Focused Review Series: Endoscopic Management for Biliary Stricture after Liver Transplantation
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Unilateral Versus Bilateral Biliary Drainage for Post-Transplant Anastomotic Stricture
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Jin Ho Choi, Woo Hyun Paik
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Clin Endosc 2020;53(3):255-260. Published online May 22, 2020
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DOI: https://doi.org/10.5946/ce.2020.079
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Abstract
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- Living donor liver transplantation is the most common type of liver transplantation in Asia. Post-transplant biliary stricture is frequent in living donor liver transplantation, and endoscopic management is considered to be the treatment of choice. However, endoscopic management is still challenging in patients who undergo right lobe living donor liver transplantation because of the anatomical alteration. In this article, we reviewed the recently updated results for proper endoscopic biliary drainage in post-living donor liver transplantation anatomical biliary stricture and compared unilateral and bilateral drainage.
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Citations
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- Digital single-operator cholangioscopy for difficult anastomotic biliary strictures in living donor liver transplant recipients after failure of standard ERCP: SPYPASS-2 study (with videos)
In Rae Cho, Sang Hyub Lee, Joongyu Kang, Junyeol Kim, Tae Seung Lee, Myeong Hwan Lee, Min Woo Lee, Jin Ho Choi, Woo Hyun Paik, Ji Kon Ryu, Yong-Tae Kim, Suk Kyun Hong, YoungRok Choi, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh
Gastrointestinal Endoscopy.2025; 101(5): 979. CrossRef - Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model
In Rae Cho, Sang Hyub Lee, Jin Ho Choi, Namyoung Park, Min Woo Lee, Joo Seong Kim, Seok Jeong, Don Haeng Lee, Tae-Won Jeong, Byoung-Yun Ki, Woo Hyun Paik, Ji Kon Ryu, Yong-Tae Kim
Frontiers in Oncology.2023;[Epub] CrossRef
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Original Article
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Efficacy of Nasobiliary Tubes and Biliary Stents in Management of Patients with Bile Leak after Liver Transplantation: A Systematic Review
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Ali Raza, Anam Omer, Sara Iqbal, Vineet Gudsoorkar, Pramoda Koduru, Kumar Krishnan
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Clin Endosc 2019;52(2):159-167. Published online March 29, 2019
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DOI: https://doi.org/10.5946/ce.2018.118
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Abstract
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- Background
/Aims: Bile leak is one of the most common complications of liver transplantation. The treatment options for bile leaks include conservative management, surgical re-intervention, percutaneous drainage and endoscopic drainage. We aimed to perform a systematic review to identify the efficacy of endoscopic treatment in the resolution of post-transplant bile leaks. Methods: Two independent reviewers performed systematic literature search in PubMed, ISI Web of Science, grey literature and relevant references in May 2017. Human studies in English with documented post-liver transplant bile leaks were included. Results: Thirty-four studies were included in the final analysis. The pooled efficacy of biliary stents for the resolution of post-transplant bile leaks was 82.43% compared with 87.15% efficacy of nasobiliary tubes. The efficacy of biliary stents was lower for anastomotic leaks (69.23%) compared to T-tube (90.9%) or cut-surface/ cystic duct stump related leaks (92.8%). Similarly, the efficacy of nasobiliary tube was also lower for anastomotic leaks (58.33%) compared to T-tube or cut-surface related leaks (100%). Conclusions: In this systematic review, the overall efficacy was 82.43% in biliary stent group, and 87.15% in nasobiliary tube group. Both biliary stent and nasobiliary tube were more effective in managing non-anastomotic leaks compared to anastomotic leaks.
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Citations
Citations to this article as recorded by

- Application of percutaneous biliary drainage in the treatment of post-operative bile leakage after liver rupture: A case report
Jinlong Chen, Zhikuan Wang, Lixin Zhang, Xi Chen, Yuanyuan Liu, Hong Chen, Xiaoqiang Tong, Yanchao Dong
Journal of Minimal Access Surgery.2025; 21(2): 200. CrossRef - Lesson learnt from 60 years of liver transplantation: Advancements, challenges, and future directions
Eyad Gadour
World Journal of Transplantation.2025;[Epub] CrossRef - Optimal timing of endoscopic biliary drainage for bile duct leaks: A multicenter, retrospective, clinical study
De-Xin Chen, Kai-Xuan Fang, Sheng-Xin Chen, Sen-Lin Hou, Gui-Hai Wen, Hai-Kun Yang, Da-Peng Shi, Qing-Xin Lu, Ya-Qi Zhai, Ming-Yang Li
World Journal of Gastrointestinal Surgery.2025;[Epub] CrossRef - Endoscopic management of bile duct leaks: Current strategies and controversies
De-Xin Chen, Sheng-Xin Chen, Guan-Jun Zhang, Ya-Wen Liang, Yu-Ming Han, Ya-Qi Zhai, Ming-Yang Li
World Journal of Gastrointestinal Endoscopy.2025;[Epub] CrossRef - A nomogram for prediction of ERCP success in patients with bile duct leaks: a multicenter study
De-xin Chen, Sheng-xin Chen, Sen-lin Hou, Gui-hai Wen, Hai-kun Yang, Da-peng Shi, Qing-xin Lu, Ya-qi Zhai, Ming-yang Li
Surgical Endoscopy.2024; 38(5): 2465. CrossRef - Complications in Post-Liver Transplant Patients
Carlotta Agostini, Simone Buccianti, Matteo Risaliti, Laura Fortuna, Luca Tirloni, Rosaria Tucci, Ilenia Bartolini, Gian Luca Grazi
Journal of Clinical Medicine.2023; 12(19): 6173. CrossRef - Nasobiliary drainage: an effective treatment for pruritus in cholestatic liver disease
Wafaa Ahmed, Rebecca Jeyaraj, David Reffitt, John Devlin, Abid Suddle, John Hunt, Michael A Heneghan, Phillip Harrison, Deepak Joshi
Frontline Gastroenterology.2022; 13(5): 416. CrossRef - A case of combined use of endoscopic drainage and percutaneous drainage for traumatic liver injury type III b
Shigekuni Okumura, Jun Oda, Yousuke Minami, Masaru Hirayama, Kennta Aida
Journal of the Japanese Society of Intensive Care Medicine.2021; 28(3): 210. CrossRef - Biliary Complications Following Adult Deceased Donor Liver Transplantation: Risk Factors and Implications at a High-volume US Center
Abraham J. Matar, Katie Ross-Driscoll, Lisa Kenney, Hannah K. Wichmann, Joseph F. Magliocca, William H. Kitchens
Transplantation Direct.2021; 7(10): e754. CrossRef - The Need for a Better-Designed Study of the Outcomes of Endoscopic Management of Bile Leak
Hyung Ku Chon, Eun Ji Shin, Seong-Hun Kim
Clinical Endoscopy.2020; 53(6): 633. CrossRef
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Two Cases of Percutaneous Transhepatic Choledochoscopy Treatment of Intrahepatic Duct Stones that Occurred after Living Donor Liver Transplantation
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Byung Jun Lee, M.D., Jong Yun Won, M.D.*, Nu Ri Chon, M.D., Se-Joon Lee, M.D. and Dong Ki Lee, M.D.
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Korean J Gastrointest Endosc 2008;36(5):318-323. Published online May 30, 2008
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Abstract
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- Percutaneous transhepatic cholangioscopy (PTCS) is the primary treatment option for general cases of intrahepatic duct stones. However, there are no reports on the use of PTCS for intrahepatic duct stones in patients who had undergone living donor liver transplantation (LDLT). We experienced two cases of successful intrahepatic stone removal by the use of PTCS in LDLT patients. With these cases, we have confirmed that PTCS management can be safely performed not only for a general bile duct stone, but also for a bile duct stone that develops in a patient that had previously undergone liver transplantation. (Korean J Gastrointest Endosc 2008;36:318-323)