Skip Navigation
Skip to contents

Clin Endosc : Clinical Endoscopy

OPEN ACCESS

Search

Page Path
HOME > Search
1 "Heavy drinking"
Filter
Filter
Article category
Keywords
Publication year
Authors
Original Article
Risk Factors for the Presence of Symptoms in Peptic Ulcer Disease
Sang Pyo Lee, In-Kyung Sung, Jeong Hwan Kim, Sun-Young Lee, Hyung Seok Park, Chan Sup Shim
Clin Endosc 2017;50(6):578-584.   Published online December 23, 2016
DOI: https://doi.org/10.5946/ce.2016.129
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background
/Aims: Peptic ulcer disease (PUD) is a common condition, but is difficult to detect in asymptomatic individuals. We aimed to investigate the prevalence of symptomatic and asymptomatic PUD during screening endoscopy and to identify risk factors for the presence of symptoms in patients with PUD.
Methods
We investigated subjects who underwent a health inspection, including endoscopy of the upper gastrointestinal (GI) tract and a serum anti-Helicobacter pylori IgG assay, and who completed a self-report questionnaire about their symptoms.
Results
Of the 12,852 subjects included in the study, 124 (1.0%) had symptomatic PUD and 309 (2.4%) had asymptomatic PUD. Old age, current smoking, and H. pylori infection were independent risk factors for symptomatic and asymptomatic PUD. Use of non-steroidal anti-inflammatory drugs (NSAIDs) was an independent risk factor only for symptomatic PUD (p=0.040). Compared to subjects with asymptomatic PUD, subjects with symptomatic PUD were more likely to have active-stage ulcers (p=0.002) and to drink more heavily (p=0.005).
Conclusions
Use of NSAIDs is a risk factor for symptomatic PUD, but not for asymptomatic PUD. Excessive alcohol consumption and active-stage ulcers in patients with PUD are related to the presence of gastroduodenal symptoms.

Citations

Citations to this article as recorded by  
  • Low prevalence of peptic ulcer disease in hospitalized patients with cystic fibrosis: A national database study
    Maya Mahmoud, Eugene Nwankwo, Zidong Zhang, Neel Matiwala, Rohan Tripathi, Islam Mohamed, Christopher Barrios, Wing-Kin Syn, Christine Hachem
    The American Journal of the Medical Sciences.2025; 369(3): 321.     CrossRef
  • Apigenin improves chronic gastric ulcer in rats: The implication of COX-1/2 and 5-LOX signaling pathways
    Islam Omar Abdel Fattah, Wael Amin Nasr El-Din
    Tissue and Cell.2025; 95: 102838.     CrossRef
  • Antiulcer activity and mechanism of action of the hydroethanolic extract of leaves of Terminalia argentea Mart. In different in vivo and in vitro experimental models
    Claudio Luis Venturini, Amilcar Sabino Damazo, Marcelo José Dias Silva, Jessica de Araujo Isaias Muller, Darley Maria Oliveira, Fabiana de Freitas Figueiredo, Bruna Fioravante Di Serio, Karuppusamy Arunachalam, Domingos Tabajara de Oliveira Martins
    Journal of Ethnopharmacology.2024; 318: 116972.     CrossRef
  • Bifidobacterium breve Bif195 ameliorates aspirin‐induced gastric mucosal damage: A randomised, double blind, placebo‐controlled crossover trial
    Nina Løn, Sara Engel, Anders Damholt, Brynjulf Mortensen, Anne B. Haaber, Anja Wellejus, Filip K. Knop
    Alimentary Pharmacology & Therapeutics.2024; 59(3): 341.     CrossRef
  • Helicobacter pylori Eradication Treatment in Older Patients
    Paulius Jonaitis, Juozas Kupcinskas, Javier P. Gisbert, Laimas Jonaitis
    Drugs & Aging.2024; 41(2): 141.     CrossRef
  • The associations among peptic ulcer disease, Helicobacter pylori infection, and abdominal aortic aneurysms: A nationwide population-based cohort study
    Chia-Wei Hong, Hsiao-Ya Tsai, Chi-Hsiang Chung, Jen-Chun Wang, Yu-Juei Hsu, Chih-Yuan Lin, Chin-Wang Hsu, Wu-Chien Chien, Shih-Hung Tsai
    Journal of Cardiology.2024; 84(3): 180.     CrossRef
  • Nutritional risk factors impact upon peptic ulcer pathogenesis – experience of the County Clinical Hospital Târgu-Mureş
    Adriana-Daniela Socianu, Adina Roman, Septimiu Voidăzan
    The Romanian Journal of Nutrition.2024; 1(1): 21.     CrossRef
  • Sex difference in the associations among hyperuricemia with self-reported peptic ulcer disease in a large Taiwanese population study
    Chi-Sheng Yang, Jiun-Hung Geng, Pei-Yu Wu, Jiun-Chi Huang, Huang-Ming Hu, Szu-Chia Chen, Chao-Hung Kuo
    Frontiers in Medicine.2024;[Epub]     CrossRef
  • Lycopene: A Potent Antioxidant with Multiple Health Benefits
    Mercy Omoye Shafe, Nontobeko Myllet Gumede, Trevor Tapiwa Nyakudya, Eliton Chivandi, Toshikazu Suzuki
    Journal of Nutrition and Metabolism.2024;[Epub]     CrossRef
  • A Study of Peptic Ulcer and Associated Risk Factors Among Patients Undergoing Upper GIT Endoscopy in Duhok, Kurdistan, Iraq
    Laween Hashim Dawood, Ibrahim Naqid, Nawfal R Hussein
    Journal of Kermanshah University of Medical Sciences.2024;[Epub]     CrossRef
  • Epidemiology of asymptomatic peptic ulcer disease diagnosed during screening endoscopy in patients with cirrhosis
    Girma Deshimo Lema, Enguday Demeke Gebeyaw
    Journal of International Medical Research.2024;[Epub]     CrossRef
  • Gastric Ulcer Bleeding Caused by Systemic Inflammatory Response to Mycobacterial Bacteremia
    Soo Bin Synn, Su Jin Kim
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2024; 24(4): 374.     CrossRef
  • Peptic ulcer disease in non-alcoholic fatty liver disease hospitalizations: A new challenge on the horizon in the United States
    Dushyant Singh Dahiya, Vinay Jahagirdar, Hassam Ali, Manesh Kumar Gangwani, Muhammad Aziz, Saurabh Chandan, Amandeep Singh, Abhilash Perisetti, Aakriti Soni, Sumant Inamdar, Madhusudhan R Sanaka, Mohammad Al-Haddad
    World Journal of Hepatology.2023; 15(4): 564.     CrossRef
  • Peptic Ulcer Disease
    Emily Tuerk, Sara Doss, Kevin Polsley
    Primary Care: Clinics in Office Practice.2023; 50(3): 351.     CrossRef
  • Genistein ameliorated experimentally induced gastric ulcer in rats via inhibiting gastric tissues fibrosis by modulating Wnt/β-catenin/TGF-β/PKB pathway
    Hanan M. Hassan, Nouf M. Alatawi, Alaa Bagalagel, Reem Diri, Ahmad Noor, Deina Almasri, Hussain T. Bakhsh, Hussam I. Kutbi, Noha Ashy, Mohammed M. H. Al-Gayyar
    Redox Report.2023;[Epub]     CrossRef
  • Úlcera péptica
    Isabel Laucirica, Pilar García Iglesias, Xavier Calvet
    Medicina Clínica.2023; 161(6): 260.     CrossRef
  • Depression during the COVID-19 pandemic among older Canadians with peptic ulcer disease: Analysis of the Canadian Longitudinal Study on Aging
    Esme Fuller-Thomson, Hannah Dolhai, Andie MacNeil, Grace Li, Ying Jiang, Margaret De Groh, Sungwoo Lim
    PLOS ONE.2023; 18(10): e0289932.     CrossRef
  • Chitin Extracted from the Shell of Blue Swimming Crabs (Portunus pelagicus Linn.) Inhibits NF-kappaB p65 in Ethanol-Induced Gastric Ulcerative Wistar Rats
    Renny Amelia, Sri Adi Sumiwi, Nyi Mekar Saptarini, Jutti Levita
    Marine Drugs.2023; 21(9): 488.     CrossRef
  • Peptic ulcer
    Isabel Laucirica, Pilar Garcia Iglesias, Xavier Calvet
    Medicina Clínica (English Edition).2023; 161(6): 260.     CrossRef
  • Role of Proton Pump Inhibitors in the Management of Peptic Ulcer
    Risha Kumari, Shweta Agarwal
    International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN).2023; 16(6): 7070.     CrossRef
  • Review of Toxic Chemical Factors Influence in Gastric and Duodenal Ulcers
    Valerii Lutenco, Adrian Beznea, Raul Mihailov, Ioana Anca Stefanopol, Valentin Bulza, Liliana Baroiu
    ARS Medica Tomitana.2023; 29(2): 112.     CrossRef
  • Gastroprotective Effect of Polypeptide-K Isolated from Momordica charantia’s Seeds on Multiple Experimental Gastric Ulcer Models in Rats
    Nurul ’Ain Abu Bakar, Muhammad Nazrul Hakim Abdullah, Vuanghao Lim, Yoke Keong Yong, Lu sa Mota da Silva
    Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1.     CrossRef
  • Gastroscopic results for the asymptomatic, average-risk population in Northern China: a cross-sectional study of 60,519 adults
    Yan Gong, Juan Kang, Rilige Wu, Fulin Ge, Yan-song Zheng, Qiang Zeng
    Scandinavian Journal of Gastroenterology.2022; 57(6): 748.     CrossRef
  • An insight into the anti-ulcerogenic potentials of medicinal herbs and their bioactive metabolites
    Sowkat Jahan Shipa, Labony Khandokar, Md. Sazzadul Bari, Nazmul Qais, Mohammad Abdur Rashid, Md. Areeful Haque, Isa Naina Mohamed
    Journal of Ethnopharmacology.2022; 293: 115245.     CrossRef
  • Peptic ulcer disease among dyspeptic patients at endoscopy unit, University of Gondar hospital, Northwest Ethiopia
    Belete Assefa, Abilo Tadesse, Zenahebezu Abay, Alula Abebe, Tsebaot Tesfaye, Melaku Tadesse, Ayenew Molla
    BMC Gastroenterology.2022;[Epub]     CrossRef
  • Self-Reported Overall Adherence and Correct Inhalation Technique Discordance in Chronic Obstructive Pulmonary Disease Population
    Tereza Hendrychova, Michal Svoboda, Josef Maly, Jiri Vlcek, Eva Zimcikova, Tomas Dvorak, Jaromir Zatloukal, Eva Volakova, Marek Plutinsky, Kristian Brat, Patrice Popelkova, Michal Kopecky, Barbora Novotna, Vladimir Koblizek
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Reciprocal association between depression and peptic ulcers: Two longitudinal follow-up studies using a national sample cohort
    So Young Kim, Chanyang Min, Dong Jun Oh, Hyo Geun Choi
    Scientific Reports.2020;[Epub]     CrossRef
  • Proton-pump inhibitor and amoxicillin-based triple therapy containing clarithromycin versus metronidazole for Helicobacter pylori: A meta-analysis
    Bo Li, Xiaoqian Lan, Li Wang, Jiani Zhao, Jingli Ding, Hao Ding, Jun Lei, Yiping Wei, Wenxiong Zhang
    Microbial Pathogenesis.2020; 142: 104075.     CrossRef
  • Spicing up gastrointestinal health with dietary essential oils
    Mahwish Tanveer, Charles Wagner, Muhammad Ikram ul Haq, Nilton C. Ribeiro, Thriumurugan Rathinasabapathy, Masood Sadiq Butt, Aamir Shehzad, Slavko Komarnytsky
    Phytochemistry Reviews.2020; 19(2): 243.     CrossRef
  • Frequency and Types of Pathological Upper Gastrointestinal Endoscopy Findings in Clinically Healthy Individuals
    Elisabeth Scheidl, Claus Benz, Peter Loeff, Volker Groneck, Andreas König, Alban Schulte-Fischedick, Hendrik Lück, Uwe Fuhr
    Drugs in R&D.2020; 20(2): 115.     CrossRef
  • Psychological effect of comprehensive nursing intervention in elderly patients with perforated peptic ulcer
    Bing Chen, Xiu-Yu Liu, Hong-Mei Zhang, Bai-Jun Zhang, Ying-Ting Wang
    Medicine.2020; 99(39): e22226.     CrossRef
  • Helicobacter pylori and nonmalignant upper gastrointestinal diseases
    Laimas Jonaitis, Rinaldo Pellicano, Limas Kupcinskas
    Helicobacter.2018;[Epub]     CrossRef
  • The relationship between occupational stress and gastrointestinal illness: A comprehensive study of public schoolteachers
    Krista Howard, Madeline Giblin, Rachel Medina
    Journal of Workplace Behavioral Health.2018; 33(3-4): 260.     CrossRef
  • Clinical Significance of Risk Factors for Asymptomatic Peptic Ulcer Disease
    Cheal Wung Huh, Byung-Wook Kim
    Clinical Endoscopy.2017; 50(6): 514.     CrossRef
  • 14,414 View
  • 407 Download
  • 33 Web of Science
  • 34 Crossref
Close layer

Clin Endosc : Clinical Endoscopy Twitter Facebook
Close layer
TOP