Clinical Endoscopy

Case Reports

Primary Gastric Small Cell Carcinoma: A Case Identified as a Large Subepithelial Tumor from Invisible State in 6 Months: Yun Im Lee, Hong Kil Jeon, Jae Wook Im, Sang Yu Oh, Kyung Bin Kim, Byunggyu Kim; Clin Endosc 2019;52(1):76-79. Published online July 6, 2018; DOI: https://doi.org/10.5946/ce.2018.062

Primary gastric small cell carcinoma (GSCC) is one of the gastroenteropancreatic neuroendocrine tumors. It is a rare cancer with a very aggressive behavior and a poor prognosis because of the high rate of metastases. It is usually found in far advanced stage. We experienced a case of GSCC which had developed into a large subepithelial tumor (SET) from invisible state in a short period. A 65-year-old man consulted our hospital because of early gastric cancer. He underwent endoscopic submucosal dissection for the early gastric cancer at high body posterior wall. After 6 months, the follow-up endoscopy showed a large newly developed SET-like lesion with central ulceration at the gastric cardia. Endoscopic biopsy revealed GSCC. Total gastrectomy was performed. One out of the 26 perigastric lymph nodes had a metastasis. He received 6 cycles of adjuvant chemotherapy with etoposide and cisplatin. He is still in good health 12 months after operation.

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Metastatic Small Cell Carcinoma of the Stomach
Mirac Gunay, Celia Leone, Oksana Albayati, Abdalla Mohamed, Nnaemeka Anyadike
ACG Case Reports Journal.2024; 11(10): e01540. CrossRef
Lysyl oxidase and hypoxia-inducible factor 1α: biomarkers of gastric cancer
Ya-Lin Han, Li Chen, Rui Qin, Guan-Qing Wang, Xiao-Hua Lin, Guang-Hai Dai
World Journal of Gastroenterology.2019; 25(15): 1828. CrossRef

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A Gastric Composite Tumor with an Adenocarcinoma and a Neuroendocrine Carcinoma: A Case Report: Jae Hyung Lee, Hyung Wook Kim, Dae Hwan Kang, Cheol Woong Choi, Su Bum Park, Suk Hun Kim; Clin Endosc 2013;46(3):280-283. Published online May 31, 2013; DOI: https://doi.org/10.5946/ce.2013.46.3.280

Abstract PDF PubReader ePub

A 70-year-old woman was admitted to our department with epigastric discomfort and nausea over the duration of 1 month. An esophagogastroduodenoscopy showed the presence of a 1.0×1.0 cm-sized flat lesion with central ulceration at the greater curvature side of the antrum. A biopsy demonstrated the presence of an adenocarcinoma of well differentiated, intestinal type in the stomach. Endoscopic submucosal dissection was done and the diagnosis of a composite neuroendocrine carcinoma with an adenocarcinoma of the stomach was confirmed. We report a case of a gastric composite tumor with an adenocarcinoma and neuroendocrine carcinoma confirmed by endoscopic submucosal dissection with a review of the literature.

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MANEC TUMOR OF RECTUM. A RARE CASE SERIES OF 3 PATIENTS AND A LITERATURE REVIEW
R. Govindaraj, Sh. Govindaraj, C. Prakash, S. Govindaraj
Experimental Oncology.2024; 45(4): 523. CrossRef
Gastric Mixed Adenoneuroendocrine Carcinoma with Revised Diagnosis after Retrospective Pathologic Review
Bo Seok Jeong, Hye Won Hwang, Jong Won Kim, In Gyu Hwang, Jae Yong Park
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2021; 21(4): 343. CrossRef
Neoadjuvant chemotherapy improves the survival of patients with neuroendocrine carcinoma and mixed adenoneuroendocrine carcinoma of the stomach
Fuhai Ma, Bingzhi Wang, Liyan Xue, Wenzhe Kang, Yang Li, Weikun Li, Hao Liu, Shuai Ma, Yantao Tian
Journal of Cancer Research and Clinical Oncology.2020; 146(8): 2135. CrossRef
Endoscopic findings of gastric mixed adenoneuroendocrine carcinoma
Keitaro Takahashi, Mikihiro Fujiya, Takahiro Sasaki, Yuya Sugiyama, Yuki Murakami, Takuya Iwama, Takehito Kunogi, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Sayaka Yuzawa, Hidehiro Takei, Toshikatsu Okumura
Medicine.2020; 99(38): e22306. CrossRef
Efficacy of XELOX adjuvant chemotherapy for gastric mixed adenoneuroendocrine carcinoma
Zhixian Lin, Jiangfeng Chen, Yong Guo
Medicine.2019; 98(23): e16000. CrossRef
Clinical characteristics of early neuroendocrine carcinoma in stomach
Xiaolong Zhu, Haiyan Jing, Takashi Yao
Medicine.2019; 98(30): e16638. CrossRef
Mixed Neuroendocrine-non-neuroendocrine Neoplasm of the Stomach that is Distributed in Depth on the Same Tumor: Inconsistent with the Definition of Mixed Adenoneuroendocrine Carcinoma in the 2010 World Health Organization Classification of Tumors of the D
Joonnho Jeong, Kyoungwon Jung, Jae Hyun Kim, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park
The Korean Journal of Gastroenterology.2019; 74(6): 349. CrossRef
Mixed adenoneuroendocrine carcinoma of the liver: A rare case report
Jiao‑Jiao Yang, Zhi‑Ping Li, Chun‑Li Luo, Yan Du, Qiu‑Yang Lu, Na Li, He Li, Tian‑Ping Yu, Xing‑Ming Huang
Molecular and Clinical Oncology.2019;[Epub] CrossRef
Mixed adenoneuroendocrine carcinoma in the stomach: a case report with a literature review
Ki Hyun Kim, Hyun Jung Lee, Si Hak Lee, Sun-Hwi Hwang
Annals of Surgical Treatment and Research.2018; 94(5): 270. CrossRef
Synchronous Triple Gastric Cancer Incorporating Mixed Adenocarcinoma and Neuroendocrine Tumor Completely Resected with Endoscopic Submucosal Dissection
Kimitoshi Kubo, Noriko Kimura, Katsuhiro Mabe, Yusuke Nishimura, Mototsugu Kato
Internal Medicine.2018; 57(20): 2951. CrossRef
Mast cell and plasma cell collision tumor in the spleen of a dog
Valarie A. Pallatto, Molly A. Bechtold
Veterinary Clinical Pathology.2018; 47(2): 303. CrossRef
Gastric adenocarcinoma is concurrent with metastatic neuroendocrine cancer treated with nivolumab and chemotherapy: A case report
Bing Yan, Meiqi Cui, Junhao You, Fang Li, Hui Liu
Molecular and Clinical Oncology.2018;[Epub] CrossRef
Gastric mixed adenoneuroendocrine carcinoma: correlation of histologic characteristics with prognosis
Ling Nie, Mingna Li, Xiaofeng He, Anning Feng, Hongyan Wu, Xiangshan Fan
Annals of Diagnostic Pathology.2016; 25: 48. CrossRef
Intramucosal Gastric Mixed Adenoneuroendocrine Carcinoma Completely Resected with Endoscopic Submucosal Dissection
Yasushi Yamasaki, Junichiro Nasu, Kou Miura, Yoshiyasu Kono, Hiromitsu Kanzaki, Keisuke Hori, Takehiro Tanaka, Masahide Kita, Takao Tsuzuki, Minoru Matsubara, Seiji Kawano, Yoshiro Kawahara, Masahiro Tabata, Hiroyuki Okada, Kazuhide Yamamoto
Internal Medicine.2015; 54(8): 917. CrossRef
Mixed adenoneuroendocrine carcinoma of gastrointestinal tract: Report of two cases
Simona Gurzu
World Journal of Gastroenterology.2015; 21(4): 1329. CrossRef
Prognostic significance of neuroendocrine components in gastric carcinomas
Ji Y. Park, Min-Hee Ryu, Young Soo Park, Hye Jin Park, Baek-Yeol Ryoo, Min Gyu Kim, Jeong Hwan Yook, Byung Sik Kim, Yoon-Koo Kang
European Journal of Cancer.2014; 50(16): 2802. CrossRef
Mixed adeno(neuro)endocrine carcinoma arising from the ectopic gastric mucosa of the upper thoracic esophagus
Toshihiro Kitajima, Sachiko Kaida, Seigi Lee, Shusuke Haruta, Hisashi Shinohara, Masaki Ueno, Koichi Suyama, Yasunori Oota, Takeshi Fujii, Harushi Udagawa
World Journal of Surgical Oncology.2013; 11(1): 218. CrossRef

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