Clinical Endoscopy

Original Articles

A “Back Light System” for Identification of Sites for Endoscopic Ultrasound-Guided Fine-Needle Aspiration in Solid Pancreatic Masses: A Prospective, Randomized Study with a Crossover Design: Ryo Harada, Hironari Kato, Soichiro Fushimi, Hirofumi Inoue, Daisuke Uchida, Yutaka Akimoto, Takeshi Tomoda, Kazuyuki Matsumoto, Yasuhiro Noma, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada; Clin Endosc 2019;52(4):334-339. Published online May 16, 2019; DOI: https://doi.org/10.5946/ce.2019.004

Background
/Aims: We applied a back light system (BLS) with a magnifying glass to improve the ability to assess the adequacy of specimen sampling using endosonography. We conducted this study to evaluate the efficacy of the BLS in sampling of specimens by endoscopic ultrasound-guided fine needle aspiration of solid pancreatic masses.
Methods
This was a prospective, randomized, crossover, single-center clinical trial. An endosonographer evaluated adequacy on gross visual inspection and identified whitish specimen sampling sites with and without the BLS according to a randomization sequence in the first and second passes with a 25-G needle. On cytological evaluation, the presence of well-defined pancreatic ductal epithelium was evaluated by a cytopathologist who was blinded to any clinical information.
Results
A total of 80 consecutive patients were eligible during the study period. Adequacy was observed for 52 specimens (65%) with the BLS and 54 (68%) without the BLS (p=0.88). In assessment of specimen adequacy on gross examination, only fair agreement was observed both with and without BLS (kappa score 0.40 and 0.29, respectively).
Conclusions
The BLS did not influence the ability to identify specimen sampling sites or reliable assessment of specimen site adequacy using gross visual inspection.

Citations

Citations to this article as recorded by

Tissue processing of endoscopic ultrasound-guided fine-needle aspiration specimens from solid pancreatic lesions
Kenji Notohara, Kaori Nakamura
Journal of Medical Ultrasonics.2024; 51(2): 261. CrossRef
Macroscopic qualitative evaluation of solid pancreatic lesion specimens from endoscopic ultrasound-guided fine needle aspiration/biopsies
Kaori Nakamura, Kenji Notohara, Ryoji Nishizaki, Etsuji Ishida, Midori Sato, Akemi Kodera, Junya Itakura, Motowo Mizuno
Pancreatology.2023; 23(8): 1028. CrossRef
Unfortunately, a “Back Light System” As a Global Positioning System Failed to Guide the Route in 25-G Fine-Needle Aspiration
Rungsun Rerknimitr, Phonthep Angsuwatcharakon
Clinical Endoscopy.2019; 52(4): 295. CrossRef

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5 Web of Science
3 Crossref

Rapid On-Site Evaluation by Endosonographers during Endoscopic Ultrasonography-Guided Fine-Needle Aspiration for Diagnosis of Gastrointestinal Stromal Tumors: Takashi Tamura, Yasunobu Yamashita, Kazuki Ueda, Yuki Kawaji, Masahiro Itonaga, Shin-ichi Murata, Kaori Yamamoto, Takeichi Yoshida, Hiroki Maeda, Takao Maekita, Mikitaka Iguchi, Hideyuki Tamai, Masao Ichinose, Jun Kato; Clin Endosc 2017;50(4):372-378. Published online January 20, 2017; DOI: https://doi.org/10.5946/ce.2016.083

Abstract PDF PubReader ePub

Background
/Aims: Endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) has been used to diagnose gastrointestinal submucosal tumors (SMTs). Although rapid on-site evaluation (ROSE) has been reported to improve the diagnostic accuracy of EUS-FNA for pancreatic lesions, on-site cytopathologists are not routinely available. Given this background, the usefulness of ROSE by endosonographers themselves for pancreatic tumors has also been reported. However, ROSE by endosonographers for diagnosis of SMT has not been reported. The aim of this study was to evaluate the diagnostic accuracy of EUS-FNA with ROSE by endosonographers for SMT, focusing on diagnosis of gastrointestinal stromal tumor (GIST), compared with that of EUS-FNA alone.
Methods
Twenty-two consecutive patients who underwent EUS-FNA with ROSE by endosonographers for SMT followed by surgical resection were identified. Ten historical control subjects who underwent EUS-FNA without ROSE were used for comparison.
Results
The overall diagnostic accuracy for SMT was significantly higher in cases with than without ROSE (100% vs. 80%, p=0.03). The number of needle passes by FNA with ROSE by endosonographers tended to be fewer, although accuracy was increased (3.3±1.3 vs. 5.9±3.8, p=0.06).
Conclusions
ROSE by endosonographers during EUS-FNA for SMT is useful for definitive diagnosis, particularly for GIST.

Citations

Citations to this article as recorded by

Diagnostic yield of endoscopic and EUS-guided biopsy techniques in subepithelial lesions of the upper GI tract: a systematic review
Cynthia A. Verloop, Jacqueline A.C. Goos, Marco J. Bruno, Rutger Quispel, Lydi M.J.W. van Driel, Lieke Hol
Gastrointestinal Endoscopy.2024; 99(6): 895. CrossRef
Gastric glomus tumor on EUS-FNA-based cytology: clinicopathologic and immunohistochemical features of 4 cases, including 1 case with associated MIR143HG-NOTCH2 fusion gene
Sameer Chhetri Aryal, Sanam Husain, Ziying Zhang, Lisi Yuan
Journal of the American Society of Cytopathology.2023; 12(4): 296. CrossRef
EUS-Guided Diagnosis of Gastric Subepithelial Lesions, What Is New?
Thomas Vasilakis, Dimitrios Ziogas, Georgios Tziatzios, Paraskevas Gkolfakis, Eleni Koukoulioti, Christina Kapizioni, Konstantinos Triantafyllou, Antonio Facciorusso, Ioannis S. Papanikolaou
Diagnostics.2023; 13(13): 2176. CrossRef
A prospective randomized noninferiority trial comparing conventional smears and SurePathTM liquid-based cytology in endoscopic ultrasound-guided sampling of esophageal, gastric, and duodenal lesions
Jae Chang Jun, Sang Hyub Lee, Han Myung Lee, Sang Gyun Kim, Hyunsoo Chung, Joo Seong Kim, Namyoung Park, Jin Ho Choi, Yoonjin Kwak, Soo-Jeong Cho
Medicine.2023; 102(29): e34321. CrossRef
The Diagnosis of Small Gastrointestinal Subepithelial Lesions by Endoscopic Ultrasound-Guided Fine Needle Aspiration and Biopsy
Masanari Sekine, Takeharu Asano, Hirosato Mashima
Diagnostics.2022; 12(4): 810. CrossRef
A Pilot Study of Image-associative Teaching Versus Traditional Didactic Teaching for Novice Endosonographers Learning Cytopathology Effectively
Yi Chu, Wenyu LI, Min Luo, HongYi Zhu, Yi Sun, Xiaolin She, Jirong Huo, Yuqian Zhou
Techniques and Innovations in Gastrointestinal Endoscopy.2022; 24(4): 324. CrossRef
Diagnostic yield of EUS-TA for gastric submucosal epithelial lesions using rapid specimen evaluation under stereomicroscopy
Tetsuhiko Hirai, Junro Ishizaki, Hiroshi Imaizumi, Myontyori Kim, Yoichi Saegusa, Akinori Tamaki, Masafumi Watanabe, Hironori Masutani, Kosuke Okuwaki, Mitsuhiro Kida, Chika Kusano
Progress of Digestive Endoscopy.2022; 100(1): 63. CrossRef
Ki‐67 index assessment on FNA specimens of gastrointestinal stromal tumor: Correlation with mitotic rate and potential predictive value for risk stratification
Xi Wang, Rita Abi‐Raad, Haiming Tang, Guoping Cai
Cancer Cytopathology.2022; 130(12): 974. CrossRef
Recent Progress and Challenges in the Diagnosis and Treatment of Gastrointestinal Stromal Tumors
Toshirou Nishida, Shigetaka Yoshinaga, Tsuyoshi Takahashi, Yoichi Naito
Cancers.2021; 13(13): 3158. CrossRef
Optimal number of needle punctures in endoscopic ultrasound-guided fine-needle biopsy for gastric subepithelial lesions without rapid on-site evaluation
Masato Suzuki, Yusuke Sekino, Kunihiro Hosono, Kenichi Kawana, Hajime Nagase, Kensuke Kubota, Atsushi Nakajima
Journal of Medical Ultrasonics.2021; 48(4): 623. CrossRef
Methodological and Technical Aspects of EUS-Guided Fine Needle Aspiration of the Upper Digestive Tract Lesions
E. A. Godzhello, N. A. Bulganina, M. V. Khrustaleva
Experimental and Clinical Gastroenterology.2020; 174(4): 107. CrossRef
Challenging biliary strictures: pathophysiological features, differential diagnosis, diagnostic algorithms, and new clinically relevant biomarkers - part 1
Jean-Marc Dumonceau, Myriam Delhaye, Nicolas Charette, Annarita Farina
Therapeutic Advances in Gastroenterology.2020;[Epub] CrossRef
Mucosal incision‐assisted biopsy versus endoscopic ultrasound‐guided fine‐needle aspiration with a rapid on‐site evaluation for gastric subepithelial lesions: A randomized cross‐over study
Takashi Osoegawa, Yosuke Minoda, Eikichi Ihara, Keishi Komori, Akira Aso, Ayako Goto, Soichi Itaba, Haruei Ogino, Kazuhiko Nakamura, Naohiko Harada, Kosuke Makihara, Shinichi Tsuruta, Hidetaka Yamamoto, Yoshihiro Ogawa
Digestive Endoscopy.2019; 31(4): 413. CrossRef
Endoscopic Ultrasound-Guided Fine Needle Aspiration and Biopsy in Gastrointestinal Subepithelial Tumors
Gyu Young Pih, Do Hoon Kim
Clinical Endoscopy.2019; 52(4): 314. CrossRef
Rapid On-Site Evaluation of Fine-Needle Aspiration by Non-Cytopathologists: A Systematic Review and Meta-Analysis of Diagnostic Accuracy Studies for Adequacy Assessment
Lauren Pearson, Rachel E. Factor, Sandra K. White, Brandon S. Walker, Lester J. Layfield, Robert L. Schmidt
Acta Cytologica.2018; 62(4): 244. CrossRef
Is a Cytopathologist Always Needed during Endoscopic Ultrasonography-Guided Tissue Acquisition?
Moon Won Lee, Gwang Ha Kim
Clinical Endoscopy.2017; 50(4): 311. CrossRef
Endoscopic Evaluation and Management of Gastric Stromal Tumors
Kambiz Kadkhodayan, Ehsan Rafiq, Robert H. Hawes
Current Treatment Options in Gastroenterology.2017; 15(4): 691. CrossRef

8,702 View
235 Download
15 Web of Science
17 Crossref

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