopic submucosal dissection: a multicentre, open-label, randomised controlled trial
    Ai Fujimoto, Yutaka Saito, Seiirhicro Abe, Shu Hoteya, Kosuke Nomura, Hiroshi Yasuda, Yasumasa Matsuo, Toshio Uraoka, Shiko Kuribayashi, Itaru Saito, Yosuke Tsuji, Tadateru Maehata, Yasutoshi Ochiai, Toshihiro Nishizawa, Naohisa Yahagi
    BMJ Open Gastroenterology.2019; 6(1): e000275.     CrossRef
  • Endoscopic Submucosal Dissection for Colitis-Associated Dysplasia
    Dong-Hoon Yang, Imelda Rey
    Clinical Endoscopy.2019; 52(2): 120.     CrossRef
  • Management of Complications of Colorectal Submucosal Dissection
    Eun Ran Kim, Dong Kyung Chang
    Clinical Endoscopy.2019; 52(2): 114.     CrossRef
  • Use of electrosurgical units in the endoscopic resection of gastrointestinal tumors
    José C. Marín-Gabriel, Raffaella Romito, Carlos Guarner-Argente, José Santiago-García, Joaquín Rodríguez-Sánchez, Takashi Toyonaga
    Gastroenterología y Hepatología.2019; 42(8): 512.     CrossRef
  • Use of electrosurgical units in the endoscopic resection of gastrointestinal tumors
    José C. Marín-Gabriel, Raffaella Romito, Carlos Guarner-Argente, José Santiago-García, Joaquín Rodríguez-Sánchez, Takashi Toyonaga
    Gastroenterología y Hepatología (English Edition).2019; 42(8): 512.     CrossRef
  • Two penetrating vessels as a novel indicator of the appropriate distal end of peroral endoscopic myotomy
    Shinwa Tanaka, Fumiaki Kawara, Takashi Toyonaga, Haruhiro Inoue, Robert Bechara, Namiko Hoshi, Hirohumi Abe, Yoshiko Ohara, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki
    Digestive Endoscopy.2018; 30(2): 206.     CrossRef
  • Short-term efficacy of potassium-competitive acid blocker following gastric endoscopic submucosal dissection: a propensity score analysis
    Yohei Horikawa, Hiroya Mizutamari, Nobuya Mimori, Yuhei Kato, Saki Fushimi, Sayaka Sato, Syunji Okubo
    Scandinavian Journal of Gastroenterology.2018; 53(2): 243.     CrossRef
  • Endoscopic submucosal tunnel dissection using a novel bracing basket: An animal feasibility study
    Min Min, Yan Liu, Xin Chen, Yiliang Bi, Wei Shen, Yang Xu
    Scientific Reports.2018;[Epub]     CrossRef
  • Endoscopic non-ablative fractional laser therapy in an orthotopic colon tumour model
    Su Woong Yoo, Gyungseok Oh, Abdul Mohaimen Safi, Soonjoo Hwang, Young-Seok Seo, Kyung-Hwa Lee, Young L. Kim, Euiheon Chung
    Scientific Reports.2018;[Epub]     CrossRef
  • Single‐center implementation of endoscopic submucosal dissection (ESD) in the colorectum: Low recurrence rate after intention‐to‐treat ESD
    Andrej Wagner, Daniel Neureiter, Tobias Kiesslich, Gernot W. Wolkersdörfer, Thomas Pleininger, Christian Mayr, Christiane Dienhart, Naohisa Yahagi, Tsuneo Oyama, Frieder Berr
    Digestive Endoscopy.2018; 30(3): 354.     CrossRef
  • Splash M-knife versus Flush Knife BT in the technical outcomes of endoscopic submucosal dissection for early gastric cancer: a propensity score matching analysis
    Mitsuru Esaki, Sho Suzuki, Yasuyo Hayashi, Azusa Yokoyama, Shuichi Abe, Taizo Hosokawa, Haruei Ogino, Hirotada Akiho, Eikichi Ihara, Yoshihiro Ogawa
    BMC Gastroenterology.2018;[Epub]     CrossRef
  • Histological Comparison of Cold versus Hot Snare Resections of the Colorectal Mucosa
    Daisuke Takayanagi, Daiki Nemoto, Noriyuki Isohata, Shungo Endo, Masato Aizawa, Kenichi Utano, Kensuke Kumamoto, Hiroshi Hojo, Alan Kawarai Lefor, Kazutomo Togashi
    Diseases of the Colon & Rectum.2018; 61(8): 964.     CrossRef
  • Usefulness of the clip-flap method of endoscopic submucosal dissection: A randomized controlled trial
    Hiromitsu Ban, Mitsushige Sugimoto, Taketo Otsuka, Masaki Murata, Toshiro Nakata, Hiroshi Hasegawa, Osamu Inatomi, Shigeki Bamba, Akira Andoh
    World Journal of Gastroenterology.2018; 24(35): 4077.     CrossRef
  • Efficacy of a new hemostatic forceps during gastric endoscopic submucosal dissection: A prospective randomized controlled trial
    Shinwa Tanaka, Takashi Toyonaga, Yoshinori Morita, Tsukasa Ishida, Namiko Hoshi, Kevin L Grimes, Yoshiko Ohara, Tetsuya Yoshizaki, Fumiaki Kawara, Eiji Umegaki, Takeshi Azuma
    Journal of Gastroenterology and Hepatology.2017; 32(4): 846.     CrossRef
  • History and Development of Accessories for Endoscopic Submucosal Dissection
    Bong Min Ko
    Clinical Endoscopy.2017; 50(3): 219.     CrossRef
  • The Psychosocial Influences of Waiting Periods on Patients Undergoing Endoscopic Submucosal Dissection
    Noriko Nagao, Aya Tsuchiya, Sae Ando, Mizue Arita, Takashi Toyonaga, Ikuko Miyawaki
    Gastroenterology Nursing.2017; 40(5): 373.     CrossRef
  • Usefulness of a novel slim type FlushKnife-BT over conventional FlushKnife-BT in esophageal endoscopic submucosal dissection
    Yoshiko Ohara, Takashi Toyonaga, Namiko Hoshi, Shinwa Tanaka, Shinichi Baba, Hiroshi Takihara, Fumiaki Kawara, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma
    World Journal of Gastroenterology.2017; 23(9): 1657.     CrossRef
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    Tsukasa Ishida, Takashi Toyonaga, Yoshiko Ohara, Tadao Nakashige, Yasuaki Kitamura, Ryusuke Ariyoshi, Hiroshi Takihara, Shinichi Baba, Tetsuya Yoshizaki, Fumiaki Kawara, Shinwa Tanaka, Yoshinori Morita, Eiji Umegaki, Namiko Hoshi, Takeshi Azuma
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