Systematic Review and Meta-analysis
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Safety of endoscopic retrograde cholangiopancreatography (ERCP) in cirrhosis compared to non-cirrhosis and effect of Child-Pugh score on post-ERCP complications: a systematic review and meta-analysis
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Zahid Ijaz Tarar, Umer Farooq, Mustafa Gandhi, Saad Saleem, Ebubekir Daglilar
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Clin Endosc 2023;56(5):578-589. Published online May 2, 2023
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DOI: https://doi.org/10.5946/ce.2023.027
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- Background
/Aims: The safety of endoscopic retrograde cholangiopancreatography (ERCP) in hepatic cirrhosis and the impact of Child-Pugh class on post-ERCP complications need to be better studied. We investigated the post-ERCP complication rates in patients with cirrhosis compared with those without cirrhosis.
Methods
We conducted a literature search of relevant databases to identify studies that reported post-ERCP complications in patients with hepatic cirrhosis.
Results
Twenty-four studies comprising 28,201 patients were included. The pooled incidence of post-ERCP complications in cirrhosis was 15.5% (95% confidence interval [CI], 11.8%–19.2%; I2=96.2%), with an individual pooled incidence of pancreatitis 5.1% (95% CI, 3.1%–7.2%; I2=91.5%), bleeding 3.6% (95% CI, 2.8%–4.5%; I2=67.5%), cholangitis 2.9% (95% CI, 1.9%–3.8%; I2=83.4%), and perforation 0.3% (95% CI, 0.1%–0.5%; I2=3.7%). Patients with cirrhosis had a greater risk of post-ERCP complications (risk ratio [RR], 1.41; 95% CI, 1.16–1.71; I2=56.3%). The risk of individual odds of adverse events between cirrhosis and non-cirrhosis was as follows: pancreatitis (RR, 1.25; 95% CI, 1.06–1.48; I2=24.8%), bleeding (RR, 1.94; 95% CI, 1.59–2.37; I2=0%), cholangitis (RR, 1.15; 95% CI, 0.77–1.70; I2=12%), and perforation (RR, 1.20; 95% CI, 0.59–2.43; I2=0%).
Conclusions
Cirrhosis is associated with an increased risk of post-ERCP pancreatitis, bleeding, and cholangitis.
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Citations
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- Predictive Factors of Post-ERCP Hepatic Decompensation in Patients with Cirrhosis: A Retrospective Case-Control Study
Mohammed Abusuliman, Sanad Dawod, Faisal Nimri, Taher Jamali, Gordon Jacobsen, Muhammad Zarrar Khan, Remy Arwani, Omar Shamaa, Suhaib Alhaj Ali, Spandana Alluri, Rami Youssef, Abdulmalik Saleem, Ahmad Alomari, Muhammad Saad Faisal, Haya Omeish, Muhammad S
Digestive Diseases and Sciences.2025;[Epub] CrossRef - The Impact of Frailty on ERCP-Related Adverse Events: Findings From a National Cohort
Umer Farooq, Zahid Ijaz Tarar, Abdallah El Alayli, Faisal Kamal, Alexander Schlachterman, Anand Kumar, David E. Loren, Thomas E. Kowalski
Techniques and Innovations in Gastrointestinal Endoscopy.2024; 26(2): 138. CrossRef - Applicability of Child-Turcotte-Pugh Score in Anticipating Post-ERCP Adverse Events in Patients With Cirrhosis
Saqr Alsakarneh, Fouad Jaber, Willie Mohammed, Mohammad Almeqdadi, Abdallah Al-Ani, Yassine Kilani, Saeed Abughazaleh, Laith Momani, Muhammad Shah Miran, Hassan Ghoz, John Helzberg, Wendell Clarkston, Mohamed Othman
Journal of Clinical Gastroenterology.2024; 58(6): 554. CrossRef - Quality Indicators of Endoscopic Retrograde Cholangiopancreatography in Korea
Hyung Ku Chon, Ki-Hyun Kim, Tae Jun Song, Dong-Won Ahn, Eaum Seok Lee, Yun Nah Lee, Yoon Suk Lee, Tae Joo Jeon, Chang Hwan Park, Kwang Bum Cho, Dong Wook Lee, Jin-Seok Park, Seung Bae Yoon, Kwang Hyun Chung, Jin Lee, Miyoung Choi
Gut and Liver.2024; 18(4): 564. CrossRef - Quality Indicators of Endoscopic Retrograde Cholangiopancreatography in Korea
Ki-Hyun Kim, Hyung Ku Chon, Tae Jun Song, Dong Won Ahn, Eaum Seok Lee, Yun Nah Lee, Yoon Suk Lee, Tae Joo Jeon, Chang Hwan Park, Kwang Bum Cho, Dong Wook Lee, Jin-Seok Park, Seung Bae Yoon, Kwang Hyung Chung, Jin Lee, Miyoung Choi
The Korean Journal of Gastroenterology.2024; 84(3): 111. CrossRef - Quality Indicators of Endoscopic Retrograde Cholangiopancreatography in Korea
Ki-Hyun Kim, Hyung Ku Chon, Tae Jun Song, Dong Won Ahn, Eaum Seok Lee, Yun Nah Lee, Yoon Suk Lee, Tae Joo Jeon, Chang Hwan Park, Kwang Bum Cho, Dong Wook Lee, Jin-Seok Park, Seung Bae Yoon, Kwang Hyung Chung, Jin Lee, Miyoung Choi
The Korean Journal of Pancreas and Biliary Tract.2024; 29(4): 144. CrossRef - ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY FOR THE MANAGEMENT OF CHOLEDOCHOLITHIASIS IN OLDER PATIENTS
Júlia Gardenyes, Pere Roura, Helena Vallverdú-Cartie, Judit Hermoso-Bosch, Cl�udia Roca, Mariona Espaulella, Antoni Casals, Héctor Ivo Marani, Joan Saló, Martín Galdín, Marta Gallach, Carles Leal
Revista Española de Enfermedades Digestivas.2023;[Epub] CrossRef
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Case Reports
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Endoscopic Extraction of Biliary Fascioliasis Diagnosed Using Intraductal Ultrasonography in a Patient with Acute Cholangitis
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Ji Su Ha, Hyun Jong Choi, Jong Ho Moon, Yun Nah Lee, Jae Woong Tae, Moon Han Choi, Tae Hoon Lee, Sang-Woo Cha
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Clin Endosc 2015;48(6):579-582. Published online November 30, 2015
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DOI: https://doi.org/10.5946/ce.2015.48.6.579
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- Fasciola hepatica infection may result in biliary obstruction with or without cholangitis in the chronic biliary phase. Because clinical symptoms and signs of F. hepatica are similar to other biliary diseases that cause bile duct obstruction, such as stones or bile duct malignancies, that are, in fact, more common, this condition may not be suspected and diagnosis may be overlooked and delayed. Patients undergoing endoscopic retrograde cholangiopancreatography or endoscopic ultrasonography for the evaluation of bile duct obstruction may be incidentally detected with the worm, and diagnosis can be confirmed by extraction of the leaf-like trematode from the bile duct. Intraductal ultrasonography (IDUS) can provide high-resolution cross-sectional images of the bile duct, and is useful in evaluating indeterminate biliary diseases. We present a case of biliary fascioliasis that was diagnosed using IDUS and managed endoscopically in a patient with acute cholangitis.
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Shankar Roy, Abhishek Mewara, Rajesh Gupta, Surinder Singh Rana
Digestive Diseases and Sciences.2023; 68(9): 3476. CrossRef - Fasciola Hepatica Induced Hepatic Abscess Treated with Triclabendazole
Hyun Joon Park, Gil-Soon Choi, Minjung Jung, Sang Uk Lee
The Korean Journal of Gastroenterology.2021; 77(1): 39. CrossRef - Pancréas parasitaire
M. Wallon, F. Bailly, F. Peyron
EMC - Hépatologie.2021; 36(3): 1. CrossRef - Biliary Fascioliasis in Chronic Calcific Pancreatitis Presenting with Ascending Cholangitis and Biliary Stricture
Tanawat Pattarapuntakul, Bancha Ovartlarnporn, Worapot Rojsanga, Thanaidpon Yungyoo
Case Reports in Gastroenterology.2019; 13(3): 438. CrossRef - Obstructive jaundice of a parasitic etiology
M.� Antonia Remacha ., M� Pilar Goñi , Jesus Espinel
Revista Española de Enfermedades Digestivas.2018;[Epub] CrossRef
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Ectopic Opening of the Common Bile Duct into the Duodenal Bulb Accompanied with Cholangitis and Gallbladder Cancer: A Report of Two Cases
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Jae Min Lee, Hong Jun Kim, Chang Yoon Ha, Hyun Ju Min, Hyunjin Kim, Tae Hyo Kim, Woon Tae Jung, Ok Jae Lee
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Clin Endosc 2015;48(3):260-264. Published online May 29, 2015
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DOI: https://doi.org/10.5946/ce.2015.48.3.260
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An ectopic opening of the common bile duct (CBD) into the duodenal bulb is a very rare congenital anomaly of the biliary system, which may cause recurrent duodenal ulcer or biliary diseases such as choledocholithiasis and cholangitis. Endoscopic retrograde cholangiopancreatography (ERCP) plays a major role in the diagnosis of this anomaly. We report two such cases: one in a 61-year-old man and the other in a 57-year-old man. In the first case, this anomaly caused acute cholangitis with multiple CBD stones, which were successfully treated by ERCP. In the second case, abdominal computed tomography showed pneumobilia, which was further evaluated using ERCP. Besides, this patient was diagnosed with an ectopic opening of the CBD associated with gallbladder cancer. We report these unusual cases and review the relevant medical literature.
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Kazuaki Hashimoto, Tsukasa Ihara, Yuichiro Maruyama, Shinichi Tomisaki, Hiroshi Harada
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Jin Hee Noh
The Korean Journal of Gastroenterology.2024; 84(3): 138. CrossRef - Ectopic ampulla with cholangitis: A case report
Kiran Shankar, Vikas Pemmada, Parvesh Kumar Jain
International Journal of Gastrointestinal Intervention.2024; 13(4): 133. CrossRef - Ectopic Opening of the Bile Duct Into the Duodenal Bulb: Complications of Biliary Drainage
James Yang, Rohit Agrawal, Constantine Melitas, Brian Boulay, Josi Herren, Ronald Gaba, Edward Villa
ACG Case Reports Journal.2023; 10(2): e00973. CrossRef - Seltene anatomische Variante im hepatobiliären System
Viliam Masaryk, Frank Meyer, Uwe Will
Die Chirurgie.2023; 94(7): 635. CrossRef - Ectopic papilla of Vater in the pylorus presenting with cholangitis: A case report with literature review
Taha Alkarboly, Dana T. Gharib, Karzan M. Salih, Shevan M. Mustafa, Abdulwahid M. Salih, Fahmi H. Kakamad
International Journal of Surgery Case Reports.2022; 93: 106887. CrossRef - Efficacy and safety of therapeutic ERCP in patients with ectopic papilla of Vater
Junbo Hong, Weiping Pan, Wei Zuo, Anjiang Wang, Liang Zhu, Xiaodong Zhou, Xiaojiang Zhou, Guohua Li, Zhijian Liu, Pi Liu, Hao Zhen, Yong Zhu, Jiuhong Ma, Jianhui Yuan, Xu Shu, Yin Zhu, Nonghua Lu, Youxiang Chen
Medicine.2020; 99(1): e18536. CrossRef - A unique case of a double common bile duct with ectopic drainage into the gastric antrum: a case report and review of the literature on double duct variants
Li Lian Kuan, John Isherwood, Cristina Pollard, Ashley Dennison
Journal of Surgical Case Reports.2020;[Epub] CrossRef - Ectopic Opening of the Common Bile Duct into the Duodenal Bulb: Diagnosis and Therapeutic Management and Considerations for Timing of Surgery and Duration of Follow-up After Initial Endoscopic Retrograde Cholangiopancreatography
Bahtiyar Muhammedoğlu
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2019; 29(5): 399. CrossRef - Aberrant Opening of the Common Bile Duct with Precancerous Change
Min Kyu Kang, Kook Hyun Kim, Tae Nyeun Kim
The Korean Journal of Pancreas and Biliary Tract.2018; 23(1): 32. CrossRef - ERCP and Direct Cholangioscopy with Gastroscope in Patients with Ectopic Opening of the Bile Duct into the Duodenal Bulb: A Report of 3 Cases
Ji Woong Jang, Sae Hee Kim, Sung Hee Jung, Anna Kim
Korean Journal of Pancreas and Biliary Tract.2016; 21(2): 112. CrossRef
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Original Article
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Extended Spectrum-β-Lactamase or Carbapenemase Producing Bacteria Isolated from Patients with Acute Cholangitis
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Ja Chung Goo, Mun Hyuk Seong, Young Kwang Shim, Hee Seung Lee, Jung-Ho Han, Kyeong Seob Shin, Jae-Woon Choi, Sei Jin Youn, Seon Mee Park
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Clin Endosc 2012;45(2):155-160. Published online June 30, 2012
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DOI: https://doi.org/10.5946/ce.2012.45.2.155
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Correction in: Clin Endosc 2012;45(4):453
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- Background/Aims
This study assessed the antibiotic resistance organisms isolated from the blood and bile of acute cholangitis and evaluated risk factors associated with them and their impact on clinical outcomes.
MethodsThe identities and antibiotic resistance profiles of bacteria isolated from 433 cases of acute cholangitis from 346 patients were analyzed. Risk factors and the outcomes of patients infected with them were assessed.
ResultsMicroorganisms were isolated from 266 of 419 blood cultures and 256 of 260 bile cultures. Isolates from bile and blood were identical in 71% of the cases. A total of 20 extended spectrum-β-lactamase (ESBL)-producers and 4 carbapenemase-producing organisms were isolated from blood, and 34 ESBL-producers and 13 carbapenemase-producers were isolated from bile. Sixty-four (14.8%) cases were infected with any one of these bacteria isolated from blood or bile. Risk factors associated with them in blood were nosocomial infection and prior biliary intervention. In bile, indwelling biliary device was a risk factor associated with them. Antibiotic-resistant bacteria were associated with mortality, independent of other prognostic factors.
ConclusionsESBL or carbapenemase-producing bacteria were frequently isolated in acute cholangitis patients especially with prior biliary intervention and nosocomial infection. Isolation of antibiotic-resistant bacteria was an independent risk factor of mortality.
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Journal of Clinical Gastroenterology.2024; 58(5): 487. CrossRef - Extended-Spectrum Beta-Lactamase Escherichia coli-Associated Acute Cholangitis: Uncommon Patient Characteristics and Clinical Implications
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Cureus.2024;[Epub] CrossRef - Acute cholangitis: a state-of-the-art review
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Annals of Medicine & Surgery.2024; 86(8): 4560. CrossRef - Updates on Antibiotic Regimens in Acute Cholecystitis
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Gut and Liver.2022; 16(6): 985. CrossRef - Korean Guidelines for Use of Antibiotics for Intra-abdominal Infections in Adults
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Ming Tan, Thøger Gorm Jensen, Stig Lønberg Nielsen, Ove B. Schaffalitzky de Muckadell, Stig Borbjerg Laursen
Scandinavian Journal of Gastroenterology.2021; 56(5): 578. CrossRef - Increasing burden of biliary tract infection caused by extended‐spectrum beta‐lactamase‐producing organisms in Korea: A nationwide population‐based study
Dong Kee Jang, Jungmee Kim, Wan Beom Park, Sun Young Yi, Jun Kyu Lee, Won Jae Yoon
Journal of Gastroenterology and Hepatology.2020; 35(1): 56. CrossRef - Use of microbiological and patient data for choice of empirical antibiotic therapy in acute cholangitis
Tassilo Kruis, Sarah Güse-Jaschuck, Britta Siegmund, Thomas Adam, Hans-Jörg Epple
BMC Gastroenterology.2020;[Epub] CrossRef - Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis
Harumi Gomi, Joseph S. Solomkin, David Schlossberg, Kohji Okamoto, Tadahiro Takada, Steven M. Strasberg, Tomohiko Ukai, Itaru Endo, Yukio Iwashita, Taizo Hibi, Henry A. Pitt, Naohisa Matsunaga, Yoriyuki Takamori, Akiko Umezawa, Koji Asai, Kenji Suzuki, Ho
Journal of Hepato-Biliary-Pancreatic Sciences.2018; 25(1): 3. CrossRef - Appendectomy as a Risk Factor for Bacteremic Biliary Tract Infection Caused by Antibiotic-Resistant Pathogens
Koki Kawanishi, Jun Kinoshita, Hiroko Abe, Tetsuhiro Kakimoto, Yuko Yasuda, Takeshi Hara, Jun Kato
BioMed Research International.2017; 2017: 1. CrossRef - Urgent ERCP for acute cholangitis reduces mortality and hospital stay in elderly and very elderly patients
Chan Sun Park, Hee Seok Jeong, Ki Bae Kim, Joung-Ho Han, Hee Bok Chae, Sei Jin Youn, Seon Mee Park
Hepatobiliary & Pancreatic Diseases International.2016; 15(6): 619. CrossRef - Antibiotic management of complicated intra-abdominal infections in adults: The Asian perspective
Asok Kurup, Kui-Hin Liau, Jianan Ren, Min-Chi Lu, Narciso S. Navarro, Muhammad Waris Farooka, Nurhayat Usman, Raul V. Destura, Boonchoo Sirichindakul, Terapong Tantawichien, Christopher K.C. Lee, Joseph S. Solomkin
Annals of Medicine and Surgery.2014; 3(3): 85. CrossRef - A patient presenting with cholangitis due to Stenotrophomonas maltophilia and Pseudomonas aeruginosa successfully treated with intrabiliary colistine
Pablo N. Pérez, María A. Ramírez, José A. Fernández, Laura Ladrón de Guevara
Infectious Disease Reports.2014; 6(2): 5147. CrossRef - Is Antibiotic Resistance Microorganism Becoming a Significant Problem in Acute Cholangitis in Korea?
Sang-Heum Park
Clinical Endoscopy.2012; 45(2): 111. CrossRef
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A Case of an Anomalous Opening of the Common Bile Duct and Pancreatic Duct into the Duodenal Bulb, and the Patient Presented with Acute Cholangitis and Recurrent Duodenal Ulcer
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Myoung Jin Cho, M.D., Mi Na Oh, M.D., Hoon Ki Baek, M.D., Ki Sung Cho, M.D., Ji Hun Kang, M.D., Young Jae Lee, M.D., Ji Woong Kim, M.D. and Jin Woong Cho, M.D.
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Korean J Gastrointest Endosc 2008;37(6):459-464. Published online December 30, 2008
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- There are various congenital anomalies of the biliary system, but an ectopic opening of the common bile duct into the duodenal bulb is an extremely rare finding. Despite the recent improvement in the diagnosis and management of pancreatobiliary lesions, the general lack of knowledge and understanding about these variations is undoubtedly responsible for many of the problems that occur during the medical and surgical management of these lesions. We report here on a case of a 65-year-old man who had an ectopic opening of the common bile duct into the duodenal bulb, and this cause acute cholangitis with bile duct sludge, and also recurrent duodenal ulcer. In this case, we used abdomen CT, MRCP, duodenoscopy, EUS and ERCP for making the diagnosis. The cholangitis and duodenal ulcer was improved with medical therapy, and the patient was discharged without any surgical procedure. We report here on this unusual case and we include a review of the relevant medical literature. (Korean J Gastrointest Endosc 2008;37:459-463)
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A Case of Clonorchiasis Presenting with Acute Pancreatitis and Cholangitis
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Ki Sung Lee, M.D., Kyung Ho Kim, M.D., So Young Park, M.D., Chi Jun Park, M.D., Ja Young Lee, M.D., Myoung Kuk Jang, M.D., Joon Yong Park, M.D., Jin Heon Lee, M.D., Hak Yang Kim, M.D. and Jae Young Yoo, M.D.
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Korean J Gastrointest Endosc 2006;32(3):231-234. Published online March 30, 2006
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Abstract
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- Clonorchiasis is a parasitic disease that is often found in Japan, Korea, China, Hong Kong as well as in countries in Southeast Asia. The disease is caused by the ingestion of infected raw freshwater fish. The clinical manifestations depend on the number of flukes in a patient, the period of infestation, and the complications. In patients with a heavy infestation, extrahepatic bile duct, the gallbladder and even the pancreas are involved. We experienced a 62-year-old man who had a history of ingestion of raw freshwater fish and presented with acute pancreatitis and cholangitis. The pancreaticobiliary-associated clonorchiasis was successfully treated with endoscopic sphincterotomy, and praziquantel. (Korean J Gastrointest Endosc 2006;32:231234)