Original Article
-
Efficacy of hemostasis by gastroduodenal covered metal stent placement for hemorrhagic duodenal stenosis due to pancreatobiliary cancer invasion: a retrospective study
-
Yasunari Sakamoto, Taku Sakamoto, Akihiro Ohba, Mitsuhito Sasaki, Shunsuke Kondo, Chigusa Morizane, Hideki Ueno, Yutaka Saito, Yasuaki Arai, Takuji Okusaka
-
Clin Endosc 2024;57(5):628-636. Published online June 14, 2024
-
DOI: https://doi.org/10.5946/ce.2023.155
-
-
Graphical Abstract
Abstract
PDF
PubReader
ePub

- Background
/Aims: Advanced pancreatic and biliary tract cancers can invade the duodenum and cause duodenal hemorrhagic stenosis. This study aimed to evaluate the efficacy of covered self-expandable metal stents in the treatment of cancer-related duodenal hemorrhage with stenosis.
Methods
Between January 2014 and December 2016, metal stents were placed in 51 patients with duodenal stenosis. Among these patients, a self-expandable covered metal stent was endoscopically placed in 10 patients with hemorrhagic duodenal stenosis caused by pancreatobiliary cancer progression. We retrospectively analyzed the therapeutic efficacy of the stents by evaluating the technical and clinical success rates based on successful stent placement, degree of oral intake, hemostasis, stent patency, and overall survival.
Results
The technical and clinical success rates were 100%. All 10 patients achieved a gastric outlet obstruction scoring system score of three within two weeks after the procedure and had no recurrence of melena. The median stent patency duration and overall survival after stent placement were 52 days (range, 20–220 days) and 66.5 days (range, 31–220 days), respectively.
Conclusions
Endoscopic placement of a covered metal stent for hemorrhagic duodenal stenosis associated with pancreatic or biliary tract cancer resulted in duodenal hemostasis, recanalization, and improved quality of life.
-
Citations
Citations to this article as recorded by

- Clinical significance of peritoneal lavage cytology in duodenal cancer
Yuya Miura, Katsuhisa Ohgi, Ryo Ashida, Yoshiyasu Kato, Shimpei Otsuka, Hideyuki Dei, Katsuhiko Uesaka, Teiichi Sugiura
Surgery.2025; 181: 109256. CrossRef - Clinical effect of percutaneous hepatic puncture biliary drainage combined with metal stent implantation in the treatment of malignant obstructive jaundice
Shoulin Zhang, Shaopeng Huang, Zheng Xing, Youwen Song, Fujian Yuan
BMC Surgery.2025;[Epub] CrossRef
-
5,730
View
-
279
Download
-
2
Web of Science
-
2
Crossref
Focused Review Series: Image-Enhanced Endoscopy: Update on Clinical Practice
-
Clinical Applications of Linked Color Imaging and Blue Laser/Light Imaging in the Screening, Diagnosis, and Treatment of Superficial Colorectal Tumors
-
Taku Sakamoto, Hourin Cho, Yutaka Saito
-
Clin Endosc 2021;54(4):488-493. Published online July 14, 2021
-
DOI: https://doi.org/10.5946/ce.2021.157
-
-
Abstract
PDF
PubReader
ePub
- Considering its contribution to reducing colorectal cancer morbidity and mortality, the most important task of colonoscopy is to find all existing polyps. Moreover, the accurate detection of existing polyps determines the risk of colorectal cancer morbidity and is an important factor in deciding the appropriate surveillance program for patients. Image-enhanced endoscopy is an easy-to-use modality with improved lesion detection. Linked color imaging (LCI) and blue laser/light imaging (BLI) are useful modalities for improving colonoscopy quality. Each mode has unique optical features; therefore, their intended use differs. LCI contributes to improved polyp detection due to its brightness and high color contrast between the lesion and normal mucosa, while BLI contributes to the characterization of detected polyps by evaluating the vessel and surface patterns of detected lesions. The proper use of these observation modes allows for more efficient endoscopic diagnosis. Moreover, recent developments in artificial intelligence will soon change the clinical practice of colonoscopy and this system will provide an efficient education modality for novice endoscopists.
-
Citations
Citations to this article as recorded by

- Improvement of Colonoscopic Image Quality Using a New LED Endoscopic System with Specialized Noise Reduction
Naohisa Yoshida, Masahiro Okada, Yoshikazu Hayashi, Reo Kobayashi, Ken Inoue, Osamu Dohi, Yoshito Itoh, Ryohei Hirose, Lucas Cardoso, Kohei Suzuki, Tomonori Yano, Hironori Yamamoto
Diagnostics.2025; 15(12): 1569. CrossRef - Classification of image-enhanced endoscopy in colon tumors
One-Zoong Kim
Clinical Endoscopy.2025; 58(3): 337. CrossRef - Texture and Color Enhanced Imaging in the Diagnosis of Colonic Neoplasia: A Systematic Review and Analysis
Ciaran Judge, David Law, Glynis Jones, Sherman Picardo, Krish Ragunath
JGH Open.2025;[Epub] CrossRef - Evaluation of the effectiveness of endoscopic diagnostics of esophagogastric junction pathology using blue light imaging (BLI)
Evgeniy O. Ilyushnikov, Dmitriy V. Sazonov, Dmitriy N. Panchenkov
Journal of Experimental and Clinical Surgery.2025; 18(4): 226. CrossRef - Endoscopic features with associated histological and molecular alterations in serrated polyps with dysplasia: Retrospective analysis of a tertiary case series
Antonello Trecca, Raffaele Borghini, Daniela Medicina, Rachele Del Sordo, Giulio Mandelli, Antonino Bella, Giuseppe Galloro, Kuang-I Fu, Vincenzo Villanacci
Digestive and Liver Disease.2024; 56(4): 687. CrossRef - Linked-color imaging with or without artificial intelligence for adenoma detection: a randomized trial
Kazuya Miyaguchi, Yoshikazu Tsuzuki, Nobutaka Hirooka, Hisashi Matsumoto, Hideki Ohgo, Hidetomo Nakamoto, Hiroyuki Imaeda
Endoscopy.2024; 56(05): 376. CrossRef - The Diagnostic Performance of Linked Color Imaging Compared to White Light Imaging in Endoscopic Diagnosis of Helicobacter pylori Infection: A Systematic Review and Meta-Analysis
Jae Gon Lee, In Kyung Yoo, Abdullah Ozgur Yeniova, Sang Pyo Lee
Gut and Liver.2024; 18(3): 444. CrossRef - Linked color imaging improves the diagnostic accuracy of eosinophilic esophagitis
Yasuhiko Abe, Yu Sasaki, Makoto Yagi, Naoko Mizumoto, Yusuke Onozato, Takashi Kon, Masakuni Shoji, Kazuhiro Sakuta, Takayuki Sakai, Matsuki Umehara, Minami Ito, Shuhei Nakamura, Hidemoto Tsuchida, Yoshiyuki Ueno
DEN Open.2023;[Epub] CrossRef - Comparison of LED and LASER Colonoscopy About Linked Color Imaging and Blue Laser/Light Imaging of Colorectal Tumors in a Multinational Study
Naohisa Yoshida, Peter V. Draganov, Sneha John, Helmut Neumann, Rafiz Abdul Rani, Wen-Hsin Hsu, Nilesh Fernandopulle, Kewin Tien Ho Siah, Ricardo Morgenstern, Yuri Tomita, Ken Inoue, Osamu Dohi, Ryohei Hirose, Yoshito Itoh, Takaaki Murakami, Yoshikazu Ina
Digestive Diseases and Sciences.2023; 68(10): 3943. CrossRef - Classification and endoscopic diagnosis of colorectal polyps
Ji Hyun Kim, Sung Chul Park
Journal of the Korean Medical Association.2023; 66(11): 633. CrossRef - Role of linked color imaging for upper gastrointestinal disease: present and future
Sang Pyo Lee
Clinical Endoscopy.2023; 56(5): 546. CrossRef - Detecting colorectal lesions with image-enhanced endoscopy: an updated review from clinical trials
Mizuki Nagai, Sho Suzuki, Yohei Minato, Fumiaki Ishibashi, Kentaro Mochida, Ken Ohata, Tetsuo Morishita
Clinical Endoscopy.2023; 56(5): 553. CrossRef - Images of laser and light‐emitting diode colonoscopy for comparing large colorectal lesion visibility with linked color imaging and white‐light imaging
Naohisa Yoshida, Yoshikazu Hayashi, Hiroshi Kashida, Yuri Tomita, Osamu Dohi, Ken Inoue, Ryohei Hirose, Yoshito Itoh, Masahiro Okada, Shiori Yoshimoto, Toshihiro Fujinuma, Hirotsugu Sakamoto, Keijiro Sunada, Yoriaki Komeda, Ikue Sekai, Natsuki Okai, Hiron
Digestive Endoscopy.2022; 34(7): 1413. CrossRef
-
8,552
View
-
219
Download
-
12
Web of Science
-
13
Crossref
Original Article
-
Reduced Intravenous Fluorescein Dose for Upper and Lower Gastrointestinal Tract Probe-Based Confocal Laser Endomicroscopy
-
Kazuya Inoki, Seiichiro Abe, Yusaku Tanaka, Koji Yamamoto, Daisuke Hihara, Ryoji Ichijima, Yukihiro Nakatani, HsinYu Chen, Hiroyuki Takamaru, Masau Sekiguchi, Masayoshi Yamada, Taku Sakamoto, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Ichiro Oda, Takahisa Matsuda, Yutaka Saito
-
Clin Endosc 2021;54(3):363-370. Published online September 8, 2020
-
DOI: https://doi.org/10.5946/ce.2020.058
-
-
Abstract
PDF
PubReader
ePub
- Background
/Aims: Probe-based confocal laser endomicroscopy (pCLE) requires the administration of intravenous (IV) fluorescein. This study aimed to determine the optimal dose of IV fluorescein for both upper and lower gastrointestinal (GI) tract pCLE.
Methods
Patients 20 to 79 years old with gastric high-grade dysplasia (HGD) or colorectal neoplasms (CRNs) were enrolled in the study. The dose de-escalation method was employed with five levels. The primary endpoint of the study was the determination of the optimal dose of IV fluorescein for pCLE of the GI tract. The reduced dose was determined based on off-line reviews by three endoscopists. An insufficient dose of fluorescein was defined as the dose of fluorescein with which the pCLE images were not deemed to be visible. If all three endoscopists determined that the tissue structure was visible, the doses were de-escalated.
Results
A total of 12 patients with gastric HGD and 12 patients with CRNs were enrolled in the study. Doses were de-escalated to 0.5 mg/kg of fluorescein for both non-neoplastic duodenal and colorectal mucosa. All gastric HGD or CRNs were visible with pCLE with IV fluorescein at 0.5 mg/kg.
Conclusions
In the present study, pCLE with IV fluorescein 0.5 mg/kg was adequate to visualize the magnified structure of both the upper and lower GI tract.
-
Citations
Citations to this article as recorded by

- Prospective assessment of probe‐based confocal laser endomicroscopy under direct cholangioscopic visualization for biliary strictures that could not be definitively diagnosed using endoscopic retrograde cholangiopancreatography (with video)
Yuki Tanisaka, Shomei Ryozawa, Masafumi Mizuide, Akashi Fujita, Ryuhei Jinushi, Ryuichi Watanabe, Ryo Sato, Tomoaki Tashima, Yumi Mashimo
DEN Open.2025;[Epub] CrossRef - Confocal Laser Endomicroscopy: Enhancing Intraoperative Decision Making in Neurosurgery
Francesco Carbone, Nicola Pio Fochi, Giuseppe Di Perna, Arthur Wagner, Jürgen Schlegel, Elena Ranieri, Uwe Spetzger, Daniele Armocida, Fabio Cofano, Diego Garbossa, Augusto Leone, Antonio Colamaria
Diagnostics.2025; 15(4): 499. CrossRef - Precision endoscopy in colorectal polyps' characterization and planning of endoscopic therapy
Francesco Vito Mandarino, Silvio Danese, Toshio Uraoka, Adolfo Parra‐Blanco, Yasuharu Maeda, Yutaka Saito, Shin‐Ei Kudo, Michael J. Bourke, Marietta Iacucci
Digestive Endoscopy.2024; 36(7): 761. CrossRef
-
7,752
View
-
131
Download
-
3
Web of Science
-
3
Crossref