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Clinical and Biological Features of Interval Colorectal Cancer
Yu Mi Lee, Kyu Chan Huh
Clin Endosc 2017;50(3):254-260.   Published online March 21, 2017
DOI: https://doi.org/10.5946/ce.2016.115
AbstractAbstract PDF
Interval colorectal cancer (I-CRC) is defined as a CRC diagnosed within 60 months after a negative colonoscopy, taking into account that 5 years is the “mean sojourn time.” It is important to prevent the development of interval cancer. The development of interval colon cancer is associated with female sex, old age, family history of CRC, comorbidities, diverticulosis, and the skill of the endoscopist. During carcinogenesis, sessile serrated adenomas/polyps (SSA/Ps) share many genomic and colonic site characteristics with I-CRCs. The clinical and biological features of I-CRC should be elucidated to prevent the development of interval colon cancer.

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