Systematic Review and Meta-Analysis
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Endoscopic diagnosis of gastric metastases from malignant melanoma: systematic review
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Helena Campoli Reggiani, Ana Clara Aguiar Pongeluppi, Vitória Froes Miraglia Martins Ferreira, Isadora Pinheiro Felix, Paulo Moacir de Oliveira Campoli
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Clin Endosc 2022;55(4):507-515. Published online June 28, 2022
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DOI: https://doi.org/10.5946/ce.2022.035
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Abstract
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- Background
/Aims: Metastases of malignant melanoma (MM) are rare and associated with poor prognosis. The objective of this study was to analyze the clinical and endoscopic characteristics of gastric metastases of MM by systematically reviewing cases and case series involving patients diagnosed using upper gastrointestinal endoscopy.
Methods
The PubMed and LILACS databases were searched. Reports containing individual patient data were included. Outcomes such as clinical data, endoscopic findings, treatments, and survival were analyzed.
Results
A total of 88 studies with individual data from 113 patients with gastric metastases of MM were included. The primary sites of MM were the skin (62%), eyes (10%), and mucous membranes (6%). Most patients (56%) had multiple metastases in the stomach, located predominantly in the gastric body (approximately 80%). The overall survival rate at 2 years was 4%. There was a significant reduction in the survival of patients with multiple gastric metastases compared to that of patients with single metastasis (hazard ratio, 0.459; 95% confidence interval, 0.235−0.895; p=0.022).
Conclusions
Gastric metastases of MM have a poor prognosis, especially in patients with multiple implants in the stomach. Additional studies are needed to verify whether ocular and mucosal melanomas are associated with a higher risk of gastric metastases than that of cutaneous melanomas.
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Citations
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- Case Report: Can You See the Elephant in the Room? Skin Melanoma Revealed by Gastric Metastasis
Ramzi Tababi, Amal Khsiba, Moufida Mahmoudi, Asma Ben Mohamed, Manel Yakoubi, Ghada Gharbi, Abir Chaabane, Emna Chelbi, Mouna Medhioub, Mohamed Lamine Hamzaoui
F1000Research.2025; 13: 1019. CrossRef - A Rare Case of Gastric Metastasis from a Rare Case of Mucosal Malignant Melanoma
Zaim Gashi, Astrit Hamza, Blerina Ukimeri, Valon Hamza, Marigona Zubaku-Rakovic
Open Access Macedonian Journal of Medical Sciences.2024; 12(2): 362. CrossRef - Case Report: Gastric Metastasis revealing a Disseminated Skin Melanoma: A Case Report and Literature Review
Ramzi Tababi, Amal Khsiba, Moufida Mahmoudi, Asma Ben Mohamed, Manel Yakoubi, Ghada Gharbi, Abir Chaabane, Emna Chelbi, Mouna Medhioub, Mohamed Lamine Hamzaoui
F1000Research.2024; 13: 1019. CrossRef - Sliced Tomato Appearance of Malignant Melanoma: Diffuse Involvement of the Upper Gastrointestinal Tract Presenting With Melena
Nathanial Bartosek, Inayat Gill, Atulkumar Patel
ACG Case Reports Journal.2024; 11(10): e01459. CrossRef - Case Report: The Elephant in the Room: Skin Melanoma Unveiled by Gastric Metastasis
Ramzi Tababi, Amal Khsiba, Moufida Mahmoudi, Asma Ben Mohamed, Manel Yakoubi, Ghada Gharbi, Abir Chaabane, Emna Chelbi, Mouna Medhioub, Mohamed Lamine Hamzaoui
F1000Research.2024; 13: 1019. CrossRef - Case report: Malignant melanoma of the lower limb with gastric metastasis
Qiang Hu, Fengru Zhou, Yuanshui Sun
Frontiers in Oncology.2023;[Epub] CrossRef
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Case Reports
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An Unusual Presentation of a Solid Pseudopapillary Tumor of the Pancreas Mimicking Adenocarcinoma
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Hyung Ku Chon, Keum Ha Choi, Tae Hyeon Kim
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Clin Endosc 2020;53(5):615-619. Published online November 22, 2019
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DOI: https://doi.org/10.5946/ce.2019.158
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Abstract
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- Solid pseudopapillary tumors of the pancreas are rare and typically occur in young women. Compared with pancreatic adenocarcinoma, solid pseudopapillary tumors are characterized by notable indolent biological behavior associated with a favorable prognosis. Despite their large size, these tumors rarely metastasize. Even in cases of hepatic metastasis, most lesions are usually solitary in distribution and are amenable to resection. We report a case of a 55-year-old man with a small solid pseudopapillary tumor (≤3-cm diameter) mimicking a pancreatic adenocarcinoma, with multiple hepatic metastases. The diagnosis was confirmed by endoscopic ultrasound-guided fine-needle biopsy using a 22-G core needle. Unfortunately, rapid tumor progression led to patient mortality 5 months after diagnosis. To our knowledge, this is the first case report that describes a small solid pseudopapillary tumor of the pancreas with multiple hepatic metastasis and poor prognosis in a patient who was diagnosed with this condition at the time of initial diagnosis.
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- Rare case of solid pseudopapillary neoplasm of the pancreas with liver and splenic metastasis in a 19-year-old girl
Chi-Chi Chen, Ting-Yuan Feng, Hsiang-Chun Jan, Shaw-Jiun Chou, Tzu-Hung Chen, Sheng-Chun Wang
International Journal of Surgery Case Reports.2024; 120: 109867. CrossRef - Large Solid Pseudopapillary Tumor Pancreas with Extensive Splenoportal Thrombosis and Malignant Transformation—A Rare Entity
Thara Pratap, Dhanya Jacob, Abhishek Yadav, Muhammed Jasim Abdul Jalal, Iona Leekha Mathew
Journal of Gastrointestinal and Abdominal Radiology.2022; 05(03): 196. CrossRef - Aggressive solid pseudopapillary tumor of the pancreas. (Literature review and case report)
D.V. Sidorov, N.A. Grishin, M.V. Lozhkin, N.N. Volchenko, Kh.S. Kosumova, A.A. Troitskii, I.V. Stepanyuk, S.A. Bykasov, R.I. Moshurov
Onkologiya. Zhurnal imeni P.A.Gertsena.2022; 11(2): 52. CrossRef
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Unusual Local Recurrence with Distant Metastasis after Successful Endoscopic Submucosal Dissection for Colorectal Mucosal Cancer
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Hyo Jeong Lee, Byong Duk Ye, Jeong-Sik Byeon, Jihun Kim, Young Soo Park, Yong Sang Hong, Yong Sik Yoon, Dong-Hoon Yang
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Clin Endosc 2017;50(1):91-95. Published online August 22, 2016
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DOI: https://doi.org/10.5946/ce.2016.054
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- Intramucosal colorectal cancer (CRC) is thought not to metastasize because the colonic lamina propria lacks lymphatics. Only a few recent case reports have suggested lymph node metastasis from intramucosal CRC, but there is no clear evidence supporting the metastatic potential of intramucosal CRC. Hence, endoscopic resection is regarded as curative treatment for intramucosal CRC. This report describes two cases of unusual local recurrence with distant metastasis in patients who had previously undergone successful endoscopic submucosal dissection for intramucosal CRC. The recurrent colorectal lesions developed at the site of the previous endoscopic submucosal dissection scars in a relatively short-term period, and the pathologic findings showed an “undermining” invasion pattern without surrounding mucosal change. Based on the clinical course and pathological findings, we concluded that the second colorectal lesions were recurrences rather than de novo cancers.
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Citations
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- Local excision after polypectomy for rectal polyp cancer: when is it worthwhile?
Helen J. S. Jones, Issam al‐Najami, Gunnar Baatrup, Chris Cunningham
Colorectal Disease.2021; 23(4): 868. CrossRef - Presacral lymph node recurrence of rectal intramucosal adenocarcinoma after endoscopic mucosal resection: a case report
Taichi Horino, Yukiharu Hiyoshi, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
Surgical Case Reports.2020;[Epub] CrossRef - Recurrence, death risk, and related factors in patients with stage 0 colorectal cancer
Ming-Hao Hsieh, Pei-Tseng Kung, Wen-Yin Kuo, Tao-Wei Ke, Wen-Chen Tsai
Medicine.2020; 99(36): e21688. CrossRef - Recurrence rate of lateral margin-positive cases after en bloc endoscopic submucosal dissection of colorectal neoplasia
Seohyun Lee, Jihun Kim, Jae Seung Soh, Jungho Bae, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Dong-Hoon Yang
International Journal of Colorectal Disease.2018; 33(6): 735. CrossRef
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7,884
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A Case of Early Gastric Cancer with Solitary Metastasis to the Pleura
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Eun Jung Hwang, Jae Young Jang, Yun Wha Kim, Seok Ho Dong, Hyo Jong Kim, Byung-Ho Kim, Young Woon Chang
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Clin Endosc 2013;46(6):666-670. Published online November 19, 2013
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DOI: https://doi.org/10.5946/ce.2013.46.6.666
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The incidence of early gastric cancer (EGC) has increased to >50% in Korea owing to a higher detection rate caused by rapid advances in diagnostic instrumentation. EGC with distant metastasis has been rarely reported. Here, we report the case of a 76-year-old woman in whom general EGC was initially diagnosed by endoscopy and endoscopic ultrasonography. She subsequently underwent endoscopic submucosal dissection (ESD). Histological examination of the ESD specimen revealed that neoplastic cells were located predominantly in the submucosal layer and submucosal lymphatic channels. Metastatic cancer cells were also found in the pleural effusion. After conducting all analyses, including immunohistochemical staining, we concluded that the patient had primary EGC with pleural metastasis.
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Citations
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- Clinicopathological Characteristics and Prognosis of cT1N0M1 Gastric Cancer: A Population-Based Study
Jianbo Han, Junhao Tu, Chaoyang Tang, Xiang Ma, Chi Huang
Disease Markers.2019; 2019: 1. CrossRef - The Value of Computed Tomography in Preoperative N Staging of Early Gastric Cancer Meeting the Endoscopic Resection Criteria
Su Jin Kim, Tae Un Kim, Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Hyeong Seok Nam, Dae Gon Ryu
The Korean Journal of Gastroenterology.2017; 70(1): 21. CrossRef - An Early Gastric Cancer Patient With Pleural Metastatic Recurrence
Asako Shimazaki, Takao Katsube, Kentaro Yamaguchi, Atsuko Usuda, Minoru Murayama, Soihi Konno, Shinichi Asaka, Hajime Yokomizo, Kazuhiko Yoshimatsu, Shunichi Shiozawa, Takeshi Shimakawa, Yoshihiko Naritaka
International Surgery.2016; 101(1-2): 84. CrossRef - Collagen Nanofibers Facilitated Presynaptic Maturation in Differentiated Neurons from Spinal-Cord-Derived Neural Stem Cells through MAPK/ERK1/2-Synapsin I Signaling Pathway
Yanling Yin, Peng Huang, Zhu Han, Guojun Wei, Changwei Zhou, Jian Wen, Bo Su, Xiaoqin Wang, Yansong Wang
Biomacromolecules.2014; 15(7): 2449. CrossRef
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6,928
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A Case of Esophageal Squamous Cell Carcinoma with Pancreatic Metastasis
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Choulki Park, Jae Young Jang, Youn Hwa Kim, Eun Jung Hwang, Ki Yong Na, Kyung-Yup Kim, Jae Hyun Park, Young Woon Chang
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Clin Endosc 2013;46(2):197-200. Published online March 31, 2013
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DOI: https://doi.org/10.5946/ce.2013.46.2.197
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Solitary pancreatic metastasis of esophageal cancer is extremely rare. We report the case of a 58-year-old male admitted with esophageal cancer. Additional asymptomatic solitary hepatic and pancreatic masses were observed in the staging work-up for esophageal cancer. The hepatic mass was confirmed as a primary hepatocellular carcinoma with an ultrasound-guided needle biopsy. An esophagectomy with a distal pancreatectomy and radiofrequency ablation for hepatocellular carcinoma were performed. Histologically, the pancreatic mass was confirmed to be a metastasis from the esophageal cancer. The patient has been followed up with chemotherapy.
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- Pancreatic Metastases of Esophageal Squamous Cell Carcinoma: A Case Report and Review of the Literature
Tivadar Bara, Alexandra Georgiana Scurtu, Tivadar Bara, Zsolt Zoltan Fulop, Renata Moriczi, Patricia Simu, Paul Borz, Simona Gurzu
Diagnostics.2024; 14(19): 2164. CrossRef - A case of esophageal squamous cell carcinoma accompanied by pancreatic and bile duct metastases: Successful treatment starts with an accurate diagnosis
Yuki Ito, Yoshihiro Ikura, Hiroaki Sawai, Tatsuya Osuga
Journal of Cancer Research and Therapeutics.2023; 19(7): 2060. CrossRef - Simultaneous presentation and resection of esophageal cancer and metastasis to the pancreas: Α case report and literature review
Yuki Denda, Yoichi Matsuo, Keisuke Nonoyama, Hiromichi Murase, Tomokatsu Kato, Yuichi Hayashi, Hiroyuki Imafuji, Kenta Saito, Mamoru Morimoto, Hiroyuki Kato, Michihiro Yoshida, Itaru Naitoh, Kazuki Hayashi, Ryo Ogawa, Hiroki Takahashi, Shuji Takiguchi
Molecular and Clinical Oncology.2023;[Epub] CrossRef - Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer
Takeshi Okamoto
World Journal of Gastroenterology.2022; 28(10): 985. CrossRef - An extremely atypical presentation of esophageal squamous cell carcinoma with pancreatic and hepatic metastases
Lei Zhang, Xin Long, Zheng-Nan Hu, Yu Wu, Jia Song, Bi-Xiang Zhang, Wei-Xun Chen
Medicine.2021; 100(20): e25785. CrossRef - Primary squamous cell carcinoma of head of the pancreas
Supratim Bhattacharyya, Padmalaya Devi, Subrat Samantara, KP Kunhi Mohammed
Oncology Journal of India.2020; 4(3): 145. CrossRef - Successful resection of pancreatic metastasis from oesophageal squamous cell carcinoma: a case report and review of the literature
Wataru Koizumi, Minoru Kitago, Masahiro Shinoda, Hiroshi Yagi, Yuta Abe, Go Oshima, Shutaro Hori, Kenta Inomata, Hirofumi Kawakubo, Miho Kawaida, Yuko Kitagawa
BMC Cancer.2019;[Epub] CrossRef - Engineered Gold Nanoshells Killing Tumor Cells: New Perspectives
Valeria De Matteis, Mariafrancesca Cascione, Chiara C. Toma, Rosaria Rinaldi
Current Pharmaceutical Design.2019; 25(13): 1477. CrossRef - An Entirely Atypical Presentation of Esophageal Squamous Cell Cancer with Pancreatic and Bone Metastases
Eric Yoon, Yousef Nassar, Juan Tejada-Almonte, Muhammad Sohail Mansoor, Kavita Umrau, Sven Hida
Case Reports in Gastroenterology.2019; 13(3): 423. CrossRef - Pancreatic Squamous Cell Carcinoma
Seyed Hassan Abedi, Alireza Ahmadzadeh, Amir Houshang Mohammad Alizadeh
Case Reports in Gastroenterology.2017; 11(1): 219. CrossRef - Esophageal Cancer Metastases to Unexpected Sites: A Systematic Review
Osama Shaheen, Abdulaziz Ghibour, Bayan Alsaid
Gastroenterology Research and Practice.2017; 2017: 1. CrossRef
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