Clinical Endoscopy

Systematic Review and Meta-analysis

Hybrid endoscopic submucosal dissection enhances efficiency with comparable curative outcomes: a Bayesian meta-analysis, systematic review, and Monte Carlo simulation of randomized controlled trials: Ashesh Das, Arpitha Sirichandana Baggu, Param Darpan Sheth, Nihal Reddy Bandi, Chandana Priya Digumurthy, Urvashi Bharia, Shah Kavya Hiteshkumar, Krishna Sai Kiran Sakalabaktula, Shankar Biswas, Riyakumari Patel, Meenakshi Reddy Yathindra, Venkata Dileep Kumar Veldi; Clin Endosc 2026;59(5):754-764. Published online September 22, 2026; DOI: https://doi.org/10.5946/ce.2025.439

Graphical Abstract Abstract PDF Supplementary Material: Background
/Aims: Gastrointestinal (GI) cancers accounted for 3.24 million deaths worldwide in 2022. Endoscopic submucosal dissection (ESD) enables en bloc resection of early neoplasms but is time-intensive and technically challenging. Hybrid ESD (H-ESD), which combines dissection with snare polypectomy, may improve efficiency while maintaining efficacy.This Bayesian meta-analysis of randomized controlled trials (RCTs) compares the safety and efficacy of H-ESD with conventional ESD (C-ESD).
Methods
We searched the PubMed, Embase, Cochrane, Scopus databases for RCTs comparing hybrid and C-ESD for superficial GI neoplasms. Bayesian modeling in Just Another Gibbs Sampler used normal-normal hierarchies for procedure time and logRR for binary outcomes with weakly informative priors. Frequentist analyses were performed using Der-Simonian-Laird τ². Heterogeneity was assessed using I²/τ².
Results
H-ESD showed comparable en bloc (RR, 0.97; 95% [CrI], 0.92–1.03; I²=22.8%) and R0 resection rates (RR, 0.97; 95% CrI, 0.90–1.04; I²=0%). Procedure time decreased significantly with H-ESD (MD, –18.05; 95% CrI, –27.77 to –8.33 minutes; I²=66.5%). Adverse events (RR, 1.08; 95% CrI, 0.44–2.63) and perforations (RR, 1.05; 95% CrI, 0.34–3.19) were similar between the two procedures.
Conclusions
H-ESD matches C-ESD in curative resection while reducing the procedure time, offering a safer and more efficient alternative. Larger RCTs are needed to confirm the long-term benefits.

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Review

Strategies for successful endoscopic submucosal dissection in difficult conditions of the upper gastrointestinal tract: Jin Woong Cho; Received December 30, 2025 Accepted January 17, 2026 Published online September 10, 2026; DOI: https://doi.org/10.5946/ce.2025.476 [Epub ahead of print]

Abstract PDF: Endoscopic submucosal dissection (ESD) is a useful method for the treatment of early cancers of the esophagus and stomach. Difficulty during gastric ESD increases the risk of local recurrence or severe complications, with risk factors including an upper gastric location, large lesions (>20 mm), submucosal cancer, and fibrotic lesions. Various types of electrosurgical knives with advanced functions have been developed, and image-enhanced endoscopy provides more accurate information for tumor assessment. Under certain conditions, the endoscopic approach to ESD can be challenging and may result in poor resection outcomes. Clip traction, changes in patient positioning, air deflation, and precise dissection can be effective options, depending on the circumstances. The pocket creation method is useful for resecting large lesions in the esophagus and stomach. Severe fibrotic lesions may require endoscopic subserosal dissection when located in the cardia, or along the lesser or greater curvature of the stomach. In addition, gastric peroral endoscopic myotomy can overcome anatomical obstacles in some cases.

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Original Article

Learning curve of pocket-creation method–assisted colorectal endoscopic submucosal dissection: a single-operator retrospective observational study from South Korea using cumulative sum analysis: Jae Hyun Kim; Received March 20, 2026 Accepted April 16, 2026 Published online August 20, 2026; DOI: https://doi.org/10.5946/ce.2026.127 [Epub ahead of print]

Graphical Abstract Abstract PDF Supplementary Material: Background
/Aims: Colorectal endoscopic submucosal dissection (C-ESD) is a technically demanding procedure with an extended learning curve. We aimed to characterize the learning process after introduction of the pocket-creation method (PCM) and provide practical guidance for endoscopists.
Methods
We retrospectively analyzed 147 colorectal lesions treated with PCM-assisted C-ESD. Learning curves for dissection speed and procedure time were evaluated using locally weighted regression. Cumulative sum (CUSUM) analysis was used to identify the point of technical stabilization, with a predefined acceptable failure rate of 10%. Outcomes were compared between the pre- and post-stabilization phases, and multivariate logistic regression was used to identify the predictors of technical failure.
Results
Dissection speed increased and procedure time decreased with experience. CUSUM analysis identified stabilization at 60 cases. Compared with the post-stabilization phase, the pre-stabilization phase showed higher technical failure rates and lower en bloc and R0 resection rates. The learning phase was the only independent predictor of technical failure. Perforation occurred in 5.4% of cases and was managed predominantly endoscopically.
Conclusions
PCM-assisted C-ESD showed a distinct learning curve, with stabilization achieved after 60 cases. Technical failure is primarily driven by operator experience rather than by lesion complexity.

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Reviews

Variety and clinical applications of endoscopic closure techniques: Osamu Goto, Eriko Koizumi; Received January 6, 2026 Accepted March 31, 2026 Published online August 19, 2026; DOI: https://doi.org/10.5946/ce.2026.010 [Epub ahead of print]

Abstract PDF: As endoscopic therapy has progressed, various endoscopic closure techniques have been developed to prevent adverse events and to facilitate complex therapeutic procedures. The development of closure techniques began in the 1970s with the introduction of clipping for mucosal defects after gastric polypectomy. Currently, these techniques are applied primarily to prevent post-procedural bleeding from mucosal defects resulting from endoscopic submucosal dissection; to repair iatrogenic perforations involving full-thickness defects; and to complete endoscopic full-thickness resection. They can be categorized into clipping, tissue apposition, suturing, and stapling, each with distinct advantages and disadvantages. Therefore, familiarity with each method and the ability to select the most appropriate technique for a given situation are essential.

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Underwater endoscopic submucosal dissection in the gastrointestinal tract: technical review and dual-approach endoscopic submucosal dissection: Mitsuru Nagata; Received September 7, 2025 Accepted November 8, 2025 Published online March 17, 2026; DOI: https://doi.org/10.5946/ce.2025.330 [Epub ahead of print]

Abstract PDF

Endoscopic submucosal dissection (ESD) has become an established technique for en bloc resection of superficial gastrointestinal neoplasms. However, conventional ESD (CESD) under gas insufflation remains technically demanding, particularly in gravity-side lesions or in cases with submucosal fibrosis. Underwater ESD (UESD) was developed to overcome these challenges. Complete submergence mitigates gravity-related difficulties, enhances visualization through the natural zoom effect, and facilitates submucosal dissection via buoyancy and water pressure. Retrospective data further suggest that UESD may reduce the risk of post-ESD coagulation syndrome, which is likely attributable to the heat sink effect. UESD can also be integrated with device-assisted traction and pocket creation methods. However, limitations, such as visual field impairment caused by bleeding or bubble formation, remain concerns, and their optimal management requires further investigation. Nevertheless, UESD allows procedural flexibility by switching between UESD and CESD within the same procedure, herein referred to as dual-approach ESD. Despite its routine use in clinical practice, dual-approach ESD has not been clearly distinguished from UESD in most clinical studies, complicating comparisons with CESD. To advance both clinical practice and research, future investigations should clearly differentiate UESD from dual-approach ESD for a more accurate evaluation. Furthermore, appropriate procedural selection requires careful consideration of multiple factors.

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Defining underwater endoscopic submucosal dissection in network meta-analysis: implications of dual-approach endoscopic submucosal dissection
Mitsuru Nagata
Gastrointestinal Endoscopy.2026; 104(4): 699. CrossRef

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Original Articles

Feasibility of Zeosuture M for gastric endoscopic submucosal dissection defect closure during anticoagulation: a preclinical porcine study from Japan: Yohei Minato, Tadateru Maehata, Yoshinori Sato, Fumio Itoh, Ken Ohata, Keisuke Tateishi; Clin Endosc 2026;59(4):593-600. Published online February 24, 2026; DOI: https://doi.org/10.5946/ce.2025.329

Graphical Abstract Abstract PDF Supplementary Material: Background
/Aims: Endoscopic submucosal dissection (ESD) in patients undergoing anticoagulant therapy carries a risk of delayed bleeding. Zeosuture M is a novel endoscopic suturing system designed for secure mucosal closure. This study evaluated the feasibility of Zeosuture M and the short-term clinical course after mucosal closure in a warfarinized porcine ESD model.
Methods
Gastric ESD was performed in four pigs under warfarin anticoagulation (three defects per animal; 12 sites). Warfarin administration began 15 days before ESD. All defects were closed using Zeosuture M. Follow-up endoscopy was performed on postoperative days (POD) 1, 2, 4, and 8. Necropsy was conducted on POD 8.
Results
Technical success was 100% (12/12). The mean specimen size was 27.5±3.4 mm, mean number of stitches 3.6±0.7, closure time 28.1±8.0 minutes, and time per stitch 8.0 minutes. No uncontrolled intraprocedural bleeding, delayed hemorrhage, perforation, or peritonitis occurred. Partial loss of apposition was observed on POD 4, and all sites reopened by POD 8 without adverse clinical events.
Conclusions
Zeosuture M provided early stabilization of ESD ulcers during continuous anticoagulation, enabling safe traversal of the high-risk period for delayed bleeding. This represents one of the first preclinical warfarinized porcine evaluations and suggests potential applicability in high-risk patients.

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Endoscopic findings are associated with histologic types of primary small intestinal lymphoma: a retrospective study in Japan: Masafumi Kitamura, Mio Sakaguchi, Hirotsugu Sakamoto, Satoshi Shinozaki, Manabu Nagayama, Tomonori Yano, Yusuke Ono, Takuma Kobayashi, Kunihiko Oguro, Shoko Miyahara, Masahiro Okada, Katsuyuki Nakazawa, Keijiro Sunada, Noriyoshi Fukushima, Hironori Yamamoto; Clin Endosc 2026;59(2):298-306. Published online January 29, 2026; DOI: https://doi.org/10.5946/ce.2025.239

Graphical Abstract Abstract PDF

Background
/Aims: Although endoscopic diagnosis of primary small intestinal lymphoma (PSIL) is important, the association between endoscopic findings and histologic types remains unclear. This study aimed to evaluate the diagnostic accuracy of endoscopic classifications and biopsies in PSIL.
Methods
We retrospectively reviewed 100 lesions from 49 patients with PSIL who underwent double-balloon enteroscopy between 2005 and 2020. Endoscopic findings were classified into six macroscopic types: polypoid, ulcerative, multiple nodules, diffuse, concentric stenosis, or unclassified.
Results
Of the 100 lesions, 47 were multiple nodules, 32 were ulcerative, 8 were polypoid, 7 were diffuse, 4 were concentric stenosis, and 2 were unclassified. Diffuse large B-cell lymphoma (DLBCL) was mainly ulcerative (72%) or polypoid (75%), whereas follicular lymphoma appeared as multiple nodules (98%) or concentric stenosis (100%) (p<0.001, Cramér’s V=0.41). The ulcerative type was associated with DLBCL (sensitivity, 0.74; specificity, 0.87), and multiple-nodule type were associated with follicular lymphoma (sensitivity, 0.75; specificity, 0.97). The overall diagnostic yield of the biopsy was 95%. Interobserver agreement was substantial (κ=0.69; agreement, 78%).
Conclusions
Endoscopic findings were significantly associated with histologic types. Endoscopic findings and biopsies provide a high diagnostic yield, supporting their central role in the diagnostic management of PSIL.

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Clinical implications of endoscopic phenotypes in primary small intestinal lymphoma
Yoo Jin Lee
Clinical Endoscopy.2026; 59(2): 242. CrossRef
Tumor laterality in primary intestinal diffuse large B-cell lymphoma: A prognostic leap or an anatomical mirage?
Shi-Qiong Zhou, Chao-Qun Zhou, Qing-Hua Ke
World Journal of Gastroenterology.2026;[Epub] CrossRef

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Clinical efficacy of endoscopic resection for subepithelial tumors in the esophagogastric junction and gastric cardia: an observational study: Sang Jin Park, Min A Yang, Jae Sun Song, Won Dong Lee, Myoung Jin Ju, Jin Woong Cho; Clin Endosc 2026;59(2):245-253. Published online January 7, 2026; DOI: https://doi.org/10.5946/ce.2025.219

Graphical Abstract Abstract PDF

Background
/Aims: Gastric subepithelial tumors (SETs) located near the esophagogastric junction (EGJ) are difficult to treat surgically and endoscopically. This study aimed to evaluate the effectiveness and safety of endoscopic resection of SETs growing from the muscularis propria located in the EGJ and gastric cardia.
Methods
This study included 26 consecutive patients who underwent endoscopic resection of 27 gastric SETs between November 2012 and May 2023.
Results
Of the 27 gastric SETs, 3 and 24 were located in the EGJ and gastric cardia, respectively. The mean tumor size, operative time, and duration of hospitalization were 21 (6–52) mm, 35.4 (9–65) minutes, and 4.2 (3–7) days, respectively. Endoscopic resection of the SETs achieved an en bloc resection rate of 100% (27/27) and a complete resection rate of 88.9% (24/27). Pathological examination confirmed four gastrointestinal stromal tumors and 23 leiomyomas. No bleeding, peritonitis, or abdominal infection occurred after the endoscopic resections. Residual lesions were identified in three patients (11.1%). No recurrence was observed during follow-up (range, 3–24 months).
Conclusions
SETs in the EGJ and gastric cardia can be resected effectively, even if they originate from the muscularis propria layer.

Citations

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Endoscopic resection for gastric subepithelial lesions: overtreatment or the next step in optimization?
Chen-Shuan Chung
Clinical Endoscopy.2026; 59(2): 234. CrossRef
A pilot study on the application and efficacy of mucosal traction-assisted clip closure in endoscopic full-thickness resection for gastric submucosal tumors
Qian Zhang, Fengcheng Zang, Jie Xu, Yunfu Feng, Zhibing Wang, Chao Ma, Luojie Liu, Xianjing Fan, Qiushi Tian
Scientific Reports.2026;[Epub] CrossRef

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Feasibility of pancreatic duct stent placement before endoscopic submucosal dissection for superficial duodenal neoplasms adjacent to the papilla: Ryosuke Kobayashi, Kingo Hirasawa, Yuichiro Ozeki, Atsushi Sawada, Masafumi Nishio, Chiko Sato, Haruo Miwa, Kazuya Sugimori, Shin Maeda; Clin Endosc 2026;59(1):89-95. Published online December 31, 2025; DOI: https://doi.org/10.5946/ce.2025.197

Graphical Abstract Abstract PDF Supplementary Material

Background
/Aims: Endoscopic submucosal dissection (ESD) for superficial non-ampullary duodenal epithelial tumors (SNADETs) is technically challenging and is associated with a risk of adverse events, particularly when lesions are located near the major papilla. Pancreatic duct (PD) stent may reduce the risk of post-ESD pancreatitis; however, no standard strategy has been established. This study aimed to evaluate the effectiveness and safety of PD stent placement combined with ESD for SNADETs near the major papilla.
Methods
This was a retrospective study of duodenal ESD after prophylactic PD stent placement in patients with SNADET near the major papilla at a university hospital between March 2014 and September 2023.
Results
Four lesions were located within 5 mm of the major papilla, and seven within 5 to 10 mm. The median interval between stent placement and ESD was 2 days. The en bloc and R0 resection rates were 100% and 90.9%, respectively. No stent migration occurred during ESD, and all mucosal defects were completely closed using endoscopic clips. Delayed bleeding and post-ESD pancreatitis were observed in one and two cases, respectively.
Conclusions
PD stent placement combined with ESD is an effective treatment strategy for SNADETs near the major papilla. However, the risk of post-ESD pancreatitis remains, indicating the need for further preventive strategies.

Citations

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Duodenal Laparoscopy and Endoscopy Cooperative Surgery Combined With Endoscopic Nasopancreatic Drainage and Endoscopic Nasobiliary Drainage for a Duodenal Adenoma Near the Papilla of Vater: A Case Report
Keisuke Manaka, Hiroki Harada, Takuya Wada, Gen Kitahara, Kosuke Okuwaki, Kota Okuno, Shohei Fujita, Tadashi Higuchi, Koshi Kumagai, Naoki Hiki
DEN Open.2027;[Epub] CrossRef
Reducing post-endoscopic submucosal dissection pancreatitis in periampullary duodenal lesions: the role of prophylactic pancreatic duct stenting
Ari Fahrial Syam
Clinical Endoscopy.2026; 59(1): 70. CrossRef
Management of non-ampullary duodenal adenomas
Gaurav B Nigam, Yash Kanani, Amol Bapaye, Pradeep Mundre
Frontline Gastroenterology.2026; 17(e1): e48. CrossRef

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Effect of double-layered suturing for mucosal defect closure after colorectal endoscopic submucosal dissection on postoperative adverse events: a propensity score-matched retrospective study in Japan: Kyohei Nishino, Hiroki Fujita, Takahiro Yuge, Masanori Hongo, Naoko Mori, Kazumi Shimamoto, Yu Kobayashi, Takashi Toyonaga, Hiromitsu Ban; Clin Endosc 2025;58(6):881-889. Published online November 6, 2025; DOI: https://doi.org/10.5946/ce.2025.053

Graphical Abstract Abstract PDF Supplementary Material

Background
/Aims: Prophylactic closure of mucosal defects after colorectal endoscopic submucosal dissection (ESD) can reduce the incidence of postoperative adverse events. However, data on this notion are limited. This study retrospectively evaluated the effect of closure using a double-layered suturing technique on postoperative adverse events.
Methods
A total of 370 lesions in 317 patients who underwent colorectal ESD were included in this analysis. Patients with 197 lesions that were completely closed were then assigned to the closure group. Patients with 173 lesions, including 55 that were partially closed and 118 that were not closed, were assigned to the non-closure group. Propensity score matching was performed, and 136 lesions were selected for each group.
Results
The closure group had a significantly lower overall incidence rate of postoperative adverse events, including delayed bleeding, delayed perforation, and post-ESD electrocoagulation syndrome, than the non-closure group (2.2% vs. 9.6%, p=0.018). The closure group had a significantly lower incidence of abdominal pain on the day after ESD than the non-closure group (2.9% vs. 11.0%, p=0.015).
Conclusions
Prophylactic closure of mucosal defects after colorectal ESD using a double-layered suturing technique could prevent postoperative adverse events and abdominal pain on the day after ESD.

Citations

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Endoloop-clip closure versus hemoclips for large sigmoid colon perforations: a randomized controlled ex vivo study
Geun Hyuk Choi, Jae Kook Yang, Young Sin Cho, Il-Kwun Chung, Yunho Jung
Scandinavian Journal of Gastroenterology.2026; 61(10): 1029. CrossRef
Endoscopic Closure After Colorectal ESD: A Literature Review and Meta-Analysis on Its Efficacy in Preventing Adverse Events
Naohisa Yoshida, Ken Inoue, Reo Kobayashi, Kazuya Maruo, Taku Kano, Katsuma Yamauchi, Hiroaki Kitae, Mayuko Seya, Mariko Kajiwara, Takeshi Yasuda, Naoto Iwai, Osamu Dohi, Kazuhiko Uchiyama, Yuri Tomita, Hardesh Dhillon, Rafiz Abdul Rani, Elsayed Ghoneem,
Diagnostics.2026; 16(14): 2148. CrossRef
Colorectal endoscopic submucosal dissection defect closure: promising but still evolving
Yunho Jung
Clinical Endoscopy.2025; 58(6): 856. CrossRef

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Efficacy and safety of endoscopic submucosal dissection versus endoscopic papillectomy for managing laterally spreading duodenal papillary tumors: Yuki Kano, Ken Ohata, Toshifumi Iida, Susumu Banjoya, Tomoya Kimura, Koichi Furuta, Shinya Nagae, Yohei Ito, Hiroshi Yamazaki, Nao Takeuchi, Shunya Takayanagi, Yoshiaki Kimoto, Yuji Koyama, Seitaro Tsujino, Takashi Sakuno, Kohei Ono, Yohei Minato, Yuji Fujita, Eiji Sakai, Hideyuki Chiba; Clin Endosc 2025;58(5):712-721. Published online August 26, 2025; DOI: https://doi.org/10.5946/ce.2025.066

Graphical Abstract Abstract PDF Supplementary Material

Background
/Aim: Endoscopic submucosal dissection (ESD) can be performed to treat laterally spreading duodenal papillary tumors (LSPTs). However, no studies have been conducted on the outcomes of ESDs for LSPTs.
Methods
We retrospectively compared 47 patients who underwent endoscopic papillectomies (EPs) for papillary tumors (PTs) between June 2007 and July 2023 (EP group) and eight patients who underwent ESDs for LSPTs between February 2022 and July 2023 (ESD group). In the subgroup analysis, five patients who underwent EPs for LSPTs were compared with eight patients who underwent ESDs for LSPTs.
Results
Procedure times and tumor diameters were significantly greater in the ESD group than in the EP group. The positive or unclear vertical margin (VM1/X) rate was significantly higher in the ESD group. Additional therapies were administered for patients with VM1/X in the ESD group, and no local recurrence was observed. No delayed adverse events occurred in the ESD group; however, delayed bleeding and perforation occurred in the EP group. In the subgroup analysis, the en bloc resection rate was significantly higher in the ESD group than in the EP group. The VM1/X rate did not differ significantly between groups.
Conclusions
We suggest that ESD is both feasible and safe for LSPTs.

Citations

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Reducing post-endoscopic submucosal dissection pancreatitis in periampullary duodenal lesions: the role of prophylactic pancreatic duct stenting
Ari Fahrial Syam
Clinical Endoscopy.2026; 59(1): 70. CrossRef
Endoscopic submucosal dissection versus endoscopic papillectomy for ampullary tumors with a lesion base ≥20 mm: a single-center retrospective comparative study (with videos)
Kazuma Fukuzawa, Takashi Hirose, Yoshihisa Takada, Kazuhiro Furukawa, Hiroyuki Shibata, Yoshiyuki Kurata, Yui Oshitani, Ryohei Kumano, Tadashi Iida, Yasuyuki Mizutani, Kentaro Yamao, Takeshi Yamamura, Takuya Ishikawa, Hiroki Kawashima
Gastrointestinal Endoscopy.2026;[Epub] CrossRef
Endoscopic Papillectomy for Ampullary Tumors in Older Patients: Balancing Oncologic Benefit and Geriatric Risk
Yoshihisa Takada, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Hironori Aoi, Ryohei Kumano, Kazuhiro Furukawa, Takeshi Yamamura, Hiroki Kawashima
Digestive Endoscopy.2026;[Epub] CrossRef

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Effectiveness of a novel ex vivo training model for gastric endoscopic submucosal dissection training: a prospective observational study conducted at a single center in Japan: Takahito Toba, Tsuyoshi Ishii, Nobuyuki Sato, Akira Nogami, Aya Hojo, Ryo Shimizu, Ai Fujimoto, Takahisa Matsuda; Clin Endosc 2025;58(1):94-101. Published online November 4, 2024; DOI: https://doi.org/10.5946/ce.2024.108

Graphical Abstract Abstract PDF

Background
/Aims: The efficacy of endoscopic submucosal dissection (ESD) for early-stage gastric cancer is well established. However, its acquisition is challenging owing to its complexity. In Japan, G-Master is a novel ex vivo gastric ESD training model. The effectiveness of training using G-Master is unknown. This study evaluated the efficacy of gastric ESD training using the G-Master to evaluate trainees’ learning curves and performance.
Methods
Four trainees completed 30 ESD training sessions using the G-Master, and procedure time, resection area, resection completion, en-bloc resection requirement, and perforation occurrence were measured. Resection speed was the primary endpoint, and learning curves were evaluated using the Cumulative Sum (CUSUM) method.
Results
All trainees completed the resection and en-bloc resection of the lesion without any intraoperative perforations. The learning curves covered three phases: initial growth, plateau, and late growth. The transition from phase 1 to phase 2 required a median of 10 sessions. Each trainee completed 30 training sessions in approximately 4 months.
Conclusions
Gastric ESD training using the G-Master is a simple, fast, and effective method for pre-ESD training in clinical practice. It is recommended that at least 10 training sessions be conducted.

Citations

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Efficacy of next-generation endoscopy training simulator in improving international trainee endoscopic submucosal dissection skills
Takeshi Uozumi, Seiichiro Abe, Reona Kawamura, Yasuhiko Mizuguchi, Ryoji Ichijima, Satoru Nonaka, Haruhisa Suzuki, Yutaka Saito
Endoscopy International Open.2026;[Epub] CrossRef
Feasibility of Duodenal Endoscopic Submucosal Dissection Training Using Thiel-Embalmed Cadavers
Keiichi Hashiguchi, Maiko Tabuchi, Yuko Akazawa, Hiroko Inomata-Kawasaki, Junya Shiota, Taro Akashi, Moto Kitayama, Kayoko Matsushima, Naoyuki Yamaguchi, Ken Ohnita, Kazunobu Saiki, Keiko Ogami-Takamura, Hisamitsu Miyaaki
Endoscopy International Open.2026;[Epub] CrossRef
Meaningful progress towards a high-fidelity endoscopic submucosal dissection training simulator model
Gin Hyug Lee, So Young Byun
Clinical Endoscopy.2025; 58(1): 77. CrossRef
Beyond the scope: unveiling the future of digestive endoscopy through experimental models
Federico Soria Gálvez
Revista Española de Enfermedades Digestivas.2025;[Epub] CrossRef

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Review

Clinical meaning of sarcopenia in patients undergoing endoscopic treatment: Hiroyuki Hisada, Yosuke Tsuji, Hikaru Kuribara, Ryohei Miyata, Kaori Oshio, Satoru Mizutani, Hideki Nakagawa, Rina Cho, Nobuyuki Sakuma, Yuko Miura, Hiroya Mizutani, Daisuke Ohki, Seiichi Yakabi, Yu Takahashi, Yoshiki Sakaguchi, Naomi Kakushima, Nobutake Yamamichi, Mitsuhiro Fujishiro; Clin Endosc 2024;57(4):446-453. Published online March 22, 2024; DOI: https://doi.org/10.5946/ce.2023.193

Abstract PDF

With increasing global life expectancy, the significance of geriatric assessment parameters has increased. Sarcopenia is a crucial assessment parameter and is defined as the age-related loss of muscle mass and strength. Sarcopenia is widely acknowledged as a risk factor for postoperative complications in diverse advanced malignancies and has a detrimental effect on the long-term prognosis. While most studies have primarily concentrated on the correlation between sarcopenia and advanced cancer, more recent investigations have focused on the relationship between sarcopenia and early-stage cancer. Endoscopic submucosal dissection (ESD), which is less invasive than surgical intervention, is extensively employed in the management of early-stage cancer, although it is associated with complications such as bleeding and perforation. In recent years, several reports have revealed the adverse consequences of sarcopenia in patients with early-stage cancer undergoing ESD. This literature review briefly summarizes the recent studies on the association between sarcopenia and ESD.

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Correlation between sarcopenia and esophageal stenosis following endoscopic submucosal dissection and construction of a postoperative stenosis risk model
Kai-Zhe Yang, Lu Chen, Li Xu, Bin-Xiang Xu, Ming-Yue Li, Zhi Wang, Qin Lu
World Journal of Gastroenterology.2026;[Epub] CrossRef
Impact of Sarcopenia on Elderly Patients Undergoing Endoscopic Resection: Scoping Review
Hiroyuki Hisada, Hiroki Asano, Yosuke Tsuji, Dai Kubota, Yuko Miura, Hiroya Mizutani, Daisuke Ohki, Chihiro Takeuchi, Seiichi Yakabi, Keiko Niimi, Naomi Kakushima, Nobutake Yamamichi, Mitsuhiro Fujishiro
Digestive Endoscopy.2026;[Epub] CrossRef
Long-term Outcomes of Endoscopic Submucosal Dissection Versus Surgery in Late Older Adult Patients Aged ≥75 Years With Early Gastric Cancer Meeting the Curative Resection Criteria
Seung Han Kim, Seon-Young Park, Young-Il Kim, Chung Hyun Tae, Hyeong Ho Jo, Jeong Hoon Lee, Ayoung Lee, Jae Myung Park, Hwoon-Yong Jung, Dae Hwan Kim, Hong Man Yoon, Hyunsoo Chung
Journal of Gastric Cancer.2026; 26(3): 448. CrossRef
Beyond local injury: Sarcopenia as a systemic host-related determinant of esophageal stenosis after endoscopic submucosal dissection
Wen-Mao Li, Bo Liu, Qing Liu
World Journal of Gastroenterology.2026;[Epub] CrossRef
Sarcopenia in the era of aging populations: its clinical implications for peptic ulcer bleeding
Hiroyuki Hisada, Yosuke Tsuji, Mitsuhiro Fujishiro
Clinical Endoscopy.2025; 58(3): 401. CrossRef
Clinical Significance of Sarcopenia in Elderly Patients Undergoing Endoscopic Submucosal Dissection: A Systematic Review and Meta-analysis
Yuanhao Su, Yongke Wu, Cheng Li, Yiyuan Zhao, Yunhao Li, Xing Jin, Zhidong Wang
Digestive Diseases and Sciences.2024; 69(8): 2970. CrossRef

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Systematic Review and Meta-analysis

Efficacy and safety of endoscopic submucosal dissection for colorectal dysplasia in patients with inflammatory bowel disease: a systematic review and meta-analysis: Talia F. Malik, Vaishnavi Sabesan, Babu P. Mohan, Asad Ur Rahman, Mohamed O. Othman, Peter V. Draganov, Gursimran S. Kochhar; Clin Endosc 2024;57(3):317-328. Published online February 29, 2024; DOI: https://doi.org/10.5946/ce.2023.205

Graphical Abstract Abstract PDF Supplementary Material

Background
/Aims: In this meta-analysis, we studied the safety and efficacy of endoscopic submucosal dissection (ESD) for colorectal dysplasia in patients with inflammatory bowel disease (IBD).
Methods
Multiple databases were searched, and studies were retrieved based on pre-specified criteria until October 2022. The outcomes assessed were resection rates, procedural complications, local recurrence, metachronous tumors, and the need for surgery after ESD in IBD. Standard meta-analysis methods were followed using the random-effects model, and I2% was used to assess heterogeneity.
Results
Twelve studies comprising 291 dysplastic lesions in 274 patients were included with a median follow-up of 25 months. The pooled en-bloc resection, R0 resection, and curative resection rates were 92.5% (95% confidence interval [CI], 87.9%–95.4%; I2=0%), 81.5% (95% CI, 72.5%–88%; I2=43%), and 48.9% (95% CI, 32.1%–65.9%; I2=87%), respectively. The local recurrence rate was 3.9% (95% CI, 2%–7.5%; I2=0%). The pooled rates of bleeding and perforation were 7.7% (95% CI, 4.5%–13%; I2=10%) and 5.3% (95% CI, 3.1%–8.9%; I2=0%), respectively. The rates of metachronous recurrence and additional surgery following ESD were 10% (95% CI, 5.2%–18.2%; I2=55%) and 13% (95% CI, 8.5%–19.3%; I2=54%), respectively.
Conclusions
ESD is safe and effective for the resection of dysplastic lesions in IBD with an excellent pooled rate of en-bloc and R0 resection.

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Original Article

Endoscopic resection of gastric gastrointestinal stromal tumor using clip-and-cut endoscopic full-thickness resection: a single-center, retrospective cohort in Korea: Yuri Kim, Ji Yong Ahn, Hwoon-Yong Jung, Seokin Kang, Ho June Song, Kee Don Choi, Do Hoon Kim, Jeong Hoon Lee, Hee Kyong Na, Young Soo Park; Clin Endosc 2024;57(3):350-363. Published online February 15, 2024; DOI: https://doi.org/10.5946/ce.2023.144

Graphical Abstract Abstract PDF Supplementary Material

Background
/Aims: To overcome the technical limitations of classic endoscopic resection for gastric gastrointestinal stromal tumors (GISTs), various methods have been developed. In this study, we examined the role and feasibility of clip-and-cut procedures (clip-and-cut endoscopic full-thickness resection [cc-EFTR]) for gastric GISTs.
Methods
Medical records of 83 patients diagnosed with GISTs after endoscopic resection between 2005 and 2021 were retrospectively reviewed. Moreover, clinical characteristics and outcomes were analyzed.
Results
Endoscopic submucosal dissection (ESD) and cc-EFTR were performed in 51 and 32 patients, respectively. The GISTs were detected in the upper third of the stomach for ESD (52.9%) and cc-EFTR (90.6%). Within the cc-EFTR group, a majority of GISTs were located in the deep muscularis propria or serosal layer, accounting for 96.9%, as opposed to those in the ESD group (45.1%). The R0 resection rates were 51.0% and 84.4% in the ESD and cc-EFTR groups, respectively. Seven (8.4%) patients required surgical treatment (six patients underwent ESD and one underwent cc-EFTR,) due to residual tumor (n=5) and post-procedure adverse events (n=2). Patients undergoing R0 or R1 resection did not experience recurrence during a median 14-month follow-up period, except for one patient in the ESD group.
Conclusions
cc-EFTR displayed a high R0 resection rate; therefore, it is a safe and effective therapeutic option for small gastric GISTs.

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Systematic Review and Meta-analysis

Comparison of scissor-type knife to non-scissor-type knife for endoscopic submucosal dissection: a systematic review and meta-analysis: Harishankar Gopakumar, Ishaan Vohra, Srinivas Reddy Puli, Neil R Sharma; Clin Endosc 2024;57(1):36-47. Published online January 5, 2024; DOI: https://doi.org/10.5946/ce.2023.122

Graphical Abstract Abstract PDF

Background
/Aims: Scissor-type endoscopic submucosal dissection (ST-ESD) knives can reduce the adverse events associated with ESDs. This study aimed to compare ST-ESD and non-scissor-type (NST)-ESD knives.
Methods
We identified ten studies that compared the performance characteristics and safety profiles of ST-ESD and NST-ESD knives. Fixed- and random-effects models were used to calculate the pooled proportions. Heterogeneity was assessed using the I2 test.
Results
On comparing ST-ESD knives to NST-ESD knives, the weighted odds of en bloc resection was 1.61 (95% confidence interval [CI], 0.90–2.90; p=0.14), R0 resection was 1.10 (95% CI, 0.71–1.71; p=0.73), delayed bleeding was 0.40 (95% CI, 0.17–0.90; p=0.03), perforation was 0.35 (95% CI, 0.18–0.70; p<0.01) and ESD self-completion by non-experts was 1.89 (95% CI, 1.20–2.95; p<0.01). There was no heterogeneity, with an I2 score of 0% (95% CI, 0%–54.40%).
Conclusions
The findings of reduced odds of perforation, a trend toward reduced delayed bleeding, and an improvement in the rates of en bloc and R0 resection with ST-ESD knives compared to NST-ESD knives support the use of ST-ESD knives when non-experts perform ESDs or as an adjunct tool for challenging ESD procedures.

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Review

Management of complications related to colorectal endoscopic submucosal dissection: Tae-Geun Gweon, Dong-Hoon Yang; Clin Endosc 2023;56(4):423-432. Published online July 27, 2023; DOI: https://doi.org/10.5946/ce.2023.104

Abstract PDF

Compared to endoscopic mucosal resection (EMR), colonoscopic endoscopic submucosal dissection (C-ESD) has the advantages of higher en bloc resection rates and lower recurrence rates of colorectal neoplasms. Therefore, C-ESD is considered an effective treatment method for laterally spread tumors and early colorectal cancer. However, C-ESD is technically more difficult and requires a longer procedure time than EMR. In addition to therapeutic efficacy and procedural difficulty, safety concerns should always be considered when performing C-ESD in clinical practice. Bleeding and perforation are the main adverse events associated with C-ESD and can occur during C-ESD or after the completion of the procedure. Most bleeding associated with C-ESD can be managed endoscopically, even if it occurs during or after the procedure. More recently, most perforations identified during C-ESD can also be managed endoscopically, unless the mural defect is too large to be sutured with endoscopic devices or the patient is hemodynamically unstable. Delayed perforations are quite rare, but they require surgical treatment more frequently than endoscopically identified intraprocedural perforations or radiologically identified immediate postprocedural perforations. Post-ESD coagulation syndrome is a relatively underestimated adverse event, which can mimic localized peritonitis from perforation. Here, we classify and characterize the complications associated with C-ESD and recommend management options for them.

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Original Articles

Significance of rescue hybrid endoscopic submucosal dissection in difficult colorectal cases: Hayato Yamaguchi, Masakatsu Fukuzawa, Takashi Kawai, Takahiro Muramatsu, Taisuke Matsumoto, Kumiko Uchida, Yohei Koyama, Akira Madarame, Takashi Morise, Shin Kono, Sakiko Naito, Naoyoshi Nagata, Mitsushige Sugimoto, Takao Itoi; Clin Endosc 2023;56(6):778-789. Published online July 26, 2023; DOI: https://doi.org/10.5946/ce.2022.268

Graphical Abstract Abstract PDF Supplementary Material

Background
/Aims: Hybrid endoscopic submucosal dissection (ESD), in which an incision is made around a lesion and snaring is performed after submucosal dissection, has some advantages in colorectal surgery, including shorter procedure time and preventing perforation. However, its value for rescue resection in difficult colorectal ESD cases remains unclear. This study evaluated the utility of rescue hybrid ESD (RH-ESD).
Methods
We divided 364 colorectal ESD procedures into the conventional ESD group (C-ESD, n=260), scheduled hybrid ESD group (SH-ESD, n=69), and RH-ESD group (n=35) and compared their clinical outcomes.
Results
Resection time was significantly shorter in the following order: RH-ESD (149 [90–197] minutes) >C-ESD (90 [60–140] minutes) >SH-ESD (52 [29–80] minutes). The en bloc resection rate increased significantly in the following order: RH-ESD (48.6%), SH-ESD (78.3%), and C-ESD (97.7%). An analysis of factors related to piecemeal resection of RH-ESD revealed that the submucosal dissection rate was significantly lower in the piecemeal resection group (25% [20%–30%]) than in the en bloc resection group (40% [20%–60%]).
Conclusions
RH-ESD was ineffective in terms of curative resection because of the low en bloc resection rate, but was useful for avoiding surgery.

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Felix Aigner, Christoph Skias, David Duller, Sebastian Wisiak, Karin Strohmeyer, Zoltan Horvath, Nicole Koter
Journal of Clinical Medicine.2025; 14(17): 6343. CrossRef
Safety and efficacy of hybrid versus conventional endoscopic submucosal dissection for removal of gastrointestinal lesions: A meta-analysis
Adnan Bhat, Allah Dad, Kinza Bakht, Muhammad Arham, Humza Saeed, Zahra Ali, Faseeh Haider, Saniya Ishtiaq, Anchit Chauhan, Danyal Bakht, Adil Ahmed, Ali Naseem, Imran Ali Reshi, Dennis Yang, Peter Vassilev Draganov
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Yunho Jung
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Planned Hybrid Endoscopic Submucosal Dissection as Alternative for Colorectal Neoplasms: A Propensity Score-Matched Study
Yu-xin Zhang, Xun Liu, Fang Gu, Shi-gang Ding
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João Paulo de Souza Pontual, Alexandre Moraes Bestetti, Diogo Turiani Hourneaux de Moura
Clinical Endoscopy.2023; 56(6): 738. CrossRef

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Usefulness of the S-O clip for duodenal endoscopic submucosal dissection: a propensity score-matched study: Ippei Tanaka, Dai Hirasawa, Hiroaki Saito, Junichi Akahira, Tomoki Matsuda; Clin Endosc 2023;56(6):769-777. Published online May 24, 2023; DOI: https://doi.org/10.5946/ce.2022.195

Graphical Abstract Abstract PDF Supplementary Material

Background
/Aims: Endoscopic submucosal dissection (ESD) for superficial non-ampullary duodenal tumors (SNADETs) is associated with a high rate of en bloc resection. However, the technique for ESD remains challenging. Recent studies have demonstrated the effectiveness of S-O clips in colonic and gastric ESD. We evaluated the efficacy and safety of duodenal ESD using an S-O clip for SNADETs.
Methods
Consecutive patients who underwent ESD for SNADETs between January 2011 and December 2021 were retrospectively enrolled. Propensity score matching analysis was used to compare patients who underwent duodenal ESD with the S-O clip (S-O group) and those who underwent conventional ESD (control group). Intraoperative perforation rate was the primary outcome, while procedure time and R0 resection rate were the secondary outcomes.
Results
After propensity score matching, 16 pairs were created: 43 and 17 in the S-O and control groups, respectively. The intraoperative perforation rate in the S-O group was significantly lower than that in the control group (p=0.033). A significant difference was observed in the procedure time between the S-O and control groups (39±9 vs. 82±30 minutes, respectively; p=0.003).
Conclusions
The S-O clip reduced the intraoperative perforation rate and procedure time, which may be useful and effective in duodenal ESD.

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Safety and Feasibility of Laparoscopic and Endoscopic Cooperative Surgery With Endoscopic Submucosal Dissection for Large Superficial Non‐Ampullary Duodenal Epithelial Tumors
Masaru Hayami, Shoichi Yoshimizu, Naoki Miyazaki, Shintaro Yamamoto, Hiroyuki Yamamoto, Motonari Ri, Rie Makuuchi, Tomoyuki Irino, Manabu Takamatsu, Souya Nunobe
Annals of Gastroenterological Surgery.2026; 10(2): 460. CrossRef
Mitigating risk following upper gastrointestinal Endoscopic Submucosal Dissection: preventing bleeding, perforation and stricture formation
Giulio Calabrese, Rossella Maresca, Livio Bonacci, Tommaso Rozera, Giuseppe Spinosa, Federico Barbaro, Sandro Sferrazza
Best Practice & Research Clinical Gastroenterology.2026; 82: 102126. CrossRef
Clinical practice guidelines for duodenal cancer 2025
Satoshi Yasuda, Kenji Nakagawa, Mitsuhiro Fujishiro, Naomi Kakushima, Takahiro Horimatsu, Ken-ichi Okada, Motohiko Kato, Osamu Dohi, Satoru Nonaka, Takashi Hirose, Shingo Kanaji, Shinji Kuroda, Takuro Saito, Chie Takishita, Chie Tanaka, Shunsuke Doi, Souy
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Huanlu Xu, Rong Hu, Ke Jiang, Xiaofeng Zhang
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Ji Hyun Kim, Seung-Joo Nam, Sung Chul Park
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Giulio Calabrese, Marcello Maida, Darshan Parekh, Yohei Minato, Alessandro Vitello, Alberto Murino, Rui Morais, Emanuele Sinagra, Daryl Ramai, Ken Ohata, Sandro Sferrazza
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Alessandro Rimondi, Elisabetta Dell’Unto, Rui Morais, Gianluca Esposito, João Santos-Antunes, Gian Eugenio Tontini, Rehan Haidry, Jérémie Jacques, Edward John Despott, Alberto Murino
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Fariha Hasan, Aizaz Ali, Umm E Salma Shabbar Banatwala, Bushra Zaman, Hassam Ali, Rahul Karna, Muhammad Ali Butt, Dushyant Singh Dahiya, Manesh Kumar Gangwani, Saurabh Chandan, Umar Hayat, Hareesha Rishab Bharadwaj, Hafiz Muzaffar Akbar Khan
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Kurato Miyazaki, Naohisa Yahagi, Motohiko Kato
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A method of “Noninjecting Resection using Bipolar Soft coagulation mode; NIRBS” for superficial non-ampullary duodenal epithelial tumor: a pilot study
Mitsuo Tokuhara, Yasushi Sano, Yoshifumi Watanabe, Hidetoshi Nakata, Hiroko Nakahira, Shingo Furukawa, Takuya Ohtsu, Naohiro Nakamura, Takashi Ito, Ikuko Torii, Takeshi Yamashina, Masaaki Shimatani, Makoto Naganuma
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Traction methods for endoscopic submucosal dissection
Ji Hyun Kim, Sung Chul Park
Journal of Innovative Medical Technology.2024; 2(2): 47. CrossRef

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Management of esophageal neoplasms by endoscopic submucosal dissection: experience over 100 consecutive procedures: Josué Aliaga Ramos, Yoshinori Morita, Takashi Toyonaga, Danilo Carvalho, Moises Salgado Pedrosa, Vitor N. Arantes; Clin Endosc 2023;56(5):613-622. Published online May 17, 2023; DOI: https://doi.org/10.5946/ce.2022.245

Graphical Abstract Abstract PDF

Background
/Aims: Endoscopic submucosal dissection (ESD) is currently considered the first-line treatment for the eradication of superficial neoplasms of the esophagus in Eastern countries. However, in the West, particularly in Latin America, the experience with esophageal ESD is still limited because of the high technical complexity required for its execution. This study aimed to present the results of the clinical application of ESD to manage superficial esophageal neoplasms in a Latin American center in over 100 consecutive cases.
Methods
This retrospective study included consecutive patients who underwent endoscopic ESD for superficial esophageal neoplasms between 2009 and 2022. The following clinical outcomes were assessed: en bloc, complete, and curative resection rates, local recurrence, adverse events, and procedure-related mortality.
Results
Esophageal ESD was performed mainly for squamous cell carcinoma (66.6%), high-grade intraepithelial neoplasia (17.1%), and adenocarcinoma (11.4%). En bloc and complete resection rates were 96.2% and 81.0%, respectively. The curative resection rate was 64.8%. Adverse events occurred in six cases (5.7%). Endoscopic follow-up was performed for an average period of 29.7 months.
Conclusions
ESD performed by trained operators is feasible, safe, and clinically effective for managing superficial neoplastic lesions of the esophagus in Latin America.

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Endoscopic treatment of esophageal high-grade intraepithelial neoplasia
Caifa Hong, Yawen Zheng
Asian Journal of Surgery.2026;[Epub] CrossRef

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109 Download
1 Crossref

The pattern of metachronous recurrence after endoscopic submucosal dissection for gastric adenocarcinoma and dysplasias: Sunah Suk, Yeon Joo Seo, Dae Young Cheung, Han Hee Lee, Jin Il Kim, Soo-Heon Park; Clin Endosc 2023;56(4):470-478. Published online April 18, 2023; DOI: https://doi.org/10.5946/ce.2022.259

Graphical Abstract Abstract PDF

Background
/Aims: Metachronous recurrence incidences and risk factors following endoscopic submucosal dissection (ESD) for gastric adenocarcinoma and dysplasias were investigated.
Methods
Retrospective review of electronic medical records of patients who underwent gastric ESD at The Catholic University of Korea, Yeouido St. Mary’s Hospital.
Results
A total of 190 subjects were enrolled for analysis during the study period. The mean age was 64.4 years-old and the male sex occupied 73.7%. The mean observation period following ESD was 3.45 years. The annual incidence rate of metachronous gastric neoplasms (MGN) was about 3.96%. The annual incidence rate was 5.36% for the low-grade dysplasia group, 6.47% for the high-grade dysplasia group, and 2.74% for the EGC group. MGN was more frequent in the dysplasia group than in the EGC group (p<0.05). For those with MGN development, the mean time interval from ESD to MGN was 4.1 (±1.8) years. By using the Kaplan–Meier model, the estimated mean MGN free survival time was 9.97 years (95% confidence interval, 8.53–11.40) The histological types of MGN were not related to the primary histology types.
Conclusions
MGN following ESD developed in 3.96% annually and MGN was more frequent in the dysplasia group. The histological types of MGN did not correlate with those of primary neoplasm.

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Bile Reflux is a Risk Factor for Metachronous Development in Patients with Early Gastric Cancer
Hiroki Murai, Takuya Yamada, Yukihiro Kusumoto, Akane Namiki, Naoko Hayata, Akino Okamoto, Munehiro Ashida, Takafumi Tanimoto, Kohsaku Ohnishi, Tomohide Kurahashi, Motohiro Hirao, Atsushi Hosui, Naoki Hiramatsu
Endoscopy International Open.2026;[Epub] CrossRef
A systematic review and meta-analysis of incidence trends and risk factors for metachronous gastric lesions following endoscopic resection
Meixi Gong, Xuanbing Li, Ruijun Xin, Yuansen Ma, Xiaomei Wu, Yan Zhao, Yu Sun, Bo Zhu
Annals of Medicine.2025;[Epub] CrossRef
Research Progress in ESD Treatment of Early Gastric Cancer
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Advances in Clinical Medicine.2024; 14(02): 4201. CrossRef
Optimal Surveillance of Metachronous Gastric Lesion after Endoscopic Resection of Early Gastric Cancer
Dong Chan Joo, Gwang Ha Kim
Gut and Liver.2024; 18(5): 781. CrossRef
Risk Assessment of Metachronous Gastric Neoplasm after Endoscopic Resection for Early Gastric Cancer According to Age at Helicobacter pylori Eradication
Seunghan Lee, Soo-Jeong Cho, Hyunsoo Chung, Bokyung Kim, Mi Jin Oh, Yun Suk Na, Jun Hee Lee, Jiyoon Kim, Sang Gyun Kim
Gut and Liver.2024; 18(6): 992. CrossRef

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4 Web of Science
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Endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma: long-term follow-up in a Western center: Andreas Probst, Alanna Ebigbo, Stefan Eser, Carola Fleischmann, Tina Schaller, Bruno Märkl, Stefan Schiele, Bernd Geissler, Gernot Müller, Helmut Messmann; Clin Endosc 2023;56(1):55-64. Published online January 13, 2023; DOI: https://doi.org/10.5946/ce.2022.093

Abstract PDF

Background
/Aims: Endoscopic submucosal dissection (ESD) has been established as a treatment modality for superficial esophageal squamous cell carcinoma (ESCC). Long-term follow-up data are lacking in Western countries. The aim of this study was to analyze long-term survival in a Western center.
Methods
Patients undergoing ESD for ESCC were included. The analysis was performed retrospectively using a prospectively collected database.
Results
R0 resection rate was 96.7% (59/61 lesions in 58 patients). Twenty-seven patients (46.6%) fulfilled the curative resection criteria (M1/M2) (group A), 11 patients (19.0%) had M3 lesions without lymphovascular invasion (LVI) (group B), and 20 patients (34.5%) had lesions with submucosal invasion or LVI (group C). Additional treatment was recommended after non-curative resection. It was not performed in 20/31 patients (64.5%), mainly because of comorbidities (75%). Twenty-nine out of 58 (50.0%) patients died during a mean follow-up of 3.7 years. Death was related to ESCC in 17.2% (5/29) of patients. The disease-specific survival rate after curative resection was 100%. Overall survival rates after 5 years were 61.5%, 63.6% and 28.1% for groups A, B, and C, respectively. The overall survival was significantly worse after non-curative resection (p=0.038).
Conclusions
Non-curative resection is frequent after ESD for ESCC in Western patients. The long-term prognosis is limited and mainly determined by comorbidity. Early diagnosis and pre-interventional assessments need to be improved.

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Outcomes of endoscopic submucosal dissection for superficial esophageal squamous neoplasms: a multicenter North American experience
Rishi Subrahmanyan, Hiroyuki Aihara, Anand Kumar, Alexander Schlachterman, Shai Friedland, Joo Ha Hwang, Mohamed Othman, Salmaan Jawaid, Lorenzo Ferri, Christopher Teshima, Jeffrey Mosko, Robert Bechara, Jason Samarasena, Dennis Yang, Michael Ujiki, Yutak
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Endoscopic submucosal dissection in early esophageal neoplasia: Celebrating efficacy, confronting heterogeneity, and refining surveillance for high-risk patients
Shi-Qiong Zhou, Qing-Hua Ke
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Long-Term Outcomes of Endoscopic Submucosal Dissection for Esophageal Squamous High-Grade Dysplasia and Early Squamous Cell Carcinoma in the West: Absolute vs Outside Criteria
Sunil Gupta, Francesco Vito Mandarino, Brian Lam, Julia Gauci, Clarence Kerrison, Duncan McLeod, Eric Lee, Nicholas Burgess, Michael J. Bourke
Clinical Gastroenterology and Hepatology.2026;[Epub] CrossRef
Curriculum for endoscopic treatment of esophageal neoplasia and precursor lesions: ESGE Position Statement – with competency assessment tools
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Charlotte N. Frederiks, Laura S. Boer, Bas Gloudemans, Lorenza Alvarez Herrero, Jacques J.G.H.M. Bergman, Roos E. Pouw, Bas L.A.M. Weusten
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João Santos-Antunes
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Yu-ping Yuan, Chi-chao Wang, Yuan-liang Zheng
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Moon Won Lee, Gwang Ha Kim
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Roberta Maselli
Gastrointestinal Endoscopy.2025; 102(4): 488. CrossRef
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Sandip Pal, Gourab Bhaduri
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Ilse N. Beaufort, Charlotte N. Frederiks, Anouk Overwater, Lodewijk A.A. Brosens, Arjun D. Koch, Roos E. Pouw, Jacques J.G.H.M. Bergman, Bas L.A.M. Weusten
Endoscopy.2024; 56(05): 325. CrossRef
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Chen-Huan Yu, Yueh-Hung Chou, Tze-Yu Shieh, Chao-Yu Liu, Jiann-Ming Wu, Chen-Hsi Hsieh, Tzong-Hsi Lee, Chen-Shuan Chung
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Yuki Okubo, Ryu Ishihara
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Endoscopic submucosal dissection in colorectal neoplasia performed with a waterjet system-assisted knife: higher en-bloc resection rate than conventional technique: Paolo Cecinato, Matteo Lucarini, Francesco Azzolini, Mariachiara Campanale, Fabio Bassi, Annalisa Cippitelli, Romano Sassatelli; Clin Endosc 2022;55(6):775-783. Published online October 6, 2022; DOI: https://doi.org/10.5946/ce.2022.099

Abstract PDF

Background
/Aims: Colorectal endoscopic submucosal dissection (ESD) is burdened by its associated high risk of adverse events and long procedure time. Recently, a waterjet-assisted knife was introduced to simplify and speed up the procedure. The aim of this study was to evaluate the efficacy and safety of waterjet-assisted ESD (WESD) compared to that of the conventional ESD (CESD) technique.
Methods
The charts of 254 consecutive patients who underwent colorectal ESD between January 2014 and February 2021 for colorectal neoplasms were analyzed. The primary outcome was the en-bloc resection rate. Secondary outcomes were complete and curative resection rates, the need to switch to a hybrid ESD, procedure speed, the adverse event rates, and the recurrence rates.
Results
Approximately 174 neoplasias were considered, of which, 123 were removed by WESD and 51 by CESD. The en-bloc resection rate was higher in the WESD group (94.3% vs. 84.3%). Complete resection rates and curative resection rates were similar. The need to switch to a hybrid ESD was greater during CESD (39.2% vs. 13.8%). Procedure speed and adverse event rates were similar. During follow-up, one recurrence occurred after a WESD.
Conclusions
WESD allows a high rate of en-bloc resections and less frequently requires a rescue switch to the hybrid ESD compared to CESD.

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Roberto de Sire, Ludovico Alfarone, Antonio Capogreco, Davide Massimi, Vincenzo Vadalà, Luca Brandaleone, Marco Spadaccini, Asma Alkandari, Pradeep Bhandari, Thomas Rosch, Cesare Hassan, Roberta Maselli, Alessandro Repici
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Yukun Lan, Wenchuan Liu, Jiren Tang, Hong Li, Shuaikang Chang, Guiqiang Hao
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Xin Li, Ren-Yi Zhang, Xu-Dong Wen, Xue-Qin Li, Wei-Hui Liu
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Hong Jun Park, Su Young Kim, Gwang Ho Baik, Myeongsook Seo, Hyun Il Seo, Sung Chul Park, Hyunil Kim, Hyun-Soo Kim
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Fengcheng Zang, Bin He, Yunfu Feng, Ye Ye, Luojie Liu, Yiqi Dai
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Francesco Cocomazzi, Sonia Carparelli, Nunzia Labarile, Antonio Capogreco, Marco Gentile, Roberta Maselli, Jahnvi Dhar, Jayanta Samanta, Alessandro Repici, Cesare Hassan, Francesco Perri, Antonio Facciorusso
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Diagnostics.2023; 13(21): 3347. CrossRef

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Intralesional steroid infusion using a spray tube to prevent stenosis after endoscopic submucosal dissection of esophageal cancer: Atsushi Goto, Takeshi Okamoto, Ryo Ogawa, Kouichi Hamabe, Shinichi Hashimoto, Jun Nishikawa, Taro Takami; Clin Endosc 2022;55(4):520-524. Published online July 28, 2022; DOI: https://doi.org/10.5946/ce.2021.262

Abstract PDF Supplementary Material

Background
/Aims: Intralesional steroid injections have been administered as prophylaxis for stenosis after esophageal endoscopic submucosal dissection. However, this method carries a risk of potential complications such as perforation because a fine needle is used to directly puncture the postoperative ulcer. We devised a new method of steroid intralesional infusion using a spray tube and evaluated its efficacy and safety.
Methods
Intralesional steroid infusion using a spray tube was performed on 27 patients who underwent endoscopic submucosal dissection for superficial esophageal cancer with three-quarters or more of the lumen circumference resected. The presence or absence of stenosis, complications, and the number of endoscopic balloon dilations (EBDs) performed were evaluated after treatment.
Results
Although stenosis was not observed in 22 of the 27 patients, five patients had stenosis and dysphagia requiring EBD. The stenosis in these five patients was relieved after four EBDs. No complications related to intralesional steroid infusion using the spray tube were observed.
Conclusions
Intralesional steroid infusion using a spray tube is a simple and safe technique that is adequately effective in preventing stenosis Clinical trial number (UMIN000037567).

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Effectiveness of glucocorticoids in preventing esophageal stricture and predictors of stricture after esophageal ESD: 5 years of experience in a single medical center
Qingxia Wang, Yuan Ding, Qiliu Qian, Yinnan Zhu, Ruihua Shi
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Predictors of stricture after endoscopic submucosal dissection of the esophagus and steroids application
Qing-Xia Wang, Yuan Ding, Qi-Liu Qian, Yin-Nan Zhu, Rui-Hua Shi
World Journal of Gastrointestinal Endoscopy.2024; 16(9): 509. CrossRef
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Takeshi Fujiyabu, Pan Qi, Kenichi Yoshie, Ayano Fujisawa, Yosuke Tsuji, Arvind Kumar Singh Chandel, Athira Sreedevi Madhavikutty, Natsuko F. Inagaki, Seiichi Ohta, Mitsuhiro Fujishiro, Taichi Ito
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Review

Endoscopic treatment for rectal neuroendocrine tumor: which method is better?: Seung Min Hong, Dong Hoon Baek; Clin Endosc 2022;55(4):496-506. Published online July 11, 2022; DOI: https://doi.org/10.5946/ce.2022.115

Abstract PDF

Recently, research on rectal neuroendocrine tumors (NETs) has increased during the last few decades. Rectal NETs measuring <10 mm without atypical features and confined to the submucosal layer have only 1% risk of metastasis, and the long-term survival probability of patients without metastasis at the time of diagnosis is approximately 100%. Therefore, the current guidelines suggest endoscopic resection of rectal NETs of <10 mm is regarded as a safe therapeutic option. However, there are currently no clear recommendations for technique selection for endoscopic resection. The choice of treatment modality for rectal NETs should be based on the lesion size, endoscopic characteristics, grade of differentiation, depth of vertical involvement, lymphovascular invasion, and risk of metastasis. Moreover, the complete resection rate, complications, and experience at the center should be considered. Modified endoscopic mucosal resection is the most suitable resection method for rectal NETs of <10 mm, because it is an effective and safe technique that is relatively simple and less time-consuming compared with endoscopic submucosal dissection. Endoscopic submucosal dissection should be considered when the tumor size is >10 mm, suctioning is not possible due to fibrosis in the lesion, or when the snaring for modified endoscopic mucosal resection does not work well.

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Original Articles

Efficacy of the pocket-creation method with a traction device in endoscopic submucosal dissection for residual or recurrent colorectal lesions: Daisuke Ide, Tomohiko Richard Ohya, Mitsuaki Ishioka, Yuri Enomoto, Eisuke Nakao, Yuki Mitsuyoshi, Junki Tokura, Keigo Suzuki, Seiichi Yakabi, Chihiro Yasue, Akiko Chino, Masahiro Igarashi, Akio Nakashima, Masayuki Saruta, Shoichi Saito, Junko Fujisaki; Clin Endosc 2022;55(5):655-664. Published online May 31, 2022; DOI: https://doi.org/10.5946/ce.2022.009

Abstract PDF Supplementary Material

Background
/Aims: Endoscopic submucosal dissection (ESD) for residual or recurrent colorectal lesions after incomplete resection is challenging because of severe fibrosis. This study aimed to compare the efficacy of the pocket-creation method (PCM) with a traction device (TD) with that of conventional ESD for residual or recurrent colorectal lesions.
Methods
We retrospectively studied 72 patients with residual or recurrent colorectal lesions resected using ESD. Overall, 31 and 41 lesions were resected using PCM with TD and conventional ESD methods, respectively. We compared patient background and treatment outcomes between the PCM with TD and conventional ESD groups, respectively. The primary endpoints were en bloc resection and R0 resection rates. The secondary endpoints were the dissection speed and incidence of adverse events.
Results
En bloc resection was feasible in all cases with PCM with TD, but failed in 22% of cases of conventional ESD. The R0 resection rates for PCM with TD and conventional ESD were 97% and 66%, respectively. Dissection was significantly faster in the PCM with TD group (13.0 vs. 7.9 mm2/min). Perforation and postoperative bleeding were observed in one patient in each group.
Conclusions
PCM with TD is an effective method for treating residual or recurrent colorectal lesions after incomplete resection.

Citations

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Gaining Traction: Is the Traction-Assisted Method Superior to the Pocket-Creation Method for Colorectal Endoscopic Submucosal Dissection?
Kengo Kasuga, Toshio Uraoka
Digestive Diseases and Sciences.2026; 71(4): 1186. CrossRef
The clinical efficacy of pocket creation method ESD and conventional ESD in the treatment of early colorectal neoplasms: a meta-analysis
Kegumei Jiekang, Linyue Zhang, Geng Chen
Frontiers in Medicine.2026;[Epub] CrossRef
Exploring different techniques for endoscopic submucosal dissection of gastrointestinal lesions: a review of the literature
Giulio Calabrese, Marcello Maida, Darshan Parekh, Yohei Minato, Alessandro Vitello, Alberto Murino, Rui Morais, Emanuele Sinagra, Daryl Ramai, Ken Ohata, Sandro Sferrazza
Expert Review of Anticancer Therapy.2025; 25(7): 755. CrossRef
Facilitating Colorectal Endoscopic Submucosal Dissection: Devices and Techniques
Teppei Akimoto, Naohisa Yahagi, Motohiko Kato
Techniques and Innovations in Gastrointestinal Endoscopy.2025; 27(4): 250932. CrossRef
A review of techniques of third space endoscopy for gastrointestinal tumors
Zaheer Nabi, D. Nageshwar Reddy
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Traction Techniques for Endoscopic Submucosal Dissection (ESD): Organ-Specific Best Practices and Western Outcomes
Emmanuel Palomera-Tejeda, Farhan Kawsar, Salmaan Jawaid
Current Gastroenterology Reports.2025;[Epub] CrossRef
Novel adjustable traction “noose knot” method for colorectal endoscopic submucosal dissection
Junki Tokura, Daisuke Ide, Keigo Suzuki, Chihiro Yasue, Akiko Chino, Masahiro Igarashi, Shoichi Saito
Endoscopy.2024; 56(S 01): E55. CrossRef
Approaches and considerations in the endoscopic treatment of T1 colorectal cancer
Yunho Jung
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Juan Du, Ting Zhang, Lei Wang, Hao Zhang, Wenquan Yi
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Francesco Cocomazzi, Sonia Carparelli, Nunzia Labarile, Antonio Capogreco, Marco Gentile, Roberta Maselli, Jahnvi Dhar, Jayanta Samanta, Alessandro Repici, Cesare Hassan, Francesco Perri, Antonio Facciorusso
Expert Review of Medical Devices.2024; 21(7): 561. CrossRef
The Derivation and External Validation of a Fibrosis Risk Model for Colorectal Tumours Undergoing Endoscopic Submucosal Dissection
Sandro Sferrazza, Marcello Maida, Giulio Calabrese, Antonio Facciorusso, Lorenzo Fuccio, Leonardo Frazzoni, Roberta Maselli, Alessandro Repici, Roberto Di Mitri, João Santos-Antunes
Journal of Clinical Medicine.2024; 13(15): 4517. CrossRef
Traction methods for endoscopic submucosal dissection
Ji Hyun Kim, Sung Chul Park
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Sukit Pattarajierapan, Hiroyuki Takamaru, Supakij Khomvilai
World Journal of Gastroenterology.2023; 29(17): 2600. CrossRef
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Gianluca Andrisani, Cesare Hassan, Margherita Pizzicannella, Francesco Pugliese, Massimiliano Mutignani, Chiara Campanale, Giorgio Valerii, Carmelo Barbera, Giulio Antonelli, Francesco Maria Di Matteo
Gastrointestinal Endoscopy.2023; 98(6): 987. CrossRef
Combination of endoscopic submucosal dissection techniques, a practical solution for difficult cases
Dong-Hoon Yang
Clinical Endoscopy.2022; 55(5): 626. CrossRef

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15 Crossref

Comparison between a novel core knife and the conventional IT knife 2 for endoscopic submucosal dissection of gastric mucosal lesions: Myeongsoon Park, Jin Wook Lee, Dong Woo Shin, Jungseok Kim, Yoo Jin Lee, Ju Yup Lee, Kwang Bum Cho; Clin Endosc 2022;55(6):767-774. Published online May 25, 2022; DOI: https://doi.org/10.5946/ce.2022.002

Abstract PDF: Background
/Aims: Few studies have compared the performances of endoscopic knives. This study aimed to compare the therapeutic outcomes of a novel core knife and the conventional IT knife 2 for endoscopic submucosal dissection (ESD) of gastric mucosal lesions.
Methods
This prospective, non-inferiority trial included patients diagnosed with gastric adenoma or early-stage adenocarcinoma at Keimyung University Dongsan Hospital between June and November 2020. The patients were randomly assigned to either the core knife or the IT knife 2 group. The operators and assistants scored the knives’ grip convenience and cutting abilities.
Results
A total of 39 patients were enrolled (core knife group, 20 patients; IT knife 2 group, 19 patients). There were no significant between-group differences in operator-assessed grip convenience (9.600 vs. 9.526, p=0.753), cutting ability (9.600 vs. 9.105, p=0.158), or assistant-assessed grip convenience (9.500 vs. 9.368, p=0.574).
Conclusions
The core knife achieved therapeutic outcomes that were comparable to those of the IT knife 2 for ESD of gastric mucosal lesions.

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Feasibility and safety of endoscopic submucosal dissection for lesions in proximity to a colonic diverticulum: Nobuaki Ikezawa, Takashi Toyonaga, Shinwa Tanaka, Tetsuya Yoshizaki, Toshitatsu Takao, Hirofumi Abe, Hiroya Sakaguchi, Kazunori Tsuda, Satoshi Urakami, Tatsuya Nakai, Taku Harada, Kou Miura, Takahisa Yamasaki, Stuart Kostalas, Yoshinori Morita, Yuzo Kodama; Clin Endosc 2022;55(3):417-425. Published online May 12, 2022; DOI: https://doi.org/10.5946/ce.2021.245

Abstract PDF Supplementary Material

Background
/Aims: Endoscopic submucosal dissection (ESD) for diverticulum-associated colorectal lesions is generally contraindicated because of the high risk of perforation. Several studies on patients with such lesions treated with ESD have been reported recently. However, the feasibility and safety of ESD for lesions in proximity to a colonic diverticulum (D-ESD) have not been fully clarified. The aim of this study was to evaluate the feasibility and safety of D-ESD.
Methods
D-ESD was defined as ESD for lesions within approximately 3 mm of a diverticulum. Twenty-six consecutive patients who underwent D-ESD were included. Two strategic approaches were used depending on whether submucosal dissection of the diverticulum-related part was required (strategy B) or not (strategy A). Treatment outcomes and adverse events associated with each strategy were analyzed.
Results
The en bloc resection rate was 96.2%. The rates of R0 and curative resection in strategies A and B were 80.8%, 73.1%, 84.6%, and 70.6%, respectively. Two cases of intraoperative perforation and one case of delayed perforation occurred. The delayed perforation case required emergency surgery, but the other cases were managed conservatively.
Conclusions
D-ESD may be a feasible treatment option. However, it should be performed in a high-volume center by expert hands because it requires highly skilled endoscopic techniques.

Citations

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Case Report: Successful endoscopic resection of a huge rectal tumor extending to the dentate line and associated with a diverticulum by endoscopic submucosal dissection
Bing-Jie Yan, Yu-Fan Li, Ze Qi, Ming-Wei Zhang, Lei Li
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Taiji Yoshimoto, Daisuke Matsuyama, Ayaka Nakanishi, Kei Nakatani, Kosuke Nagakura, Hiroo Ishii, Hiroshi Takihara
Oxford Medical Case Reports.2026;[Epub] CrossRef
Novel technique “short myotomy” during endoscopic submucosal dissection for a diverticulum‐associated colonic lesion
Ryosuke Kobayashi, Kingo Hirasawa, Shin Maeda
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Predictive Factors for Procedure Time for Closure of Mucosal Defect Following Colorectal Endoscopic Submucosal Dissection
Hideaki Kazumori, Rurika Masatsugu, Kousuke Fukuda, Koji Onishi, Yasuhiko Ohno
JGH Open.2025;[Epub] CrossRef
Endoscopic cap-assisted mucosal resection of intradiverticular polyp
Lorenzo Del Nero, Massimo Conio
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Yuuri Hatsuzawa, Shingo Tsujinaka, Tomoya Miura, Yoh Kitamura, Atsushi Mitamura, Kentaro Sawada, Makoto Hikage, Toru Nakano, Chikashi Shibata
World Journal of Gastrointestinal Endoscopy.2025;[Epub] CrossRef
Closure with a dual-action tissue clip for full-thickness defects following endoscopic submucosal dissection of a lesion involving a colonic diverticulum
Ryosuke Kobayashi, Kingo Hirasawa, Atsushi Sawada, Masafumi Nishio, Chiko Sato, Shin Maeda
Endoscopy.2025; 57(S 01): E1421. CrossRef
Endoscopic submucosal dissection for diverticulum using combination of countertraction and circumferential-inversion method
Hiroshi Takayama, Yoshinori Morita, Toshitatsu Takao, Douglas Motomura, Madoka Takao, Takashi Toyonaga, Yuzo Kodama
Endoscopy.2024; 56(S 01): E91. CrossRef
Traction-assisted endoscopic submucosal dissection for resection of ileocecal valve neoplasia: a French retrospective multicenter case series
Clara Yzet, Timothée Wallenhorst, Jérémie Jacques, Mariana Figueiredo Ferreira, Jérôme Rivory, Florian Rostain, Louis-Jean Masgnaux, Jean Grimaldi, Romain Legros, Pierre Lafeuille, Jérémie Albouys, Fabien Subtil, Marion Schaefer, Mathieu Pioche
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Sol Kim, Bo-In Lee
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Strategies to successfully complete complex ESD in the colon
David Barquero Declara, Alex Blasco Pelicano, Claudia Berbel Comas, Alfredo Mata Bilbao
Endoscopy International Open.2024; 12(07): E914. CrossRef
Successful planned piecemeal endoscopic resection using gel immersion and an over-the-scope clip for a lesion extensively extended into the colonic diverticulum
Tomoaki Tashima, Takahiro Muramatsu, Tomonori Kawasaki, Tsubasa Ishikawa, Shomei Ryozawa
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Sen Lu, Cheng-You Jia, Jian-She Yang
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Iatrogenic colorectal perforation caused by a clip
Hirotaka Oura, Yasuki Hatayama, Erika Nomura, Harutoshi Sugiyama, Daisuke Murakami, Makoto Arai, Takayoshi Nishino
Endoscopy.2023; 55(S 01): E1091. CrossRef

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Outcomes of endoscopic submucosal dissection for superficial esophageal neoplasms in patients with liver cirrhosis: Young Kwon Choi, Jin Hee Noh, Do Hoon Kim, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung; Clin Endosc 2022;55(3):381-389. Published online April 20, 2022; DOI: https://doi.org/10.5946/ce.2021.242

Abstract PDF Supplementary Material

Background
/Aims: The treatment of superficial esophageal neoplasms (SENs) in cirrhotic patients is challenging and rarely investigated. We evaluated the outcomes of endoscopic submucosal dissection (ESD) to determine the efficacy and safety of treating SENs in patients with liver cirrhosis.
Methods
The baseline characteristics and treatment outcomes of patients who underwent ESD for SENs between November 2005 and December 2017 were retrospectively reviewed.
Results
ESD was performed in 437 patients with 481 SENs, including 15 cirrhotic patients with 17 SENs. En bloc resection (88.2% vs. 97.0%) and curative resection (64.7% vs. 78.9%) rates were not different between the cirrhosis and non-cirrhosis groups (p=0.105 and p=0.224, respectively). Bleeding was more common in cirrhotic patients (p=0.054), and all cases were successfully controlled endoscopically. The median procedure and hospitalization duration did not differ between the groups. Overall survival was lower in cirrhotic patients (p=0.003), while disease-specific survival did not differ between the groups (p=0.85).
Conclusions
ESD could be a safe and effective treatment option for SENs in patients with cirrhosis. Detailed preprocedural assessments are needed, including determination of liver function, esophageal varix status, and remaining life expectancy, to identify patients who will obtain the greatest benefit.

Citations

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Endoscopic resection of early esophageal neoplasia in patients with esophageal varices: a systematic review
Charlotte N. Frederiks, Laura S. Boer, Bas Gloudemans, Lorenza Alvarez Herrero, Jacques J.G.H.M. Bergman, Roos E. Pouw, Bas L.A.M. Weusten
Endoscopy.2025; 57(07): 769. CrossRef
Clinical outcomes of endoscopic submucosal dissection for esophageal squamous cell carcinoma with esophageal varices: Multicenter retrospective study
Yosuke Toya, Waku Hatta, Tomohiro Shimada, Tamotsu Matsuhashi, Takeharu Shiroki, Yu Sasaki, Tetsuya Tatsuta, Jun Nakamura, Norihiro Hanabata, Yohei Horikawa, Ko Nagino, Tomoyuki Koike, Atsushi Masamune, Yoshihiro Harada, Tetsuya Ohira, Katsunori Iijima, Y
Digestive Endoscopy.2024; 36(3): 314. CrossRef
Clinical outcomes of endoscopic submucosal dissection for superficial esophageal neoplasia in close proximity to esophageal varices: a multicenter international experience
Shruti Mony, Bing Hu, Abel Joseph, Hiroyuki Aihara, Lorenzo Ferri, Amit Bhatt, Amit Mehta, Peng-Sheng Ting, Alex Chen, Andrew Kalra, Jad Farha, Manabu Onimaru, Long He, Qi Luo, Andrew Y. Wang, Haruhiro Inoue, Saowanee Ngamruengphong
Endoscopy.2024; 56(02): 119. CrossRef
Risk associated with endoscopic treatment of early upper gastrointestinal cancer in patients with liver cirrhosis and management strategies
Yu-Yong Tan, Yu-Min Qing, Jian Gong, De-Liang Liu
World Chinese Journal of Digestology.2024; 32(2): 102. CrossRef
Radical chemoradiotherapy for superficial esophageal cancer complicated with liver cirrhosis
Hejing Bao, Hehong Bao, Liping Lin, Yuhuan Wang, Longbin Zhang, Li Zhang, Han Zhang, Lingxiang Liu, Xiaolong Cao
PeerJ.2024; 12: e18065. CrossRef
Endoscopic management of early esophageal cancer in patients with concomitant cirrhosis
Linlin Zhu, Zhenming Zhang
Chinese Medical Journal.2024; 137(24): 3142. CrossRef
Endoscopic submucosal dissection for early cancers or precancerous lesions of the upper GI tract in cirrhotic patients with esophagogastric varices: 10-year experience from a large tertiary center in China
Shuai Zhang, Ying-Di Liu, Ning-Li Chai, Yi Yao, Fei Gao, Bo Liu, Zhan-Di He, Lu Bai, Xin Huang, Chao Gao, En-Qiang Linghu, Lian-Yong Li
Gastrointestinal Endoscopy.2023; 97(6): 1031. CrossRef
Endoscopic Submucosal Dissection for Treatment of Early-Stage Cancer or Precancerous Lesion in the Upper Gastrointestinal Tract in Patients with Liver Cirrhosis
Yuyong Tan, Yumin Qing, Deliang Liu, Jian Gong
Journal of Clinical Medicine.2023; 12(20): 6509. CrossRef

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Efficacy and Safety of Endoscopic Submucosal Dissection for Superficial Gastric Neoplasms: A Latin American Cohort Study: Fernando Palacios-Salas, Harold Benites-Goñi, Luis Marin-Calderón, Paulo Bardalez-Cruz, Jorge Vásquez-Quiroga, Edgar Alva-Alva, Bryan Medina-Morales, Jairo Asencios-Cusihuallpa; Clin Endosc 2022;55(2):248-255. Published online November 12, 2021; DOI: https://doi.org/10.5946/ce.2021.192

Abstract PDF

Background
/Aims: Endoscopic submucosal dissection (ESD) is the preferred technique for treating early gastric cancer (EGC). However, very few studies have been conducted in South America. This study aimed to assess the efficacy and safety of ESD for EGC.
Methods
We analyzed data from a prospective cohort from 2013 to 2020. A total of 152 superficial gastric neoplasms that fulfilled the absolute or expanded criteria for ESD were included. Outcomes were en bloc, R0, and curative resection rates, incidence of adverse events, and length of procedure.
Results
The age of the enrolled patients was 68.4±11.3 years. The number of included patients based on the absolute and expanded indications was 150 and 2, respectively. En bloc, R0, and curative resections were achieved in 98.0%, 96.1%, and 89.5% of the cases, respectively. Bleeding and perforation were reported in 5.9% and 6.6% of the cases, respectively. Histopathological examination revealed lowgrade dysplasia, high-grade dysplasia, well-differentiated adenocarcinoma, and poorly differentiated adenocarcinoma in 13, 20, 117, and 2 cases, respectively.
Conclusions
Our study shows that ESD performed by properly trained endoscopists in reference centers is safe and effective, with comparable therapeutic outcomes to those reported in the Eastern series.

Citations

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Chilean Association of Digestive Endoscopy (ACHED) guidelines for the detection of early gastric cancer and surveillance of gastric premalignant conditions in high-risk populations
Gonzalo Latorre, Alberto Espino, Raúl Araya, Matías Arteaga, Harold Benites-Goñi, María Ester Bufadel, Dacio Cabrera-Hinojosa, Roberto Candia, Julian Cordero, Oscar Corsi, Pablo Cortés, Felipe Donoso, Fabian Emura, Carolina Heredia, Daniel Martínez, Rodri
Gastroenterología y Hepatología.2026; 49(3): 502633. CrossRef
Chilean Association of Digestive Endoscopy (ACHED) guidelines for the detection of early gastric cancer and surveillance of gastric premalignant conditions in high-risk populations
Gonzalo Latorre, Alberto Espino, Raúl Araya, Matías Arteaga, Harold Benites-Goñi, María Ester Bufadel, Dacio Cabrera-Hinojosa, Roberto Candia, Julian Cordero, Oscar Corsi, Pablo Cortés, Felipe Donoso, Fabian Emura, Carolina Heredia, Daniel Martínez, Rodri
Gastroenterología y Hepatología (English Edition).2026; 49(3): 502633. CrossRef
Treatment of early gastric cancer in Sweden: A nationwide registry-based cohort study
Henrik Maltzman, Peter Elbe, Martin Jeremiasen, Masami Omae, Francisco Baldaque-Silva, Erik von Seth, Mats Lindblad, Fredrik Klevebro
Scandinavian Journal of Surgery.2026;[Epub] CrossRef
Outcomes and validity of risk stratification tools for endoscopic submucosal dissection of early gastric cancer in Western Australia
Ciaran Judge, Abir Halder, Puraskar Pateria, Tzeng Khor, Niroshan Muwanwella, Marcus Chin, Krish Ragunath
JGH Open.2024;[Epub] CrossRef
Disección submucosa endoscópica en cáncer gástrico temprano indiferenciado: evaluación de los primeros casos y análisis de su aplicación como indicación absoluta en Perú
Fernando Palacios-Salas, Luis Marin-Calderón, Juan Chirinos-Vega, Paulo Bardalez-Cruz, Patricia Valera-Luján, Dacio Cabrera-Hinojosa, Harold Benites-Goñi
Revista de Gastroenterología del Perú.2024; 44(4): 333. CrossRef
Short-Term and Long-Term Outcomes of Liver Cirrhosis in Gastric Neoplasm Patients Undergoing Endoscopic Submucosal Dissection
Xu-Rui Liu, Lian-Shuo Li, Fei Liu, Zi-Wei Li, Xiao-Yu Liu, Wei Zhang, Dong Peng
Journal of Laparoendoscopic & Advanced Surgical Techniques.2023; 33(7): 640. CrossRef
Endoscopic submucosal dissection for early gastric cancer: It is time to consider the quality of its outcomes
Gwang Ha Kim
World Journal of Gastroenterology.2023; 29(43): 5800. CrossRef
Endoscopic diagnosis of early gastric cancer
Dong Chan Joo, Gwang Ha Kim
Journal of the Korean Medical Association.2022; 65(5): 267. CrossRef
Therapeutic approach to non-curative resection after endoscopic treatment in early gastric cancer
Eun Jeong Gong, Chang Seok Bang
Journal of the Korean Medical Association.2022; 65(5): 284. CrossRef

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Clinical Impact of Different Reconstruction Methods on Remnant Gastric Cancer at the Anastomotic Site after Distal Gastrectomy: Kei Matsumoto, Shinwa Tanaka, Takashi Toyonaga, Nobuaki Ikezawa, Mari Nishio, Masanao Uraoka, Tomoatsu Yoshihara, Hiroya Sakaguchi, Hirofumi Abe, Tetsuya Yoshizaki, Madoka Takao, Toshitatsu Takao, Yoshinori Morita, Hiroshi Yokozaki, Yuzo Kodama; Clin Endosc 2022;55(1):86-94. Published online August 13, 2021; DOI: https://doi.org/10.5946/ce.2021.084

Abstract PDF Supplementary Material: Background
/Aims: The anastomotic site after distal gastrectomy is the area most affected by duodenogastric reflux. Different reconstruction methods may affect the lesion characteristics and treatment outcomes of remnant gastric cancers at the anastomotic site. We retrospectively investigated the clinicopathologic and endoscopic submucosal dissection outcomes of remnant gastric cancers at the anastomotic site.
Methods
We recruited 34 consecutive patients who underwent endoscopic submucosal dissection for remnant gastric cancer at the anastomotic site after distal gastrectomy. Clinicopathology and treatment outcomes were compared between the Billroth II and non-Billroth II groups.
Results
The tumor size in the Billroth II group was significantly larger than that in the non-Billroth II group (22 vs. 19 mm; p=0.048). More severe gastritis was detected endoscopically in the Billroth II group (2 vs. 1.33; p=0.0075). Moreover, operation time was longer (238 vs. 121 min; p=0.004) and the frequency of bleeding episodes was higher (7.5 vs. 3.1; p=0.014) in the Billroth II group.
Conclusions
Compared to remnant gastric cancers in non-Billroth II patients, those in the Billroth II group had larger lesions with a background of severe remnant gastritis. Endoscopic submucosal dissection for remnant gastric cancers in Billroth II patients involved longer operative times and more frequent bleeding episodes than that in patients without Billroth II.

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Clinical Outcomes and Adverse Events of Gastric Endoscopic Submucosal Dissection of the Mid to Upper Stomach under General Anesthesia and Monitored Anesthetic Care: Jong-In Chang, Tae Jun Kim, Na Young Hwang, Insuk Sohn, Yang Won Min, Hyuk Lee, Byung-Hoon Min, Jun Haeng Lee, Poong-Lyul Rhee, Jae J Kim; Clin Endosc 2022;55(1):77-85. Published online July 5, 2021; DOI: https://doi.org/10.5946/ce.2021.002

Abstract PDF Supplementary Material

Background
/Aims: Endoscopic submucosal dissection (ESD) of gastric tumors in the mid-to-upper stomach is a technically challenging procedure. This study compared the therapeutic outcomes and adverse events of ESD of tumors in the mid-to-upper stomach performed under general anesthesia (GA) or monitored anesthesia care (MAC).
Methods
Between 2012 and 2018, 674 patients underwent ESD for gastric tumors in the midbody, high body, fundus, or cardia (100 patients received GA; 574 received MAC). The outcomes of the propensity score (PS)-matched (1:1) patients receiving either GA or MAC were analyzed.
Results
The PS matching identified 94 patients who received GA and 94 patients who received MAC. Both groups showed high rates of en bloc resection (GA, 95.7%; MAC, 97.9%; p=0.68) and complete resection (GA, 81.9%; MAC, 84.0%; p=0.14). There were no significant differences between the rates of adverse events (GA, 16.0%; MAC, 8.5%; p=0.18) in the anesthetic groups. Logistic regression analysis indicated that the method of anesthesia did not affect the rates of complete resection or adverse events.
Conclusions
ESD of tumors in the mid-to-upper stomach at our high-volume center had good outcomes, regardless of the method of anesthesia. Our results demonstrate no differences between the efficacies and safety of ESD performed under MAC and GA.

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Case Report

Gastric Angiolipoma Resected with Endoscopic Submucosal Dissection: Sang Myung Yeo, Jae Kwang Lee, Hyun Soo Kim, Chang Geun Park, Jae Kwon Jung, Dae Jin Kim, Yun Jin Chung, Han Jun Ryu; Clin Endosc 2021;54(3):432-435. Published online March 15, 2021; DOI: https://doi.org/10.5946/ce.2020.146

Abstract PDF

Angiolipoma is a benign fatty neoplasm that has components of proliferating blood vessels. These types of lesions commonly occur in the subcutaneous tissue of the limbs and trunk. Angiolipoma in the gastrointestinal tract is extremely rare, and the final diagnosis generally depends on histological examination of the excised biopsy. In most previously reported cases, the lesions were diagnosed and treated with surgical management. In this study, we report a case of gastric angiolipoma of approximately 4 cm in size that was diagnosed and treated with endoscopic submucosal dissection.

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Yuanning Ye, Futao Wu, Siqi Yang, Lingling Guo, Jianqun Cai, Bo Fu, Aimin Li
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Xiufan Ni, Sujun Gao, Lei Chen, Li Zhang, Jian Yin, Zhen Zhu
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A Huge Gastric Angiolipoma Presenting with Acute Upper Gastrointestinal Hemorrhage: A Case Report
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Current Medical Imaging Formerly Current Medical Imaging Reviews.2023;[Epub] CrossRef

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Original Article

Endoscopic Submucosal Dissection versus Surgery for Undifferentiated-Type Early Gastric Cancer: A Systematic Review and Meta-Analysis: Cheal-Wung Huh, Dae Won Ma, Byung-Wook Kim, Joon Sung Kim, Seung Jae Lee; Clin Endosc 2021;54(2):202-210. Published online February 17, 2021; DOI: https://doi.org/10.5946/ce.2020.121

Abstract PDF

Background
/Aims: The use of endoscopic submucosal dissection (ESD) for treating undifferentiated-type early gastric cancer is controversial. The objective of this study was to perform a meta-analysis to compare the long-term outcomes of ESD and surgery for undifferentiated-type early gastric cancer.
Methods
The PubMed, Cochrane Library, and EMBASE databases were used to search for relevant studies comparing ESD and surgery for undifferentiated-type early gastric cancer. The methodological quality of the included publications was evaluated using the Risk of Bias Assessment tool for Nonrandomized Studies. The rates of overall survival, recurrence, adverse event, and complete resection were determined. Odds ratios (ORs) and 95% confidence intervals (CIs) were also evaluated.
Results
This meta-analysis enrolled five studies with 429 and 1,236 participants undergoing ESD and surgery, respectively. No significant difference was found in the overall survival rate between the ESD and surgery groups (OR, 2.29; 95% CI, 0.98–5.36; p=0.06). However, ESD was associated with a higher recurrence rate and a lower complete resection rate. The adverse event rate was similar between the two groups.
Conclusions
ESD with meticulous surveillance esophagogastroduodenoscopy may be as effective and safe as surgery in patients with undifferentiated-type early gastric cancer. Further large-scale, randomized, controlled studies from additional regions are required to confirm these findings.

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Case Reports

Successful Endoscopic Resection of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Unresponsive to Helicobacter pylori Eradication Therapy: Jeongmin Choi; Clin Endosc 2022;55(1):136-140. Published online November 16, 2020; DOI: https://doi.org/10.5946/ce.2020.232

Abstract PDF

Eradication of Helicobacter pylori is the first-line treatment for gastric mucosa-associated lymphoid tissue (MALT) lymphomas; however, lesions may persist in 20% of patients after initial treatment, thereby necessitating the use of an additional therapeutic approach. Other treatment options include radiation therapy, chemotherapy, endoscopic resection, rituximab therapy, or watchful waiting. We present a case of localized gastric MALT lymphoma that did not respond to H. pylori eradication therapy. The patient waited for 12 months but the tumor showed no signs of regression endoscopically. Histologic examination revealed residual MALT lymphoma. The tumor was then successfully treated using endoscopic submucosal dissection and the patient remained disease-free for 4 years. To our knowledge, this is the first case in which a gastric MALT lymphoma was treated with endoscopic submucosal dissection. In conclusion, endoscopic resection may be recommended as second-line therapy for properly selected patients with gastric MALT lymphoma as it is effective and minimally invasive.

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A Common Symptom With an Uncommon Diagnosis: A Case of Primary Esophageal Diffuse Large B-cell Lymphoma
Shruthi Narasimha, Rasiq Zackria, Jonathan Hughes, Vijay Jayaraman
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A Case of Esophageal MALT Lymphoma Mimicking a Subepithelial Tumor
Ha Eun Lee, Gwang Ha Kim, Min Ji Kim, Kyung Bin Kim, Dong Chan Joo, Hye Kyung Jeon, Moon Won Lee, Bong Eun Lee
The Korean Journal of Gastroenterology.2024; 83(4): 157. CrossRef
Characteristics of Gastric Mucosa-associated Lymphoid Tissue Lymphoma in Korea
Tae-Woo Kim, Joon Sung Kim
The Korean Journal of Gastroenterology.2024; 84(6): 243. CrossRef
Clinical Management of Patients with Gastric MALT Lymphoma: A Gastroenterologist’s Point of View
Tamara Matysiak-Budnik, Kateryna Priadko, Céline Bossard, Nicolas Chapelle, Agnès Ruskoné-Fourmestraux
Cancers.2023; 15(15): 3811. CrossRef
Endoscopic Submucosal Dissection for Treatment of Localized Gastric Mucosa-associated Lymphoid Tissue Lymphoma: A Case Series
Jun-young Seo, Kee Don Choi, In Hye Song, Young Soo Park, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2023; 23(3): 188. CrossRef
Bacteria-Mediated Oncogenesis and the Underlying Molecular Intricacies: What We Know So Far
Shashanka K. Prasad, Smitha Bhat, Dharini Shashank, Akshatha C. R., Sindhu R., Pornchai Rachtanapun, Devananda Devegowda, Prasanna K. Santhekadur, Sarana Rose Sommano
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Junchi Qu, Yanyan Zhuang, Dandan Zheng, Fengting Huang, Shineng Zhang
Cureus.2021;[Epub] CrossRef

9,109 View
243 Download
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7 Crossref

Perforation of a Gastric Tear during Esophageal Endoscopic Submucosal Dissection under General Anesthesia: Tomoaki Yamasaki, Yuhei Sakata, Takehisa Suekane, Hiroko Nebiki; Clin Endosc 2021;54(6):916-919. Published online November 12, 2020; DOI: https://doi.org/10.5946/ce.2020.220

Abstract PDF

Mallory-Weiss tears (MWT) are occasionally encountered during endoscopic procedures. Esophageal endoscopic submucosal dissection (ESD) is widely performed under general anesthesia to avoid unexpected body movements. We present the case of a 68-year-old woman with squamous cell carcinoma. Although ESD was performed under general anesthesia, a gastric perforation at the MWT caused by gastric inflation was observed after the procedure. The perforation was closed endoscopically, and she was discharged without any sequelae. Although general anesthesia is useful for esophageal ESD, it should be noted that it can cause MWT, and in rare cases, gastric perforation, due to gastric inflation during the procedure.

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Gastric Perforation Encountered during Duodenal Stent Insertion
Sung Woo Ko, Hoonsub So, Sung Jo Bang
The Korean Journal of Gastroenterology.2022; 80(5): 221. CrossRef

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107 Download
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Successful Endoscopic Resection of Residual Colonic Mucosa-Associated Lymphoid Tissue Lymphoma after Polypectomy: Jeongmin Choi; Clin Endosc 2021;54(5):759-762. Published online November 6, 2020; DOI: https://doi.org/10.5946/ce.2020.233

Abstract PDF

Mucosa-associated lymphoid tissue (MALT) lymphomas are typically found in the stomach, while colonic MALT lymphoma is rarely found. Considering its rarity, definitive treatment of colonic MALT lymphoma has not been established. Different from that in the stomach, Helicobacter pylori infection might play a minor role while determining the treatment of colonic MALT lymphoma. If colonic MALT lymphoma is localized, treatment options are surgical resection, radiation, endoscopic resection, or combination therapy. Here, we report a case of residual colonic MALT lymphoma after endoscopic mucosal resection, which was a 1.5-cm-sized tumor confined to the superficial wall of the rectum. The lesion was successfully treated using the endoscopic submucosal dissection technique. The patient remained disease-free for 4 years. This case provides rationale for endoscopic submucosal dissection treatment as a salvage therapy for residual tumors in properly selected patients with colonic MALT lymphoma.

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Kyoung Wan Kim, Minjee Kim, Sung Noh Hong, Dong Kyung Chang, Young Ho Kim, Eun Ran Kim, Ji Eun Kim
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Jian Han, Zhe Zhu, Chao Zhang, Hua-ping Xie
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Original Article

Efficacy of the Envelope Method in Applying Polyglycolic Acid Sheets to Post-Endoscopic Submucosal Dissection Ulcers in Living Pigs: Hiroya Sakaguchi, Toshitatsu Takao, Yoshitaka Takegawa, Yuki Koga, Kazunori Yamanaka, Masataka Sagata, Shinwa Tanaka, Yoshinori Morita, Takashi Toyonaga, Yuzo Kodama; Clin Endosc 2021;54(1):64-72. Published online July 16, 2020; DOI: https://doi.org/10.5946/ce.2020.014

Abstract PDF Supplementary Material

Background
/Aims: Application of polyglycolic acid (PGA) sheets using fibrin glue in post-endoscopic submucosal dissection (ESD) ulcers to prevent bleeding has been reported to be difficult with the conventional delivery method because of gravity. This study assessed the usefulness of the envelope-based delivery system with and against gravity in living pigs.
Methods
PGA sheets were applied on post-ESD ulcers with and against gravity six times each using the conventional and envelope methods, respectively. The PGA sheet delivery time and the endoscopic and histological findings of the treated ulcer floors were compared.
Results
With gravity, the median PGA sheet application time was 1.00 (0.68–1.30) min/cm² and 0.32 (0.18–0.52) min/cm² with the conventional and envelope techniques (p=0.002), respectively, and against gravity, it was 1.20 (1.13–1.63) min/cm² and 0.50 (0.39–0.58) min/cm² (p=0.002), respectively. Against gravity, the endoscopic and histological findings revealed that the conventional group had insufficient fixation of the PGA sheets, but the envelope groups had sufficient fixation. The results with gravity were similar between the groups.
Conclusions
The envelope method makes it possible to deliver PGA sheets to the stomach quickly and cover ulcers appropriately both with and against gravity in living pigs.

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Yoshitaka Takegawa, Toshitatsu Takao, Hiroya Sakaguchi, Tatsuya Nakai, Kazuhiro Takeo, Yoshinori Morita, Takashi Toyonaga, Yuzo Kodama
Scientific Reports.2022;[Epub] CrossRef
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Meng Li, Haifeng Jin, Changpei Shi, Bin Lyu, Xiao Ying, Yuan Shi
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143 Download
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Review

Photodynamic Therapy for Esophageal Cancer: Takahiro Inoue, Ryu Ishihara; Clin Endosc 2021;54(4):494-498. Published online May 19, 2020; DOI: https://doi.org/10.5946/ce.2020.073

Abstract PDF

Photodynamic therapy, a curative local treatment for esophageal squamous cell carcinoma, involves a photosensitizing drug (photosensitizer) with affinity for tumors and a photodynamic reaction triggered by laser light. Previously, photodynamic therapy was used to treat superficial esophageal squamous cell carcinoma judged to be difficult to undergo endoscopic resection. Recently, photodynamic therapy has mainly been performed for local failure after chemoradiotherapy. Although surgery is the most promising treatment for local failure after chemoradiotherapy, its morbidity and mortality rates are high. Endoscopic resection is feasible for local failure after chemoradiotherapy but requires advanced skills, and its indication is limited to within the submucosal layer by depth. Photodynamic therapy is less invasive than surgery and has a wider indication than endoscopic resection. Porfimer sodium (a first-generation photosensitizer) causes a high frequency of side effects related to photosensitivity and requires the long-term sunshade period. Talaporfin (a second-generation photosensitizer) requires a much shorter sun-shade period than porfimer sodium. Photodynamic therapy will profoundly change treatment strategies for local failure after chemoradiotherapy.

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Original Articles

Efficacy and Safety of Endoscopic Treatment for Gastrointestinal Stromal Tumors in the Upper Gastrointestinal Tract: Cicilia Marcella, Shakeel Sarwar, Hui Ye, Rui Hua Shi; Clin Endosc 2020;53(4):458-465. Published online March 17, 2020; DOI: https://doi.org/10.5946/ce.2019.121

Abstract PDF

Background
/Aims: Endoscopic treatment (ET) has been applied for decades to treat subepithelial tumors, including gastrointestinal stromal tumors (GISTs). However, the efficacy of ET remains debatable. In this study, we evaluated the efficacy and safety of ET for GISTs in the upper gastrointestinal tract.
Methods
This retrospective single-center study included 97 patients who underwent ET. All patients were enrolled from July 2014 to July 2018. Parameters such as demographics, size, resection margin, complications, pathological features, procedure time, total cost, and follow-up were investigated and analyzed.
Results
Our study achieved 100% en bloc resection and 77.4% (72/93) R0 resection. The most common location was the fundus with a mean tumor size of 2.1±1.43 cm. The mean age, procedure time, hospital stay, and cost were 59.7±11.29 years, 64.7±35.23 minutes, 6.8 days, and 5,337 dollars, respectively. According to National Institutes of Health classification, 63 (64.9%), 26 (26.8%), 5 (5.2%), and 3 (3.1%) patients belonged to the very low, low, intermediate, and high risk classification, respectively. Immunohistochemistry results showed a 100% positive rate of CD34, DOG-1, CD117, and Ki67. A mean follow-up of 21.3±13.0 months showed no recurrence or metastasis.
Conclusions
ET is effective and safe for curative removal of GISTs in the upper gastrointestinal tract, and it can be a treatment of choice for patients with no metastasis.

Citations

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Seong-Jung Kim, Eun Jeong Kim, Min Hyeok Lee, Jun Lee
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Jinping Yang, Muhan Ni, Jingwei Jiang, Ximei Ren, Tingting Zhu, Shouli Cao, Shahzeb Hassan, Ying Lv, Xiaoqi Zhang, Yongyue Wei, Lei Wang, Guifang Xu
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Jinlong Hu, Xinzhu Sun, Nan Ge, Sheng Wang, Jintao Guo, Xiang Liu, Guoxin Wang, Siyu Sun
BMC Gastroenterology.2022;[Epub] CrossRef
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Seokin Kang, Do Hoon Kim, Yuri Kim, Dongsub Jeon, Hee Kyong Na, Jeong Hoon Lee, Ji Yong Ahn, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Journal of Korean Medical Science.2022;[Epub] CrossRef
Massive Digestive Hemorrhagia Revealing a Gastro-Intestinal Stromal Tumor of the Jejunum
Yasmine Cherouaqi, Fatima zahra Belabbes, Hanane Delsa, Anass Nadi, Fedoua Rouibaa
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Recent advances in the management of gastrointestinal stromal tumor
Monjur Ahmed
World Journal of Clinical Cases.2020; 8(15): 3142. CrossRef

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Efficacy and Safety of Complete Endoscopic Resection of Colorectal Neoplasia Using a Stepwise Endoscopic Protocol with SOUTEN, a Novel Multifunctional Snare: Shinji Yoshii, Marina Kubo, Mio Matsumoto, Takefumi Kikuchi, Yasunari Takakuwa; Clin Endosc 2020;53(2):206-212. Published online February 27, 2020; DOI: https://doi.org/10.5946/ce.2019.117

Abstract PDF Supplementary Material

Background
/Aims: A multifunctional snare SOUTEN has a sharp tip at the top of the snare loop that enables incision of the mucosa, dissection of the submucosal layer, and snaring of lesion. This study assessed the efficacy and safety of complete endoscopic resection of colorectal neoplasia using SOUTEN.
Methods
We analyzed the rates of gross en bloc resection and complete resections of 108 consecutive tumors from 69 patients resected by precutting endoscopic mucosal resection (precutting), hybrid endoscopic submucosal dissection (hybrid), or conventional endoscopic submucosal dissection (conventional) using SOUTEN.
Results
Out of the 108 tumors, 50 were resected by precutting, 27 were resected by hybrid after attempting precutting, and the remaining 31 were resected by conventional after attempting precutting and hybrid resections. The median tumor sizes were 14.5 mm for precutting, 16.4 mm for hybrid, and 21.1 mm for conventional. The success rate of gross en bloc resection and histological complete resection were 100% and 94.0% for precutting, 96.4% and 96.4% for hybrid, and 100% and 100% for conventional method, respectively. No procedure-related complication occurred.
Conclusions
By using SOUTEN, precutting and hybrid were successfully performed on 10–30 mm tumors with a shorter procedure time than conventional without major complications.

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Case Report

Endoscopic Submucosal Dissection of a Colonic Calcifying Fibrous Tumor: Jaeyoung Kim, Seongyul Ryu, Yeon-Ji Kim; Clin Endosc 2020;53(4):487-490. Published online January 21, 2020; DOI: https://doi.org/10.5946/ce.2019.138

Abstract PDF

A 49-year-old woman was referred to our hospital for further treatment due to the suspicion of a submucosal tumor in a routine screening colonoscopy. On colonoscopy, a 1-cm sized subepithelial mass with normal overlying mucosa in the hepatic flexure was found. Endoscopic ultrasonography (EUS) showed a homogenous hypoechoic lesion arising from the second and third layer. We were unable to make a final diagnosis because the lesion showed a small tumor with atypical macroscopic morphology including EUS findings. Therefore, endoscopic submucosal dissection was performed for the diagnostic treatment of the tumor. Submucosal dissection was performed just above the muscle layer, and the tumor was removed completely and reliably without any acute complications such as perforation. Based on histopathological findings, we diagnosed a benign, calcifying fibrous tumor (CFT). The present case is the first report of successful endoscopic diagnosis and treatment of colonic CFT mimicking a submucosal tumor.

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Eun Young Park, Dong Hoon Baek, Seung Min Hong, Bong Eun Lee, Moon Won Lee, Gwang Ha Kim, Geun Am Song
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Focused Review Series: Cutting Edge of Advanced Therapeutic Endoscopy

Present Status of Endoscopic Submucosal Dissection for Non-Ampullary Duodenal Epithelial Tumors: Naomi Kakushima, Masao Yoshida, Yohei Yabuuchi, Noboru Kawata, Kohei Takizawa, Yoshihiro Kishida, Sayo Ito, Kenichiro Imai, Kinichi Hotta, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Hiroyuki Ono; Clin Endosc 2020;53(6):652-658. Published online January 15, 2020; DOI: https://doi.org/10.5946/ce.2019.184

Abstract PDF

Prediction of histology by endoscopic examination is important in the clinical management of non-ampullary duodenal epithelial tumors (NADETs), including adenoma and adenocarcinoma. The use of a simple scoring system based on the findings of white-light endoscopy or magnified endoscopy with narrow-band imaging is useful to differentiate between Vienna category 3 (C3) and C4/5 lesions. Less invasive endoscopic resection procedures, such as cold snare polypectomy, are quick to perform and convenient for small (<10 mm) C3 lesions. Neoplasms with higher grade histology, such as C4/5 lesions, should be treated by endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), or surgery. Although EMR often requires piecemeal resection, the complication rate is acceptable. Excellent complete resection rates could be achieved by ESD; however, it remains a challenging method considering the high risk of complications. Shielding or closure of the ulcer after ESD is effective at decreasing the risk of delayed bleeding and perforation. Laparoscopic endoscopic cooperative surgery is an ideal treatment with a high rate of en bloc resection and a low rate of complications, although it is limited to high-volume centers. Patients with NADETs could benefit from a multidisciplinary approach to stratify the optimal treatment based on endoscopic diagnoses.

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Original Articles

Endoscopic Factors that Can Predict Histological Ulcerations in Early Gastric Cancers: Jaesin Lee, Byung-Wook Kim, Cheal Wung Huh, Joon Sung Kim, Lee-So Maeng; Clin Endosc 2020;53(3):328-333. Published online January 7, 2020; DOI: https://doi.org/10.5946/ce.2019.133

Abstract PDF

Background
/Aims: Predicting histological ulceration in early gastric cancer (EGC) during endoscopic examination is crucial for endoscopists deciding on the treatment modality. The aim of this study was to investigate the endoscopic factors that can predict histological ulcerations in EGCs.
Methods
We retrospectively analyzed patients who underwent endoscopic submucosal dissection (ESD) for EGC. Clinical features and endoscopic characteristics of EGC such as location, histological differentiation, longest diameter, tumor morphology, mucosal break, converging fold, color change, and surface irregularity were reviewed. Histological ulceration was defined based on ESD specimens.
Results
A total of 633 EGC lesions from 613 patients were included and histological ulcerations were found in 90 lesions (14.2%). Presence of converging folds, tumor morphology, and color changes on endoscopic examination were related to histological ulceration in the univariate analysis and converging folds along with color changes were statistically significant factors in the multivariate analysis. Kaplan–Meier analysis showed that patients with histological ulcerations in EGCs tended to have higher marginal recurrence rates.
Conclusions
Mucosal breaks are not equivalent to histological ulcerations. Rather, the existence of converging folds and color changes during endoscopic examination suggest histological ulcerations. Endoscopists should consider these factors when they decide the treatment modality for EGCs.

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Risk Factors and Clinical Outcomes of Non-Curative Resection in Patients with Early Gastric Cancer Treated with Endoscopic Submucosal Dissection: A Retrospective Multicenter Study in Korea: Si Hyung Lee, Min Cheol Kim, Seong Woo Jeon, Kang Nyeong Lee, Jong Jae Park, Su Jin Hong, Korean Society of Gastrointestinal Endoscopy Endoscopic Submucosal Dissection Research Group; Clin Endosc 2020;53(2):196-205. Published online October 25, 2019; DOI: https://doi.org/10.5946/ce.2019.123

Abstract PDF

Background
/Aims: The purpose of this study was to investigate the risk factors and long-term clinical outcomes of non-curative resection (NCR) in a large-scale patient population.
Methods
We retrospectively analyzed the clinical data of 3,094 patients who underwent endoscopic submucosal dissection (ESD) of early gastric cancer from March 2005 to March 2018 at 13 institutions in Korea. We analyzed the risk factors for NCR and the survival between patients with curative resection and those with NCR with no additional treatment.
Results
The NCR rate was 21.4% (661/3,094). In multivariate regression analysis, the risk factors affecting NCR with ESD were old age, undifferentiated tumor, tumor location in the upper body, tumor size ≥2 cm, and presence of an ulcer. In Cox proportional hazard regression analysis, tumor size ≥2 cm, submucosal invasion, positive horizontal margin, and lymphovascular invasion were risk factors for local recurrence. In Kaplan-Meier analysis, there was no statistically significant difference in the overall survival between the two groups (log-rank p=0.788). However, disease-specific survival was significantly lower in the NCR group (log-rank p=0.038).
Conclusions
Clinicians should be aware of the risk factors for NCR and local recurrence after ESD for early gastric cancer, and should consider providing additional treatment after NCR.

Citations

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育池刘
Advances in Clinical Medicine.2026; 16(01): 2515. CrossRef
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The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2026; 26(1): 50. CrossRef
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Clinical Usefulness of Dual Red Imaging in Gastric Endoscopic Submucosal Dissection: A Pilot Study: Naoki Yorita, Shiro Oka, Shinji Tanaka, Takahiro Kotachi, Naoko Nagasaki, Kosaku Hata, Kazutaka Kuroki, Kazuhiko Masuda, Mio Kurihara, Mariko Kiso, Tomoyuki Boda, Masanori Ito, Kazuaki Chayama; Clin Endosc 2020;53(1):54-59. Published online September 3, 2019; DOI: https://doi.org/10.5946/ce.2019.065

Abstract PDF

Background
/Aims: Dual red imaging (DRI) is a new, image-enhanced endoscopy technique. There are few reports about the usefulness of DRI during gastric endoscopic submucosal dissection (ESD). We aimed to examine the usefulness of DRI in endoscopic hemostasis during gastric ESD.
Methods
We enrolled a total of 20 consecutive patients who underwent gastric ESD. Five endoscopists compared DRI with white light imaging (WLI) for the visibility of blood vessels and bleeding points while performing endoscopic hemostasis.
Results
The visibility of blood vessels was increased in 56% (19/34) of the cases, and the visibility of bleeding points was improved in 55% (11/20) of the cases with the use of DRI compared with the use of WLI.
Conclusions
DRI improved the visibility of blood vessels and bleeding points in cases with oozing bleeding, blood pooling around the bleeding points, and multiple bleeding points.

Citations

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Case Report

Pyogenic Liver Abscess Caused by Endoscopic Submucosal Dissection for Early Colon Cancer: Joon Seop Lee, Yong Hwan Kwon; Clin Endosc 2019;52(6):620-623. Published online July 30, 2019; DOI: https://doi.org/10.5946/ce.2018.185

Abstract PDF: Endoscopic submucosal dissection (ESD) is widely used for the treatment of colorectal neoplasia in patients who are candidates for endoscopic resection. In particular, pyogenic liver abscess (PLA), although rare, can occur. To our knowledge, there are no reports of PLA cases after ESD. Therefore, we report a rare case of PLA caused by ESD. A 76-year-old man was referred from a local clinic and admitted to our hospital for colonic ESD for a large polypoid mass. During colonoscopy, a 5-cm mass was seen in the cecum. ESD was performed. Four days after the procedure, he complained of myalgia and abdominal discomfort. Computed tomography revealed a 5.4- cm PLA in the medial segments of the liver. He was treated with antibiotics, and a percutaneous drainage catheter was inserted. Here, we report a very rare complication (PLA) after ESD. In conclusion, comprehensive awareness of the development of PLA is needed in ESD cases.

7,836 View
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Original Articles

Efficacy of Endoscopic Submucosal Dissection of Esophageal Neoplasms under General Anesthesia: Koichi Hamada, Koichiro Kawano, Atsushi Yamauchi, Ryota Koyanagi, Yoshinori Horikawa, Shinya Nishida, Yoshiki Shiwa, Noriyuki Nishino, Michitaka Honda; Clin Endosc 2019;52(3):252-257. Published online May 23, 2019; DOI: https://doi.org/10.5946/ce.2018.151

Abstract PDF

Background
/Aims: Evidence that general anesthesia (GA) reduces the operative time of esophageal endoscopic submucosal dissection (ESD) is currently insufficient. This study aims to evaluate the efficacy and safety of esophageal ESD under GA.
Methods
A total of 227 lesions from 198 consecutive patients with superficial esophageal neoplasms treated by ESD at 3 Japanese institutions between April 2011 and September 2017 were included in this retrospective study. For ESD, GA and deep sedation (DS) were used in 102 (51.5%, GA group) and 96 patients (48.5%, DS group), respectively.
Results
There were no statistically significant differences in age, sex, or comorbidities between the groups. In the GA group, the tumor size was larger (21 [3–77] mm vs. 14 [3–63] mm, p<0.001), luminal circumference was larger (≥2/3; 13.9% vs. 5.4%, p=0.042), procedure time was shorter (28 [5–202] min vs. 40 [8–249] min, p<0.001), and submucosal dissection speed was faster (25.2 [7.8–157.2] mm2 /min vs. 16.2 [2.4–41.3] mm2 /min, p<0.001). The rates of intraoperative perforation and aspiration pneumonia were lower in the GA group, but the difference did not achieve statistical significance (p=0.242 and p=0.242).
Conclusions
GA shortens the procedure time of esophageal ESD.

Citations

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DEN Open.2027;[Epub] CrossRef
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Yuya Nakano, Tomoaki Tashima, Ryuhei Jinushi, Rie Terada, Yumi Mashimo, Tomonori Kawasaki, Toshio Uraoka, Shomei Ryozawa
Endoscopy International Open.2022; 10(09): E1302. CrossRef
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Chang Seok Bang, Jae Jun Lee, Gwang Ho Baik
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Keiichi Ashikari, Takashi Nonaka, Takuma Higurashi, Tomohiro Takatsu, Tsutomu Yoshihara, Noboru Misawa, Jun Arimoto, Kenji Kanoshima, Tetsuya Matsuura, Akiko Fuyuki, Hidenori Ohkubo, Hideyuki Chiba, Atsushi Nakajima
Journal of Gastroenterology and Hepatology.2021; 36(7): 1920. CrossRef
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Seok Kyeong Oh, Seung Inn Cho, Young Ju Won, Jin Hee Yun
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Tomoaki Yamasaki, Yuhei Sakata, Takehisa Suekane, Hiroko Nebiki
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Feasibility of the lidocaine injection method during esophageal endoscopic submucosal dissection
Tetsuya Yoshizaki, Daisuke Obata, Chise Ueda, Norio Katayama, Yasuhiro Aoki, Norihiro Okamoto, Hiroki Hashimura, Masanori Matsumoto, Megumi Takagi, Seitaro Ikeoka, Ryutaro Yoshida, Kenji Momose, Takaaki Eguchi, Hiroshi Yamashita, Akihiko Okada
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Immunohistochemical Expression of Epithelial-Mesenchymal Transition Markers in Early Gastric Cancer: Cancer Tissue versus Noncancer Tissue: Hee Jae Jung, Su Jin Hong, Shin Hee Kim; Clin Endosc 2019;52(5):464-471. Published online May 22, 2019; DOI: https://doi.org/10.5946/ce.2018.181

Abstract PDF

Background
/Aims: Epithelial-mesenchymal transition (EMT) is a developmental process, wherein the epithelial cells show reduced intercellular adhesions and acquire migratory fibroblastic properties. EMT is associated with downregulation in epithelial marker expression, abnormal translocation of E-cadherin, and upregulation in mesenchymal marker expression. Here, we investigated the immunohistochemical (IHC) expression of EMT markers in early gastric cancer (EGC) between cancer and noncancer tissues.
Methods
Tissue samples were prospectively obtained from 19 patients with EGC that underwent endoscopic submucosal dissection (ESD). We compared the expression level of transforming growth factor (TGF)-β, vascular endothelial growth factor (VEGF), E-cadherin, α-smooth muscle actin (α-SMA), and vimentin between cancer and noncancer tissues using IHC. Among the 19 patients, 15 patients had follow-up biopsy at 3 months after ESD for EGC.
Results
Cancer tissues presented higher values of EMT mesenchymal markers (α-SMA/vimentin/TGF-β/VEGF) than the noncancerous tissues (p<0.05) that were significantly low after ESD (p<0.05). No significant correlation was reported for tumor location and initial Helicobacter pylori infection.
Conclusions
The mesenchymal expression of EMT markers was higher in the cancerous tissues than in the noncancer tissues.

Citations

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Exploring the role of LINC-ROR in epithelial-mesenchymal transition and its correlation with CD44 and TWIST1 in gastric cancer progression
Reihaneh Alsadat Mahmoudian, Fatemeh Fardi Golyan, Mohammad Mahdi Forghanifard, Mehran Gholamin, Atena Mansouri, Hamid Tanzadehpanah, Mohammad Reza Abbaszadegan
Human Gene.2025; 44: 201394. CrossRef
Gastric Carcinoma with low ROR alpha, low E- Cadherin and High LAPTM4B Immunohistochemical Profile; is associated with unfavorable prognosis in Egyptian patients
Shereen Nagib El Mashad, Mona Abd El Halim Kandil, Taysseer Abd El-Hamid Talab, Abd El Naby Saied Abd El Naby, Mervat Mahmoud Sultan, Ahmed Sohaib, Aiat Shaban Hemida
Journal of Immunoassay and Immunochemistry.2024; 45(1): 50. CrossRef
Hematological, histomorphological, and immunohistochemical diagnosis of bilateral testicular Sertoli cell tumor in a Mongrel dog: a case history
Samson Eneojo Abalaka, Zakariya Audu
Comparative Clinical Pathology.2024; 33(4): 511. CrossRef
MiR-522-3p Targets Transcription Factor 4 to Overcome Cisplatin Resistance of Gastric Cells
Guofeng Ma, Wen Xue, Jie Ni, Ran Tao, Xiangya Ding
Journal of Oncology.2022; 2022: 1. CrossRef
Investigating Helicobacter pylori-related pyloric hypomotility: functional, histological, and molecular alterations
Aya Aly Ashraf, Sarah Mahmoud Gamal, Hend Ashour, Basma Emad Aboulhoda, Laila Ahmed Rashed, Inas Anas Harb, Gaber Hassan Abdelfattah, Eman Ahmed El-Seidi, Heba Mohamed Shawky
American Journal of Physiology-Gastrointestinal and Liver Physiology.2021; 321(5): G461. CrossRef

10,072 View
169 Download
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Effectiveness of Autologous Platelet-Rich Plasma for the Healing of Ulcers after Endoscopic Submucosal Dissection: Eunju Jeong, In kyung Yoo, Ozlem Ozer Cakir, Hee Kyung Kim, Won Hee Kim, Sung Pyo Hong, Joo Young Cho; Clin Endosc 2019;52(5):472-478. Published online May 17, 2019; DOI: https://doi.org/10.5946/ce.2018.152

Abstract PDF

Background
/Aims: Platelet-rich plasma (PRP) has been used for wound healing in various medical fields. The aim of this study was to evaluate the clinical efficacy and safety of local PRP injections after endoscopic submucosal dissection (ESD).
Methods
Patients were non-randomly divided into the following two groups: (1) control group in which patients were administered only an intravenous proton pump inhibitor (PPI), and (2) a study group in which patients were administered an intravenous PPI and a topical PRP injection. We assessed the reduction in the ulcer area and stage of the ulcer after the procedure (24 hours, 48 hours, and 28 days after endoscopic surgery).
Results
We enrolled 7 study and 7 control patients. In the study group, the rate of ulcer reduction was 59% compared to 52% in the control group (p=0.372), 28 days after ESD. There were 5 patients in the S stage and 2 patients in the H stage in the study group compared to no patient in the S stage and 7 patients in the H stage in the control group (p=0.05), 28 days after ESD. There were no serious complications in either group.
Conclusions
The local injection of PRP is a safe and effective procedure for ulcer healing after ESD.

Citations

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Platelet‐rich plasma for pediatric refractory esophageal strictures: Promising early results require careful validation
Peter D. Ngo
Journal of Pediatric Gastroenterology and Nutrition.2026;[Epub] CrossRef
Endoscopic‐guided platelet‐rich plasma for refractory oesophageal strictures in children: A single‐arm cohort study
Ileana González‐Natale, Daysmar Salazar, Maylin Davila, Yurihelis Saveri, María Eugenia Guerrero, Miguel Puga‐Tejada, Alberto Baptista
Journal of Pediatric Gastroenterology and Nutrition.2026;[Epub] CrossRef
Clinical efficacy of blood derivatives on wound healing: A systematic review and network meta‐analysis
Yanhong Wu, Guang Peng, Yuzhi Wang, Jianwu Chen, Bin Zhang, Jianbing Tang, Biao Cheng
International Wound Journal.2024;[Epub] CrossRef
Endoscopic Shielding With Platelet-rich Plasma After Resection Of Large Colorectal Lesions
Vicente Lorenzo-Zúñiga, Vicente Moreno de Vega, Ramón Bartolí
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2021; 31(3): 376. CrossRef
The Additive Effect of Platelet-Rich Plasma in the Treatment of Actively Bleeding Peptic Ulcer
Waseem M. Seleem, Amr Shaaban Hanafy
Clinical Endoscopy.2021; 54(6): 864. CrossRef
Endless Challenges in Overcoming Complications Associated with Endoscopic Submucosal Dissection
Satoshi Ono, Shun Ito, Kenji Ogata
Clinical Endoscopy.2019; 52(5): 395. CrossRef

10,772 View
174 Download
6 Web of Science
6 Crossref

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