Systematic Review and Meta-Analysis
-
Mucosal incision-assisted biopsy versus endoscopic ultrasound-assisted tissue acquisition for subepithelial lesions: a systematic review and meta-analysis
-
Suprabhat Giri
, Shivaraj Afzalpurkar
, Sumaswi Angadi
, Sridhar Sundaram
-
Clin Endosc 2022;55(5):615-625. Published online August 4, 2022
-
DOI: https://doi.org/10.5946/ce.2022.133
-
-
Abstract
PDF
Supplementary Material
- Background
/Aims: Mucosal incision-assisted biopsy (MIAB) for tissue acquisition (TA) from subepithelial lesions (SELs) is emerging as an alternative to endoscopic ultrasound (EUS)-guided TA. Only a limited number of studies compared the diagnostic utility of MIAB and EUS for upper gastrointestinal (GI) SELs; therefore, we conducted this systematic review and meta-analysis.
Methods
A comprehensive literature search from January 2020 to January 2022 was performed to compare the diagnostic accuracy and safety of MIAB and EUS-guided TA for upper GI SELs.
Results
Seven studies were included in this meta-analysis. The pooled technical success rate (risk ratio [RR], 0.96; 95% confidence interval [CI], 0.89–1.04) and procedural time (mean difference=–4.53 seconds; 95% CI, –22.38 to 13.31] were comparable between both the groups. The overall chance of obtaining a positive diagnostic yield was lower with EUS than with MIAB for all lesions (RR, 0.83; 95% CI, 0.71–0.98) but comparable when using a fine-needle biopsy needle (RR, 0.93; 95% CI, 0.83–1.04). The positive diagnostic yield of MIAB was higher for lesions <20 mm (RR, 0.75; 95% CI, 0.63–0.89). Six studies reported no adverse events.
Conclusions
MIAB can be considered an effective alternative to EUS-guided TA for upper GI SELs without an increased risk of adverse events.
-
Citations
Citations to this article as recorded by

- Endoscopic Diagnosis of Gastric Subepithelial Lesions < 20 mm: Current Strategies and Emerging Solutions
Yosuke Minoda, Shuzaburo Nagatomo, Haruei Ogino, Nao Fujimori, Eikichi Ihara
Digestive Endoscopy.2026;[Epub] CrossRef - Population-Based Efficacy of Tissue Acquisition for Subepithelial Lesions in the Upper Gastrointestinal Tract
Cynthia A. Verloop, Lieke Hol, Lars Perk, Femme Dircksmeier-Harinck, Pieter Honkoop, Tessa Romkens, Ingrid Schot, Jilling Bergmann, Rutger Quispel, Marco J. Bruno, Lydi M.J.W. van Driel
Journal of Clinical Gastroenterology.2026;[Epub] CrossRef - Upfront unroofing of subepithelial lesions using cold snare in the upper and lower gastrointestinal tract: a retrospective study from Switzerland
Bernhard Morell, Jasmina El Hadad-Burla, Frans Olivier The, Fabian Reinisch, Christoph Gubler, Fritz Ruprecht Murray
Clinical Endoscopy.2026; 59(4): 633. CrossRef - S2k-Leitlinie Qualitätsanforderungen in der gastrointestinalen Endoskopie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)
Zeitschrift für Gastroenterologie.2026; 64(08): 1139. CrossRef - Diagnostic ability and adverse events of mucosal incision‐assisted biopsy for gastric subepithelial tumors: Systematic review and meta‐analysis
Eriko Koizumi, Osamu Goto, Akihisa Matsuda, Toshiaki Otsuka, Yumiko Ishikawa, Shun Nakagome, Masahiro Niikawa, Tsugumi Habu, Keiichiro Yoshikata, Kumiko Kirita, Hiroto Noda, Kazutoshi Higuchi, Takeshi Onda, Jun Omori, Naohiko Akimoto, Hiroshi Yoshida, Kat
Digestive Endoscopy.2025; 37(3): 236. CrossRef - Current Management Strategies for Patients with Gastrointestinal and Pulmonary Neuroendocrine Tumors
Yulia V. Mikheeva, Pavel O. Rumyantsev, Konstantin K. Puzakov, Konstantin Yu. Slashchuk, Daniil D. Omelchuk, Anastasia V. Potapenko, Sergey P. Medvedev
Russian Journal of Oncology.2025; 30(1): 41. CrossRef - Approach to upper gastrointestinal subepithelial lesions
Shrihari Anil Anikhindi, Rajesh Puri, Noriya Uedo, Kamlesh Taori, Anil Arora
Expert Review of Gastroenterology & Hepatology.2025; 19(7): 789. CrossRef - Diagnostic challenges of inflammatory submucosal tumor-like lesions: a multicenter propensity score-matching analysis
Mengting Yu, Jiao Li, Yongfeng Yan, Xiaoxiang Wang, Yanhui Mao, Dandan Jiang, Zhengkui Zhou, Yuanyuan Chen, Xiaobin Sun
BMC Gastroenterology.2025;[Epub] CrossRef - Technical outcomes and postprocedural courses of mucosal incision‐assisted biopsy for possible gastric gastrointestinal stromal tumors: A series of 48 cases (with video)
Eriko Koizumi, Osamu Goto, Shun Nakagome, Tsugumi Habu, Yumiko Ishikawa, Kumiko Kirita, Hiroto Noda, Kazutoshi Higuchi, Takeshi Onda, Teppei Akimoto, Jun Omori, Naohiko Akimoto, Katsuhiko Iwakiri
DEN Open.2024;[Epub] CrossRef - The Diagnostic Approach of Benign Esophageal Tumors: A Narrative Review
Alex R. Jones, Preksha Vankawala, Tarek Sawas
Current Treatment Options in Gastroenterology.2024; 22(2): 44. CrossRef - Unroofing of subepithelial lesions in the upper gastrointestinal tract using cold snare: an easy and efficient technique for diagnosis
Bernhard Morell, Frans Olivier The, Christoph Gubler, Fritz Ruprecht Murray
Clinical Endoscopy.2024; 57(2): 274. CrossRef - Diagnostic yield of endoscopic and EUS-guided biopsy techniques in subepithelial lesions of the upper GI tract: a systematic review
Cynthia A. Verloop, Jacqueline A.C. Goos, Marco J. Bruno, Rutger Quispel, Lydi M.J.W. van Driel, Lieke Hol
Gastrointestinal Endoscopy.2024; 99(6): 895. CrossRef - Small gastric subepithelial lesions: A sand in the eye
Tanyaporn Chantarojanasiri, Nikhil Sonthalia, Rashid N. Lui
Journal of Gastroenterology and Hepatology.2024; 39(7): 1207. CrossRef - EUS‐guided tissue acquisition from gastric subepithelial lesions—The optimal technique still remains undecided
Suprabhat Giri, Sridhar Sundaram
Australasian Journal of Ultrasound in Medicine.2024; 27(4): 263. CrossRef - Endoscopic Ultrasound and Gastric Sub-Epithelial Lesions: Ultrasonographic Features, Tissue Acquisition Strategies, and Therapeutic Management
Marzia Varanese, Marco Spadaccini, Antonio Facciorusso, Gianluca Franchellucci, Matteo Colombo, Marta Andreozzi, Daryl Ramai, Davide Massimi, Roberto De Sire, Ludovico Alfarone, Antonio Capogreco, Roberta Maselli, Cesare Hassan, Alessandro Fugazza, Alessa
Medicina.2024; 60(10): 1695. CrossRef - Efficacy of EUS-guided keyhole biopsies in diagnosing subepithelial lesions of the upper gastrointestinal tract
Sen Verhoeve, Cynthia Verloop, Marco Bruno, Valeska Terpstra, Lydi Van Driel, Lars Perk, Lieke Hol
Endoscopy International Open.2024; 12(10): E1183. CrossRef - Approach to Small Gastric Subepithelial Lesions
Moon Won Lee, Bong Eun Lee
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2023; 23(1): 28. CrossRef - Is the canalization to obtain deep biopsy of gastrointestinal subepithelial tumors miniprobe-guidded as an alternative to conventional known techniques?
Modesto Varas Lorenzo, Ramón Abad Belando
Revista Española de Enfermedades Digestivas.2023;[Epub] CrossRef - Role of Advanced Gastrointestinal Endoscopy in the Comprehensive Management of Neuroendocrine Neoplasms
Harishankar Gopakumar, Vinay Jahagirdar, Jagadish Koyi, Dushyant Singh Dahiya, Hemant Goyal, Neil R. Sharma, Abhilash Perisetti
Cancers.2023; 15(16): 4175. CrossRef
-
7,622
View
-
175
Download
-
14
Web of Science
-
19
Crossref
Focused Review Series: Endoscopic Accessories Used for ESD
-
History and Development of Accessories for Endoscopic Submucosal Dissection
-
Bong Min Ko
-
Clin Endosc 2017;50(3):219-223. Published online May 31, 2017
-
DOI: https://doi.org/10.5946/ce.2017.078
-
-
Abstract
PDF
- Endoscopic submucosal dissection (ESD) procedure is composed of circumferential mucosal incision and submucosal dissection. A variety of endoscopic accessories are required to perform mucosal incision and submucosal dissection safely. As a result of the improvements in ESD devices and peripheral equipment and development of the ESD technique, ESD procedures have been performed extensively worldwide. Here I review the history of the development of accessories used in performing ESD procedures.
-
Citations
Citations to this article as recorded by

- The Current Landscape of Endoscopic Submucosal Training in the United States
Mike T. Wei, Shai Friedland, Joo Ha Hwang
Current Gastroenterology Reports.2025;[Epub] CrossRef - Endoscopic Submucosal Dissection with Rubber Bands and Clips Compared to Conventional Endoscopic Submucosal Dissection: A Systematic Review and Meta-Analysis
Abdelaziz A. Awad, Hazem Abosheaishaa, Malak A. Hassan, Mohamed Mahmoud Marey, Ahmed Bahnasy, Rashad G. Mohamed, Menna A. Keshk, Yousef Radwan Alnomani, Manar A. Balouz, Ahmed Abdelgayed M Hussein, Fatma S. Mohamed, Mohammed A. Alaeb, Mohamed S. Sharaf, O
Digestive Diseases and Sciences.2025; 70(8): 2823. CrossRef - A novel model of dual-network composite hydrogels for application in endoscopic submucosal dissection
Fei Zhao, YunFang Bai, JunJie Wu, ZhiHao Zhu, JinLei Mao, Aikebaier Aili, HongRun Gu, ShiJie Yu, ZhiFei Wang
BMC Gastroenterology.2025;[Epub] CrossRef - Advanced endoscopic resection for early gastrointestinal cancers in India: Challenges and opportunities await!
Sridhar Sundaram, Akhil Mahajan, Prachi Patil
Indian Journal of Gastroenterology.2024; 43(5): 866. CrossRef - Experience in the development of various devices for therapeutic endoscopy
Do Hoon Kim
Journal of Innovative Medical Technology.2024; 2(2): 35. CrossRef - Settings of a novel electrosurgical generator to enable efficient and safe submucosal endoscopic procedures
Salmaan Jawaid, Tara Keihanian, Mai Khalaf, Margarita Riojas-Barrett, Wesam Abdeljaber, Michael Mercado, Noor Zabad, Mohamed O. Othman
Endoscopy International Open.2023; 11(08): E743. CrossRef - Design and validation of performance-oriented injectable chitosan thermosensitive hydrogels for endoscopic submucosal dissection
Jia Liu, Panxianzhi Ni, Yi Wang, Zhengkui Zhou, Junlin Li, Tianxu Chen, Tun Yuan, Jie Liang, Yujiang Fan, Jing Shan, Xiaobin Sun, Xingdong Zhang
Biomaterials Advances.2023; 146: 213286. CrossRef - Efficacy and Safety of ClearCut™ Knife H-type in Endoscopic Submucosal Dissection for Gastric Neoplasms: A Multicenter, Randomized Trial
Eun Jeong Gong, Hyun Lim, Sang Jin Lee, Do Hoon Kim
Journal of Gastric Cancer.2023; 23(3): 451. CrossRef - Understanding hybrid endoscopic submucosal dissection subtleties
João Paulo de Souza Pontual, Alexandre Moraes Bestetti, Diogo Turiani Hourneaux de Moura
Clinical Endoscopy.2023; 56(6): 738. CrossRef - The application of endoscopic loop ligation in defect repair following endoscopic full-thickness resection of gastric submucosal tumors originating from the muscularis propria layer
Guoxiang Wang, Yanli Xiang, Yangde Miao, Honggang Wang, Meidong Xu, Guang Yu
Scandinavian Journal of Gastroenterology.2022; 57(1): 119. CrossRef - A Novel Knife for Endoscopic Submucosal Dissection in Early Gastric Cancer
Seokin Kang, Jeong Hoon Lee
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(1): 3. CrossRef - The Efficacy of a Novel Type of Integrated Knife for Endoscopic Submucosal Dissection in Early Gastric Cancer
Eun Ju Choe, Han Ho Jeon, Yong Suk Cho, Sun Young Won, Jeong Hun Seo, Jong Won Choi, Chun Kyon Lee, Byung Kyu Park, Yong Kang Lee
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(1): 50. CrossRef - The future of endoscopic resection for early gastric cancer
Raquel Ortigão, Diogo Libânio, Mário Dinis‐Ribeiro
Journal of Surgical Oncology.2022; 125(7): 1110. CrossRef - Comparison between a novel core knife and the conventional IT knife 2 for endoscopic submucosal dissection of gastric mucosal lesions
Myeongsoon Park, Jin Wook Lee, Dong Woo Shin, Jungseok Kim, Yoo Jin Lee, Ju Yup Lee, Kwang Bum Cho
Clinical Endoscopy.2022; 55(6): 767. CrossRef - Snare Tip Is an Alternative Tool for Colorectal Endoscopic Submucosal Dissection
Chih-Chien Wu, Min-Chi Chang, Ming-Hung Lee, Chiao-Hui Hsu, Chao-Wen Hsu
Diseases of the Colon & Rectum.2021; 64(2): 241. CrossRef - Lactobionic acid-modified chitosan thermosensitive hydrogels that lift lesions and promote repair in endoscopic submucosal dissection
Panxianzhi Ni, Renpeng Li, Sheng Ye, Jing Shan, Tun Yuan, Jie Liang, Yujiang Fan, Xingdong Zhang
Carbohydrate Polymers.2021; 263: 118001. CrossRef - Chitosan thermosensitive hydrogels based on lyophilizate powders demonstrate significant potential for clinical use in endoscopic submucosal dissection procedures
Panxianzhi Ni, Sheng Ye, Renpeng Li, Jing Shan, Tun Yuan, Jie Liang, Yujiang Fan, Xingdong Zhang
International Journal of Biological Macromolecules.2021; 184: 593. CrossRef - Diode Laser—Can It Replace the Electrical Current Used in Endoscopic Submucosal Dissection? (with Video)
Yunho Jung, Gwang Ho Baik, Weon Jin Ko, Bong Min Ko, Seong Hwan Kim, Jin Seok Jang, Jae-Young Jang, Wan-Sik Lee, Young Kwan Cho, Sun Gyo Lim, Hee Seok Moon, In Kyung Yoo, Joo Young Cho
Clinical Endoscopy.2021; 54(4): 555. CrossRef - Review on colorectal endoscopic submucosal dissection focusing on the technical aspect
Tak Lit Derek Fung, Chi Woo Samuel Chow, Pak Tat Chan, Kam Hung Kwok
Surgical Endoscopy.2020; 34(9): 3766. CrossRef - Determining the Safety and Effectiveness of Electrocautery Enhanced Scissors for Peroral Endoscopic Myotomy (with Video)
Kelly E. Hathorn, Walter W. Chan, Hiroyuki Aihara, Christopher C. Thompson
Clinical Endoscopy.2020; 53(4): 443. CrossRef - Long-Term Outcomes and Prognostic Factors of Endoscopic Submucosal Dissection for Early Gastric Cancer in Patients Aged ≥75 Years
Jin Won Chang, Da Hyun Jung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee
Cancers.2020; 12(11): 3222. CrossRef
-
12,807
View
-
292
Download
-
18
Web of Science
-
21
Crossref
Focused Review Series: Advanced Endoscopic Treatment for Pancreaticobiliary Diseases
-
Burdick's Technique for Biliary Access Revisited
-
Mahesh Kumar Goenka, Vijay Kumar Rai
-
Clin Endosc 2015;48(1):20-23. Published online January 31, 2015
-
DOI: https://doi.org/10.5946/ce.2015.48.1.20
-
-
Abstract
PDF
The precut sphincterotomy is used to facilitate selective biliary access in cases of difficult biliary cannulation. Needle-knife precut papillotomy is the standard of care but is associated with a high rate of complications such as pancreatitis, duodenal perforation, bleeding, etc. Sometimes during bowing of the sphincterotome/cannula and the use of guide wire to facilitate biliary cannulation, inadvertent formation of a false passage occurs in the 10 to 11 o'clock direction. Use of this step to access the bile duct by the intramucosal incision technique was first described by Burdick et al., and since then two more studies have also substantiated the safety and efficacy of this non-needle type of precut sphincterotomy. In this review, we discuss this non-needle technique of precut sphincterotomy and also share our experience using this "Burdick's technique."
-
Citations
Citations to this article as recorded by

- Burdick’s technique: Correcting the false tract to facilitate biliary cannulation
Venkatesh Vaithiyam, Ashok Dalal, Sanjeev Sachdeva, Siddharth Srivastava
Indian Journal of Gastroenterology.2026;[Epub] CrossRef - Causes and Countermeasures of Difficult Selective Biliary Cannulation: A Large Sample Size Retrospective Study
Yang Liu, Wei Liu, Junbo Hong, Guohua Li, Youxiang Chen, Yong Xie, Xiaojiang Zhou
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2021; 31(5): 533. CrossRef - Difficult Biliary Cannulation in Endoscopic Retrograde Cholangiopancreatography: An Overview of Advanced Techniques
Brian M. Fung, Teodor C. Pitea, James H. Tabibian
EMJ Hepatology.2021; : 73. CrossRef - Difficult Biliary Access
Anish Mammen, Gregory Haber
Gastrointestinal Endoscopy Clinics of North America.2015; 25(4): 619. CrossRef
-
9,527
View
-
136
Download
-
2
Web of Science
-
4
Crossref