Skip Navigation
Skip to contents

Clin Endosc : Clinical Endoscopy

OPEN ACCESS

Search

Page Path
HOME > Search
4 "Aspirin"
Filter
Filter
Article category
Keywords
Publication year
Authors
Original Article
Efficacy of Albis for the Prevention of Gastric Mucosal Injury Concomitant with the Use of Low-Dose Aspirin: A Prospective, Randomized, Placebo-Controlled Study
Sang Gyun Kim, Nayoung Kim, Sung Kwan Shin, In Kyung Sung, Su Jin Hong, Hyo-Jin Park
Clin Endosc 2017;50(2):179-184.   Published online May 19, 2016
DOI: https://doi.org/10.5946/ce.2016.031
AbstractAbstract PDFPubReaderePub
Background
/Aims: Long-term use of aspirin can be a risk factor of peptic ulcer diseases. The aim of this study was to evaluate the efficacy of Albis (Daewoong Pharmaceutical Co., Ltd.) for the prevention of gastric mucosal injury caused by aspirin.
Methods
Aspirin users were enrolled and randomized into the Albis or placebo group. Screening and follow-up endoscopy were performed for modified Lanza scores (MLSs). Primary outcome was measured by the incidence rate of peptic ulcer, and secondary outcomes were measured by the incidence rate of gastritis, improvement in MLS and subjective symptoms.
Results
In total, 81 aspirin users were randomized, 43 in the Albis group and 38 in the placebo group. There was no incidence of peptic ulcer in both groups. The incidence of gastritis was significantly higher in the placebo group (44.4% vs. 10.0%, p=0.003); however, the scores of mucosal edema, hyperemia and hemorrhage were not statistically different between the two groups (p>0.05). The frequency of subjective symptoms were more improved in the Albis group than in the placebo group (p=0.023).
Conclusions
The incidence of gastritis was lower in the group that received low-dose aspirin and Albis. The development of peptic ulcer due to long-term use of aspirin might be prevented with concomitant use of Albis.

Citations

Citations to this article as recorded by  
  • Review on recent advancements in understanding acetylsalicylic acid-induced gastrointestinal injury: mechanisms, medication, and dosage refinement
    Jiahui Zhou, Na Li, Xinzhong Li, Jingxue Ye, Min Wang, Guibo Sun
    Naunyn-Schmiedeberg's Archives of Pharmacology.2024;[Epub]     CrossRef
  • Xiaojianzhong decoction attenuates gastric mucosal injury by activating the p62/Keap1/Nrf2 signaling pathway to inhibit ferroptosis
    Juan Chen, Jiaxiang Zhang, Ting Chen, Shengchuan Bao, Jingtao Li, Hailiang Wei, Xin Hu, Yan Liang, Fanrong Liu, Shuguang Yan
    Biomedicine & Pharmacotherapy.2022; 155: 113631.     CrossRef
  • A measure of asymmetry for ordinal square contingency tables with an application to modified LANZA score data
    Satoru Shinoda, Kouji Yamamoto, Kouji Tahata, Sadao Tomizawa
    Journal of Applied Statistics.2020; 47(7): 1251.     CrossRef
  • 8,474 View
  • 176 Download
  • 3 Web of Science
  • 3 Crossref
Close layer
Case Report
Intramural Hematoma of the Esophagus after Endoscopic Pinch Biopsy
Eun Soo Jeong, Min Jeong Kim, Seung Hyen Yoo, Dong Hyun Kim, Jin Sung Jung, Nam Ho Koo, Se Heon Chang
Clin Endosc 2012;45(4):417-420.   Published online November 30, 2012
DOI: https://doi.org/10.5946/ce.2012.45.4.417
AbstractAbstract PDFPubReaderePub

Intramural hematoma of the esophagus (IHE) is an uncommon form of esophageal injury, which may be an intermediate of mucosal tear (Mallory-Weiss syndrome) or transmural rupture (Boerhaave's syndrome). To date, the pathogenesis of IHE has not been well documented. IHE may occur within the submucosal layer of the esophagus following dissection of the mucosa. The most commonly presented symptoms are sudden retrosternal pain, dysphagia and hematemesis. The disorder can occur spontaneously or secondarily to trauma. In this report, we present a case of IHE which occurred after endoscopic biopsy and was recovered following conservative management in a patient who was taking long-term aspirin medication.

Citations

Citations to this article as recorded by  
  • A case of spontaneous esophageal submucosal hematoma
    Shintaro Uchida, Hideyuki Saito, Kengo Kuriyama, Tomonori Yoshida, Keigo Hara, Makoto Sakai, Makoto Sohda, Hiroshi Saeki, Ken Shirabe
    Clinical Journal of Gastroenterology.2022; 15(3): 522.     CrossRef
  • Submucosal hematoma with a wide range of lesions, severe condition and atypical clinical symptoms: A case report
    Liang Liu, Xing-Jie Shen, Li-Jun Xue, Shu-Kun Yao, Jing-Yu Zhu
    World Journal of Clinical Cases.2021; 9(20): 5683.     CrossRef
  • Massive bleeding due to dissecting esophageal hematoma: A diagnostic dilemma
    Şehmus ÖLMEZ, Adnan TAŞ, Banu KARA, Bünyamin SARITAŞ
    Endoskopi Gastrointestinal.2018; 26(2): 66.     CrossRef
  • Esophageal submucosal hematoma developed after endovascular surgery for unruptured cerebral aneurysm under general anesthesia: a case report
    Sachiko Ito, Shihoko Iwata, Izumi Kondo, Motoyo Iwade, Makoto Ozaki, Tatsuya Ishikawa, Takakazu Kawamata
    JA Clinical Reports.2017;[Epub]     CrossRef
  • Intramural esophageal dissection caused by upper endoscopy
    A.F. Romano-Munive, G. Grajales-Figueroa, F.I. Téllez-Ávila
    QJM.2016; 109(1): 73.     CrossRef
  • Esophageal Submucosal Hematoma Possibly Caused by Gastric Tube Insertion Under General Anesthesia
    Yuri Fujimoto, Kazuhiro Shirozu, Noritoshi Shirozu, Kozaburo Akiyoshi, Ataru Nishimura, Sho Kawasaki, Yoshimasa Motoyama, Tadashi Kandabashi, Koji Iihara, Sumio Hoka
    A & A Case Reports.2016; 7(8): 169.     CrossRef
  • Acute oesophageal symptoms
    SM Noor Hossain, John de Caestecker
    Clinical Medicine.2015; 15(5): 477.     CrossRef
  • 8,723 View
  • 73 Download
  • 7 Crossref
Close layer
Intramural Hematoma of the Esophagus after Endoscopic Pinch Biopsy and Endoscopic Band Ligation
Jae Nam Yang, M.D., Yun Jeong Lim, M.D., Ji Hun Kang, M.D., Hyoun Woo Kang, M.D., Jun Kyu Lee, M.D., Yong Seok Lee, M.D.*, Jong Sun Choi, M.D. and Jin Ho Lee, M.D.
Korean J Gastrointest Endosc 2010;40(2):107-110.   Published online February 27, 2010
AbstractAbstract PDF
Esophageal intramural hematoma (EIH) is an uncommon clinical entity among the acute esophageal injuries, and EIH predominantly occurs in middle-aged women. The pathogenesis of EIH has not been clarified, yet this. Seems to occur within the submucosal layer of the esophagus after dissection of the mucosa. EIH may occur spontaneously or secondary to trauma. Patients usually complain of a sudden onset of severe retrosternal chest pain, hematemesis, back pain or dysphagia. Most EIHs show improvement through conservative management, including fasting and intravenous hydration, and this usually completely recovers within a period of 2∼3 weeks. We report here on a case that EIH occurred after endoscopic pinch biopsy and endoscopic band ligation and this EIH was exacerbated in a patient who was taking long-term aspirin medication. (Korean J Gastrointest Endosc 2010;40: 107-110)
  • 2,267 View
  • 10 Download
Close layer
Multiple Gastrointestinal Drug Induced Ulcers Associated with Aspirin and Non-steroidal Anti-inflammatory Drugs: A Case Report and Review of the Literature
Hyun Jin Kim, M.D., Woo Chul Chung, M.D., Kang Moon Lee, M.D., Chang Nyol Paik, M.D., Seung Hye Jung, M.D., Jin Dong Kim, M.D., Sung Hoon Jung, M.D. and Jae Wuk Kwak, M.D.
Korean J Gastrointest Endosc 2009;39(6):379-383.   Published online December 30, 2009
AbstractAbstract PDF
Aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed drugs, and they are known to be responsible for many cases of gastroduodenal ulcerations by inhibiting prostaglandin synthesis via blocking the cyclo-oxygenase production. Colonic side effects of these drugs are rare, but they are increasingly being reported to be due to the popularization of colonoscopy and the new formulations of drugs such as enteric coated pills or slow release pills. There is currently no consensus for making the clinical diagnosis and administering the proper therapy for drug-induced colonopathy in Korea. We experienced the patient who had multiple colonic ulcers after ingesting large amounts of aspirin and NSAIDs. In near future, we hope to determine the clinical and endoscopic features of drug associated colon injury. (Korean J Gastrointest Endosc 2009;39:379-383)
  • 2,182 View
  • 25 Download
Close layer

Clin Endosc : Clinical Endoscopy Twitter Facebook
Close layer
TOP