Clinical Endoscopy

Original Article

Efficacy of Nasobiliary Tubes and Biliary Stents in Management of Patients with Bile Leak after Liver Transplantation: A Systematic Review: Ali Raza, Anam Omer, Sara Iqbal, Vineet Gudsoorkar, Pramoda Koduru, Kumar Krishnan; Clin Endosc 2019;52(2):159-167. Published online March 29, 2019; DOI: https://doi.org/10.5946/ce.2018.118

Background
/Aims: Bile leak is one of the most common complications of liver transplantation. The treatment options for bile leaks include conservative management, surgical re-intervention, percutaneous drainage and endoscopic drainage. We aimed to perform a systematic review to identify the efficacy of endoscopic treatment in the resolution of post-transplant bile leaks. Methods: Two independent reviewers performed systematic literature search in PubMed, ISI Web of Science, grey literature and relevant references in May 2017. Human studies in English with documented post-liver transplant bile leaks were included. Results: Thirty-four studies were included in the final analysis. The pooled efficacy of biliary stents for the resolution of post-transplant bile leaks was 82.43% compared with 87.15% efficacy of nasobiliary tubes. The efficacy of biliary stents was lower for anastomotic leaks (69.23%) compared to T-tube (90.9%) or cut-surface/ cystic duct stump related leaks (92.8%). Similarly, the efficacy of nasobiliary tube was also lower for anastomotic leaks (58.33%) compared to T-tube or cut-surface related leaks (100%). Conclusions: In this systematic review, the overall efficacy was 82.43% in biliary stent group, and 87.15% in nasobiliary tube group. Both biliary stent and nasobiliary tube were more effective in managing non-anastomotic leaks compared to anastomotic leaks.

Citations

Citations to this article as recorded by

Application of percutaneous biliary drainage in the treatment of post-operative bile leakage after liver rupture: A case report
Jinlong Chen, Zhikuan Wang, Lixin Zhang, Xi Chen, Yuanyuan Liu, Hong Chen, Xiaoqiang Tong, Yanchao Dong
Journal of Minimal Access Surgery.2025; 21(2): 200. CrossRef
Lesson learnt from 60 years of liver transplantation: Advancements, challenges, and future directions
Eyad Gadour
World Journal of Transplantation.2025;[Epub] CrossRef
Optimal timing of endoscopic biliary drainage for bile duct leaks: A multicenter, retrospective, clinical study
De-Xin Chen, Kai-Xuan Fang, Sheng-Xin Chen, Sen-Lin Hou, Gui-Hai Wen, Hai-Kun Yang, Da-Peng Shi, Qing-Xin Lu, Ya-Qi Zhai, Ming-Yang Li
World Journal of Gastrointestinal Surgery.2025;[Epub] CrossRef
Endoscopic management of bile duct leaks: Current strategies and controversies
De-Xin Chen, Sheng-Xin Chen, Guan-Jun Zhang, Ya-Wen Liang, Yu-Ming Han, Ya-Qi Zhai, Ming-Yang Li
World Journal of Gastrointestinal Endoscopy.2025;[Epub] CrossRef
A nomogram for prediction of ERCP success in patients with bile duct leaks: a multicenter study
De-xin Chen, Sheng-xin Chen, Sen-lin Hou, Gui-hai Wen, Hai-kun Yang, Da-peng Shi, Qing-xin Lu, Ya-qi Zhai, Ming-yang Li
Surgical Endoscopy.2024; 38(5): 2465. CrossRef
Complications in Post-Liver Transplant Patients
Carlotta Agostini, Simone Buccianti, Matteo Risaliti, Laura Fortuna, Luca Tirloni, Rosaria Tucci, Ilenia Bartolini, Gian Luca Grazi
Journal of Clinical Medicine.2023; 12(19): 6173. CrossRef
Nasobiliary drainage: an effective treatment for pruritus in cholestatic liver disease
Wafaa Ahmed, Rebecca Jeyaraj, David Reffitt, John Devlin, Abid Suddle, John Hunt, Michael A Heneghan, Phillip Harrison, Deepak Joshi
Frontline Gastroenterology.2022; 13(5): 416. CrossRef
A case of combined use of endoscopic drainage and percutaneous drainage for traumatic liver injury type III b
Shigekuni Okumura, Jun Oda, Yousuke Minami, Masaru Hirayama, Kennta Aida
Journal of the Japanese Society of Intensive Care Medicine.2021; 28(3): 210. CrossRef
Biliary Complications Following Adult Deceased Donor Liver Transplantation: Risk Factors and Implications at a High-volume US Center
Abraham J. Matar, Katie Ross-Driscoll, Lisa Kenney, Hannah K. Wichmann, Joseph F. Magliocca, William H. Kitchens
Transplantation Direct.2021; 7(10): e754. CrossRef
The Need for a Better-Designed Study of the Outcomes of Endoscopic Management of Bile Leak
Hyung Ku Chon, Eun Ji Shin, Seong-Hun Kim
Clinical Endoscopy.2020; 53(6): 633. CrossRef

9,690 View
112 Download
8 Web of Science
10 Crossref

First
Prev
Page of 1
Next
Last

Search