Clinical Endoscopy

Reviews

Efficacy of image-enhanced endoscopy for colorectal polyp detection: Reo Kobayashi, Naohisa Yoshida, Ken Inoue; Clin Endosc 2026;59(4):485-496. Published online March 3, 2026; DOI: https://doi.org/10.5946/ce.2025.221

Abstract PDF: Colonoscopy plays a key role in reducing the incidence and mortality of colorectal cancer by detecting precancerous lesions, such as adenomas. Image-enhanced endoscopy (IEE) has been reported to effectively improve lesion detection and characterization in many cases. With the development of new endoscopic instruments, the IEE technology is rapidly advancing, and new endoscopes using light-emitting diode light sources, in addition to xenon and laser light sources, have been introduced, and various types of IEEs are used. Several observational methods have been validated for detecting and preventing missed lesions, such as narrow-band imaging (NBI), blue laser/light imaging (BLI), linked color imaging, and texture and color enhancement imaging, which have been suggested to be more effective than white light observation. The Japan NBI Expert Team classification, a unified classification of NBI magnification developed in Japan, can be used alongside NBI and BLI magnification to evaluate surface and vessel patterns and diagnose lesions. In this review, we describe the usefulness of each IEE with reference to the latest data.

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Role of image-enhanced endoscopy for the diagnosis of gastric intestinal metaplasia: Sang Pyo Lee, Shin Hee Kim; Clin Endosc 2026;59(4):523-528. Published online February 13, 2026; DOI: https://doi.org/10.5946/ce.2025.260

Abstract PDF: Gastric intestinal metaplasia (IM) is a key precursor lesion in gastric cancer progression, as described by the Correa model. Image-enhanced endoscopy (IEE) with magnifying endoscopy has significantly improved the visualization of the mucosal surfaces and microvascular structures, aiding in the accurate diagnosis of IM. While histological evaluation remains the gold standard, IEE might provide a practical and cost-effective alternative for the risk stratification of gastric IM.

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Image-enhanced endoscopy in upper gastrointestinal disease: focusing on texture and color enhancement imaging and red dichromatic imaging: Jae Yong Park; Clin Endosc 2025;58(2):163-180. Published online November 6, 2024; DOI: https://doi.org/10.5946/ce.2024.159

Abstract PDF

Endoscopic examination plays a crucial role in the diagnosis of upper gastrointestinal (UGI) tract diseases. Despite advancements in endoscopic imaging, the detection of subtle early cancers and premalignant lesions using white-light imaging alone remains challenging. This review discusses two novel image-enhanced endoscopy (IEE) techniques–texture and color enhancement imaging (TXI) and red dichromatic imaging (RDI)–and their potential applications in UGI diseases. TXI enhances texture, brightness, and color tone, which improves the visibility of mucosal irregularities and facilitates earlier detection of neoplastic lesions. Studies have suggested that TXI enhances the color differences between lesions and the surrounding mucosa and improves the visibility of the lesion. TXI aids in the diagnosis of various UGI diseases, including early gastric cancer, esophageal cancer, premalignant conditions such as atrophic gastritis and Barrett’s esophagus, and duodenal tumors. RDI utilizes specific wavelengths to enhance the visualization of deep blood vessels or bleeding points, aiding in the rapid and accurate identification of bleeding sources during endoscopic procedures. Although promising, TXI and RDI require further large-scale studies across diverse populations to establish their clinical utility, diagnostic performance, and cost-effectiveness before integration into the guidelines. Standardized training is also required for effective utilization. Overall, these IEE techniques has the potential to improve the diagnosis and management of UGI.

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Evaluating the efficacy of texture and colour enhancement imaging versus white light imaging in colonic adenoma detection: a systematic review and meta-analysis of randomized controlled trials
Abdallfatah Abdallfatah, Ahmed W. Hageen, Samaa Daoud, Hazem Abosheaishaa, Douglas G. Adler
European Journal of Gastroenterology & Hepatology.2026; 38(5): 650. CrossRef
Navigating the Treatment Landscape for Widespread Superficial Esophageal Squamous Cell Neoplasia
Moon Won Lee, Gwang Ha Kim
Gut and Liver.2025; 19(3): 305. CrossRef
Classification of image-enhanced endoscopy in colon tumors
One-Zoong Kim
Clinical Endoscopy.2025; 58(3): 337. CrossRef
Deep Learning Based Detection and Classification of Gastrointestinal Abnormalities from Endoscopic Imaging Data
Swetha Kumari T, Vasuki R
International Research Journal of Multidisciplinary Technovation.2025; : 223. CrossRef
Limited Diagnostic Yield of Routine Gastroscopy in FIT-Positive Patients
Majd Khader, Fadi Abu Baker, Jorge-Shmuel Delgado, Avraham Yitzhak, Revital Guterman, Ruhama Elhayany, Or Bakshi, Vered Klaitman, Tali Braun, Naim Abu-Freha, Rimon Artoul
Diagnostics.2025; 15(21): 2781. CrossRef

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Current status of image-enhanced endoscopy in inflammatory bowel disease: Young Joo Yang; Clin Endosc 2023;56(5):563-577. Published online September 26, 2023; DOI: https://doi.org/10.5946/ce.2023.070

Abstract PDF

In inflammatory bowel disease (IBD), chronic inflammation leads to unfavorable clinical outcomes and increases the risk of developing colorectal neoplasm (CRN); thereby highlighting the importance of endoscopically evaluating disease activity as well as detecting and characterizing CRN in patients with IBD. With recent advances in image-enhanced endoscopic (IEE) technologies, especially virtual chromoendoscopy (VCE) platforms, this review discusses state-of-the-art IEE techniques and their applicability in assessing disease activity and surveillance colonoscopy in patients with IBD. Among various IEE, VCE demonstrated the capacity to identify quiescent disease activity. And endoscopic remission defined by the new scoring system using VCE platform better predicted clinical outcomes, which may benefit the tailoring of therapeutic strategies in patients with IBD. High-definition dye-chromoendoscopy (HD-DCE) is numerically superior to high-definition white light endoscopy (HD-WLE) in detecting CRN in IBD; however, discrepancy is observed in the statistical significance. VCE showed comparable performance in detecting dysplasia to HD-WLE or DCE and potential for optical diagnosis to differentiate neoplastic from nonneoplastic lesions during surveillance colonoscopy. Applying these novel advanced IEE technologies would provide opportunities for personalized medicine in IBD and optimal treatment of CRN in patients with IBD.

Citations

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New Technologies for IBD Endoscopy
Cristina Bezzio, Valeria Farinola, Giuseppe Privitera, Arianna Dal Buono, Roberto Gabbiadini, Laura Loy, Gianluca Franchellucci, Erica Bartolotta, Giulia Migliorisi, Alessandro Armuzzi
Journal of Clinical Medicine.2026; 15(7): 2539. CrossRef
Beyond conventional endoscopy: Image-enhanced techniques in quiescent ulcerative colitis assessment
Vedran Tomašić, Petra Ćaćić, Neven Baršić, Alen Bišćanin
World Journal of Gastrointestinal Endoscopy.2026;[Epub] CrossRef
Advanced Endoscopic Imaging for Detection of Dysplasia in Inflammatory Bowel Disease
Laura Alexandra Lucaciu, Edward John Despott
Gastrointestinal Endoscopy Clinics of North America.2025; 35(1): 141. CrossRef
Seeing Is Believing: Does Red Dichromatic Imaging (RDI) Predict Histological Remission and Clinical Outcomes in Ulcerative Colitis Patients?
Vedran Tomašić
Digestive Diseases and Sciences.2025; 70(7): 2254. CrossRef
Classification of image-enhanced endoscopy in colon tumors
One-Zoong Kim
Clinical Endoscopy.2025; 58(3): 337. CrossRef
Advanced diagnostic and resection endoscopic techniques in managing colitis-associated neoplasia: standard of care or still utopia?
Rossella Maresca, Giulio Calabrese, Stefano Andrea Marchitto, Tommaso Schepis, Silvia Pecere, Marcello Maida, Cristiano Spada, Sandro Sferrazza, Federico Barbaro, Olga Maria Nardone
Best Practice & Research Clinical Gastroenterology.2025; 78: 102051. CrossRef
Optical Imaging Technologies and Clinical Applications in Gastrointestinal Endoscopy
Khyati Bidani, Vishali Moond, Madhvi Nagar, Arkady Broder, Nirav Thosani
Diagnostics.2025; 15(20): 2625. CrossRef
Advances in endoscopic techniques for early detection and treatment of gastrointestinal cancers: A systematic review
Mehak Gul Mastoi, Ali Karim, Fnu Jaslok, Muhammad Bari Hassan, Fnu Neelam, Fnu Prity, Hina Kumari, Sadia Manan, Sadia Siddique, Sana Danish, Sitara Jabeen, Aniket Tara, Ali Umair, Kirshan Lal, Fnu Arti, Abida Parveen
Medicine.2025; 104(42): e45315. CrossRef
The application of the combination between artificial intelligence and endoscopy in gastrointestinal tumors
Shen Li, Maosen Xu, Yuanling Meng, Haozhen Sun, Tao Zhang, Hanle Yang, Yueyi Li, Xuelei Ma
MedComm – Oncology.2024;[Epub] CrossRef

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Detecting colorectal lesions with image-enhanced endoscopy: an updated review from clinical trials: Mizuki Nagai, Sho Suzuki, Yohei Minato, Fumiaki Ishibashi, Kentaro Mochida, Ken Ohata, Tetsuo Morishita; Clin Endosc 2023;56(5):553-562. Published online July 26, 2023; DOI: https://doi.org/10.5946/ce.2023.055

Abstract PDF

Colonoscopy plays an important role in reducing the incidence and mortality of colorectal cancer by detecting adenomas and other precancerous lesions. Image-enhanced endoscopy (IEE) increases lesion visibility by enhancing the microstructure, blood vessels, and mucosal surface color, resulting in the detection of colorectal lesions. In recent years, various IEE techniques have been used in clinical practice, each with its unique characteristics. Numerous studies have reported the effectiveness of IEE in the detection of colorectal lesions. IEEs can be divided into two broad categories according to the nature of the image: images constructed using narrowband wavelength light, such as narrowband imaging and blue laser imaging/blue light imaging, or color images based on white light, such as linked color imaging, texture and color enhancement imaging, and i-scan. Conversely, artificial intelligence (AI) systems, such as computer-aided diagnosis systems, have recently been developed to assist endoscopists in detecting colorectal lesions during colonoscopy. To better understand the features of each IEE, this review presents the effectiveness of each type of IEE and their combination with AI for colorectal lesion detection by referencing the latest research data.

Citations

Citations to this article as recorded by

Comment on “Comparison of the diagnostic performance of narrow-band imaging endocytoscopy and staining-based endocytoscopy for colorectal lesions”
Ehtisham Haider, Tuba Zia, Muddassir Khalid, Fred Segawa
Digestive and Liver Disease.2026; 58(2): 284. CrossRef
European cancer mortality predictions for the year 2026: the levelling of female lung cancer mortality
C. Santucci, S. Mignozzi, F. Levi, M. Malvezzi, P. Boffetta, E. Negri, C. La Vecchia
Annals of Oncology.2026; 37(4): 555. CrossRef
Evaluation of Visibility With an Eye‐tracking System: Effectiveness of Narrow‐Band Imaging for Detecting Colorectal Adenoma and Serrated Lesions
Moegi Mochizuki, Akiko Ohno, Shiori Tsubata, Ryutaro Sumi, Takahiro Shirakawa, Ryosuke Kaji, Yoko Jinbo, Yu Hada, Jun Miyoshi, Tadakazu Hisamatsu
DEN Open.2026;[Epub] CrossRef
High Detection Rates and Associated Factors of Colorectal Serrated Lesions: A Multicenter Prospective Study in the Asia-Pacific
Masau Sekiguchi, Yasuhiko Mizuguchi, Jun Konishi, Kenichiro Imai, Hyun-Soo Kim, Daizen Hirata, Rashid N. Lui, Jae Myung Cha, Li-Chun Chang, Tiing Leong Ang, Wei Jie Jonathan Lee, Keiko Nakamura, Yasuo Kakugawa, Nozomu Kobayashi, Yutaka Saito, Maki Konno,
American Journal of Gastroenterology.2026;[Epub] CrossRef
Screening for Colorectal Cancer with Colonoscopy
Akwi W. Asombang, Nkengeh Tazinkeng, Yakira David, Douglas K. Rex
Gastrointestinal Endoscopy Clinics of North America.2026;[Epub] CrossRef
Diagnostic accuracy of magnifying Image‐enhanced endoscopy for predicting the invasion depth of superficial esophageal neoplasm: a meta-analysis
Wanting Jiang, Yafang Huang, Jiale Pang, Simiao Yang, Runhua Chen
European Journal of Surgical Oncology.2026; 52(6): 111808. CrossRef
The slope of enlightenment: Towards a more realistic understanding of the strengths and weaknesses of artificial intelligence for colorectal polyp assessment
Pieter Sinonquel, Giulio Antonelli
Digestive and Liver Disease.2026; 58(9): 1117. CrossRef
Customized CycleGAN with balanced skip-networked residual layer (CCGAN-BSNRL) to enhance colonoscopy image by narrow-band imaging translation
Zayed-Us Salehin, Khan A. Wahid, Francis M. Bui
Royal Society Open Science.2026;[Epub] CrossRef
Advanced Endoscopic Imaging for Detection of Dysplasia in Inflammatory Bowel Disease
Laura Alexandra Lucaciu, Edward John Despott
Gastrointestinal Endoscopy Clinics of North America.2025; 35(1): 141. CrossRef
Practical utility of linked color imaging in colonoscopy: Updated literature review
Fumiaki Ishibashi, Sho Suzuki
Digestive Endoscopy.2025; 37(2): 147. CrossRef
Survey of the Actual Practices Used for Endoscopic Removal of Colon Polyps in Korea: A Comparison with the Current Guidelines
Jeongseok Kim, Tae-Geun Gweon, Min Seob Kwak, Su Young Kim, Seong Jung Kim, Hyun Gun Kim, Sung Noh Hong, Eun Sun Kim, Chang Mo Moon, Dae Seong Myung, Dong-Hoon Baek, Shin Ju Oh, Hyun Jung Lee, Ji Young Lee, Yunho Jung, Jaeyoung Chun, Dong-Hoon Yang, Eun R
Gut and Liver.2025; 19(1): 77. CrossRef
European cancer mortality predictions for the year 2025 with focus on breast cancer
C. Santucci, S. Mignozzi, F. Levi, M. Malvezzi, P. Boffetta, E. Negri, C. La Vecchia
Annals of Oncology.2025; 36(4): 460. CrossRef
Classification of image-enhanced endoscopy in colon tumors
One-Zoong Kim
Clinical Endoscopy.2025; 58(3): 337. CrossRef
Advantages of new generation colonoscopes on adenoma detection: A propensity-score matching study
Toshihiro Nishizawa, Osamu Toyoshima, Shuntaro Yoshida, Yoshiyuki Takahashi, Hideki Nakagawa, Hiroya Mizutani, Yosuke Kataoka, Takamitsu Kanazawa, Hirotoshi Ebinuma, Keisuke Hata
World Journal of Gastrointestinal Endoscopy.2025;[Epub] CrossRef
Efficacy of additional tissue sections for diminutive colorectal adenomas pathologically diagnosed as normal mucosa: a retrospective, cross-sectional study in Japan
Tsuyoshi Ishii, Toshihiro Nishizawa, Hidenobu Watanabe, Masaya Sano, Ai Fujimoto, Yoshiyuki Takahashi, Ryo Shimizu, Hirotoshi Ebinuma, Takahisa Matsuda, Osamu Toyoshima
Clinical Endoscopy.2025; 58(4): 577. CrossRef
Enhancing adenoma detection rates: The case for upgrading to advanced colonoscopy technology
Eyad Gadour
World Journal of Gastrointestinal Endoscopy.2025;[Epub] CrossRef
Advancements in Image‐Based Analyses for Morphology and Staging of Colon Cancer: A Comprehensive Review
Samuel Arthur Ameyaw, Derrick Adu Afari, John Boateng, Marcello Maida
BioMed Research International.2025;[Epub] CrossRef
Optical Imaging Technologies and Clinical Applications in Gastrointestinal Endoscopy
Khyati Bidani, Vishali Moond, Madhvi Nagar, Arkady Broder, Nirav Thosani
Diagnostics.2025; 15(20): 2625. CrossRef
Efficacy of Texture and Color Enhancement Imaging for Detecting Colorectal Lesions: A Multicenter Randomized Controlled Trial
Byung Wook Jung
The Korean Journal of Gastroenterology.2025; 85(4): 579. CrossRef
Evaluation of linked-color imaging endoscopy combined with CAD EYE for the detection and characterization of right-sided colon polyps
Phuoc Huu Tran, Thi Huyen Thuong Nguyen, Van Huy Tran
Arab Journal of Gastroenterology.2025; 26(4): 452. CrossRef
Approaches and considerations in the endoscopic treatment of T1 colorectal cancer
Yunho Jung
The Korean Journal of Internal Medicine.2024; 39(4): 563. CrossRef
The Past, Present and Future of Imaging Enhanced Endoscopy in Colon Tumor
Kyueng-Whan Min, One-Zoong Kim
Journal of Digestive Cancer Research.2024; 12(2): 90. CrossRef
Texture and color enhancement imaging versus white light imaging for the detection of colorectal adenomas: Systematic review and meta-analysis
Stefan Mitev, Humza Saeed, Ch Faizan Rasheed, Abdullah, Stefan Murvakov, Vassil Sirakov, Stefan Tchernodrinski, Zoya Spassova
Endoscopy International Open.2024;[Epub] CrossRef
Strategy for post-polypectomy colonoscopy surveillance: focus on the revised Korean guidelines
Yong Soo Kwon, Su Young Kim
Journal of the Korean Medical Association.2023; 66(11): 652. CrossRef
AI-powered medical devices for practical clinicians including the diagnosis of colorectal polyps
Donghwan Kim, Eunsun Kim
Journal of the Korean Medical Association.2023; 66(11): 658. CrossRef

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Original Articles

Peroral Pancreatoscopy with Videoscopy and Narrow-Band Imaging in Intraductal Papillary Mucinous Neoplasms with Dilatation of the Main Pancreatic Duct: Yui Kishimoto, Naoki Okano, Ken Ito, Kensuke Takuma, Seiichi Hara, Susumu Iwasaki, Kensuke Yoshimoto, Yuto Yamada, Koji Watanabe, Yusuke Kimura, Hiroki Nakagawa, Yoshinori Igarashi; Clin Endosc 2022;55(2):270-278. Published online December 6, 2021; DOI: https://doi.org/10.5946/ce.2021.083; Correction in: Clin Endosc 2023;56(2):261

Abstract PDF

Background
/Aims: Endoscopic evaluation of intraductal papillary mucinous neoplasms (IPMNs) is useful in determining whether the lesions are benign or malignant. This study aimed to examine the usefulness of peroral pancreatoscopy (POPS) in determining the prognosis of IPMNs.
Methods
POPS with videoscopy was performed using the mother–baby scope technique. After surgery, computed tomography/magnetic resonance cholangiopancreatography or ultrasonography and blood tests were performed every 6 months during the follow-up.
Results
A total of 39 patients with main pancreatic duct (MPD)–type IPMNs underwent POPS using a videoscope, and the protrusions in the MPD were observed in 36 patients. The sensitivity and specificity of cytology/biopsy performed at the time of POPS were 85% and 87.5%, respectively. Of 19 patients who underwent surgery, 18 (95%) patients had negative surgical margins and 1 (5%) patient had a positive margin.
Conclusions
In IPMNs with dilatation of the MPD, POPS is considered effective if the lesions can be directly observed. The diagnosis of benign and malignant lesions is possible depending on the degree of lesion elevation. However, in some cases, slightly elevated lesions may increase in size during the follow-up or multiple lesions may be simultaneously present; therefore, careful follow-up is necessary.

Citations

Citations to this article as recorded by

PERORAL PANCREATOSCOPY IN THE EVALUATION AND MANAGEMENT OF PANCREATIC DUCT DISORDERS: A NARRATIVE REVIEW
Wojciech Sołtys, Magdalena Stolarczyk, Aleksandra Jagura-Sukiennik, Cezary Kosmecki, Mateusz Stronczyński, Łukasz Deska, Jędrzej Zaguła, Justyna Jankowska, Natalia Kamińska, Dawid Głaz, Maksymilian Głaz
International Journal of Innovative Technologies in Social Science.2026;[Epub] CrossRef
Identification of the course of plastic stent‐induced pancreatic duct mucosal change in chronic pancreatitis using peroral pancreatoscopy (with video)
Kensuke Takuma, Naoki Okano, Yusuke Kimura, Koji Watanabe, Hiroki Nakagawa, Kensuke Hoshi, Masashi Miura, Naobumi Tochigi, Yoshinori Igarashi, Takahisa Matsuda
DEN Open.2025;[Epub] CrossRef
Pancreatoscopy in the evaluation and management of pancreatic disorders
Rodrigo Mansilla-Vivar, Eduardo Segovia-Vergara, Vicente Pons-Beltrán
World Journal of Gastrointestinal Endoscopy.2025;[Epub] CrossRef
Pancreatic Cancer Detection in Intraductal Papillary Mucinous Neoplasm (IPMN)—New Insights
Wojciech Pawłowski, Mateusz Stefański, Barbara Włodarczyk, Łukasz Durko, Ewa Małecka-Wojciesko
Cancers.2025; 17(20): 3341. CrossRef
Pancreatoscopy-Guided Endotherapies for Pancreatic Diseases
Yuri Hanada, Raj J. Shah
Gastrointestinal Endoscopy Clinics of North America.2024; 34(3): 417. CrossRef
Peroral pancreatoscopy with videoscopy and narrow-band imaging in intraductal papillary mucinous neoplasms with dilatation of the main pancreatic duct
Yui Kishimoto, Naoki Okano, Ken Ito, Kensuke Takuma, Seiichi Hara, Susumu Iwasaki, Kensuke Yoshimoto, Yuto Yamada, Koji Watanabe, Yusuke Kimura, Hiroki Nakagawa, Yoshinori Igarashi
Clinical Endoscopy.2023; 56(2): 261. CrossRef
Predicting Malignancy by Peroral Pancreatoscopy of an Intraductal Papillary Mucinous Neoplasm with a Dilated Main Pancreatic Duct: Is Seeing Enough?
Yun Nah Lee, Jong Ho Moon
Clinical Endoscopy.2022; 55(2): 213. CrossRef

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Clinical Usefulness of Dual Red Imaging in Gastric Endoscopic Submucosal Dissection: A Pilot Study: Naoki Yorita, Shiro Oka, Shinji Tanaka, Takahiro Kotachi, Naoko Nagasaki, Kosaku Hata, Kazutaka Kuroki, Kazuhiko Masuda, Mio Kurihara, Mariko Kiso, Tomoyuki Boda, Masanori Ito, Kazuaki Chayama; Clin Endosc 2020;53(1):54-59. Published online September 3, 2019; DOI: https://doi.org/10.5946/ce.2019.065

Abstract PDF

Background
/Aims: Dual red imaging (DRI) is a new, image-enhanced endoscopy technique. There are few reports about the usefulness of DRI during gastric endoscopic submucosal dissection (ESD). We aimed to examine the usefulness of DRI in endoscopic hemostasis during gastric ESD.
Methods
We enrolled a total of 20 consecutive patients who underwent gastric ESD. Five endoscopists compared DRI with white light imaging (WLI) for the visibility of blood vessels and bleeding points while performing endoscopic hemostasis.
Results
The visibility of blood vessels was increased in 56% (19/34) of the cases, and the visibility of bleeding points was improved in 55% (11/20) of the cases with the use of DRI compared with the use of WLI.
Conclusions
DRI improved the visibility of blood vessels and bleeding points in cases with oozing bleeding, blood pooling around the bleeding points, and multiple bleeding points.

Citations

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Recent Advances in Endoscopic Submucosal Dissection for Gastric Cancer: Focusing on Expanded Indications and Technological Innovations
Waku Hatta, Yohei Ogata, Koya Ogasawara, Yutaka Hatayama, Masahiro Saito, Takeshi Kanno, Tomoyuki Koike, Atsushi Masamune
Journal of Gastric Cancer.2026; 26(1): 76. CrossRef
The use of diluted epinephrine during gastric endoscopic submucosal dissection: an international randomized controlled trial
Hon Chi Yip, Noriya Uedo, Hiroyoshi Iwagami, Kotaro Waki, Kensei Ohtsu, Masaki Miyaoka, Kenshi Yao, Takuji Akamatsu, Takafumi Konishi, Shogo Nakano, Hiroyoshi Nakanishi, Hisashi Doyama, Hirohisa Machida, Kyoungwon Jung, Philip Chiu, Takehiro Iwasaki, Kuni
Gastrointestinal Endoscopy.2026; 104(3): 387. CrossRef
Improved visibility of palisade vessels within Barrett’s esophagus using red dichromatic imaging: a retrospective cross-sectional study in Japan
Chise Ueda, Shinwa Tanaka, Tetsuya Yoshizaki, Hirofumi Abe, Masato Kinoshita, Hiroya Sakaguchi, Hiroshi Takayama, Hitomi Hori, Ryosuke Ishida, Shinya Houki, Hiroshi Tanabe, Eri Nishikawa, Madoka Takao, Toshitatsu Takao, Yoshinori Morita, Takashi Toyonaga,
Clinical Endoscopy.2025; 58(2): 269. CrossRef
Red dichromatic imaging enhances submucosal visibility during endoscopic submucosal dissection: Pilot study
Tsubasa Ishikawa, Tomoaki Tashima, Tomonori Kawasaki, Kankei Fujimoto, Kei Sugimoto, Takahiro Shin, Takahiro Muramatsu, Yumi Mashimo, Shomei Ryozawa
Endoscopy International Open.2025;[Epub] CrossRef
Color differences of intraprocedural bleeding between white light and red dichromatic imaging during endoscopic submucosal dissection: a post hoc analysis of a multicenter, open-label, randomized controlled trial (with videos)
Mai Makiguchi, Seiichiro Abe, Ai Fujimoto, Ryosuke Kawagoe, Takeshi Uozumi, Mitsunori Kusuhara, Yasuhiko Mizuguchi, Naoya Toyoshima, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Issay Kitabayashi, Hiroyuki Daiko, Yutaka Saito, Naohisa Yahagi
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Louis Jean Masgnaux, Jean Grimaldi, Jérémie Jacques, Jérôme Rivory, Mathieu Pioche
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Joshua Melson
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Aoi Kita, Shiko Kuribayashi, Yuki Itoi, Keigo Sato, Yu Hashimoto, Kengo Kasuga, Hirohito Tanaka, Hiroko Hosaka, Kazue Nagai, Hemchand Ramberan, Toshio Uraoka
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Kohei Oka, Naoto Iwai, Takashi Okuda, Toshifumi Tsuji, Hiroaki Sakai, Chie Hattori, Masashi Taniguchi, Tasuku Hara, Toshiyuki Komaki, Junichi Sakagami, Keizo Kagawa, Osamu Dohi, Yoshito Itoh
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Yoshihiro Furuichi, Masakazu Abe, Hirohito Takeuchi, Yuu Yoshimasu, Takao Itoi
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Ai Fujimoto, Yutaka Saito, Seiichiro Abe, Syu Hoteya, Kosuke Nomura, Hiroshi Yasuda, Yasumasa Matsuo, Toshio Uraoka, Shiko Kuribayashi, Yosuke Tsuji, Daisuke Ohki, Tadateru Maehata, Motohiko Kato, Naohisa Yahagi
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Yuichiro Hirai, Ai Fujimoto, Naomi Matsutani, Soichiro Murakami, Yuki Nakajima, Ryoichi Miyanaga, Yoshihiro Nakazato, Kazuyo Watanabe, Masahiro Kikuchi, Naohisa Yahagi
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Soma Fukuda, Taku Sakamoto, Hideo Suzuki, Toshiaki Narasaka, Kiichiro Tsuchiya
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Focused Review Series: Image Enhanced Endoscopys

Advanced Imaging Technology Other than Narrow Band Imaging: Jun-Hyung Cho; Clin Endosc 2015;48(6):503-510. Published online November 30, 2015; DOI: https://doi.org/10.5946/ce.2015.48.6.503

Abstract PDF

To improve the detection rate of gastrointestinal tumors, image-enhanced endoscopy has been widely used during screening and surveillance endoscopy in Korea. In addition to narrow band imaging (NBI) with/without magnification, various types of electronic chromoendoscopies have been used, including autofluorescence imaging, I-scan, and flexible spectral imaging color enhancement. These technologies enable the accurate characterization of tumors because they enable visualization of microvascular and microsurface patterns. The present review focuses on understanding the principle and clinical applications of advanced imaging technologies other than NBI.

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Advanced Imaging Technology in Biliary Tract Diseases:Narrow-Band Imaging of the Bile Duct: Hyun Jong Choi, Jong Ho Moon, Yun Nah Lee; Clin Endosc 2015;48(6):498-502. Published online November 30, 2015; DOI: https://doi.org/10.5946/ce.2015.48.6.498

Abstract PDF

Newly introduced direct peroral cholangioscopy and the development of video choledochoscopes have enabled more defined observation of bile duct mucosal lesions with clearer images. Narrow-band imaging (NBI) is a unique endoscopic imaging technology that provides enhanced endoscopic images of surface mucosal structures and its superficial microvessels. Advanced cholangioscopy and NBI are expected to be useful for precise evaluation and correct diagnosis of biliary tract diseases. However, the diagnostic value of advanced bile duct imaging with cholangioscopy requires further evaluation.

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The Past, Present, and Future of Image-Enhanced Endoscopy: Jae-Young Jang; Clin Endosc 2015;48(6):466-475. Published online November 30, 2015; DOI: https://doi.org/10.5946/ce.2015.48.6.466

Abstract PDF

Despite the remarkable progress recently made to enhance the resolution of white-light endoscopy, detection, and diagnosis of premalignant lesions, such as adenomas and subtle early-stage cancers, remains a great challenge. As for example, although chromoendoscopy, such as endoscopy using indigo carmine, is useful for the early diagnosis of subtle lesions, the technique presents various disadvantages ranging from the time required for spray application of the dye and suctioning of excess dye to the increased difficulty in identifying lesions in the presence of severe inflammation and obstruction of visual field due to the pooling of solution in depressed-type lesions. To overcome these diagnostic problems associated with chromoendoscopy, research has focused on the development of endoscopes based on new optical technologies. Several types of image-enhanced endoscopy methods have recently been presented. In particular, image-enhanced endoscopy has emerged as a new paradigm for the diagnosis of gastrointestinal disorders. Image-enhanced endoscopes provide high-contrast images of lesions by means of optical or electronic technologies, including the contrast enhancement of the mucosal surface and of blood vessels. Chromoendoscopy, narrow-band imaging, i-SCAN, and flexible spectral imaging color enhancement are representative examples of image-enhanced endoscopy discussed in this paper.

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