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Review
Endoscopic findings of immune checkpoint inhibitor-related gastrointestinal adverse events
Min Kyu Kim, Sung Wook Hwang
Clin Endosc 2024;57(6):725-734.   Published online August 29, 2024
DOI: https://doi.org/10.5946/ce.2024.003
AbstractAbstract PDFPubReaderePub
The use of immune checkpoint inhibitors (ICIs) for the treatment of various malignancies is increasing. Immune-related adverse events can occur after ICI administration, with gastrointestinal adverse events constituting a significant proportion of these events. When ICI-related diarrhea/colitis is suspected, endoscopic evaluation is recommended to differentiate it from other etiologies and assess the severity of colitis. The distribution of intestinal inflammation in ICI-related colitis demonstrates a high frequency of extensive colitis (23–86%). However, isolated right-sided colitis (3–8%) and ileitis (2–16%) are less prevalent. Endoscopic findings vary and predominantly encompass features indicative of inflammatory bowel disease, including aphthae, ulcers, diffuse or patchy erythema, mucosal edema, loss of vascular pattern, and friability. The presence of ulcers and extensive intestinal inflammation are associated with a reduced response to treatment. Microscopic inflammation can be observed even in endoscopically normal mucosa, underscoring the need for biopsies of seemingly normal mucosa. Histological findings present with acute/chronic inflammation and occasionally exhibit characteristics observed in inflammatory bowel disease, microscopic colitis, or ischemic colitis. The first-line therapeutic choice for ICI-related diarrhea/colitis with a common terminology criteria for adverse events grade of 2 or above is corticosteroids, whereas infliximab and vedolizumab are recommended for refractory cases.

Citations

Citations to this article as recorded by  
  • Who is at risk for immune checkpoint inhibitor-induced colitis among Korean patients?
    Ji Hyun Kim, Sung Chul Park
    The Korean Journal of Internal Medicine.2025; 40(1): 3.     CrossRef
  • CD8+ cell dominance in immune checkpoint inhibitor-induced colitis and its heterogeneity across endoscopic features
    Min Kyu Kim, Hye-Nam Son, Seung Wook Hong, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Shinkyo Yoon, Sung Wook Hwang
    Therapeutic Advances in Gastroenterology.2024;[Epub]     CrossRef
  • 2,346 View
  • 348 Download
  • 2 Web of Science
  • 2 Crossref
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Original Articles
Artificial Intelligence-Based Colorectal Polyp Histology Prediction by Using Narrow-Band Image-Magnifying Colonoscopy
Istvan Racz, Andras Horvath, Noemi Kranitz, Gyongyi Kiss, Henriett Regoczi, Zoltan Horvath
Clin Endosc 2022;55(1):113-121.   Published online September 23, 2021
DOI: https://doi.org/10.5946/ce.2021.149
AbstractAbstract PDFPubReaderePub
Background
/Aims: We have been developing artificial intelligence based polyp histology prediction (AIPHP) method to classify Narrow Band Imaging (NBI) magnifying colonoscopy images to predict the hyperplastic or neoplastic histology of polyps. Our aim was to analyze the accuracy of AIPHP and narrow-band imaging international colorectal endoscopic (NICE) classification based histology predictions and also to compare the results of the two methods.
Methods
We studied 373 colorectal polyp samples taken by polypectomy from 279 patients. The documented NBI still images were analyzed by the AIPHP method and by the NICE classification parallel. The AIPHP software was created by machine learning method. The software measures five geometrical and color features on the endoscopic image.
Results
The accuracy of AIPHP was 86.6% (323/373) in total of polyps. We compared the AIPHP accuracy results for diminutive and non-diminutive polyps (82.1% vs. 92.2%; p=0.0032). The accuracy of the hyperplastic histology prediction was significantly better by NICE compared to AIPHP method both in the diminutive polyps (n=207) (95.2% vs. 82.1%) (p<0.001) and also in all evaluated polyps (n=373) (97.1% vs. 86.6%) (p<0.001)
Conclusions
Our artificial intelligence based polyp histology prediction software could predict histology with high accuracy only in the large size polyp subgroup.

Citations

Citations to this article as recorded by  
  • Colon polyps: updates in classification and management
    David Dornblaser, Sigird Young, Aasma Shaukat
    Current Opinion in Gastroenterology.2024; 40(1): 14.     CrossRef
  • Employing deep learning for predicting the thermal properties of water and nano-encapsulated phase change material
    Saihua Xu, Ali Basem, Hasan A Al-Asadi, Rishabh Chaturvedi, Gulrux Daminova, Yasser Fouad, Dheyaa J Jasim, Javid Alhoee
    International Journal of Low-Carbon Technologies.2024; 19: 1453.     CrossRef
  • Endoscopic Artificial Intelligence for Image Analysis in Gastrointestinal Neoplasms
    Ryosuke Kikuchi, Kazuaki Okamoto, Tsuyoshi Ozawa, Junichi Shibata, Soichiro Ishihara, Tomohiro Tada
    Digestion.2024; 105(6): 419.     CrossRef
  • Detecting colorectal lesions with image-enhanced endoscopy: an updated review from clinical trials
    Mizuki Nagai, Sho Suzuki, Yohei Minato, Fumiaki Ishibashi, Kentaro Mochida, Ken Ohata, Tetsuo Morishita
    Clinical Endoscopy.2023; 56(5): 553.     CrossRef
  • AI-powered medical devices for practical clinicians including the diagnosis of colorectal polyps
    Donghwan Kim, Eunsun Kim
    Journal of the Korean Medical Association.2023; 66(11): 658.     CrossRef
  • Artificial Intelligence-Based Colorectal Polyp Histology Prediction: High Accuracy in Larger Polyps
    Naoki Muguruma, Tetsuji Takayama
    Clinical Endoscopy.2022; 55(1): 45.     CrossRef
  • Artificial intelligence-based colorectal polyp histology prediction using narrow-band image-magnifying colonoscopy: a stepping stone for clinical practice
    Ji Young Chang
    Clinical Endoscopy.2022; 55(5): 699.     CrossRef
  • Response to Artificial intelligence-based colorectal polyp histology prediction using narrow-band image-magnifying colonoscopy: a stepping stone for clinical practice
    Istvan Racz, Andras Horvath, Zoltán Horvath
    Clinical Endoscopy.2022; 55(5): 701.     CrossRef
  • 5,314 View
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Comparative Study of Narrow-Band Imaging and i-scan for Predicting the Histology of Intermediate-to-Large Colorectal Polyps: A Prospective, Randomized Pilot Study
Joon Seop Lee, Seong Woo Jeon, Yong Hwan Kwon
Clin Endosc 2021;54(6):881-887.   Published online January 6, 2021
DOI: https://doi.org/10.5946/ce.2020.257
AbstractAbstract PDFPubReaderePub
Background
/Aims: To date, no reports have compared the diagnostic efficacy of narrow-band imaging (NBI) and i-scan for the histologic prediction of intermediate-to-large colorectal polyps. We aimed to compare the diagnostic accuracy of NBI and i-scan in predicting histology, and their inter-/intra-observer agreement.
Methods
We performed a prospective, randomized study that included 66 patients (NBI, n=33 vs. i-scan, n=33) with colorectal polyps (size >10 mm but <50 mm) who underwent colonoscopic resection. During the procedure, three endoscopists documented their prediction using the Japan NBI Expert Team (JNET) classification. Two months after study completion, the endoscopists reviewed still images and video clips for analysis.
Results
The overall diagnostic accuracies in the NBI and i-scan groups were 73.7% (73/99) and 75.8% (75/99), respectively, and there was no statistical significance between the two groups (p=0.744). The JNET classification as applied to NBI and i-scan showed substantial inter-observer agreement (NBI κ-value 0.612, p=0.001 vs. i-scan κ-value 0.662, p=0.002). Additionally, the κ-values of intra-observer agreement were in the range of 0.385–0.660 with NBI and 0.364–0.741 with i-scan.
Conclusions
NBI and i-scan have similar diagnostic accuracies for the histologic prediction of intermediate-to-large colorectal polyps. Furthermore, the inter-/intra-observer agreement was acceptable for both modalities when the JNET classification was applied.

Citations

Citations to this article as recorded by  
  • Ultra-minimally invasive endoscopic techniques and colorectal diseases: Current status and its future
    Nalini Kanta Ghosh, Ashok Kumar
    Artificial Intelligence in Gastrointestinal Endoscopy.2024;[Epub]     CrossRef
  • The Utility of Narrow-Band Imaging International Colorectal Endoscopic Classification in Predicting the Histologies of Diminutive Colorectal Polyps Using I-Scan Optical Enhancement: A Prospective Study
    Yeo Wool Kang, Jong Hoon Lee, Jong Yoon Lee
    Diagnostics.2023; 13(16): 2720.     CrossRef
  • Detecting colorectal lesions with image-enhanced endoscopy: an updated review from clinical trials
    Mizuki Nagai, Sho Suzuki, Yohei Minato, Fumiaki Ishibashi, Kentaro Mochida, Ken Ohata, Tetsuo Morishita
    Clinical Endoscopy.2023; 56(5): 553.     CrossRef
  • Classification and endoscopic diagnosis of colorectal polyps
    Ji Hyun Kim, Sung Chul Park
    Journal of the Korean Medical Association.2023; 66(11): 633.     CrossRef
  • Usefulness of optical enhancement endoscopy combined with magnification to improve detection of intestinal metaplasia in the stomach
    Sergio Sobrino-Cossío, Oscar Teramoto-Matsubara, Fabian Emura, Raúl Araya, Vítor Arantes, Elymir S. Galvis-García, Marisi Meza-Caballero, Blanca Sinahi García-Aguilar, Arturo Reding-Bernal, Noriya Uedo
    Endoscopy International Open.2022; 10(04): E441.     CrossRef
  • Interventions to improve adenoma detection rates for colonoscopy
    Aasma Shaukat, Anne Tuskey, Vijaya L. Rao, Jason A. Dominitz, M. Hassan Murad, Rajesh N. Keswani, Fateh Bazerbachi, Lukejohn W. Day
    Gastrointestinal Endoscopy.2022; 96(2): 171.     CrossRef
  • A modified fujinon intelligent color enhancement (FICE) in the diagnostics of superficial epithelial neoplasms of the colon
    V. A. Duvanskiy, A. V. Belkov
    Experimental and Clinical Gastroenterology.2022; (5): 154.     CrossRef
  • Mucosal imaging in colon polyps: New advances and what the future may hold
    Edward John Young, Arvinf Rajandran, Hamish Lachlan Philpott, Dharshan Sathananthan, Sophie Fenella Hoile, Rajvinder Singh
    World Journal of Gastroenterology.2022; 28(47): 6632.     CrossRef
  • Commentary on “Comparative Study of Narrow-Band Imaging and i-scan for Predicting the Histology of Intermediate-to-Large Colorectal Polyps: A Prospective, Randomized Pilot Study”
    Yunho Jung, Masayuki Kato
    Clinical Endoscopy.2021; 54(6): 781.     CrossRef
  • 5,303 View
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Focused Review Series: Endoscopic Submucosal Dissection for Undifferentiated-Type Early Gastric Cancer
Strategy for Curative Endoscopic Resection of Undifferentiated-Type Early Gastric Cancer
Jie-Hyun Kim
Clin Endosc 2019;52(1):9-14.   Published online January 24, 2019
DOI: https://doi.org/10.5946/ce.2018.199
AbstractAbstract PDFPubReaderePub
Endoscopic resection (ER) of undifferentiated-type early gastric cancer (UD-EGC) has a lower curative resection (CR) rate than differentiated-type EGC. However, if UD-EGC is curatively resected using ER, long-term outcomes can be favorable. Thus, the strategy for CR by ER is important in UD-EGC. To achieve CR in UD-EGC, biological behaviors including tumor growth patterns must be considered. This review aims to describe what is important for curative ER of UD-EGC.

Citations

Citations to this article as recorded by  
  • Long-term outcomes of endoscopic resection followed by additional surgery after non-curative resection in undifferentiated-type early gastric cancer: a nationwide multi-center study
    Jie-Hyun Kim, Young-Il Kim, Ji Yong Ahn, Woon Geon Shin, Hyo-Joon Yang, Su Youn Nam, Byung-Hoon Min, Jae-Young Jang, Joo Hyun Lim, Wan Sik Lee, Bong Eun Lee, Moon Kyung Joo, Jae Myung Park, Hang Lak Lee, Tae-Geun Gweon, Moo In Park, Jeongmin Choi, Chung H
    Surgical Endoscopy.2022; 36(3): 1847.     CrossRef
  • Diffuse-type Gastric Cancer
    Jie-Hyun Kim
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(1): 11.     CrossRef
  • The future of endoscopic resection for early gastric cancer
    Raquel Ortigão, Diogo Libânio, Mário Dinis‐Ribeiro
    Journal of Surgical Oncology.2022; 125(7): 1110.     CrossRef
  • Therapeutic approach to non-curative resection after endoscopic treatment in early gastric cancer
    Eun Jeong Gong, Chang Seok Bang
    Journal of the Korean Medical Association.2022; 65(5): 284.     CrossRef
  • Establishing Machine Learning Models to Predict Curative Resection in Early Gastric Cancer with Undifferentiated Histology: Development and Usability Study
    Chang Seok Bang, Ji Yong Ahn, Jie-Hyun Kim, Young-Il Kim, Il Ju Choi, Woon Geon Shin
    Journal of Medical Internet Research.2021; 23(4): e25053.     CrossRef
  • Risk Factors and Clinical Outcomes of Non-Curative Resection in Patients with Early Gastric Cancer Treated with Endoscopic Submucosal Dissection: A Retrospective Multicenter Study in Korea
    Si Hyung Lee, Min Cheol Kim, Seong Woo Jeon, Kang Nyeong Lee, Jong Jae Park, Su Jin Hong
    Clinical Endoscopy.2020; 53(2): 196.     CrossRef
  • 6,975 View
  • 185 Download
  • 5 Web of Science
  • 6 Crossref
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Review
Endoscopic Submucosal Dissection for Early Gastric Cancers with Uncommon Histology
Gwang Ha Kim
Clin Endosc 2016;49(5):434-437.   Published online September 30, 2016
DOI: https://doi.org/10.5946/ce.2016.127
AbstractAbstract PDFPubReaderePub
Endoscopic submucosal dissection (ESD) enables en bloc curative resection of early gastric cancers (EGCs) with a negligible risk of lymph node metastasis (LNM). Although ESD for EGCs with absolute and expanded indications is safe, the results differ between EGCs with specialized and common histologies. EGC with papillary adenocarcinoma is a differentiated-type adenocarcinoma. At present, it is treated with ESD according to the same criteria as other differentiated-type adenocarcinomas. The LNM rate under the current indication criteria is high, and over half of the patients who undergo ESD as a primary treatment for EGC with papillary adenocarcinoma achieve an out-of-ESD result. Gastric carcinoma with lymphoid stroma in EGC has a low LNM rate and a favorable outcome, despite deep submucosal invasion. Patients with this gastric cancer subtype may be good candidates for ESD, even with deep submucosal invasion. Large-scale prospective multi-center studies with longer follow-up periods are needed to set proper ESD criteria for these tumors. Clinicians should be aware of these disease entities and ESD should be more carefully considered for EGCs with papillary adenocarcinoma and gastric carcinoma with lymphoid stroma.

Citations

Citations to this article as recorded by  
  • Gastric carcinoma with lymphoid stroma derived from hamartomatous inverted polyp with osteoclast-like giant cells: a case report
    Shoko Yamashita, Masaaki Nishi, Kozo Yoshikawa, Toshihiro Nakao, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Yuma Wada, Toshiaki Yoshimoto, Yosuke Iwakawa, Takeshi Oya, Koichi Tsuneyama, Mitsuo Shimada
    International Cancer Conference Journal.2022; 11(3): 196.     CrossRef
  • Endoscopic Submucosal Dissection of Papillary Gastric Adenocarcinoma; Systematic Review
    Chang Seok Bang, Jae Jun Lee, Gwang Ho Baik
    Journal of Clinical Medicine.2020; 9(5): 1465.     CrossRef
  • Pitfalls in the Interpretation of Publications about Endoscopic Submucosal Dissection of Early Gastric Cancer with Undifferentiated-Type Histology
    Chang Seok Bang, Gwang Ho Baik
    Clinical Endoscopy.2019; 52(1): 30.     CrossRef
  • A new Schiff base coordinated copper(II) compound induces apoptosis and inhibits tumor growth in gastric cancer
    Yan Xia, Xingkai Liu, Luping Zhang, Jinzhu Zhang, Chaoying Li, Nan Zhang, Hong Xu, Yan Li
    Cancer Cell International.2019;[Epub]     CrossRef
  • 7,988 View
  • 171 Download
  • 7 Web of Science
  • 4 Crossref
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Original Article
A Randomized Controlled Clinical Study Comparing the Diagnostic Accuracy of the Histologic Prediction for Colorectal Polyps Depending on the Use of Either Magnified or Nonmagnified Narrow Band Imaging
Jin Joo Kim, Kyoung Sup Hong, Joo Sung Kim, Hyun Chae Jung
Clin Endosc 2015;48(6):528-533.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.528
AbstractAbstract PDFPubReaderePub
Background
/Aims: The aim of this study was to compare the diagnostic capabilities of narrow band imaging (NBI) colonoscopy with and without optical magnification in differentiating neoplastic from nonneoplastic colorectal polyps.
Methods
Between April 2012 and March 2013, 122 patients with colorectal polyps detected by using diagnostic conventional colonoscopy were prospectively enrolled. A total of 236 polyps were evaluated with NBI, in vivo in real time during therapeutic colonoscopy, by one experienced endoscopist. Whether magnification was used or not was determined by randomization. After an in vivo real-time endoscopic prediction of histology, all lesions were endoscopically excised. Surgical pathologic reports were used as the criterion standards. The sensitivity (Sn), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) of identifying neoplastic polyps were calculated.
Results
A total of 236 lesions with an average size of 5.6 mm in 122 patients were assessed (159 neoplastic, 77 nonneoplastic). The Sn, Sp, PPV, and NPV in differentiating neoplastic from nonneoplastic lesions with the magnified NBI were 97.5%, 83.3%, 94.0%, and 92.6%, respectively, whereas those of the nonmagnified NBI group were 97.5%, 85.1%, 91.7%, and 95.2%, respectively.
Conclusions
Nonmagnified NBI colonoscopy distinguishes neoplastic from nonneoplastic colorectal polyps as accurately as does magnified NBI colonoscopy.

Citations

Citations to this article as recorded by  
  • Utility of the narrow-band imaging international colorectal endoscopic classification for optical diagnosis of colorectal polyp histology in clinical practice: a retrospective study
    Yasuhiko Hamada, Kyosuke Tanaka, Masaki Katsurahara, Noriyuki Horiki, Reiko Yamada, Tomomi Yamada, Yoshiyuki Takei
    BMC Gastroenterology.2021;[Epub]     CrossRef
  • Feasibility of using narrow band imaging international colorectal endoscopic classification for diagnosing colorectal neoplasia in China: A multicenter pilot observational study
    Qing Wei Zhang, Jing Jing Zhang, Ai Ming Yang, Jian Qiu Sheng, Yu Lan Liu, Zhao Shen Li, Hai Ying Chen, Nan Feng, Qing Wei Jiang, Peng Jin, Li Ming Zhang, Hong Yu Fu, Yun Jie Gao, Zhi Zheng Ge, Xiao Bo Li
    Journal of Digestive Diseases.2020; 21(2): 88.     CrossRef
  • Narrow-Band Imaging: Clinical Application in Gastrointestinal Endoscopy
    Sandra Barbeiro, Diogo Libânio, Rui Castro, Mário Dinis-Ribeiro, Pedro Pimentel-Nunes
    GE - Portuguese Journal of Gastroenterology.2019; 26(1): 40.     CrossRef
  • The value of narrow band imaging in diagnosis of head and neck cancer: a meta-analysis
    Hui Zhou, Jing Zhang, Linghong Guo, Ji Nie, Chenjing Zhu, Xuelei Ma
    Scientific Reports.2018;[Epub]     CrossRef
  • Comparison of narrow-band imaging and confocal laser endomicroscopy for the detection of neoplasia in Barrett's esophagus: A meta-analysis
    Yi-Quan Xiong, Shu-Juan Ma, Hao-Yue Hu, Jing Ge, Li-Zhi Zhou, Shu-Ting Huo, Min Qiu, Qing Chen
    Clinics and Research in Hepatology and Gastroenterology.2018; 42(1): 31.     CrossRef
  • Endoscopic classification for colorectal tumors using narrow‐band imaging
    Gian Eugenio Tontini, Helmut Neumann
    Digestive Endoscopy.2016; 28(5): 537.     CrossRef
  • Narrow Band Imaging as an Efficient and Economical Tool in Diagnosing Colorectal Polyps
    Naoki Muguruma, Tetsuji Takayama
    Clinical Endoscopy.2015; 48(6): 461.     CrossRef
  • 8,095 View
  • 81 Download
  • 8 Web of Science
  • 7 Crossref
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Case Report
Liver Metastasis of Early Gastric Cancer with Mixed Histology after Endoscopic Submucosal Dissection
Yang Hee Han, Jong Kyu Park, Jun Sung Kwon, Young Don Kim, Woo Jin Jeong, Sang Jin Lee, Koon Hee Han, Gab Jin Cheon
Clin Endosc 2015;48(3):247-250.   Published online May 29, 2015
DOI: https://doi.org/10.5946/ce.2015.48.3.247
AbstractAbstract PDFPubReaderePub

The Japanese Classification of Gastric Carcinoma histologically classifies endoscopically resected gastric cancer into differentiated and undifferentiated types according to the presence or absence of tubular structures on histology. The former includes papillary adenocarcinoma and tubular types, and the latter includes poorly differentiated adenocarcinoma, signet ring cell carcinoma and mucinous adenocarcinoma. However, gastric cancer sometimes contains a mixture of differentiated and undifferentiated components, and the clinical outcomes of the histological mixture are unknown, especially following endoscopic resection of early gastric cancer (EGC). This case was within the guideline indications for endoscopic submucosal resection (ESD), although it contained a partly signet ring cell carcinoma component; it recurred after 19 months with multiple lymph node and liver metastases. This case shows that additional surgical resection after ESD should be performed for patients with any mixed signet ring cell component, even in mild or moderately differentiated EGC.

Citations

Citations to this article as recorded by  
  • Clinical significance of computed tomography-detected ascites in gastric cancer patients with peritoneal metastases
    Su Hwan Kim, Young Ho Choi, Ji Won Kim, Sohee Oh, Seohui Lee, Byeong Gwan Kim, Kook Lae Lee
    Medicine.2018; 97(8): e9343.     CrossRef
  • A primary tumor of mixed histological type is a novel poor prognostic factor for patients undergoing resection of liver metastasis from gastric cancer
    Naoki Ikari, Kiyoaki Taniguchi, Akiko Serizawa, Takuji Yamada, Masakazu Yamamoto, Toru Furukawa
    Journal of Hepato-Biliary-Pancreatic Sciences.2017; 24(5): 281.     CrossRef
  • 8,057 View
  • 100 Download
  • 3 Web of Science
  • 2 Crossref
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Original Article
Correlation of Narrow Band Imaging with Magnifying Colonoscopy and Histology in Colorectal Tumors
Hee Yong Yoo, Moon Sung Lee, Bong Min Ko, Hee Kyung Kim, Hyung Su Ahn, Seung Hyo Han, Jun Yong Bae, Seul Ki Min, Jong Chan Lee, Chang Beom Ryu
Clin Endosc 2011;44(1):44-50.   Published online September 30, 2011
DOI: https://doi.org/10.5946/ce.2011.44.1.44
AbstractAbstract PDFPubReaderePub
Background/Aims

Narrow band imaging (NBI) is a new technique that uses optical filters for imaging of mucosal morphology. The aim of this study was to correlate findings of NBI with magnifying colonoscopy and histology for prediction of neoplastic colorectal lesion.

Methods

Between September 2005 and December 2007, 107 colon polyps from 68 patients were detected by conventional colonoscopy and subsequently evaluated by NBI with magnifying colonoscopy and analyzed for a pit pattern and a capillary pattern. More analysis was done regarding thickness and irregularity of capillary features.

Results

Pit pattern with NBI magnification to discriminate between neoplastic and non-neoplastic lesions had a sensitivity of 88.9% and a specificity of 87.5%; capillary pattern yielded test performance characteristics of 91.9% and 87.5%. In respect of capillary thickness, invisible capillaries were found significantly more often in hyperplastic lesions. All thick capillaries were found in neoplastic polyps, and found significantly more often in carcinomas with submucosal massive invasion (sm-m) (p<0.01). In respect of capillary irregularity, invisible capillaries were found significantly more often in hyperplasic lesions, and severely irregular capillaries were found significantly more often in sm-m lesions (p<0.01).

Conclusions

Observation of capillary thickness and irregularity by NBI magnification is useful for correlating histological grade with carcinoma, especially with depth of submucosal invasion.

Citations

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  • Multidisciplinary Treatment Strategy for Early Colon Cancer: A Review-An English Version
    Gyung Mo Son, Su Bum Park, Tae Un Kim, Byung-Soo Park, In Young Lee, Joo-Young Na, Dong Hoon Shin, Sang Bo Oh, Sung Hwan Cho, Hyun Sung Kim, Hyung Wook Kim
    Journal of the Anus, Rectum and Colon.2022; 6(4): 203.     CrossRef
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    Chan Hyuk Park, Dong-Hoon Yang, Jong Wook Kim, Jie-Hyun Kim, Ji Hyun Kim, Yang Won Min, Si Hyung Lee, Jung Ho Bae, Hyunsoo Chung, Kee Don Choi, Jun Chul Park, Hyuk Lee, Min-Seob Kwak, Bun Kim, Hyun Jung Lee, Hye Seung Lee, Miyoung Choi, Dong-Ah Park, Jong
    Intestinal Research.2021; 19(2): 127.     CrossRef
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    Chan Hyuk Park, Dong-Hoon Yang, Jong Wook Kim, Jie-Hyun Kim, Ji Hyun Kim, Yang Won Min, Si Hyung Lee, Jung Ho Bae, Hyunsoo Chung, Kee Don Choi, Jun Chul Park, Hyuk Lee, Min-Seob Kwak, Bun Kim, Hyun Jung Lee, Hye Seung Lee, Miyoung Choi, Dong-Ah Park, Jong
    Clinical Endoscopy.2020; 53(2): 142.     CrossRef
  • Clinical Practice Guideline for Endoscopic Resection of Early Gastrointestinal Cancer
    Chan Hyuk Park, Dong-Hoon Yang, Jong Wook Kim, Jie-Hyun Kim, Ji Hyun Kim, Yang Won Min, Si Hyung Lee, Jung Ho Bae, Hyunsoo Chung, Kee Don Choi, Jun Chul Park, Hyuk Lee, Min-Seob Kwak, Bun Kim, Hyun Jung Lee, Hye Seung Lee, Miyoung Choi, Dong-Ah Park, Jong
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2020; 20(2): 117.     CrossRef
  • Clinical Practice Guideline for Endoscopic Resection of Early Gastrointestinal Cancer
    Chan Hyuk Park, Dong-Hoon Yang, Jong Wook Kim, Jie-Hyun Kim, Ji Hyun Kim, Yang Won Min, Si Hyung Lee, Jung Ho Bae, Hyunsoo Chung, Kee Don Choi, Jun Chul Park, Hyuk Lee, Min-Seob Kwak, Bun Kim, Hyun Jung Lee, Hye Seung Lee, Miyoung Choi, Dong-Ah Park, Jong
    The Korean Journal of Gastroenterology.2020; 75(5): 264.     CrossRef
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    Sam E. Mason, Liam Poynter, Zoltan Takats, Ara Darzi, James M. Kinross
    American Journal of Gastroenterology.2019; 114(8): 1219.     CrossRef
  • Effectiveness of systematic training in the application of narrow‐band imaging international colorectal endoscopic (NICE) classification for optical diagnosis of colorectal polyps: Experience from a single center in China
    Yinhe Sikong, Xiangchun Lin, Kuiliang Liu, Jing Wu, Wu Lin, Nan Wei, Guojun Jiang, Weiping Tai, Hui Su, Hong Liu, Mingming Meng
    Digestive Endoscopy.2016; 28(5): 583.     CrossRef
  • Observation of microvessels and invasion in early colorectal neoplasms on narrow band imaging
    Ling Yin Zhu, Lin Ren, Zhizheng Ge, Xiao Bo Li
    European Journal of Gastroenterology & Hepatology.2014; 26(12): 1428.     CrossRef
  • Diagnostic performance of narrowed spectrum endoscopy, autofluorescence imaging, and confocal laser endomicroscopy for optical diagnosis of colonic polyps: a meta-analysis
    Linda K Wanders, James E East, Sanne E Uitentuis, Mariska M G Leeflang, Evelien Dekker
    The Lancet Oncology.2013; 14(13): 1337.     CrossRef
  • Colonic Polyps
    Cesare Hassan, Alessandro Repici, Angelo Zullo, Vijay Kanakadandi, Prateek Sharma
    Gastrointestinal Endoscopy Clinics of North America.2013; 23(3): 663.     CrossRef
  • Introduction: What Are New Roles of Current Colonoscopy?
    Hyung Wook Kim
    Clinical Endoscopy.2013; 46(2): 118.     CrossRef
  • New Paradigms for Colonoscopic Management of Diminutive Colorectal Polyps: Predict, Resect, and Discard or Do Not Resect?
    Cesare Hassan, Alessandro Repici, Angelo Zullo, Prateek Sharma
    Clinical Endoscopy.2013; 46(2): 130.     CrossRef
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Clinical Features of Re-infection of Helicobacter pylori after Successful Eradication
Jai Hwan Kim, M.D., Hyo Joon Yang, M.D., Eun Sun Jang, M.D., Eun Ju Jo, M.D., Hyun Jin Jo, M.D., Jae Young Chun, M.D., Jong Kyung Choi, M.D., Sung Wook Hwang, M.D., Sang Hyub Lee, M.D.*, Young Soo Park, M.D.*, Jin Hyeok Hwang, M.D.*, Jin Wook Kim, M.D.*,
Korean J Gastrointest Endosc 2008;37(3):161-166.   Published online September 30, 2008
AbstractAbstract PDF
Background
/Aims:Studies on re-infection of Helicobacter pylori are limited. This study was designed to determine if there are clinical features of H. pylori re- infection related to gastroduodenal diseases or histological findings. Methods: From a population of patients that were treated for H. pylori eradication from May 2003 to September 2007, 129 subjects were enrolled. Regimens were PPI-based triple or quadruple agents and follow-up methods were UBT, CLO or histology. Results: A total of 29 subjects experienced a recurrence (within one year, 17 subjects; between one and two years, eight subjects; more than two years, four subjects). Recurrence periods were 2 to 32 months, and the mean period was 12.62± 8.40 months. Among 29 subjects, eight subjects had chronic atrophic gastritis, 14 subjects had a peptic ulcer, five subjects had stomach cancer and two subjects had a MALT lymphoma; there were no statistical differences of the odds ratio between matched diseases. By use of the Updated Sydney System, neither H. pylori colonization density nor neutrophil infiltration nor monocyte infiltration grade in histology was associated with recurrence or re-infection. Conclusions: Neither histological findings nor gastroduodenal diseases was associated with H. pylori re-infection. The re-infection rate in this study was approximately 6.2%. This rate was slightly higher than rates reported in other recent studies in Korea. (Korean J Gastrointest Endosc 2008;37:161-166)
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위에 발생한 사구종야 1예 ( A Case of Glomus Tumor Arising in the Stomach )
Korean J Gastrointest Endosc 2000;21(1):559-562.   Published online November 30, 1999
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It is very important to be aware of occurrence and distinctive histologic features of gastric glomus tumor because its clinical presentation and endoscopic ficdings are indistinguishable from other gastric tumors. A 58-year-old man was admitted because of intermittent epigastric pain and indigestion for 2 months. Physical examination and laboratory findings revealed within normal limits. Upper gastroendoscopy demonstrated a submucosal mass near the antrum with central mucosal depressionand peripheral multiple erosions. Endoscopic ultrasonography revealed a circumscribed mass that continued to the third and fourth layers which demonstrated a heterogeneous low echo pattern mixed with internal high echo spots. Histologically, the tumor cells have uniform small nuclei with inconspicuous nucleoli. Immunochemical analysis on the tumor cells expressed alpha 1 smooth muscle actin and the tumor cells are enveloped by reticulin fiber, individually or grouped. A case of glomus tumor of the stomach is herein reported with a review of literature. (Korean J Gastrointest Endosc 2000;21:559-562)
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