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Original Article
Capsule Endoscopy in Refractory Diarrhea-Predominant Irritable Bowel Syndrome and Functional Abdominal Pain
Manuel Valero, Gladys Bravo-Velez, Roberto Oleas, Miguel Puga-Tejada, Miguel Soria-Alcívar, Haydee Alvarado Escobar, Jorge Baquerizo-Burgos, Hannah Pitanga-Lukashok, Carlos Robles-Medranda
Clin Endosc 2018;51(6):570-575.   Published online November 16, 2018
DOI: https://doi.org/10.5946/ce.2018.055
AbstractAbstract PDFPubReaderePub
Background
/Aims: Capsule endoscopy is a diagnostic method for evaluating the small bowel lumen and can detect undiagnosed lesions. The aim of this study was to evaluate the diagnostic yield and clinical impact of capsule endoscopy in patients with refractory diarrhea-predominant irritable bowel syndrome and functional abdominal pain.
Methods
This study involved a retrospective analysis of prospectively collected data, maintained in a database. Patients with refractory diarrhea-predominant irritable bowel syndrome and functional abdominal pain within the period of March 2012 to March 2014 were included. Capsule endoscopy was used to detect small bowel pathologies in both groups.
Results
Sixty-five patients (53.8% female) fulfilled the inclusion criteria and had a mean (±standard deviation) age of 50.9±15.9 years. Clinically significant lesions were detected via capsule endoscopy in 32.5% of the patients in the abdominal pain group and 54.5% of the patients in the diarrhea group. Overall, 48% of patients had small bowel pathologies detected during the capsule endoscopy study. Inflammatory lesions and villous atrophy were the most frequent lesions identified in 16.9% and 15.3% of patients in the abdominal pain and the diarrhea groups, respectively.
Conclusions
Routine use of capsule endoscopy in patients with irritable bowel syndrome should not be recommended. However, in patients with refractory conditions, capsule endoscopy may identify abnormalities.

Citations

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  • Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility
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    Clinical Endoscopy.2021; 54(1): 85.     CrossRef
  • Diagnostic yield of esophagogastroduodenoscopy, colonoscopy, and small bowel endoscopy in Thai adults with chronic diarrhea
    Julajak Limsrivilai, Choompunuj Sakjirapapong, Onuma Sattayalertyanyong, Tanawat Geeratragool, Phalat Sathirawich, Ananya Pongpaibul, Piyaporn Apisarnthanarak, Phutthaphorn Phaophu, Nichcha Subdee, Phunchai Charatcharoenwitthaya, Nonthalee Pausawasdi
    BMC Gastroenterology.2021;[Epub]     CrossRef
  • Refractory Irritable Bowel Syndrome and Functional Abdominal Pain Syndrome: Should Small Bowel Endoscopy Be Performed?
    Sung Kyun Yim, Sang Wook Kim
    Clinical Endoscopy.2018; 51(6): 508.     CrossRef
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Review
Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives
Hyun Ho Choi, Young-Seok Cho
Clin Endosc 2016;49(3):257-265.   Published online March 9, 2016
DOI: https://doi.org/10.5946/ce.2015.117
AbstractAbstract PDFPubReaderePub
Fecal microbiota transplantation (FMT) is the infusion of liquid filtrate feces from a healthy donor into the gut of a recipient to cure a specific disease. A fecal suspension can be administered by nasogastric or nasoduodenal tube, colonoscope, enema, or capsule. The high success rate and safety in the short term reported for recurrent Clostridium difficile infection has elevated FMT as an emerging treatment for a wide range of disorders, including Parkinson’s disease, fibromyalgia, chronic fatigue syndrome, myoclonus dystopia, multiple sclerosis, obesity, insulin resistance, metabolic syndrome, and autism. There are many unanswered questions regarding FMT, including donor selection and screening, standardized protocols, long-term safety, and regulatory issues. This article reviews the efficacy and safety of FMT used in treating a variety of diseases, methodology, criteria for donor selection and screening, and various concerns regarding FMT.

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Case Report
A Case of Parasite Invasion of the Intestinal Tract: A Missed Diagnosis in Irritable Bowel Syndrome
Kang Hun Koh, Sang Wook Kim, So Young Lee, Hee Jung Lee, Hea Min Yu, Byung Jun Jeon, Dae Hun Kwon, Soo Teik Lee
Clin Endosc 2013;46(6):671-674.   Published online November 19, 2013
DOI: https://doi.org/10.5946/ce.2013.46.6.671
AbstractAbstract PDFPubReaderePub

Irritable bowel syndrome (IBS) is a gastrointestinal disorder characterized by chronic abdominal pain and altered bowel habits in the absence of any organic cause. As the clinical manifestations are very diverse and associated with nonspecific symptoms, research seeking to identify organic causes to rule out IBS and to enable differential diagnosis is required. A 24-year-old man was referred to our hospital for specialized management of IBS. He had a 7-month history of intermittent epigastric and lower abdominal pain. On the basis of clinical examination, he was diagnosed with IBS and administered medication at a primary clinic. However, his symptoms did not improve after treatment. We performed capsule endoscopy at our hospital and identified a parasite (Ancylostoma duodenale) in the proximal jejunum. We therefore report a case of parasitic infection found by additional examination while evaluating symptoms associated with a previous diagnosis of refractory IBS.

Citations

Citations to this article as recorded by  
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    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2018; 18(1): 61.     CrossRef
  • Refractory Irritable Bowel Syndrome and Functional Abdominal Pain Syndrome: Should Small Bowel Endoscopy Be Performed?
    Sung Kyun Yim, Sang Wook Kim
    Clinical Endoscopy.2018; 51(6): 508.     CrossRef
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