Clinical Endoscopy

A Gastric Composite Tumor with an Adenocarcinoma and a Neuroendocrine Carcinoma: A Case Report: Jae Hyung Lee, Hyung Wook Kim, Dae Hwan Kang, Cheol Woong Choi, Su Bum Park, Suk Hun Kim; Clin Endosc 2013;46(3):280-283. Published online May 31, 2013; DOI: https://doi.org/10.5946/ce.2013.46.3.280

A 70-year-old woman was admitted to our department with epigastric discomfort and nausea over the duration of 1 month. An esophagogastroduodenoscopy showed the presence of a 1.0×1.0 cm-sized flat lesion with central ulceration at the greater curvature side of the antrum. A biopsy demonstrated the presence of an adenocarcinoma of well differentiated, intestinal type in the stomach. Endoscopic submucosal dissection was done and the diagnosis of a composite neuroendocrine carcinoma with an adenocarcinoma of the stomach was confirmed. We report a case of a gastric composite tumor with an adenocarcinoma and neuroendocrine carcinoma confirmed by endoscopic submucosal dissection with a review of the literature.

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A Case of a Gastric Composite Tumor with an Adenocarcinoma and a Large Cell Neuroendocrine Carcinoma: Jin Hwan Jung, M.D., Yong Cheol Kim, M.D., Jeong Ho Kim, M.D., Hui Sung Chung, M.D., Dae Young Cheung, M.D., Jin Il Kim, M.D., Soo Heon Park, M.D. and Jae Kwang Kim, M.D.; Korean J Gastrointest Endosc 2009;39(2):93-96. Published online August 30, 2009

Abstract PDF: A 55 year-old man was admitted with epigastric pain of one-month duration. We performed an esophagogastroduodenoscopy that showed the presence of a 3 cm sized polypoid mass at the lesser curvature side of the antrum. A biopsy demonstrated the presence of a neuroendocrine carcinoma of the stomach. A subtotal gastrectomy with D2 lymph node dissection was performed and the microscopic features of the resected specimen confirmed the diagnosis of a composite large cell neuroendocrine carcinoma with an adenocarcinoma of the stomach. A gastric neuroendocrine carcinoma is extremely rare and a composite neuroendocrine carcinoma with an adenocarcinoma of the stomach has been rarely reported. We report a case of a gastric composite tumor with an adenocarcinoma and a large cell neuroendocrine carcinoma. (Korean J Gastrointest Endosc 2009;39:93-96)

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A Case of Rectal Adenocarcinoid Tumor: Seong Deuk Baek, M.D., Jung Hyun Lee, M.D., Jung Il Seo, M.D., Chang Woo Lee, M.D., Jong Im Lee, M.D.*, Dong Hun Kim, M.D.*, Tae Jung Jang, M.D.* and Jung Ran Kim, M.D.*; Korean J Gastrointest Endosc 2007;35(6):391-394. Published online December 30, 2007

Abstract PDF: An adenocarcinoid is a mixed tumor comprised of both carcinoid and adenocarcinomatous components that is commonly found in the esophagus, stomach, duodenum, small bowel and appendix, and is also rarely found in the large bowel. A 61 year old male visited our institution because of a change in bowel habitus 3 months prior to the time of his visit. Colonoscopic findings revealed a 2×2 cm round smooth surface mass 7 cm from the anal verge, and an endoscopic ultrasonograph revealed a round hypoechoic mass in the submucosal layer. The mass was resected by endoscopic mucosal resection using a cap- fitted endoscope. Pathologic analysis of the mass confirmed that it was a composite tumor comprised of carcinoid and adenocarcinomatous components. To the best of our knowledge, this paper is the first case of rectal adenocarcinoid reported in Korea. (Korean J Gastrointest Endosc 2007; 35:391-394)

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Composite Tumor of Gastric Adenoma with Carcinoid Tumor: Hee Jeong Hwang, M.D., Woo Chul Chung, M.D., Hyun Joo Choi, M.D.*, Kang Moon Lee, M.D., Jin Mo Yang, M.D., Jae Kwang Kim, M.D., Sok Won Han, M.D., Kyu Yong Choi, M.D. and In-Sik Chung, M.D.; Korean J Gastrointest Endosc 2007;34(4):214-218. Published online April 30, 2007

Abstract PDF: A gastric carcinoid is a rare disease that accounts for only 0.3% of all primary gastric tumors. It can be multiple or occur with other types of tumor. However, there has been a recent increase in incidence. While carcinoids of the appendix and rectum are accompanied by adenoma or adenocarcinoma, a gastric carcinoid rarely occurs with an adenocarcinoma, particularly with a gastric adenoma. We encountered a case of a gastric adenoma and carcinoid mixed as a composite tumor, which became a lesion. The lesion resembled a type IIc early gastric cancer at the endoscopic examination and was removed by an endoscopic mucosal resection. We report a composite tumor of the gastric antrum composed of areas of adenoma and carcinoid, with an analysis of the histological components by immunohistochemical staining. Microscopically, the lesion was composed of a gastric adenoma and carcinoid as a composite tumor. (Korean J Gastrointest Endosc 2007;34:214⁣218)

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