Original Article
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Current status and clinical outcome of endoscopic hemostatic powder in gastrointestinal bleeding: a retrospective multicenter study
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Zie Hae Lim, Seung In Seo, Dae-Seong Myung, Seung Han Kim, Han Hee Lee, Selen Kim, Bo-In Lee
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Clin Endosc 2024;57(5):620-627. Published online March 8, 2024
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DOI: https://doi.org/10.5946/ce.2023.179
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- Background
/Aims: Few multicenter studies have investigated the efficacy of hemostatic powders in gastrointestinal (GI) bleeding. We aimed to investigate the clinical outcomes of hemostatic powder therapy and the independent factors affecting rebleeding rates.
Methods
We retrospectively recruited patients who underwent a new hemostatic adhesive powder (UI-EWD; Next-Biomedical) treatment for upper and lower GI bleeding between January 1, 2020 and March 1, 2023. We collected patients’ medical records and bleeding lesions. The primary outcomes were clinical and technical success rates, and the secondary outcomes were early, delayed, and refractory bleeding, mortality, and factors affecting early rebleeding rates.
Results
This study enrolled 135 patients (age: 67.7±13.6 years, male: 74.1%) from five hospitals. Indications for UI-EWD were peptic ulcers (51.1%), post-procedure-related bleeding (23.0%), and tumor bleeding (19.3%). The clinical and technical success rates were both 97%. The early, delayed, and refractory rebleeding rates were 19.3%, 11.1%, and 12.8%, respectively. Initially elevated blood urea nitrogen (BUN) levels (p=0.014) and Forrest classification IA or IB compared with IIA or IIB (p=0.036) were factors affecting early rebleeding.
Conclusions
UI-EWD showed high clinical and technical success rates; however, rebleeding after UI-EWD therapy in patients with initially high BUN levels and active bleeding, according to the Forrest classification, should be considered.
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Citations
Citations to this article as recorded by

- Endoscopic hemostatic powder as a salvage treatment for acute gastrointestinal bleeding
Duc Trong Quach
Clinical Endoscopy.2024; 57(5): 606. CrossRef
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322
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1
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Review
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Endoscopic clipping in non-variceal upper gastrointestinal bleeding treatment
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Giuseppe Galloro, Angelo Zullo, Gaetano Luglio, Alessia Chini, Donato Alessandro Telesca, Rosa Maione, Matteo Pollastro, Giovanni Domenico De Palma, Raffaele Manta
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Clin Endosc 2022;55(3):339-346. Published online April 28, 2022
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DOI: https://doi.org/10.5946/ce.2021.249
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- Since the earliest reports, advanced clipping systems have been developed, and it is possible to choose among many models with different structural and technical features. The main drawback of through-the-scope clips is their small size, which allows the compression of limited amounts of tissue needed for large-size vessel treatment. Therefore, the over-the-scope clip system was realized, allowing a larger and stronger mechanical compression of large tissue areas, with excellent results in achieving a definitive hemostasis in difficult cases. Many studies have analyzed the indications and efficacy of two-pronged endoclips and have shown good results for initial and permanent hemostasis. The aim of this review was to provide updated information on indications, positioning techniques, and results of clip application for endoscopic treatment of upper gastrointestinal non-variceal bleeding lesions.
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Citations
Citations to this article as recorded by

- Adverse Events of Endoscopic Clip Placement
Daryl Ramai, Smit S. Deliwala, Daniel Mozell, Antonio Facciorusso, Saurabh Chandan, Alana Persaud, Kelita Singh, Andrea Anderloni, Monique T. Barakat
Journal of Clinical Gastroenterology.2024; 58(1): 76. CrossRef - Right tool for the right bleeder
Ding Ek Toh, Sheng Wei Lo, Andrew Tsoi, Jonathan P Segal, Joshua Butt
Gut.2024; 73(1): 206. CrossRef - Could a bleeding-sensor device be established as a new paradigm for detecting upper gastrointestinal bleeding before performing endoscopy?
Sun Gyo Lim
Clinical Endoscopy.2024; 57(2): 191. CrossRef - Usage of Padlock Over-the-Scope-Clip in Difficult-to-Control Recurrent Gastrointestinal Bleeding Due to a Gastric Dieulafoy Lesion
John Joyce, Vishnu Kumar, Dayana Nasr, Ganesh Aswath, Hafiz M. Khan, Savio John
Journal of Investigative Medicine High Impact Case Reports.2024;[Epub] CrossRef - Comparison of mechanical and thermal therapy in upper gastrointestinal bleeding: an analysis of efficacy outcomes
Rahul Karna, Bandhul Hans, Thayer Nasereddin, Dhruv Chaudhary, Manish Dhawan
Baylor University Medical Center Proceedings.2024; 37(5): 734. CrossRef - Turn over the new leaf of the treatment in peptic ulcer bleeding: a review of the literature
Meng-Hsuan Lu, Hsueh-Chien Chiang
Therapeutic Advances in Gastroenterology.2024;[Epub] CrossRef - Current status and clinical outcome of endoscopic hemostatic powder in gastrointestinal bleeding: a retrospective multicenter study
Zie Hae Lim, Seung In Seo, Dae-Seong Myung, Seung Han Kim, Han Hee Lee, Selen Kim, Bo-In Lee
Clinical Endoscopy.2024; 57(5): 620. CrossRef - Evaluating the efficacy of a novel hemostatic powder compared with traditional treatments in nonvariceal upper GI bleeding: a multicenter, randomized, noninferiority study
Da Hyun Jung, Jun Chul Park, Joon Sung Kim, Moon Won Lee, Hyuk Lee, Gwang Ha Kim
Gastrointestinal Endoscopy.2024;[Epub] CrossRef - Sustained Hemostasis With the Padlock™ Over-the-scope Clip for Gastric Fundus Dieulafoy’s Lesion in the Setting of Anticoagulation Following Hemorrhagic Shock From Two Dieulafoy’s Lesions
Jonathan J Cho, Chelsea M Forbes, Benjamin D Fiore, Joshua D McCarron, Leybelis Padilla
Military Medicine.2023; 188(9-10): e3265. CrossRef - Management of complications related to colorectal endoscopic submucosal dissection
Tae-Geun Gweon, Dong-Hoon Yang
Clinical Endoscopy.2023; 56(4): 423. CrossRef - Novel removable endoscopic clip: Usefulness in failure of traction method during endoscopic submucosal dissection
Nobukazu Agatsuma, Takahiro Utsumi, Hirokazu Higuchi, Takahiro Inoue, Yukari Tanaka, Yuki Nakanishi, Hiroshi Seno
Endoscopy.2023; 55(S 01): E1031. CrossRef
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9
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Original Articles
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Acute Gastrointestinal Bleeding in COVID-19 Patients: A Systematic Review and Meta-Analysis
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Umair Iqbal, Hafsa Anwar, Hafiz Umair Siddiqui, Muhammad Ali Khan, Faisal Kamal, Bradley D. Confer, Harshit S. Khara
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Clin Endosc 2021;54(4):534-541. Published online June 25, 2021
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DOI: https://doi.org/10.5946/ce.2021.071
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- Background
/Aims: More than 100 million people to date have been affected by the coronavirus disease-2019 (COVID-19) pandemic. Patients with COVID-19 have a higher risk of bleeding complications. We performed a systematic review and meta-analysis to evaluate the outcomes of COVID-19 patients with signs and symptoms of acute gastrointestinal bleeding (GIB).
Methods
A systematic literature search was carried out for articles published until until November 11, 2020, in the Embase, MEDLINE, Web of Science, and Cochrane Library databases. We included studies on COVID-19 patients with signs and symptoms of GIB.
Results
Our search yielded 49 studies, of which eight with a collective 127 patients (86 males and 41 females) met our inclusion criteria. Conservative management alone was performed in 59% of the patients, endoscopic evaluation in 31.5%, and interventional radiology (IR) embolization in 11%. Peptic ulcer disease was the most common endoscopic finding, diagnosed in 47.5% of the patients. Pooled overall mortality was 19.1% (95% confidence interval [CI]; 12.7%-27.6%) and pooled mortality secondary to GIB was 3.5% (95% CI; 1.3%–9.1%). The pooled risk of rebleeding was 11.3% (95% CI; 6.8%–18.4%).
Conclusions
The majority of COVID-19 patients with GIB responded to conservative management, with a low mortality rate associated with GIB and the risk of rebleeding. Thus, we suggest limiting endoscopic and IR interventions to those with hemodynamic instability and those for whom conservative management was unsuccessful.
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Citations
Citations to this article as recorded by

- Prevalence and outcomes of upper gastrointestinal bleeding in COVID‐19: A systematic review and meta‐analysis
Sawai Singh Rathore, Zario Shai Wint, Aman Goyal, Bijay Mukesh Jeswani, Ameer Mustafa Farrukh, María Alejandra Nieto‐Salazar, Thanmai Reddy Thugu, Snigdha Erva, Raafay Mehmood, Adriana Carolina Toro‐velandia, Hamam Aneis, Sunny Ratnani, Ibrahim Marouf Yas
Reviews in Medical Virology.2024;[Epub] CrossRef - Inpatient outcomes of inflammatory bowel disease in hospitalized patients with COVID-19: analysis of a nationally representative sample
Mohammad Aldiabat, Saqr Alsakarneh, Tyrell Daniel, Muhammad Ali Butt, Balaji Jagdish, James Rock, Aarushi Sudan, Majd Al-Ahmad, Ahmad Jabri, Yassine Kilani, Tarek Odah, Laith Alhuneafat, Mir Zulqarnain, Jana G. Hashash, Hassan Ghoz
Baylor University Medical Center Proceedings.2024; 37(2): 239. CrossRef - Rates, Risk Factors, and Outcomes of Nonvariceal Upper Gastrointestinal Bleeding in Patients Hospitalized for COVID-19 in the United States
Mohammad Aldiabat, Wesam Aleyadeh, Taimur Muzammil, Kemi Adewuyi, Majd Alahmad, Ahmad Jabri, Laith Alhuneafat, Yassine Kilani, Saqr Alsakarneh, Mohammad Bilal
Current Medical Science.2024; 44(6): 1202. CrossRef - Increasing inpatient mortality of nonvariceal upper gastrointestinal bleeding during the COVID-19 pandemic: a nationwide retrospective cohort study
Waqas Rasheed, Gnanashree Dharmarpandi, Ola Al-Jobory, Anass Dweik, Muhammad Anil, Sameer Islam
Baylor University Medical Center Proceedings.2023; 36(3): 286. CrossRef - Outcomes in Patients Admitted for Upper Gastrointestinal Bleeding and COVID-19 Infection: A Study of Two Years of the Pandemic
Sergiu Cazacu, Daniela Burtea, Vlad Iovănescu, Dan Florescu, Sevastița Iordache, Adina Turcu-Stiolica, Victor Sacerdotianu, Bogdan Ungureanu
Life.2023; 13(4): 890. CrossRef - Prevalence, causes, medical interventions, and mortality outcome of acute gastrointestinal bleeding among COVID-19 inpatients
Mai N. Luu, Thinh P. Dang, Minh-Cong H. Vo, Duc T. Quach
Current Medical Research and Opinion.2023; 39(5): 731. CrossRef - Gastrointestinal Bleeding in Patients With New Coronavirus Infection COVID-19
V. D. Anosov, S. A. Domrachev, S. V. Ovchinnikov, N. O. Solovyov
Russian Sklifosovsky Journal "Emergency Medical Care".2023; 12(3): 458. CrossRef - Clinical and Endoscopic Outcomes in COVID-19 Patients With Gastrointestinal Bleeding
Hassan Ashktorab, Tiziano Russo, Gholamreza Oskrochi, Giovanni Latella, Sara Massironi, Martina Luca, Lakshmi G. Chirumamilla, Adeyinka O. Laiyemo, Hassan Brim
Gastro Hep Advances.2022; 1(4): 487. CrossRef - Clinical Characteristics of Hospitalized COVID-19 Patients Who Have Gastrointestinal Bleeds Requiring Intervention: A Case-Control Study
Ahmad Abulawi, Ali Al-Tarbsheh, Annie Leamon, Paul Feustel, Amit Chopra, Asra Batool
Cureus.2022;[Epub] CrossRef - Clinical features of thrombosis and bleeding in COVID-19
Mari R. Thomas, Marie Scully
Blood.2022; 140(3): 184. CrossRef - Mortality Rate in Upper Gastrointestinal Bleeding Associated with Anti-Thrombotic Therapy Before and During Covid-19 Pandemic
Petrica Popa, Sevastita Iordache, Dan Nicolae Florescu, Vlad Florin Iovanescu, Alexandru Vieru, Valentin Barbu, Maria-Cristina Bezna, Dragos Ovidiu Alexandru, Bogdan Silviu Ungureanu, Sergiu Marian Cazacu
Journal of Multidisciplinary Healthcare.2022; Volume 15: 2679. CrossRef - Coronavirus Disease in the Abdomen
Mark A. Anderson, Mark A. Khauli, Reece J. Goiffon, Avinash Kambadakone
Advances in Clinical Radiology.2022; 4(1): 25. CrossRef - Сauses, risk factors, diagnostics and treatment of gastrointestinal bleeding in patients with a novel coronavirus infection (COVID-19)
A. A. Sheptulin, S. S. Kardasheva, A. A. Kurbatova
Clinical Medicine (Russian Journal).2022; 100(7-8): 341. CrossRef - The frequency of ulcerative-erosive defects and ulcerative bleeding of the gastroduodenal zone in patients with coronavirus infection COVID-19
N. N. Butorin, V. V. Tsukanov, R. V. Asyayev, M. N. Butorina, A. V. Vasyutin, J. L. Tonkikh
Experimental and Clinical Gastroenterology.2022; (5): 5. CrossRef
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The Additive Effect of Platelet-Rich Plasma in the Treatment of Actively Bleeding Peptic Ulcer
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Waseem M. Seleem, Amr Shaaban Hanafy
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Clin Endosc 2021;54(6):864-871. Published online May 25, 2021
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DOI: https://doi.org/10.5946/ce.2021.004
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Abstract
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- Background
/Aims: Peptic ulcer bleeding is the most common cause of upper gastrointestinal tract bleeding. Platelet-rich plasma (PRP) enhances tissue repair, and is therefore used in various medical treatments. A combination of mechanical or electrothermal hemostasis has been recommended for upper gastrointestinal tract bleeding treatment. This study evaluated the additive efficacy of PRP in bleeding peptic ulcer hemostasis and recovery.
Methods
Eighty patients with peptic ulcer bleeding were initially treated by hemoclipping, and were randomly chosen for either additional PRP (n=40) or additional epinephrine (n=40) injections. Both groups were compared with regard to achieving hemostasis and the frequency of complications.
Results
Hemostasis was immediately achieved in both groups. Two patients (5%) in the PRP group and 8 (20%) patients in the epinephrine group experienced rebleeding after 15.9±2.8 and 12.3±3.7 days, respectively. They were managed by PRP injection in addition to proton pump inhibitor infusion. Hemoglobin was substantially increased in the PRP-treated group with full recovery occurring in 60.5% compared to 31.3% of patients in the epinephrine group (p=0.001). There was no recurrent bleeding in the PRP group, but 4/32 (12.5%) patients in the epinephrine group exhibited rebleeding.
Conclusions
PRP showed additional benefit in reducing peptic ulcer bleeding with no reported significant complications. Clinical trial (NCT03733171).
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Citations
Citations to this article as recorded by

- The impact of submucosal PRP injection on wound healing after endoscopic sinus surgery: a randomized clinical trial
Konstantina Dinaki, Nikolaos Grigoriadis, Ioannis S. Vizirianakis, Jannis Constantinidis, Stefanos Triaridis, Petros Karkos
European Archives of Oto-Rhino-Laryngology.2024; 281(7): 3587. CrossRef
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4,357
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Positive Fecal Occult Blood Test is a Predictive Factor for Gastrointestinal Bleeding after Capsule Endoscopy in Patients with Unexplained Iron Deficiency Anemia: A Korean Multicenter CAPENTRY Study
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Ji Young Chang, Chang Mo Moon, Ki-Nam Shim, Dae Young Cheung, Hyun Seok Lee, Yun Jeong Lim, Seong Ran Jeon, Soo Jung Park, Kyeong Ok Kim, Hyun Joo Song, Hyun Joo Jang, Ji Hyun Kim
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Clin Endosc 2020;53(6):719-726. Published online November 6, 2020
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DOI: https://doi.org/10.5946/ce.2019.149
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Abstract
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- Background
/Aims: Capsule endoscopy (CE) is recommended as the primary method for the evaluation of unexplained anemia. This study aimed to assess the diagnostic yield of CE in patients with unexplained iron deficiency anemia (IDA) without overt bleeding, and to evaluate their long-term outcomes and related clinical factors.
Methods
Data of patients who underwent CE for the evaluation of IDA were reviewed from a CE registry in Korea. Additional clinical data were collected by the involved investigators of each hospital through a review of medical records.
Results
Among a total of 144 patients, the diagnostic yield of CE was 34%. Gastrointestinal (GI) bleeding was found in 6.3% (n=9) of the patients (occult bleeding in four patients and overt bleeding in five patients) during a mean follow-up of 17.8 months. Patients with a positive fecal occult blood test (FOBT) result at the initial diagnosis had a higher rate of GI bleeding after CE (p=0.004). In addition, a positive FOBT result was the only independent predictive factor for GI bleeding (hazard ratio, 5.30; 95% confidence interval, 1.41–19.85; p=0.013).
Conclusions
Positive FOBT is a predictive factor for GI bleeding during follow-up after CE in patients with unexplained IDA without overt bleeding. Thus, patients with positive FOBT need to be more closely followed up.
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Citations
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- Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2022
Marco Pennazio, Emanuele Rondonotti, Edward J. Despott, Xavier Dray, Martin Keuchel, Tom Moreels, David S. Sanders, Cristiano Spada, Cristina Carretero, Pablo Cortegoso Valdivia, Luca Elli, Lorenzo Fuccio, Begona Gonzalez Suarez, Anastasios Koulaouzidis,
Endoscopy.2023; 55(01): 58. CrossRef - Predictive Model for Positive Video Capsule Endoscopy in Iron Deficiency Anemia
Shadi Hamdeh, Jihan Fathallah, Hui Zhang, Amber Charoen, Barakat Aburajab Altamimi, Florence-Damilola Odufalu, Devashree Dave, Amer El Sayed, Laura R. Glick, Scott Grisolano, Christine Hachem, Muhammad Bader Hammami, Khaldoun Haj Mahmoud, Alexander N. Lev
Digestive Diseases and Sciences.2023; 68(7): 3083. CrossRef - Predictors of Positive Video Capsule Endoscopy Findings for Chronic Unexplained Abdominal Pain: Single-Center Retrospective Study and Meta-Analysis
Wonshik Kim, Beomjae Lee, Ahyoung Yoo, Seunghan Kim, Moonkyung Joo, Jong-Jae Park
Diagnostics.2021; 11(11): 2123. CrossRef
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6,595
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136
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4
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3
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Prospective Comparison of the AIMS65 Score, Glasgow-Blatchford Score, and Rockall Score for Predicting Clinical Outcomes in Patients with Variceal and Nonvariceal Upper Gastrointestinal Bleeding
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Arunchai Chang, Chokethawee Ouejiaraphant, Keerati Akarapatima, Attapon Rattanasupa, Varayu Prachayakul
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Clin Endosc 2021;54(2):211-221. Published online July 16, 2020
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DOI: https://doi.org/10.5946/ce.2020.068
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Abstract
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- Background
/Aims: This study aimed to determine the performance of the AIMS65 score (AIMS65), Glasgow-Blatchford score (GBS), and Rockall score (RS) in predicting outcomes in patients with upper gastrointestinal bleeding (UGIB), and to compare the results between patients with nonvariceal UGIB (NVUGIB) and those with variceal UGIB (VUGIB).
Methods
We conducted a prospective observational study between March 2016 and December 2017. Receiver operating characteristic curve analysis was performed for all outcomes for comparison. The associations of all three scores with mortality were evaluated using multivariate logistic regression analysis.
Results
Of the total of 337 patients with UGIB, 267 patients (79.2%) had NVUGIB. AIMS65 was significantly associated (odds ratio [OR], 1.735; 95% confidence interval [CI], 1.148–2.620), RS was marginally associated (OR, 1.225; 95% CI, 0.973–1.543), but GBS was not associated (OR, 1.017; 95% CI, 0.890–1.163) with mortality risk in patients with UGIB. However, all three scores accurately predicted all other outcomes (all p<0.05) except rebleeding (p>0.05). Only AIMS65 precisely predicted mortality, the need for blood transfusion and the composite endpoint (all p<0.05) in patients with VUGIB.
Conclusions
AIMS65 is superior to GBS and RS in predicting mortality in patients with UGIB, and also precisely predicts the need for blood transfusion and the composite endpoint in patients with VUGIB. No scoring system could satisfactorily predict rebleeding in all patients with UGIB.
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Citations
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- Similar Effect of Vonoprazan and Oral Proton Pump Inhibitors for Preventing Rebleeding in Cases of Upper Gastrointestinal Bleeding
Hiroko Abe, Kunio Tarasawa, Waku Hatta, Tomoyuki Koike, Isao Sato, Yoshitaka Ono, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Kenji Fujimori, Kiyohide Fushimi, Atsushi Masamune
Internal Medicine.2024; 63(7): 911. CrossRef - Comparison of scoring systems for predicting clinical outcomes of acute lower gastrointestinal bleeding: A prospective cohort study
Kamales Prasitvarakul, Nawawich Attanath, Arunchai Chang
World Journal of Surgery.2024; 48(2): 474. CrossRef - Lactate level as a predictor of outcomes in patients with acute upper gastrointestinal bleeding: A systematic review and meta‑analysis
Fanshu Zeng, Li Du, Ling Ling
Experimental and Therapeutic Medicine.2024;[Epub] CrossRef - The Prediction and Treatment of Bleeding Esophageal Varices in the Artificial Intelligence Era: A Review
María Isabel Murillo Pineda, Tania Siu Xiao, Edgar J Sanabria Herrera, Alberto Ayala Aguilar, David Arriaga Escamilla, Alejandra M Aleman Reyes, Andreina D Rojas Marron, Roberto R Fabila Lievano, Jessica J de Jesús Correa Gomez, Marily Martinez Ramirez
Cureus.2024;[Epub] CrossRef - Mortality Risk Scoring System in Patients after Bleeding from Cancers in the Upper Gastrointestinal Tract
Hyun Min Kim, Donghoon Kang, Jun Young Park, Yu Kyung Cho, Myung-Gyu Choi, Jae Myung Park
Gut and Liver.2024; 18(2): 222. CrossRef - Could a bleeding-sensor device be established as a new paradigm for detecting upper gastrointestinal bleeding before performing endoscopy?
Sun Gyo Lim
Clinical Endoscopy.2024; 57(2): 191. CrossRef - ASSESSMENT OF PATIENTS WITH NON-VARICEAL UPPER GASTROINTESTINAL BLEEDING USING AIMS65 SCORE
Farahnaz Joukar, Raheleh Sadat Hosseini Basti, Fakhrieh Sadat Hosseini Basti, Fatemeh Mosafer, Hoorieh Sadat Hosseini Basti, Zahra Hedayatzadeh, Afshin Shafaghi
Studies in Medical Sciences.2024; 35(1): 51. CrossRef - Current status and clinical outcome of endoscopic hemostatic powder in gastrointestinal bleeding: a retrospective multicenter study
Zie Hae Lim, Seung In Seo, Dae-Seong Myung, Seung Han Kim, Han Hee Lee, Selen Kim, Bo-In Lee
Clinical Endoscopy.2024; 57(5): 620. CrossRef - AIMS65 Scoring System for Predicting Clinical Outcomes Among Emergency Department Patients with Upper Gastrointestinal Bleeding
Rifaldy Nabiel, Al Munawir, Jauhar Firdaus
Indonesian Journal of Anesthesiology and Reanimation.2024; 6(1): 58. CrossRef - Comparison of Four Scoring Systems for Patients With Nonvariceal Upper Gastrointestinal Bleeding
Elrasheed M Elsabani, Badr A Badr, Mohammad Dhalaan , Anwar Alotaibi, Abdulrahman Alrujaib , Rabab Alahmed, Abdulrahman Alabbadi, Omer Kheir
Cureus.2024;[Epub] CrossRef - Construction and validation of a predictive model for the risk of rebleeding in patients with esophageal and gastric varices hemorrhage
Wei Gao, Yu-Shuang Huang, Ying-De Wang
BMC Gastroenterology.2024;[Epub] CrossRef - External validation and comparison of the Glasgow-Blatchford score, modified Glasgow-Blatchford score, Rockall score and AIMS65 score in patients with upper gastrointestinal bleeding: a cross-sectional observational study in Western Switzerland
Sirio Rivieri, Pierre-Nicolas Carron, Alain Schoepfer, Francois-Xavier Ageron
European Journal of Emergency Medicine.2023; 30(1): 32. CrossRef - Comparison of Glasgow Blatchford and New Risk Scores to Predict Outcomes in Patients with Acute Upper GI Bleeding
Bahadır TAŞLIDERE, Elmas BİBERCİ KESKİN, Serdar ÖZDEMİR, Ahmet ATSIZ, Ertan SÖNMEZ
Bezmialem Science.2023; 11(1): 100. CrossRef - Comparative Evaluation of the ABC Score to Other Risk Stratification Scales in Managing High-risk Patients Presenting With Acute Upper Gastrointestinal Bleeding
Omar Kherad, Sophie Restellini, Majid Almadi, Myriam Martel, Alan N. Barkun
Journal of Clinical Gastroenterology.2023; 57(5): 479. CrossRef - Progress in the Evaluation of Acute Upper Gastrointestinal Bleeding with AIMS65 Scoring System
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Advances in Clinical Medicine.2023; 13(05): 8163. CrossRef - Risk analysis of 30-day rebleeding in acute non-variceal upper gastrointestinal bleeding
Xu Wang, Meiling Yang, Jianhua Xu, Yaxian Kuai, Bin Sun
Arab Journal of Gastroenterology.2023; 24(2): 136. CrossRef - Age, blood tests and comorbidities and AIMS65 risk scores outperform Glasgow-Blatchford and pre-endoscopic Rockall score in patients with upper gastrointestinal bleeding
Bianca-Codrina Morarasu, Victorita Sorodoc, Anca Haisan, Stefan Morarasu, Cristina Bologa, Raluca Ecaterina Haliga, Catalina Lionte, Emilia Adriana Marciuc, Mohammed Elsiddig, Diana Cimpoesu, Gabriel Mihail Dimofte, Laurenţiu Sorodoc
World Journal of Clinical Cases.2023; 11(19): 4513. CrossRef - Strengths and limitations of risk stratification tools for patients with upper gastrointestinal bleeding: a narrative review
Ali A. Alali, Antoine Boustany, Myriam Martel, Alan N. Barkun
Expert Review of Gastroenterology & Hepatology.2023; 17(8): 795. CrossRef - A nomogram to predict in-hospital mortality of gastrointestinal bleeding patients in the intensive care unit
Xueyan Zhang, Jianfang Ni, Hongwei Zhang, Mengyuan Diao
Frontiers in Medicine.2023;[Epub] CrossRef - Research Status of Pre-Endoscopic Scoring System for Upper Gastrointestinal Bleeding
莎 吴
Advances in Clinical Medicine.2023; 13(11): 17097. CrossRef - Recurrent Non-Variceal Upper Gastrointestinal Bleeding among Patients Receiving Dual Antiplatelet Therapy
Ah Young Yoo, Moon Kyung Joo, Jong-Jae Park, Beom Jae Lee, Seung Han Kim, Won Shik Kim, Hoon Jai Chun
Diagnostics.2023; 13(22): 3444. CrossRef - Modified N score is helpful for identifying patients who need endoscopic intervention among those with black stools without hematemesis
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Digestive Endoscopy.2022; 34(6): 1157. CrossRef - Usefulness of the d-dimer to albumin ratio for risk assessment in patients with acute variceal bleeding at the emergency department: retrospective observational study
Jun Seok Seo, Yongwon Kim, Yoonsuk Lee, Ho Young Chung, Tae Youn Kim
BMC Emergency Medicine.2022;[Epub] CrossRef - Effect of holiday admission on clinical outcome of patients with upper gastrointestinal bleeding: A real-world report from Thailand
Arunchai Chang, Chokethawee Ouejiaraphant, Nuttanit Pungpipattrakul, Keerati Akarapatima, Attapon Rattanasupar, Varayu Prachayakul
Heliyon.2022; 8(8): e10344. CrossRef - The Value of Risk Scores to Predict Clinical Outcomes in Patients with Variceal and Non-Variceal Upper Gastrointestinal Bleeding
James Yun-wong Lau
Clinical Endoscopy.2021; 54(2): 145. CrossRef - Role of lactulose for prophylaxis against hepatic encephalopathy in cirrhotic patients with upper gastrointestinal bleeding: A randomized trial
Attapon Rattanasupar, Arunchai Chang, Keerati Akarapatima, Thanongsak Chaojin, Teerha Piratvisuth
Indian Journal of Gastroenterology.2021; 40(6): 621. CrossRef - Perfusion index: Could this be a new triage tool for upper gastrointestinal system bleeding in the emergency department? A prospective cohort study
Basak Toptas Firat, Muge Gulen, Salim Satar, Ahmet Firat, Selen Acehan, Cem Isikber, Adem Kaya, Gonca Koksaldi Sahin, Haldun Akoglu
Sao Paulo Medical Journal.2021; 139(6): 583. CrossRef - Systematic review and meta-analysis of risk scores in prediction for the clinical outcomes in patients with acute variceal bleeding
Ling Yang, Rui Sun, Ning Wei, Hong Chen
Annals of Medicine.2021; 53(1): 1806. CrossRef
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Clinical Usefulness of Dual Red Imaging in Gastric Endoscopic Submucosal Dissection: A Pilot Study
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Naoki Yorita, Shiro Oka, Shinji Tanaka, Takahiro Kotachi, Naoko Nagasaki, Kosaku Hata, Kazutaka Kuroki, Kazuhiko Masuda, Mio Kurihara, Mariko Kiso, Tomoyuki Boda, Masanori Ito, Kazuaki Chayama
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Clin Endosc 2020;53(1):54-59. Published online September 3, 2019
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DOI: https://doi.org/10.5946/ce.2019.065
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Abstract
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- Background
/Aims: Dual red imaging (DRI) is a new, image-enhanced endoscopy technique. There are few reports about the usefulness of DRI during gastric endoscopic submucosal dissection (ESD). We aimed to examine the usefulness of DRI in endoscopic hemostasis during gastric ESD.
Methods
We enrolled a total of 20 consecutive patients who underwent gastric ESD. Five endoscopists compared DRI with white light imaging (WLI) for the visibility of blood vessels and bleeding points while performing endoscopic hemostasis.
Results
The visibility of blood vessels was increased in 56% (19/34) of the cases, and the visibility of bleeding points was improved in 55% (11/20) of the cases with the use of DRI compared with the use of WLI.
Conclusions
DRI improved the visibility of blood vessels and bleeding points in cases with oozing bleeding, blood pooling around the bleeding points, and multiple bleeding points.
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Citations
Citations to this article as recorded by

- Red Dichromatic Imaging Improves the Recognition of Bleeding Points During Endoscopic Submucosal Dissection
Yosuke Mori, Taro Iwatsubo, Akitoshi Hakoda, Shin Kameishi, Kazuki Takayama, Shun Sasaki, Ryoji Koshiba, Shinya Nishida, Satoshi Harada, Hironori Tanaka, Noriaki Sugawara, Kazuhiro Ota, Shinpei Kawaguchi, Yuichi Kojima, Toshihisa Takeuchi, Kazuhide Higuch
Digestive Diseases and Sciences.2024; 69(1): 216. CrossRef - Technical Advances in Endoscopic Resection Techniques for Lower GI Malignancies
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Joshua Melson
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Aoi Kita, Shiko Kuribayashi, Yuki Itoi, Keigo Sato, Yu Hashimoto, Kengo Kasuga, Hirohito Tanaka, Hiroko Hosaka, Kazue Nagai, Hemchand Ramberan, Toshio Uraoka
Surgical Endoscopy.2023; 37(1): 503. CrossRef - Red dichromatic imaging improves visibility of bleeding during gastric endoscopic submucosal dissection
Kohei Oka, Naoto Iwai, Takashi Okuda, Toshifumi Tsuji, Hiroaki Sakai, Chie Hattori, Masashi Taniguchi, Tasuku Hara, Toshiyuki Komaki, Junichi Sakagami, Keizo Kagawa, Osamu Dohi, Yoshito Itoh
Scientific Reports.2023;[Epub] CrossRef - Near infrared imaging system for preventing blood vision obstruction in endoscopy
Meng-Huang Wu, Jason C. Hsu, Jin-Sung Kim, Tsung-Jen Huang, Yi-Hung Huang, Hon Pan Yiu, Ching-Yu Lee, Jowy Tani, Cheng-Chun Chang
Optics Express.2023; 31(26): 43877. CrossRef - Red dichromatic imaging reduces endoscopic treatment time of esophageal varices by increasing bleeding point visibility (with video)
Yoshihiro Furuichi, Masakazu Abe, Hirohito Takeuchi, Yuu Yoshimasu, Takao Itoi
Digestive Endoscopy.2022; 34(1): 87. CrossRef - Clinical usefulness of red dichromatic imaging in hemostatic treatment during endoscopic submucosal dissection: First report from a multicenter, open‐label, randomized controlled trial
Ai Fujimoto, Yutaka Saito, Seiichiro Abe, Syu Hoteya, Kosuke Nomura, Hiroshi Yasuda, Yasumasa Matsuo, Toshio Uraoka, Shiko Kuribayashi, Yosuke Tsuji, Daisuke Ohki, Tadateru Maehata, Motohiko Kato, Naohisa Yahagi
Digestive Endoscopy.2022; 34(2): 379. CrossRef - Evaluation of the visibility of bleeding points using red dichromatic imaging in endoscopic hemostasis for acute GI bleeding (with video)
Yuichiro Hirai, Ai Fujimoto, Naomi Matsutani, Soichiro Murakami, Yuki Nakajima, Ryoichi Miyanaga, Yoshihiro Nakazato, Kazuyo Watanabe, Masahiro Kikuchi, Naohisa Yahagi
Gastrointestinal Endoscopy.2022; 95(4): 692. CrossRef - Utility of red dichromatic imaging for identifying the bleeding point in endoscopic hemostasis of colonic diverticular bleeding
Soma Fukuda, Taku Sakamoto, Hideo Suzuki, Toshiaki Narasaka, Kiichiro Tsuchiya
VideoGIE.2022; 7(4): 149. CrossRef - Red dichromatic imaging reduces bleeding and hematoma during submucosal injection in esophageal endoscopic submucosal dissection
Kurato Miyazaki, Motohiko Kato, Motoki Sasaki, Kentaro Iwata, Teppei Masunaga, Yoko Kubosawa, Yukie Hayashi, Mari Mizutani, Yoshiyuki Kiguchi, Yusaku Takatori, Makoto Mutaguchi, Noriko Matsuura, Atsushi Nakayama, Kaoru Takabayashi, Takanori Kanai, Naohisa
Surgical Endoscopy.2022; 36(11): 8076. CrossRef - Endoscopic treatment for early gastric cancer
Ji Yong Ahn
Journal of the Korean Medical Association.2022; 65(5): 276. CrossRef - Novel image enhancement technology that helps find bleeding points during endoscopic submucosal dissection of gastric neoplasms
Kohei Funasaka, Ryoji Miyahara, Noriyuki Horiguchi, Takafumi Omori, Hayato Osaki, Dai Yoshida, Hyuga Yamada, Keishi Koyama, Mitsuo Nagasaka, Yoshiyuki Nakagawa, Senju Hashimoto, Tomoyuki Shibata, Yoshiki Hirooka
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Risa Nakamura, Haruka Toyonaga, Akio Katanuma
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Therapeutic Advances in Gastroenterology.2022;[Epub] CrossRef - Endoscopic submucosal dissection of early-stage rectal cancer using full-time red dichromatic imaging to minimize and avoid significant bleeding
Aoi Kita, Hirohito Tanaka, Hemchand Ramberan, Shiko Kuribayashi, Toshio Uraoka
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Anudeep KV, Mohan Ramchandani, Pradev Inavolu, Zaheer Nabi, D. Nageshwar Reddy
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Hiroki Kurumi, Kouichi Nonaka, Yuichiro Ikebuchi, Akira Yoshida, Koichiro Kawaguchi, Kazuo Yashima, Hajime Isomoto
Journal of Clinical Medicine.2021; 10(13): 2918. CrossRef - Visibility of the bleeding point in acute rectal hemorrhagic ulcer using red dichromatic imaging: A case report
Yuichiro Hirai, Atsuto Kayashima, Yoshihiro Nakazato, Ai Fujimoto
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In Kyung Yoo, Joo Young Cho
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Tadateru Maehata, Ai Fujimoto, Toshio Uraoka, Motohiko Kato, Joichiro Horii, Motoki Sasaki, Yoshiyuki Kiguchi, Teppei Akimoto, Atsushi Nakayama, Yasutoshi Ochiai, Osamu Goto, Toshihiro Nishizawa, Naohisa Yahagi
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Heng Guo, Ying Li, Weizhi Qi, Lei Xi
Journal of Biophotonics.2020;[Epub] CrossRef
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6,769
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Case Report
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Massive Duodenal Bleeding after the Migration of Endovascular Coils into the Small Bowel
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Chung-Jo Choi, Hyun Lim, Dong-Suk Kim, Yong-Seol Jeong, Sang-Young Park, Jeong-Eun Kim
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Clin Endosc 2019;52(6):612-615. Published online May 20, 2019
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DOI: https://doi.org/10.5946/ce.2019.020
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Abstract
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- Among gastrointestinal emergencies, acute upper gastrointestinal bleeding remains a challenging clinical problem owing to significant patient morbidity and costs involved in management. Endoscopic hemostatic therapy is the mainstay of treatment and decreases the incidence of re-bleeding, the need for surgery, morbidity, and mortality. However, in 8%–15% of patients with upper gastrointestinal bleeding, endoscopic hemostatic therapy does not successfully control bleeding. Trans-arterial coil embolization is an effective alternative treatment for endoscopic hemostatic failure; however, this procedure can induce adverse outcomes, such as non-target vessel occlusion, vessel dissection and perforation, and coil migration. Coil migration is rare but causes severe complications, such as re-bleeding and bowel ischemia. However, in most cases, coil migration is local and involves spontaneous healing without serious complications. Here, we report the case of a patient who underwent trans-arterial coil embolization of the gastroduodenal artery with the purpose of controlling massive duodenal bleeding, resulting in a fatal outcome caused by coil migration.
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Focused Review Series: Endoscopic Submucosal Dissection for Colorectal Tumors
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Management of Complications of Colorectal Submucosal Dissection
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Eun Ran Kim, Dong Kyung Chang
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Clin Endosc 2019;52(2):114-119. Published online March 29, 2019
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DOI: https://doi.org/10.5946/ce.2019.063
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Abstract
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- Endoscopic submucosal dissection (ESD) is a useful procedure for the treatment of superficial gastrointestinal neoplasm. Compared with endoscopic mucosal resection (EMR), ESD has several benefits, which include resectability of various difficult lesion, accurate histologic assessment of specimen, and lower recurrence rate. However, the risk of procedure- related complications is higher with ESD than with EMR. Moreover, because the colon has a thin wall and limited endoscopic maneuverability, ESD is considered a more challenging and risky procedure when performed in the colon than in the stomach. ESD-related complications are more likely to occur. The significant complications associated with ESD are bleeding, perforation, coagulation syndrome and stenosis, most of which can be treated and prevented by endoscopic intervention and preparation. Therefore, it is important to know how to occur and manage the ESD related complication.
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Case Report
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Giant Brunner’s Gland Hamartoma of the Duodenal Bulb Presenting with Upper Gastrointestinal Bleeding and Obstruction
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Ju Hyoung Lee, Kyeong Min Jo, Tae Oh Kim, Jong Ha Park, Seung Hyun Park, Jae Won Jung, So Chong Hur, Sung Yeun Yang
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Clin Endosc 2016;49(6):570-574. Published online October 13, 2016
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DOI: https://doi.org/10.5946/ce.2016.022
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Abstract
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- Brunner’s gland hamartomas are small benign lesions that are most commonly found in the bulb of the duodenum. They are very uncommon, and most are found incidentally during upper gastrointestinal series or esophagogastroduodenoscopy. The lesions tend to be asymptomatic, but patients may present with symptoms of duodenal obstruction or hemorrhage secondary to ulceration. Histologically, a Brunner's gland hamartoma consists of the components of Brunner's gland cells, as well as glandular, adipose and muscle cells. In this study, we report the case of a 30-year-old man who presented with upper gastrointestinal bleeding and obstructive symptoms due to a giant Brunner's gland hamartoma in the duodenal bulb. The hamartoma was successfully removed by endoscopic resection. No significant complications were observed. Microscopically, the lesion was found to be entirely composed of variable Brunner's glands and adipocytes.
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Citations
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- A case of primary duodenal Brunner's gland hamartoma that gradually underwent morphological changes over a period of 10 years
Yusuke Sunada, Hiromichi Yamane, Nobuaki Ochi, Hirohito Kirishi, Takako Saitou, Masafumi Miura, Hidekazu Nakanishi, Hideyo Fujiwara, Nagio Takigawa
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Manar Shmais, Ahmad Mousawi, Fadi Mourad, Ala I. Sharara
Arab Journal of Gastroenterology.2024; 25(1): 70. CrossRef - The Characteristics and Treatment Outcomes of 71 Duodenal Brunner’s Gland Adenomas with Endoscopic Submucosal Dissection
Ying Xiang, Jinyan Liu, Nan ya Wang, Dehua Tang, Lei Wang, Ping xiao Zou, Guifang Xu, Qin Huang
Digestive Diseases.2023; 41(6): 852. CrossRef - Giant brunner gland hamartoma: An unusual cause of upper gastrointestinal bleed
Bershic Valantine, ManjunathB Venkatapur, Sultan Nawahirsha, SBabu Kumar
Gastroenterology, Hepatology and Endoscopy Practice.2023; 3(3): 90. CrossRef - A giant Brunner’s gland hamartoma being treated as a pedunculated polyp: a case report
Lizhi Yi, Zhengyu Cheng, Huarong Qiu, Jianjun Yang, Tao Wang, Ke Liu
BMC Gastroenterology.2019;[Epub] CrossRef
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9,599
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Review
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Diagnosis of Obscure Gastrointestinal Bleeding
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Satoshi Tanabe
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Clin Endosc 2016;49(6):539-541. Published online February 11, 2016
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DOI: https://doi.org/10.5946/ce.2016.004
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Abstract
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- Obscure gastrointestinal bleeding (OGIB) is defined as gastrointestinal bleeding from a source that cannot be identified on upper or lower gastrointestinal endoscopy. OGIB is considered an important indication for capsule endoscopy (CE). CE is particularly useful for the detection of vascular and small ulcerative lesions, conditions frequently associated with OGIB, particularly in Western countries. On the other hand, balloon enteroscopy (BE) can facilitate the diagnosis of lesions presenting with minimal changes of the mucosal surface, such as submucosal tumors, and can be used not only for diagnosis, but also for treatment, including endoscopic hemostasis. In other words, the complementary use of both CE and BE enables OGIB to be more efficiently diagnosed and treated. However, rebleeding can occur even in patients with negative results of CE, and such patients require repeat CE or BE. It is essential to effectively use both CE and BE based on a thorough understanding of the strong points and weak points of these procedures. Further advances and developments in virtual endoscopy incorporating computed tomography and magnetic resonance imaging are expected in the future.
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Amy Donovan, Sandun Abeyasundara, Hajir Nabi
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Wenju Du, Nini Rao, Dingyun Liu, Hongxiu Jiang, Chengsi Luo, Zhengwen Li, Tao Gan, Bing Zeng
IEEE Access.2019; 7: 142053. CrossRef - Preoperative detection and localization of small bowel hemangioma: Two case reports
Nobuhisa Takase, Keisuke Fukui, Takafumi Tani, Tohru Nishimura, Tomohiro Tanaka, Naoki Harada, Kimihiko Ueno, Manabu Takamatsu, Akihiko Nishizawa, Akiharu Okamura, Kunihiko Kaneda
World Journal of Gastroenterology.2017; 23(20): 3752. CrossRef
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5
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Original Article
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Roles of Capsule Endoscopy and Single-Balloon Enteroscopy in Diagnosing Unexplained Gastrointestinal Bleeding
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Shohei Ooka, Kiyonori Kobayashi, Kana Kawagishi, Masaru Kodo, Kaoru Yokoyama, Miwa Sada, Satoshi Tanabe, Wasaburo Koizumi
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Clin Endosc 2016;49(1):56-60. Published online January 28, 2016
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DOI: https://doi.org/10.5946/ce.2016.49.1.56
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Abstract
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- Background
/Aims: The diagnostic algorithms used for selecting patients with obscure gastrointestinal bleeding (OGIB) for capsule endoscopy (CE) or balloon-assisted enteroscopy (BE) vary among facilities. We aimed to demonstrate the appropriate selection criteria of CE and single balloon-assisted enteroscopy (SBE) for patients with OGIB according to their conditions, by retrospectively comparing the diagnostic performances of CE and BE for detecting the source of the OGIB.
Methods
We investigated 194 patients who underwent CE and/or BE. The rate of positive findings, details of the findings, accidental symptoms, and hemostasis methods were examined and analyzed.
Results
CE and SBE were performed in 103 and 91 patients, respectively, and 26 patients underwent both examinations. The rate of positive findings was significantly higher with SBE (73.6%) than with CE (47.5%, p<0.01). The rate of positive findings was higher in overt bleeding cases than in occult bleeding cases for both BE and SBE. Among the overt bleeding cases, the rate was significantly higher in ongoing bleeding cases than in previous bleeding cases.
Conclusions
Both CE and SBE are useful to diagnose OGIB. For overt bleeding cases and ongoing bleeding cases, SBE may be more appropriate than CE because endoscopic diagnosis and treatment can be completed simultaneously.
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Citations
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- The Role of Capsule Endoscopy in the Diagnosis and Management of Small Bowel Tumors: A Narrative Review
Stefano Fantasia, Pablo Cortegoso Valdivia, Stefano Kayali, George Koulaouzidis, Marco Pennazio, Anastasios Koulaouzidis
Cancers.2024; 16(2): 262. CrossRef - Research Progress of the Use of Balloon-Assisted Enteroscopy (BAE) in Small Bowel Diseases
芸玲 李
Advances in Clinical Medicine.2024; 14(09): 555. CrossRef - Inpatient Small Bowel Capsule Endoscopy: Not Associated With Bleeding Site Identification or 30-Day Readmission Prevention
Ismail Ghafary, Talal Seoud, Michael Jorgensen, Jade Marhaba, William M Briggs, Daniel S Jamorabo
Cureus.2024;[Epub] CrossRef - Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2022
Marco Pennazio, Emanuele Rondonotti, Edward J. Despott, Xavier Dray, Martin Keuchel, Tom Moreels, David S. Sanders, Cristiano Spada, Cristina Carretero, Pablo Cortegoso Valdivia, Luca Elli, Lorenzo Fuccio, Begona Gonzalez Suarez, Anastasios Koulaouzidis,
Endoscopy.2023; 55(01): 58. CrossRef - Use of device-assisted enteroscopy in small bowel disease: an expert consensus statement by the Korean Association for the Study of Intestinal Diseases
Han Hee Lee, Jin Su Kim, Hyeon Jeong Goong, Shin Hee Lee, Eun Hye Oh, Jihye Park, Min Cheol Kim, Kwangwoo Nam, Young Joo Yang, Tae Jun Kim, Seung-Joo Nam, Hee Seok Moon, Jae Hyun Kim, Duk Hwan Kim, Seong-Eun Kim, Seong Ran Jeon, Seung-Jae Myung
Intestinal Research.2023; 21(1): 3. CrossRef - Use of Device-Assisted Enteroscopy in Small Bowel Disease: An Expert Consensus Statement by the Korean Association for the Study of Intestinal Diseases
Han Hee Lee, Jin Su Kim, Hyeon Jeong Goong, Shin Hee Lee, Eun Hye Oh, Jihye Park, Min Cheol Kim, Kwangwoo Nam, Young Joo Yang, Tae Jun Kim, Seung-Joo Nam, Hee Seok Moon, Jae Hyun Kim, Duk Hwan Kim, Seong-Eun Kim, Seong Ran Jeon, Seung-Jae Myung
The Korean Journal of Gastroenterology.2023; 81(1): 1. CrossRef - Updates in the diagnosis and management of small-bowel tumors
Erasmia Vlachou, Apostolos Koffas, Christos Toumpanakis, Martin Keuchel
Best Practice & Research Clinical Gastroenterology.2023; 64-65: 101860. CrossRef - Diagnostic and therapeutic yields of early capsule endoscopy and device-assisted enteroscopy in the setting of overt GI bleeding: a systematic review with meta-analysis
Maria Manuela Estevinho, Rolando Pinho, Carlos Fernandes, Adélia Rodrigues, Ana Ponte, Ana Catarina Gomes, Edgar Afecto, João Correia, João Carvalho
Gastrointestinal Endoscopy.2022; 95(4): 610. CrossRef - Clinical features of capsule endoscopy in young adults: A single‐center retrospective study
Hui‐Wen Xu, Yi‐Ru Chen, Mei‐Qian Wang, Sen‐Lin Zhu
JGH Open.2022; 6(9): 637. CrossRef - Occult Small Bowel Bleeding
Perry K. Pratt, Haleh Vaziri
Current Treatment Options in Gastroenterology.2021; 19(2): 211. CrossRef - Technical and Clinical Aspects of Diagnostic Single-Balloon Enteroscopy in the First Decade of Use: A Systematic Review and Meta-Analysis
Ye Gao, Lei Xin, Yi-Tong Zhang, Xiao-Rong Guo, Qian-Qian Meng, Zhao-Shen Li, Zhuan Liao
Gut and Liver.2021; 15(2): 262. CrossRef - Timing of enteroscopy in overt-obscure gastrointestinal bleeding - a systematic review and meta-analysis
Ana Catarina Gomes, Rolando Taveira Pinho, Ana Ponte, Manuela Estevinho, Jo�o Carvalho
Revista Española de Enfermedades Digestivas.2021;[Epub] CrossRef - Anisakiasis in the Small Intestine with Excessive Bleeding That Was Difficult to Diagnose Endoscopically
Kazumasa Kawashima, Tatsuo Fujiwara, Kyoko Katakura, Naohiko Gunji, Aki Yokokawa, Ayumu Sakamoto, Takuto Hikichi, Koji Kono, Hiromasa Ohira
Internal Medicine.2019; 58(1): 63. CrossRef - Diagnostic Value and Safety of Emergency Single-Balloon Enteroscopy for Obscure Gastrointestinal Bleeding
Yipin Liu, Weiwei Jiang, Guoxun Chen, Yanqing Li
Gastroenterology Research and Practice.2019; 2019: 1. CrossRef - UEG Week 2018 Poster Presentations
United European Gastroenterology Journal.2018;[Epub] CrossRef
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8,226
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15
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Focused Review Series: Current Issues and Future Directions of Small Bowel Endoscopic Evaluation
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The Role of Capsule Endoscopy in Patients with Obscure Gastrointestinal Bleeding
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Yang Won Min, Dong Kyung Chang
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Clin Endosc 2016;49(1):16-20. Published online January 28, 2016
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DOI: https://doi.org/10.5946/ce.2016.49.1.16
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Abstract
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- Obscure gastrointestinal bleeding (OGIB) accounts for 5% of all gastrointestinal (GI) bleeding cases and is often caused by small bowel lesions. Capsule endoscopy (CE), which allows non-invasive visualization of the small bowel mucosa, has revolutionized the evaluation of OGIB. CE is preferred by both patients and physicians mainly because of its non-invasiveness, and is widely used as the first-line diagnostic modality for OGIB. The diagnostic yield of CE in OGIB has been reported to be in the range of 32% to 83%. Although no direct comparison has been made, a meta-analysis showed similar diagnostic yields between CE and double-balloon enteroscopy (DBE) for OGIB. However, CE could enhance the yield of subsequent DBE and serve as a guide for optimizing the insertion route for DBE. Even after negative CE, selected patients could benefit from second-look CE for OGIB. In terms of outcomes, a favorable clinical impact after CE has been reported in several studies. However, observations indicate that CE might not influence clinical outcomes directly, but rather play a role in selecting patients with OGIB who are likely to benefit from subsequent evaluation and intervention.
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Citations
Citations to this article as recorded by

- Inpatient Small Bowel Capsule Endoscopy: Not Associated With Bleeding Site Identification or 30-Day Readmission Prevention
Ismail Ghafary, Talal Seoud, Michael Jorgensen, Jade Marhaba, William M Briggs, Daniel S Jamorabo
Cureus.2024;[Epub] CrossRef - Experiencia con el uso de videocápsula endoscópica en pacientes con anemia ferropénica inexplicada
Rosangela Ramirez Barranco, Valeria Atenea Costa Barney, Reinaldo Andres Rincón
Revista colombiana de Gastroenterología.2022; 37(1): 33. CrossRef - Concordancia diagnóstica entre la videocápsula endoscópica y enteroscopia mono y de doble balón en la hemorragia de intestino delgado en un hospital de alta complejidad en Bogotá, Colombia
R. Cañadas Garrido, R.A. Rincón Sánchez, V.A. Costa Barney, P.A. Roa Ballestas, C.A. Espinosa Martínez, D.F. Pinzón Arenas, R. Ramirez Barranco
Revista de Gastroenterología de México.2021; 86(1): 51. CrossRef - Effect of Nonsteroidal Anti-inflammatory Agents on Small Intestinal Injuries as Evaluated by Capsule Endoscopy
Sang Pyo Lee, Jin Lee, Sea Hyub Kae, Hyun Joo Jang, Eun Suk Jung
Digestive Diseases and Sciences.2021; 66(8): 2724. CrossRef - Diagnostic agreement between video capsule endoscopy and single and double balloon enteroscopy for small bowel bleeding at a tertiary care hospital in Bogota, Colombia
R. Cañadas Garrido, R.A. Rincón Sánchez, V.A. Costa Barney, P.A. Roa Ballestas, C.A. Espinosa Martínez, D.F. Pinzón Arenas, R. Ramírez Barranco
Revista de Gastroenterología de México (English Edition).2021; 86(1): 51. CrossRef - CapsoCam SV-1 Versus PillCam SB 3 in the Detection of Obscure Gastrointestinal Bleeding
Lilli L. Zwinger, Britta Siegmund, Andrea Stroux, Andreas Adler, Winfried Veltzke-Schlieker, Robert Wentrup, Christian Jürgensen, Bertram Wiedenmann, Felix Wiedbrauck, Stephan Hollerbach, Thomas Liceni, Christian Bojarski
Journal of Clinical Gastroenterology.2019; 53(3): e101. CrossRef - Clinical Utility of Emergency Capsule Endoscopy for Diagnosing the Source and Nature of Ongoing Overt Obscure Gastrointestinal Bleeding
Sumio Iio, Shiro Oka, Shinji Tanaka, Akiyoshi Tsuboi, Ichiro Otani, Sayoko Kunihara, Kazuaki Chayama
Gastroenterology Research and Practice.2019; 2019: 1. CrossRef - Diagnostic Benefit of Simultaneous Capsule Endoscopy Using Two Different Systems
Seung Han Kim, Hyuk Soon Choi, Hoon Jai Chun, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Hong Sik Lee, Soon Ho Um, Chang Duck Kim
Gastroenterology Research and Practice.2018; 2018: 1. CrossRef - Management of occult obscure gastrointestinal bleeding patients based on long-term outcomes
Sayoko Kunihara, Shiro Oka, Shinji Tanaka, Akiyoshi Tsuboi, Ichiro Otani, Kazuaki Chayama
Therapeutic Advances in Gastroenterology.2018;[Epub] CrossRef - Magnetic-Guided Capsule Endoscopy in the Diagnosis of Gastrointestinal Diseases in Minors
Yuting Qian, Tingting Bai, Juanjuan Li, Yi Zang, Tong Li, Mingping Xie, Qi Wang, Lifu Wang, Ruizhe Shen
Gastroenterology Research and Practice.2018; 2018: 1. CrossRef - What is the Role of Double-Balloon Endoscopy in Patients Presenting with Obscure Gastrointestinal Bleeding?
Jung Ho Kim, Kwang An Kwon
Clinical Endoscopy.2017; 50(1): 8. CrossRef - Intérêt de l’exploration de l’intestin grêle dans les hémorragies digestives
Chloé Leandri, Benoit Bordacahar, Sophie Ribiere, Ammar Oudjit, Marie-Anne Guillaumot, Bertrand Brieau, Frédéric Prat, Vered Abitbol, Stanislas Chaussade, Romain Coriat
La Presse Médicale.2017; 46(10): 903. CrossRef - Development and validation of a new scoring system to determine the necessity of small-bowel endoscopy in obscure gastrointestinal bleeding
Genta Uchida, Masanao Nakamura, Osamu Watanabe, Takeshi Yamamura, Takuya Ishikawa, Kazuhiro Furukawa, Kohei Funasaka, Eizaburo Ohno, Hiroki Kawashima, Ryoji Miyahara, Hidemi Goto, Yoshiki Hirooka
Digestive and Liver Disease.2017; 49(11): 1218. CrossRef
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Original Article
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Risk Factors for Dieulafoy Lesions in the Upper Gastrointestinal Tract
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Hae Jin Shin, Jong Seok Ju, Ki Dae Kim, Seok Won Kim, Sung Hoon Kang, Sun Hyung Kang, Hee Seok Moon, Jae Kyu Sung, Hyun Yong Jeong
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Clin Endosc 2015;48(3):228-233. Published online May 29, 2015
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DOI: https://doi.org/10.5946/ce.2015.48.3.228
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Abstract
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- Background/Aims
The purpose of this study is to verify the risk factors associated with Dieulafoy lesion formation in the upper gastrointestinal tract.
MethodsA case-control study was performed by reviewing the electronic medical records of 42 patients who were admitted to a tertiary medical center in the Daejeon region for Dieulafoy lesions from September 2008 to October 2013, and the records of 132 patients who were admitted during the same period and who underwent endoscopic examination for reasons other than bleeding. We analyzed clinical and endoscopic findings retrospectively, and searched for risk factors associated with Dieulafoy lesion formation.
ResultsAll 42 patients diagnosed with Dieulafoy lesion had accompanying bleeding, and the location of the bleeding was proximal in 25 patients (59.5%), the middle portion in seven patients (16.7%), and distal in 10 patients (23.8%). Antiplatelet agents (p=0.022) and alcohol (p=0.001) use showed statistically significant differences between the two groups. The odds ratios (95% confidence intervals) of the two factors were 2.802 (1.263 to 6.217) and 3.938 (1.629 to 9.521), respectively.
ConclusionsThis study showed that antiplatelet agents and alcohol consumption were risk factors associated with Dieulafoy lesion formation in the upper gastrointestinal tract.
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Citations
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- Can Segmental Branch Embolization of the Left Gastric Artery Be an Alternative in the Treatment of Recurrent Dieulafoy Lesion Bleeding? A Case report
Gamze Sönmez, Serez İleri, Ferdi Çay, Bora Peynircioğlu, Onur Keskin
Akademik Gastroenteroloji Dergisi.2024; 23(2): 67. CrossRef - Usage of Padlock Over-the-Scope-Clip in Difficult-to-Control Recurrent Gastrointestinal Bleeding Due to a Gastric Dieulafoy Lesion
John Joyce, Vishnu Kumar, Dayana Nasr, Ganesh Aswath, Hafiz M. Khan, Savio John
Journal of Investigative Medicine High Impact Case Reports.2024;[Epub] CrossRef - Fatal exulceratio simplex (dieulafoy lesion) – a case report and review
Luzern Tan, John D. Gilbert, Roger W. Byard
Forensic Science, Medicine and Pathology.2024;[Epub] CrossRef - Sustained Hemostasis With the Padlock™ Over-the-scope Clip for Gastric Fundus Dieulafoy’s Lesion in the Setting of Anticoagulation Following Hemorrhagic Shock From Two Dieulafoy’s Lesions
Jonathan J Cho, Chelsea M Forbes, Benjamin D Fiore, Joshua D McCarron, Leybelis Padilla
Military Medicine.2023; 188(9-10): e3265. CrossRef - Multiple Gastric Dieulafoy Lesions
Vikas Pemmada, Ganesh Bhat, Athish Shetty, Bharath Kumar Bhat, Megha Murali, Geetha Vasudevan
ACG Case Reports Journal.2023; 10(6): e01053. CrossRef - Retrospective analysis of patients with Dieulafoy’s lesions
Bünyamin SARITAŞ, Şehmus ÖLMEZ, Adnan TAŞ, Nevin AKÇAER ÖZTÜRK, Banu KARA
Akademik Gastroenteroloji Dergisi.2023; 22(3): 136. CrossRef - Gastrointestinal Bleeding From a Transverse Colon Dieulafoy Lesion
Xinyu Xie, Jian Qin, Xiaojua Ma, Shanshan Liu
Cureus.2023;[Epub] CrossRef - Cliniccal Analysis of 5 Cases of Upper Gastrointestinal Bleeding Caused by Duodenal Dieulafoy’s Disease
金明 张
Advances in Clinical Medicine.2023; 13(10): 15268. CrossRef - Case report: The first description of a Dieulafoy's lesion in the gastric mucosa of a dog
Daniel Felipe Barrantes Murillo, Michael Tillson, Jennifer W. Koehler, Maninder Sandey
Frontiers in Veterinary Science.2022;[Epub] CrossRef - Diagnosis and Treatment of a Recurrent Bleeding Dieulafoy’s Lesion: A Case Report
Amanda R Levy, Sierra Broad, James R Loomis III, Julie A Thomas
Cureus.2022;[Epub] CrossRef - Dieulafoy lesions as cause of upper gastrointestinal bleeding in a patient with portal hypertension
Fahad Malik, Omar Al Salman, Marwah Alchalabi, Shobhana Chaudhari, Ali Tariq Khan
Journal of Community Hospital Internal Medicine Perspectives.2021; 11(1): 94. CrossRef - Jejunal Dieulafoy’s Lesion: A Systematic Review of Evaluation, Diagnosis, and Management
Adnan Malik, Faisal Inayat, Muhammad Hassan Naeem Goraya, Talal Almas, Rizwan Ishtiaq, Sohira Malik, Zahid Ijaz Tarar
Journal of Investigative Medicine High Impact Case Reports.2021;[Epub] CrossRef - Dieulafoy Lesion as a Source of Bleeding: A Report of Two Clinical Cases
Goran Sarafiloski, Mimi R. Marinova, Pencho T. Tonchev
Journal of Biomedical and Clinical Research.2021; 14(2): 186. CrossRef - Incidental massive lower gastrointestinal hemorrhage caused by a rectal Dieulafoy’s lesion
Genesis Perez Del Nogal, Rangesh Modi, Ivania Salinas, Kalyan Chakrala
BMJ Case Reports.2021; 14(9): e244264. CrossRef - Gastrointestinal Bleeding at CT Angiography and CT Enterography: Imaging Atlas and Glossary of Terms
Flavius F. Guglielmo, Michael L. Wells, David H. Bruining, Lisa L. Strate, Álvaro Huete, Avneesh Gupta, Jorge A. Soto, Brian C. Allen, Mark A. Anderson, Olga R. Brook, Michael S. Gee, David J. Grand, Martin L. Gunn, Ashish Khandelwal, Seong Ho Park, Vijay
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Keisuke Kinoshita, Osamu Matsunari, Akira Sonoda, Kensuke Fukuda, Kazuhisa Okamoto, Ryo Ogawa, Kazuhiro Mizukami, Tadayoshi Okimoto, Masaaki Kodama, Kazunari Murakami
Clinical Journal of Gastroenterology.2020; 13(4): 564. CrossRef - Dieulafoy's Lesion: Decade-Long Trends in Hospitalizations, Demographic Disparity, and Outcomes
Raja Chandra Chakinala, Shantanu Solanki, Khwaja F Haq, Jagmeet Singh, Harshil Shah, Dhanshree Solanki, Asim Kichloo, Khwaja S Haq, Azam H Burney, Shanza Waqar, Manasee Vyas, Savneek Chugh, Christopher Nabors
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Benjamín Gallo Arriaga, José Raúl Nieto Saucedo, Benjamín Gallo Chico, J Jesús Ibarra Rodríguez, Karla Edith Santibáñez Bedolla, Carlos Hidalgo Valadez
Acta Médica Grupo Ángeles.2020; 18(3): 302. CrossRef - Gastric vascular abnormalities: diagnosis and management
Mohanad Awadalla, Mohamed Mahmoud, Philip McNamara, Wahid Wassef
Current Opinion in Gastroenterology.2020; 36(6): 538. CrossRef - Dieulafoy Lesion: Predictive Factors of Early Relapse and Long-Term Follow-Up
Paulo Massinha, Inês Cunha, Luís Tomé
GE - Portuguese Journal of Gastroenterology.2020; 27(4): 237. CrossRef - Lesión de Dieulafoy en estómago como causa de sangrado gastrointestinal alto: presentación de un caso
Jairo Alonso Sierra-Avendaño, Fabián Andrés Mejía-Casadiegos, María Paula Pérez-Barón, Gabriel Eduardo Pérez-García
Revista Médicas UIS.2019; 32(1): 27. CrossRef - Massive Gastrointestinal Bleeding from a Jejunal Dieulafoy Lesion: An Extraordinary Presentation
Majdi Saada, Shay Perek, Mohammad Agbaria, Ayelet Raz-Pasteur
Case Reports in Gastroenterology.2019; 13(3): 508. CrossRef - Postural Syncope and Constipation: An Unusual Presentation of a Duodenal Dieulafoy’s Lesion
Ahmed Dirweesh, Alvarez Chikezie, Muhammad Yasir Khan, Sana Zia, Muhammad Tahir
Case Reports in Gastrointestinal Medicine.2017; 2017: 1. CrossRef
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Case Report
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Esophageal Involvement of Pemphigus Vulgaris Associated with Upper Gastrointestinal Bleeding
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Sooyun Chang, Soo Jung Park, Sun Wook Kim, Moo-Nyun Jin, Jung-Hee Lee, Hyun Ju Kim, Sung Pil Hong, Tae Il Kim
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Clin Endosc 2014;47(5):452-454. Published online September 30, 2014
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DOI: https://doi.org/10.5946/ce.2014.47.5.452
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Esophageal involvement of pemphigus vulgaris is rare, and when present, the most common presenting symptoms reported in the medical literature are odynophagia and dysphagia. Here, we present two cases of pemphigus vulgaris presenting with upper gastrointestinal hemorrhage because of esophageal involvement of the disease. In case 1, a 41-year-old female patient with a prior diagnosis of pemphigus vulgaris presented with hematemesis. Esophagogastroduodenoscopy showed diffuse mucosal exfoliation and oozing bleeding of the oropharynx and esophagus. The patient recovered after the administration of high-dose corticosteroids and immunosuppressants. In case 2, a 30-year-old female patient with known pemphigus vulgaris also presented with hematemesis, showing similar endoscopic findings to the first case. She also responded to the same treatment. Esophageal involvement of pemphigus vulgaris responds to high-dose corticosteroids and immunosuppressants. Thus, in patients with pemphigus vulgaris with signs or symptoms of upper gastrointestinal bleeding, an early endoscopy for the evaluation of esophageal involvement is beneficial.
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- Hematemesis in pemphigus vulgaris: A challenging case of isolated esophageal flare in patient in remission
Maninder Kaur, Nagbhushan Hedge, Ashish Agarwal, Vikarn Vishwajeet, Suman Patra, Saurabh Singh
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Maninder Kaur, Nagbhushan Hedge, Ashish Agarwal, Vikarn Vishwajeet, Suman Patra, Saurabh Singh
JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2023; 21(12): 1551. CrossRef - A Case of Exfoliative Esophagitis with Pemphigus Vulgaris
Wei-Feng Huang, Wei Liu
Indian Journal of Surgery.2022; 84(3): 563. CrossRef - Pemphigus for the Inpatient Dermatologist
Connor Cole, Kyle Amber
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Victoria Malone, Kieran Sheahan
Histopathology.2021; 78(1): 4. CrossRef - Esophageal Pemphigus Vulgaris: A Rare Etiology of Upper Gastrointestinal Hemorrhage
Jennifer Rose F. Del Castillo, Muhammad Nadeem Yousaf, Fizah S. Chaudhary, Nahar Saleh, Lawrence Mills, Yoshiro Kawahara
Case Reports in Gastrointestinal Medicine.2021; 2021: 1. CrossRef - Pemphigus Vulgaris and Bullous Pemphigoid of the Upper Aerodigestive Tract: A Review Article and Novel Approaches to Management
Mohammed Hassan Hussain, Faiz Tanweer, Georgios Sakagiannis, Manish Mair, Sara Mahmood, Sithamparappillai Ashokkumar
ORL.2021; 83(6): 395. CrossRef - Gastrointestinal involvement of primary skin diseases
C.‐Y. Lu, M.‐S. Hsieh, K.‐C. Wei, M. Ezmerli, C.‐H. Kuo, W. Chen
Journal of the European Academy of Dermatology and Venereology.2020; 34(12): 2766. CrossRef - Oesophageal pemphigoid: a rare cause of dysphagia
Michael McFarlane, Ayesha Azam, David Snead, Ben Disney
Clinical Journal of Gastroenterology.2019; 12(1): 25. CrossRef - Esophagitis unrelated to reflux disease: current status and emerging diagnostic challenges
Melanie E. Johncilla, Amitabh Srivastava
Virchows Archiv.2018; 472(1): 29. CrossRef - Pemphigus Vulgaris in the Mouth and Esophageal Mucosa
Angelo Gualberto de Macedo, Erika Ruback Bertges, Luiz Carlos Bertges, Renata Alvim Mendes, Thais Abranches Bueno Sabino Bertges, Klaus Ruback Bertges, Fernando Monteiro Aarestrup
Case Reports in Gastroenterology.2018; 12(2): 260. CrossRef - Ulcerative colitis associated with pemphigus: a population-based large-scale study
Khalaf Kridin, Shira Zelber-Sagi, Doron Comaneshter, Arnon D. Cohen
Scandinavian Journal of Gastroenterology.2017; 52(12): 1360. CrossRef
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Review
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Endoscopy for Nonvariceal Upper Gastrointestinal Bleeding
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Ki Bae Kim, Soon Man Yoon, Sei Jin Youn
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Clin Endosc 2014;47(4):315-319. Published online July 28, 2014
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DOI: https://doi.org/10.5946/ce.2014.47.4.315
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Abstract
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Endoscopy for acute nonvariceal upper gastrointestinal bleeding plays an important role in primary diagnosis and management, particularly with respect to identification of high-risk stigmata lesions and to providing endoscopic hemostasis to reduce the risk of rebleeding and mortality. Early endoscopy, defined as endoscopy within the first 24 hours after presentation, improves patient outcome and reduces the length of hospitalization when compared with delayed endoscopy. Various endoscopic hemostatic methods are available, including injection therapy, mechanical therapy, and thermal coagulation. Either single treatment with mechanical or thermal therapy or a treatment that combines more than one type of therapy are effective and safe for peptic ulcer bleeding. Newly developed methods, such as Hemospray powder and over-the-scope clips, may provide additional options. Appropriate decisions and specific treatment are needed depending upon the conditions.
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Citations
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V. L. Poluektov, V. N. Nikitin, S. G. Klipach, A. A. Artemiyeva
Khirurgiya. Zhurnal im. N.I. Pirogova.2019; (5): 77. CrossRef - New endoscopic techniques in treating gastrointestinal bleeding
Young Sin Cho
International Journal of Gastrointestinal Intervention.2018; 7(3): 131. CrossRef - Acute gastrointestinal bleeding cases presenting to the emergency department are associated with age, sex and seasonal and circadian factors
Henrike Lenzen, Eliane Musmann, Martina Kottas, Bastian Schönemeier, Thomas Köhnlein, Michael P. Manns, Tim O. Lankisch
European Journal of Gastroenterology & Hepatology.2017; 29(1): 78. CrossRef - Volume of hospital is important for the prognosis of high-risk patients with nonvariceal upper gastrointestinal bleeding (NVUGIB)
Jin Woo Choi, Seong Woo Jeon, Jung Gu Kwon, Dong Wook Lee, Chang Yoon Ha, Kwang Bum Cho, Byung Ik Jang, Jung Bae Park, Youn Sun Park
Surgical Endoscopy.2017; 31(8): 3339. CrossRef - A Rare Case of Pancreas Divisum Accompanied by Acute Pancreatitis Following Endoscopic Hemostasis for Duodenal Ulcer Bleeding
Yong Hyeok Choi, Soon Man Yoon, Eun Bee Kim, Youngmin Oh, Keunmo Kim, Jisun Lee, Seon Mee Park, Sei Jin Youn
The Korean Journal of Gastroenterology.2017; 69(4): 248. CrossRef - Transcatheter embolization in prevention of recurrent bleeding from stomach ulcers
N. V. Lebedev, G. E. Belozerov, A. E. Klimov, P. Yu. Sokolova, A. A. Spasskiy, A. A. Barkhudarov
Khirurgiya. Zhurnal im. N.I. Pirogova.2017; (5): 31. CrossRef - Value in palliative cancer surgery: A critical assessment
Ian W. Folkert, Robert E. Roses
Journal of Surgical Oncology.2016; 114(3): 311. CrossRef - Risk Strategy in Non-Variceal Upper Gastrointestinal Bleeding
Joon Sung Kim, Byung-Wook Kim
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2016; 16(4): 173. CrossRef - Endoscopic Management of Peptic Ulcer Bleeding
Joon Sung Kim, Sung Min Park, Byung-Wook Kim
Clinical Endoscopy.2015; 48(2): 106. CrossRef - Endoscopic Management of Nonvariceal Upper Gastrointestinal Bleeding: State of the Art
Naoki Muguruma, Shinji Kitamura, Tetsuo Kimura, Hiroshi Miyamoto, Tetsuji Takayama
Clinical Endoscopy.2015; 48(2): 96. CrossRef - Endoscopic Management of Dieulafoy's Lesion
Hye Kyung Jeon, Gwang Ha Kim
Clinical Endoscopy.2015; 48(2): 112. CrossRef - Endoscopic Management of Tumor Bleeding from Inoperable Gastric Cancer
Young-Il Kim, Il Ju Choi
Clinical Endoscopy.2015; 48(2): 121. CrossRef - Laboratory test variables useful for distinguishing upper from lower gastrointestinal bleeding
Minoru Tomizawa
World Journal of Gastroenterology.2015; 21(20): 6246. CrossRef - Highlights from the 50th Seminar of the Korean Society of Gastrointestinal Endoscopy
Eun Young Kim, Il Ju Choi, Kwang An Kwon, Ji Kon Ryu, Seok Ho Dong, Ki Baik Hahm
Clinical Endoscopy.2014; 47(4): 285. CrossRef
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Case Report
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Successful Treatment of Duodenal Variceal Bleeding by Endoscopic Clipping
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Su Bin Park, Sang Ho Lee, Jin Hee Kim, Hyun Jung Lee, Sung Pil Jang, Jae Nam Lee, Jong Ho Hwang
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Clin Endosc 2013;46(4):403-406. Published online July 31, 2013
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DOI: https://doi.org/10.5946/ce.2013.46.4.403
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Abstract
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Duodenal varix bleeding is an uncommon cause of gastrointestinal bleeding in patients with portal hypertension but can cause severe and potentially fatal bleeding. However, the incidence is low and a good treatment method has not been well established yet. Duodenal variceal bleeding can be treated surgically or nonsurgically. We have successfully treated a patient with duodenal variceal bleeding secondary to liver cirrhosis using hemoclips to control the bleeding.
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Citations
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International Journal of Gastrointestinal Intervention.2020; 9(3): 125. CrossRef - Percutaneous Trans-splenic Obliteration for Duodenal Variceal bleeding: A Case Report
Hyun Woo Kim, Jun Sik Yoon, Seung Jung Yu, Tae Heon Kim, Jae Heon Seol, Dan Kim, Jun Young Jung, Pyeong Hwa Jeong, Hoon Kwon, Hong Sub Lee, Sang Heon Lee, Jung Sik Choi, Sung Jae Park, Sam Ryong Jee, Youn Jae Lee, Sang Yong Seol
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Special Issue Articles of IDEN 2012
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New Endoscopic Hemostasis Methods
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En-Ling Leung Ki, James Y W Lau
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Clin Endosc 2012;45(3):224-229. Published online August 22, 2012
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DOI: https://doi.org/10.5946/ce.2012.45.3.224
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Abstract
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Endoscopic treatment for non-variceal upper gastrointestinal bleeding has evolved over decades. Injection with diluted epinephrine is considered as a less than adequate treatment, and the current standard therapy should include second modality if epinephrine injection is used initially. Definitive hemostasis rate following mono-therapy with either thermo-coagulation or hemo-clipping compares favorably with dual therapies. The use of adsorptive powder (Hemo-spray) is a promising treatment although it needs comparative studies between hemospray and other modalities. Stronger hemo-clips with better torque control and wider span are now available. Over-the-scope clips capture a large amount of tissue and may prove useful in refractory bleeding. Experimental treatments include an endoscopic stitch device to over-sew the bleeding lesion and targeted therapy to the sub-serosal bleeding artery as guided by echo-endoscopy. Angiographic embolization of bleeding artery should be considered in chronic ulcers that fail endoscopic treatment especially in elderly patients with a major bleed manifested in hypotension.
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Citations
Citations to this article as recorded by

- A System-on-Chip Solution for a Low Power Active Capsule Endoscope with Therapeutic Capabilities for Clip Application in the Gastrointestinal Tract
Oscar Alonso, Angel Diéguez, Sebastian Schostek, Marc O. Schurr
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K Siau, W Chapman, N Sharma, D Tripathi, T Iqbal, N Bhala
Journal of the Royal College of Physicians of Edinburgh.2017; 47(3): 218. CrossRef - ACG Clinical Guideline: Management of Patients With Acute Lower Gastrointestinal Bleeding
Lisa L Strate, Ian M Gralnek
American Journal of Gastroenterology.2016; 111(4): 459. CrossRef - New insights on an old medical emergency: non-portal hypertension related upper gastrointestinal bleeding
Tiago Cúrdia Gonçalves, Bruno Rosa, José Cotter
Revista Española de Enfermedades Digestivas.2016;[Epub] CrossRef - Uso de Hemospray® en sangrado post-escleroterapia
Beatriz González Ortiz, Dora María Tapia Monge, Alicia Reyes Cerecedo, Oscar Hernández Mondragón
Boletín Médico del Hospital Infantil de México.2016; 73(5): 335. CrossRef - Use of Hemospray® in post-sclerotherapy bleeding
Beatriz González Ortiz, Dora María Tapia Monge, Alicia Reyes Cerecedo, Oscar Hernández Mondragón
Boletín Médico Del Hospital Infantil de México (English Edition).2016; 73(5): 335. CrossRef - Deployment of a Short, Single-Opening Endoscopic Clip Versus a Long, Reopening Endoscopic Clip in Clinical Practice
Eric Wee, Mathew Philip Sachin, Uthamanand Chinnappa, Su Chang, Cherng Hann Benjamin Yip
Digestive Diseases and Sciences.2015; 60(8): 2287. CrossRef - Poudres hémostatiques et hémorragies digestives
M. Vincent
Acta Endoscopica.2015; 45(1-2): 2. CrossRef - Endoscopic Management of Tumor Bleeding from Inoperable Gastric Cancer
Young-Il Kim, Il Ju Choi
Clinical Endoscopy.2015; 48(2): 121. CrossRef - Endoscopic Management of Nonvariceal Upper Gastrointestinal Bleeding: State of the Art
Naoki Muguruma, Shinji Kitamura, Tetsuo Kimura, Hiroshi Miyamoto, Tetsuji Takayama
Clinical Endoscopy.2015; 48(2): 96. CrossRef - Hemostatic powder spray: a new method for managing gastrointestinal bleeding
Kinesh Changela, Haris Papafragkakis, Emmanuel Ofori, Mel A. Ona, Mahesh Krishnaiah, Sushil Duddempudi, Sury Anand
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Ki Bae Kim, Soon Man Yoon, Sei Jin Youn
Clinical Endoscopy.2014; 47(4): 315. CrossRef - Spontaneous Healing of Gastric Perforation after Endoscopic Ligation for Gastric Varices
Jung Ho Kim, Hong Dae Ahn, Kwang An Kwon, Yoon Jae Kim, Jun-Won Chung, Dong Kyun Park, Ju Hyun Kim
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Young‐Il Kim, Il Ju Choi, Soo‐Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Mi‐Jung Kim, Keun Won Ryu, Young‐Woo Kim, Young Iee Park
Journal of Gastroenterology and Hepatology.2013; 28(9): 1489. CrossRef - Neue Optionen der endoskopischen Blutstillung bei gastrointestinalen Blutungen
A. Hoffman, J.W. Rey, R. Kiesslich
Der Gastroenterologe.2013; 8(2): 140. CrossRef - Gastrointestinal bleeding with the new oral anticoagulants – defining the issues and the management strategies
Jay Desai, Jennifer Kolb, Jeffrey Weitz, James Aisenberg
Thrombosis and Haemostasis.2013; 110(08): 205. CrossRef - Upper Endoscopy in International Digestive Endoscopy Network 2012: Towards Upper End of Quality
Il Ju Choi
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Indications for Enteroscopy: Which Patients Should Be Recommended for Enteroscopy?
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Hwang Choi, M.D.
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Korean J Gastrointest Endosc 2011;42(3):137-142. Published online March 28, 2011
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Abstract
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- Balloon-assisted endoscopy (double-balloon or single-balloon endoscopy) is a novel method used to examine the entire small bowel. Enteroscopy has advantages in that tissues can be obtained to get a detailed image, and it is feasible for endoscopic treatments such as hemostasis, dilatation, and polypectomy. Indications for enteroscopy are obscure gastrointestinal bleeding, small bowel involvement due to inflammatory bowel disease, an investigation of a small bowel tumor or polyposis, and difficulty of a colonoscopy. Enteroscopy should be recommended to patients with recurrent mid-gut bleeding of obscure origin, suspected Crohn's disease, suspicious small bowel tumor on abnormal imaging, and surveillance of polyposis syndrome including familial adenomatous polyposis and Peutz-Jeghers syndrome. We may consider enteroscopy in patients with chronic abdominal pain or diarrhea and increased inflammatory markers. We must also understand the contraindications, complications, and limitations of enteroscopy. (Korean J Gastrointest Endosc 2011;42:137-142)
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The Role of Endoscopy in Obscure Gastrointestinal Bleeding
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Chang Soo Eun, M.D.
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Korean J Gastrointest Endosc 2010;41(6):329-337. Published online December 30, 2010
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Abstract
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- Obscure gastrointestinal bleeding (OGIB) is defined as occult or overt bleeding of unknown origin that persists or recurs after an initial negative endoscopic evaluation by gastroscopy or colonoscopy. Most of these problems occur in the small bowel, and it is not an uncommon condition encountered by gastroenterologists, accounting for approximately 5% of all GIB. Traditional endoscopic techniques, including push enteroscopy, have a limited role in diagnosing patients with OGIB because of the inaccessibility of a large part of the small bowel using an endoscopic procedure. The recent introduction of new enteroscopic modalities including capsule endoscopy (CE) and double balloon enteroscopy have allowed mucosal visualization of the entire small bowel, revolutionizing the diagnosis and treatment of patients with OGIB. The respective roles of CE and deep enteroscopy in patients with OGIB are discussed in this review. (Korean J Gastrointest Endosc 2010;41:329-337)
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A Case of a Patient Presenting with Upper Gastrointestinal Bleeding Due to Direct Stomach Invasion by Hepatocellular Carcinoma
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Joon Mo Park, M.D. and Dong Hee Kim, M.D.
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Korean J Gastrointest Endosc 2010;41(4):232-235. Published online October 30, 2010
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- Gastrointestinal bleeding is a common complication of hepatocellular carcinoma, and the most common causes are esophageal varix, gastric varix and a bleeding ulcer. Hepatocellular carcinoma rarely invades the gastrointestinal tract, and this has been shown to occur in 0.7∼2% of the clinical hepatocellular carcinoma cases. A 52-year old male who had a history of a huge hepatocellular carcinoma on the left lobe of the liver and this had been by chemoembolization was admitted due to hematemesis and melena. Esophagogastroduodenoscopy showed a huge fungating mass with easy contact bleeding in the lesser curvature of the gastric body. The histology was consistent with the diagnosis of metastatic hepatocellular carcinoma and results of the CT scan supported this finding. This case illustrates a rare event of direct invasion of hepatocellular carcinoma into the stomach and this was followed by gastrointestinal hemorrhage. (Korean J Gastrointest Endosc 2010;41:232-235)
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Characteristics of Lesions Misdiagnosed as Obscure Gastrointestinal Bleeding
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Hyun Sook Choi, M.D., Jin Oh Kim, M.D., Dong Kyun Kim, M.D., Sung Ran Jeon, M.D., Yoon Ho Jung, M.D.,
Hyun Gun Kim, M.D., Tae Hee Lee, M.D., Won Young Cho, M.D., Wan Jung Kim, M.D., Bong Min Ko, M.D., Moon Sung Lee, M.D., Joo Young Cho,
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Korean J Gastrointest Endosc 2010;41(2):79-84. Published online August 30, 2010
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Abstract
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- Background
/Aims: Double balloon enteroscopy (DBE) and capsule endoscopy (CE) are useful for evaluation of obscure gastrointestinal bleeding (OGIB). However, many bleeding sources within reach of conventional upper and lower endoscopes can be missed in patients who have undergone DBE and CE for OGIB. The aim of this study was to determine the incidence and characteristics of OGIB lesions within reach of a conventional endoscope in patients undergoing DBE and CE for the indication of OGIB.
Methods
This retrospective study included 134 patients who were evaluated for OGIB between March 2003 and May 2009 at Soonchunhyang University Hospital.
Results
Of the 134 patients, 76 underwent CE, 28 patients underwent DBE, and 30 underwent both CE and DBE. The incidence of OGIB lesions within reach of a conventional upper and lower endoscopy was 9.7% (n=13) and the mean age of patients was 51 years (range: 20 to 69 years). The most commonly missed lesion was duodenal ulcer (n=8). The other missed lesions were gastric ulcer (n=2), terminal ileal ulcer (n=2) and ileocecal valve ulcer (n=1).
Conclusions
The duodenum should be observed closely in initial upper and lower endoscopy by experienced endoscopists. Performing a second EGD and ileocolonoscopy before DBE and CE may increase the diagnostic yield and improve cost-effectiveness in patients with OGIB. (Korean J Gastrointest Endosc 2010;41: 79-84)
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A Case of Transparent Cap-fitted Endoscopic Hemoclipping on a Bleeding Dieulafoy's Lesion in the Ampulla of Vater
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Hoon Sup Koo, M.D., Yong Seok Kim, M.D., Gwang Il Kim, M.D., Jung Kyung Yang, M.D., Seung Min Kim, M.D., Sang Yeol Cheon, M.D., Je Hyung Sun, M.D. and Sun Moon Kim, M.D.
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Korean J Gastrointest Endosc 2010;40(1):45-48. Published online January 30, 2010
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Abstract
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- Dieulafoy's lesion is a rare cause of repetitive and massive gastrointestinal bleeding, and this is characterized by an isolated arteriole protruding through a small mucosal defect. Dieulafoy's lesion is generally found in the stomach within 6 cm of the gastroesophageal junction, and usually on the lesser curvature, but many lesions have been reported in extragastric locations, including the esophagus, small bowel and rectum. A Dieulafoy's lesion in the ampulla of Vater is extremely rare, and only one such case has been reported in the Korean population. We experienced a rare case of Dieulafoy's lesion in the ampulla of Vater with massive pulsatile bleeding, and this was successfully treated by transparent cap-assisted endoscopic hemoclipping. We report here on this case with a review of the relevant literature. (Korean J Gastrointest Endosc 2010;40:45-48)
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Usefulness of Capsule Endoscopy in Children with Suspected Small Bowel Disease
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Hae Jin Park, M.D., So Yeon Lee, M.D., Jae Sung Ko, M.D. and Jeong Kee Seo, M.D.
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Korean J Gastrointest Endosc 2009;39(6):346-351. Published online December 30, 2009
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Abstract
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- Background
/Aims: The aim of our study is to investigate the diagnostic value and safety of capsule endoscopy (CE) in the pediatric patients with small bowel (SB) disease.
Methods
We retrospectively reviewed the records of 29 children (mean age: 11.8 year) who underwent CE at Seoul National University Children's Hospital between November 2004 and April 2009.
Results
Six (20%) of the total 29 patients could not swallow the capsule (mean age: 10.5 years), so the capsule was endoscopically placed into the stomach of these 6 patients. The CE examination for the entire SB was finished in 89.6% of the patients. The indications for CE studies were obscure gastrointestinal bleeding (OGIB) or anemia in 14 patients, intestinal polyposis in 8, abdominal pain in 4 and Crohn's disease in 3. The diagnostic yield of CE was 35.7% for OGIB or anemia, 37.5% for intestinal polyposis, 25% for abdominal pain and 33.3% for Crohn's disease. One patient had capsule retention during our CE investigations.
Conclusions
CE is a safe and valuable tool for the detection of SB Crohn's disease, the focus of OGIB and the presence of SB polyps in pediatric patients. (Korean J Gastrointest Endosc 2009;39:346-351)
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A Case of Dieulafoy-like Lesion with Massive Bleeding at Ileocecal Valve Following Acute Infectious Colitis in a Pediatric Patient
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Jae Seung Soh, M.D., Seong Hun Kim, M.D., Yoon Jae Lee, M.D., In Hee Kim, M.D., Sang Wook Kim, M.D., Seung Ok Lee, M.D., Dae Ghon Kim, M.D. and Soo Teik Lee, M.D.
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Korean J Gastrointest Endosc 2009;39(3):166-168. Published online September 30, 2009
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Abstract
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- The common causes of lower gastrointestinal bleeding in children are intussusception, rectal juvenile polyp, chronic inflammatory colitis and Meckel's diverticulum. Bleeding from Dieulafoy's ulcer at the lower gastrointestinal tract is rare, but this often occurs in the rectum. So far, there has been no report that a Dieulafoy lesion in the ileocecal valve might be formed after acute colitis in a pediatric patient. In this case report, a Dieulafoy-like lesion at the ileocecal valve caused lower gastrointestinal bleeding in an asymptomatic 14-year-old woman. A careful history taking and medical examination are mandatory to identify the bleeding focus in the GI tract and this can be treated by endoscopy. (Korean J Gastrointest Endosc 2009;39:166-168)
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A Case of Polyarteritis Nodosa That Presented as Hemobilia
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Joo Wook Sung, M.D., Yun Jeong Lim, M.D., Jae Hyun Kwon, M.D.*, Kyung Jo Kim, M.D.† and Jin Ho Lee, M.D.
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Korean J Gastrointest Endosc 2009;38(6):364-367. Published online June 30, 2009
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- Hemobilia is defined as hemorrhage into the biliary tract, and the patients with hemobilia present with abdominal pain, jaundice and gastrointestinal bleeding. The causes of hemobilia are traumatic or operative injury to the liver or bile ducts, intraductal rupture of the hepatic abscess or aneurysm of the hepatic artery. Cholecystitis can also develop in patients with hemobilia. Polyarteritis nodosa (PAN) is a multisystem, necrotizing vasculitis of the small and medium-sized muscular arteries and patients with this illness may present with fever, sweats, weight loss, severe arthralgia and myalgia. Mesentery artery involvement that can result in gastrointestinal hemorrhage, bowel infarction and perforation is rare, yet very serious in patients with PAN. We report here on a rare case of PAN that presented as hemobilia due to rupture of a hepatic arterial aneurysm. (Korean J Gastrointest Endosc 2009;38:364-367)
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The Usefulness of a Suspected Blood Identification System (SBIS) in Capsule Endoscopy according to Various Small Bowel Bleeding Lesions
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Ju Young Kim, M.D., Hoon Jai Chun, M.D., Chul Young Kim, M.D., Jin Su Jang, M.D., Yong Dae Kwon, M.D., Sanghoon Park, M.D., Bora Keum, M.D., Yeon Seok Seo, M.D., Yong Sik Kim, M.D., Yoon Tae Jeen, M.D., Hong Sik Lee, M.D., Soon Ho Um, M.D., Sang Woo Lee,
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Korean J Gastrointest Endosc 2008;37(4):253-258. Published online October 30, 2008
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- Background/Aims: Substantial time and attention are required to read and interpret the recordings of capsule endoscopic images. A suspected blood identification system (SBIS) has been developed to assist in the reading of capsule images. This software automatically marks "red tags" that correlate with suspected blood or red areas. However, the sensitivity and accuracy of the system have not been well characterized. We investigated the usefulness of the SBIS in capsule endoscopy according to various small bowel bleeding lesions. Methods: Two expert endoscopists reviewed the capsule images. Angiodysplasias, ulcers and erosion were considered as significant lesions, and active bleeding lesions were considered when bleeding or blood clots were seen in the capsule images. The red tags that were automatically marked by the use of the rapid software were compared to the significant lesions reviewed by the endoscopists. Results: A total of 95 patients were enrolled in the study. The endoscopists identified 159 significant lesions and 71 lesions marked by red tags were identified by the SBIS. Among the 71 lesions, 31 lesions correctly coincided with the significant lesions. The overall sensitivity and positive predictive value of the use of the SBIS were 20% and 44%, respectively. The sensitivities of active ulcers and active bleeding lesions were 83% and 93%, respectively. Conclusions: The SBIS should be considered as a rapid screening tool to identify active bleeding lesions, and a complete review of capsule images by a physician is still needed. (Korean J Gastrointest Endosc 2008;37:253-258)
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Clinical Overview of Acute Lower Gastrointestinal Bleeding
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Kyeong Ok Kim, M.D., Byung Ik Jang, M.D., Tae Nyeun Kim, M.D., Jong Ryul Eun, M.D., Kyu Hyung Lee, M.D., Si Hyung Lee, M.D., Jae Won Choi, M.D. and Youn Sun Park, M.D.
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Korean J Gastrointest Endosc 2008;36(5):262-267. Published online May 30, 2008
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Abstract
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- Background
/Aims: Acute lower gastrointestinal bleeding (LGIB) is a common disorder that requires hospitalization. Colonoscopy is considered as the procedure of choice for diagnosing acute LGIB. The aim of this study was to analyze the clinical characteristics, endoscopic diagnosis and clinical course of acute LGIB. Methods: From January 2000 to August 2007, 117 patients with hematochezia, who visited Yeungnam University hospital emergency center and underwent colonoscopy or sigmoidoscopy, were reviewed retrospectively. The male to female ratio was 2.25 (81:36). The mean age was 59.1±16.9 years. Results: The mean time from presentation to endoscopy was 12.6 hours. The cause of bleeding was identified in 88.9% of the cases after endoscopy. The causes of the acute LGIB were colitis: 26 cases, post polypectomy bleeding: 17 cases, colon ulcer: 16 cases, diverticular bleeding: 13 cases, colon cancer: 9 cases, angiodysplasia: 7 cases and hemorrhoid: 6 cases. Thirty six patients were treated by the endoscopic method; the mean duration of admission was 10.6±10.0 days and the mean amount of transfusion was 3.0±1.9 U. Those numbers showed statistically significant differences according to the diagnosis. Conclusions: The most common cause of acute LGIB was colitis and the causes of bleeding were a significant factor that affects the severity of bleeding and the duration of admission. (Korean J Gastrointest Endosc 2008;36:262-267)
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A Case of Acute Lower Gastrointestinal Bleeding from a Benign Appendiceal Ulcer
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Sang Cheol Cho, M.D., Young Ho Seo, M.D., Chung Su Park, M.D., Sang Hyun Park, M.D., An Doc Chung, M.D., Bong Kyu Lee, M.D., So Young Chu, M.D., Nam Hun Lee, M.D., Keun Yeong Song, M.D.*, Sung Hwan Song, M.D.*, In Kyoung Lee M.D.† and Hya
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Korean J Gastrointest Endosc 2008;36(3):173-176. Published online March 30, 2008
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Abstract
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- A hemorrhoid is the most common cause of acute lower gastrointestinal (LGI) bleeding. Diverticulosis, angiodysplasia and ischemic colitis can also cause LGI bleeding. Acute LGI bleeding from the appendix is very rare. We experienced a case of a 33‐year‐old woman with acute LGI bleeding from the appendix. Colonoscopy demonstrated an active hemorrhage from the orifice of the appendix. The patient was treated with a appendectomy, and a histological examination showed the presence of a small ulcer with inflamed granulation tissue in the mucosa and submucosa. (Korean J Gastrointest Endosc 2008;36: 173-176)
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An Ampulla of Vater Carcinoid Tumor that Presented with Upper Gastrointestinal Bleeding
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Jae Serk Park, M.D., Sung Jo Bang, M.D., Seok Won Jung, M.D., Sung Ho Kwon, M.D., Byung Chul Kim, M.D., Dong Ha Han, M.D., Hyun Soo Kim, M.D., Young Min Kim, M.D.*, Chang Woo Nam, M.D.† and Do Ha Kim, M.D.
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Korean J Gastrointest Endosc 2007;35(6):420-423. Published online December 30, 2007
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- A Carcinoid tumor of the ampulla of Vater is extremely rare, accounting for less than 0.3% of all gastrointestinal carcinoids. Most reported cases have arisen from the gallbladder. An ampullary carcinoid most commonly presents with jaundice or upper abdominal discomfort, and bleeding from the tumor is exceedingly rare. A diagnosis is most frequently made postoperatively due to submucosal spread of the tumor. As the metastatic potential cannot be predicted by tumor size, a Whipple pancreaticoduodenectomy rather than local excision is considered the treatment of choice. We herein report a case of a primary carcinoid tumor located at the ampulla of Vater that presented as gastrointestinal bleeding; the tumor was diagnosed by an endoscopic biopsy after a papillary sphinterotomy. (Korean J Gastrointest Endosc 2007;35:420-423)