Original Articles
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Short-term outcome of endoscopic submucosal dissection using a clutch cutter for subepithelial lesions within the esophagogastric submucosa: a Japanese prospective observational study
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Kazuya Akahoshi, Kazuki Inamura, Kazuaki Akahoshi, Shigeki Osada, Shinichi Tamura, Yoshihiro Oishi, Masafumi Oya, Hidenobu Koga
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Received April 21, 2024 Accepted June 10, 2024 Published online October 10, 2024
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DOI: https://doi.org/10.5946/ce.2024.094
[Epub ahead of print]
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- Background
/Aims: The efficacy and safety of endoscopic submucosal dissection using a clutch cutter (ESD-CC) for subepithelial lesions within the esophagogastric submucosa (SELEGSM) has not been investigated. This study aimed to assess the efficacy and safety of ESD-CC for the treatment of SELEGSM.
Methods
This prospective study included 15 consecutive patients with 18 SELEGSMs diagnosed by endoscopic ultrasonography. The primary outcomes were short-term outcomes including en bloc resection rate, R0 resection rate, procedure time, and complication rate. The secondary outcome was final histological diagnosis.
Results
Among the participants, 18 lesions were identified: 12 in the stomach (nine patients) and six in the esophagus (six patients). The en bloc resection rate was 94.4% (17/18). The R0 resection rate was 88.9% (16/18). The median operating time was 39 min, and no instances of perforation or bleeding were observed. The final diagnoses of SELEGSM included six neuroendocrine tumors (33.3%), six granular cell tumors (33.3%), two ectopic pancreases (11.1%), one inflammatory fibroid polyp (5.6%), one leiomyoma (5.6%), one lipoma (5.6%), and one leiomyosarcoma (5.6%).
Conclusions
ESD-CC appears to be a technically efficient and safe approach for SELEGSM resection, suggesting its potential as a valuable treatment option.
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Prevalence and natural course of incidental gastric subepithelial tumors
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Dae-Hyuk Heo, Min A Yang, Jae Sun Song, Won Dong Lee, Jin Woong Cho
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Clin Endosc 2024;57(4):495-500. Published online March 29, 2024
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DOI: https://doi.org/10.5946/ce.2023.124
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- Background
/Aims: Gastric subepithelial tumors (SETs) are often encountered during the upper gastrointestinal endoscopic screening. We assessed the prevalence of gastric SETs and the risk factors for their progression.
Methods
We reviewed the electronic medical records of 30,754 patients who underwent upper gastrointestinal endoscopic screening at our medical center between January 2013 and December 2016.
Results
Among the 30,754 patients examined, 599 (1.94%) had gastric SETs. The prevalence increased with age and was 9.56% in patients aged ≥70 years. In total, 262 patients underwent serial endoscopy for more than 6 months. The median age was 68 years (interquartile range [IQR], 61–74), and the number of females was 167 (63.7%). During a median follow-up of 58 months (IQR, 38–75), 22 patients (8.4%) showed significant changes in tumor size. An irregular border (odds ratio, 4.623; 95% confidence interval, 1.093–19.558; p=0.037) was a significant risk factor for progression. Seven patients underwent surgical or endoscopic resections. The pathologies of gastric SETs included leiomyomas (n=3), gastrointestinal stromal tumors (n=2), and lipomas (n=2).
Conclusions
The prevalence of gastric SETs increases with age. Most gastric SETs do not progress during long-term endoscopic examinations, and the risk of an increase in size is low in asymptomatic small SETs without irregular borders.
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Citations
Citations to this article as recorded by

- Artificial Intelligence-Based Diagnosis of Gastric Mesenchymal Tumors Using Digital Endosonography Image Analysis
Dong Chan Joo, Gwang Ha Kim, Moon Won Lee, Bong Eun Lee, Ji Woo Kim, Kwang Baek Kim
Journal of Clinical Medicine.2024; 13(13): 3725. CrossRef
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Review
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Application of artificial intelligence for diagnosis of early gastric cancer based on magnifying endoscopy with narrow-band imaging
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Yusuke Horiuchi, Toshiaki Hirasawa, Junko Fujisaki
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Clin Endosc 2024;57(1):11-17. Published online January 5, 2024
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DOI: https://doi.org/10.5946/ce.2023.173
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- Although magnifying endoscopy with narrow-band imaging is the standard diagnostic test for gastric cancer, diagnosing gastric cancer using this technology requires considerable skill. Artificial intelligence has superior image recognition, and its usefulness in endoscopic image diagnosis has been reported in many cases. The diagnostic performance (accuracy, sensitivity, and specificity) of artificial intelligence using magnifying endoscopy with narrow band still images and videos for gastric cancer was higher than that of expert endoscopists, suggesting the usefulness of artificial intelligence in diagnosing gastric cancer. Histological diagnosis of gastric cancer using artificial intelligence is also promising. However, previous studies on the use of artificial intelligence to diagnose gastric cancer were small-scale; thus, large-scale studies are necessary to examine whether a high diagnostic performance can be achieved. In addition, the diagnosis of gastric cancer using artificial intelligence has not yet become widespread in clinical practice, and further research is necessary. Therefore, in the future, artificial intelligence must be further developed as an instrument, and its diagnostic performance is expected to improve with the accumulation of numerous cases nationwide.
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Citations
Citations to this article as recorded by

- Combination of artificial intelligence endoscopic diagnosis and Kimura‐Takemoto classification determined by endoscopic experts may effectively evaluate the stratification of gastric atrophy in post‐eradication status
Kumiko Kirita, Seiji Futagami, Ken Nakamura, Shuhei Agawa, Nobue Ueki, Kazutoshi Higuchi, Mayu Habiro, Rie Kawawa, Yusuke Kato, Tomohiro Tada, Katsuhiko Iwakiri
DEN Open.2025;[Epub] CrossRef - Identification and validation of serum MUC17 as a non‐invasive early warning biomarker for screening of gastric intraepithelial neoplasia
Bingxue Yang, Xiaoli Xie, Xiaoxu Jin, Xiuhong Huang, Yujian He, Kaige Yin, Chenguang Ji, Li Liu, Zhijie Feng
Translational Oncology.2025; 51: 102207. CrossRef - Pitfalls in Endoscopic Submucosal Dissection for Early Gastric Cancer with Papillary Adenocarcinoma
Gwang Ha Kim
Gut and Liver.2024; 18(3): 368. CrossRef - Edge Artificial Intelligence Device in Real-Time Endoscopy for Classification of Gastric Neoplasms: Development and Validation Study
Eun Jeong Gong, Chang Seok Bang, Jae Jun Lee
Biomimetics.2024; 9(12): 783. CrossRef
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4
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Original Article
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Association between occurrence of multiple white and flat elevated gastric lesions and oral proton pump inhibitor intake
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Rino Hasegawa, Kenshi Yao, Takao Kanemitsu, Hisatomi Arima, Takayuki Hirase, Yuuya Hiratsuka, Kazuhiro Takeda, Kentaro Imamura, Kensei Ohtsu, Yoichiro Ono, Masaki Miyaoka, Takashi Hisabe, Toshiharu Ueki, Hiroshi Tanabe, Atsuko Ohta, Satoshi Nimura
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Clin Endosc 2024;57(1):65-72. Published online May 9, 2023
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DOI: https://doi.org/10.5946/ce.2022.257
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- Background
/Aims: Multiple white and flat elevated lesions (MWFL) that develop from the gastric corpus to the fornix may be strongly associated with oral antacid intake. Therefore, this study aimed to determine the association between the occurrence of MWFL and oral proton pump inhibitor (PPI) intake and clarify the endoscopic and clinicopathological characteristics of MWFL.
Methods
The study included 163 patients. The history of oral drug intake was collected, and serum gastrin levels and anti-Helicobacter pylori immunoglobulin G antibody titers were measured. Upper gastrointestinal endoscopy was performed. The primary study endpoint was the association between MWFL and oral PPI intake.
Results
In the univariate analyses, MWFL were observed in 35 (49.3%) of 71 patients who received oral PPIs and 10 (10.9%) of 92 patients who did not receive oral PPIs. The occurrence of MWFL was significantly higher among patients who received PPIs than in those who did not (p<0.001). Moreover, the occurrence of MWFL was significantly higher in patients with hypergastrinemia (p=0.005). In the multivariate analyses, oral PPI intake was the only significant independent factor associated with the presence of MWFL (p=0.001; odds ratio, 5.78; 95% confidence interval, 2.06–16.2).
Conclusions
Our findings suggest that oral PPI intake is associated with the presence of MWFL (UMINCTR 000030144).
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Citations
Citations to this article as recorded by

- Endoscopic findings and outcomes of gastric mucosal changes relating to potassium‐competitive acid blocker and proton pump inhibitor therapy
Satoshi Shinozaki, Hiroyuki Osawa, Yoshimasa Miura, Hiroaki Nomoto, Hirotsugu Sakamoto, Yoshikazu Hayashi, Tomonori Yano, Edward J. Despott, Hironori Yamamoto
DEN Open.2025;[Epub] CrossRef - Clinicians should be aware of proton pump inhibitor–related changes in the gastric mucosa
Gwang Ha Kim
Clinical Endoscopy.2024; 57(1): 51. CrossRef - Drug-induced mucosal alterations observed during esophagogastroduodenoscopy
Masaya Iwamuro, Seiji Kawano, Motoyuki Otsuka
World Journal of Gastroenterology.2024; 30(16): 2220. CrossRef
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3,553
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Systematic Review and Meta-Analysis
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Endoscopic diagnosis of gastric metastases from malignant melanoma: systematic review
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Helena Campoli Reggiani, Ana Clara Aguiar Pongeluppi, Vitória Froes Miraglia Martins Ferreira, Isadora Pinheiro Felix, Paulo Moacir de Oliveira Campoli
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Clin Endosc 2022;55(4):507-515. Published online June 28, 2022
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DOI: https://doi.org/10.5946/ce.2022.035
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- Background
/Aims: Metastases of malignant melanoma (MM) are rare and associated with poor prognosis. The objective of this study was to analyze the clinical and endoscopic characteristics of gastric metastases of MM by systematically reviewing cases and case series involving patients diagnosed using upper gastrointestinal endoscopy.
Methods
The PubMed and LILACS databases were searched. Reports containing individual patient data were included. Outcomes such as clinical data, endoscopic findings, treatments, and survival were analyzed.
Results
A total of 88 studies with individual data from 113 patients with gastric metastases of MM were included. The primary sites of MM were the skin (62%), eyes (10%), and mucous membranes (6%). Most patients (56%) had multiple metastases in the stomach, located predominantly in the gastric body (approximately 80%). The overall survival rate at 2 years was 4%. There was a significant reduction in the survival of patients with multiple gastric metastases compared to that of patients with single metastasis (hazard ratio, 0.459; 95% confidence interval, 0.235−0.895; p=0.022).
Conclusions
Gastric metastases of MM have a poor prognosis, especially in patients with multiple implants in the stomach. Additional studies are needed to verify whether ocular and mucosal melanomas are associated with a higher risk of gastric metastases than that of cutaneous melanomas.
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Citations
Citations to this article as recorded by

- Case Report: Can You See the Elephant in the Room? Skin Melanoma Revealed by Gastric Metastasis
Ramzi Tababi, Amal Khsiba, Moufida Mahmoudi, Asma Ben Mohamed, Manel Yakoubi, Ghada Gharbi, Abir Chaabane, Emna Chelbi, Mouna Medhioub, Mohamed Lamine Hamzaoui
F1000Research.2025; 13: 1019. CrossRef - A Rare Case of Gastric Metastasis from a Rare Case of Mucosal Malignant Melanoma
Zaim Gashi, Astrit Hamza, Blerina Ukimeri, Valon Hamza, Marigona Zubaku-Rakovic
Open Access Macedonian Journal of Medical Sciences.2024; 12(2): 362. CrossRef - Case Report: Gastric Metastasis revealing a Disseminated Skin Melanoma: A Case Report and Literature Review
Ramzi Tababi, Amal Khsiba, Moufida Mahmoudi, Asma Ben Mohamed, Manel Yakoubi, Ghada Gharbi, Abir Chaabane, Emna Chelbi, Mouna Medhioub, Mohamed Lamine Hamzaoui
F1000Research.2024; 13: 1019. CrossRef - Sliced Tomato Appearance of Malignant Melanoma: Diffuse Involvement of the Upper Gastrointestinal Tract Presenting With Melena
Nathanial Bartosek, Inayat Gill, Atulkumar Patel
ACG Case Reports Journal.2024; 11(10): e01459. CrossRef - Case Report: The Elephant in the Room: Skin Melanoma Unveiled by Gastric Metastasis
Ramzi Tababi, Amal Khsiba, Moufida Mahmoudi, Asma Ben Mohamed, Manel Yakoubi, Ghada Gharbi, Abir Chaabane, Emna Chelbi, Mouna Medhioub, Mohamed Lamine Hamzaoui
F1000Research.2024; 13: 1019. CrossRef - Case report: Malignant melanoma of the lower limb with gastric metastasis
Qiang Hu, Fengru Zhou, Yuanshui Sun
Frontiers in Oncology.2023;[Epub] CrossRef
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3,252
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Original Articles
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Underestimation of endoscopic size in large gastric epithelial neoplasms
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Jae Sun Song, Byung Sun Kim, Min A Yang, Young Jae Lee, Gum Mo Jung, Ji Woong Kim, Jin Woong Cho
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Clin Endosc 2022;55(6):760-766. Published online May 19, 2022
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DOI: https://doi.org/10.5946/ce.2021.269
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- Background
/Aims: Endoscopic submucosal dissection (ESD) is an effective method for resecting gastric adenomas and adenocarcinomas. A significant discrepancy was observed between endoscopic and pathological sizes in samples obtained from patients undergoing ESD. This study elucidates the factors affecting size discrepancy after formalin fixation.
Methods
The records of 64 patients with 69 lesions were analyzed, including 50 adenomas and 19 adenocarcinomas. Data on location, gross shape, histology, and size after fixation in formalin were collected.
Results
The mean size of the resected specimen appeared to decrease after formalin fixation (37.5 mm prefixation vs. 35.8 mm postfixation, p<0.05). The mean long axis diameter of the lesions was 20.3±7.9 mm prefixation and 13.4±7.9 mm postfixation. Size differences in lesions smaller than 20 mm were significantly greater than those in lesions larger than 20 mm (7.6±5.6 mm vs. 2.5±5.8 mm, p<0.01). In multivariate analysis, a tumor size of ≥20 mm was found to be an independent factor affecting size postformalin fixation (p<0.05).
Conclusions
The endoscopic size of lesions before ESD may be underestimated in tumors larger than 20 mm in size. Therefore, increased attention must be paid during ESD to avoid instances of incomplete resection.
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Citations
Citations to this article as recorded by

- Transcecal endoscopic appendectomy for management of complex appendiceal polyps extending into the appendiceal orifice
Tara Keihanian, Mai A Khalaf, Fuad Zain Aloor, Dina Hani Zamil, Salmaan Jawaid, Mohamed O. Othman
Endoscopy International Open.2024; 12(08): E932. CrossRef
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Predictive Factors for Differentiating Gastrointestinal Stromal Tumors from Leiomyomas Based on Endoscopic Ultrasonography Findings in Patients with Gastric Subepithelial Tumors: A Multicenter Retrospective Study
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Sun Moon Kim, Eun Young Kim, Jin Woong Cho, Seong Woo Jeon, Ji Hyun Kim, Tae Hyeon Kim, Jeong Seop Moon, Jin-Oh Kim, the Research Group for Endoscopic Ultrasound of the Korean Society of Gastrointestinal Endoscopy
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Clin Endosc 2021;54(6):872-880. Published online November 18, 2021
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DOI: https://doi.org/10.5946/ce.2021.251
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- Background
/Aims: The utility of endoscopic ultrasonography (EUS) for differentiating gastrointestinal stromal tumors (GISTs) and leiomyomas of the stomach is not well known. We aimed to evaluate the ability of EUS for differentiating gastric GISTs and leiomyomas.
Methods
We retrospectively reviewed the medical records of patients with histopathologically proven GISTs (n=274) and leiomyomas (n=87). In two consensus meetings, the inter-observer variability in the EUS image analysis was reduced. Using logistic regression analyses, we selected predictive factors and constructed a predictive model and nomogram for differentiating GISTs from leiomyomas. A receiver operating characteristic (ROC) curve analysis was performed to measure the discrimination performance in the development and internal validation sets.
Results
Multivariate analysis identified heterogeneity (odds ratio [OR], 9.48), non-cardia (OR, 19.11), and older age (OR, 1.06) as independent predictors of GISTs. The areas under the ROC curve of the predictive model using age, sex, and four EUS factors (homogeneity, location, anechoic spaces, and dimpling or ulcer) were 0.916 (sensitivity, 0.908; specificity, 0.793) and 0.904 (sensitivity, 0.908; specificity, 0.782) in the development and internal validation sets, respectively.
Conclusions
The predictive model and nomogram using age, sex and homogeneity, tumor location, presence of anechoic spaces, and presence of dimpling or ulcer on EUS may facilitate differentiation between GISTs and leiomyomas.
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Citations
Citations to this article as recorded by

- Results of the interim analysis of a prospective, multicenter, observational study of small subepithelial lesions in the stomach
Masaya Iwamuro, Toshiharu Mitsuhashi, Tomoki Inaba, Kazuhiro Matsueda, Teruya Nagahara, Yoji Takeuchi, Hisashi Doyama, Masakatsu Mizuno, Tomoyuki Yada, Yoshinari Kawai, Jun Nakamura, Minoru Matsubara, Hiroko Nebiki, Keiko Niimi, Tatsuya Toyokawa, Ryuta Ta
Digestive Endoscopy.2024; 36(3): 323. CrossRef - Diagnostic Endoscopic Ultrasound (EUS) of the Luminal Gastrointestinal Tract
Giovanna Impellizzeri, Giulio Donato, Claudio De Angelis, Nico Pagano
Diagnostics.2024; 14(10): 996. CrossRef - Differential diagnosis of gastrointestinal stromal tumors versus leiomyomas by special stains
Shiwei Zhang, Pan Qin, Hongliang Ji
BMC Gastroenterology.2024;[Epub] CrossRef - Endoscopic Ultrasound Advanced Techniques for Diagnosis of Gastrointestinal Stromal Tumours
Socrate Pallio, Stefano Francesco Crinò, Marcello Maida, Emanuele Sinagra, Vincenzo Francesco Tripodi, Antonio Facciorusso, Andrew Ofosu, Maria Cristina Conti Bellocchi, Endrit Shahini, Giuseppinella Melita
Cancers.2023; 15(4): 1285. CrossRef - Endoscopic ultrasound artificial intelligence-assisted for prediction of gastrointestinal stromal tumors diagnosis: A systematic review and meta-analysis
Rômulo Sérgio Araújo Gomes, Guilherme Henrique Peixoto de Oliveira, Diogo Turiani Hourneaux de Moura, Ana Paula Samy Tanaka Kotinda, Carolina Ogawa Matsubayashi, Bruno Salomão Hirsch, Matheus Oliveira Veras, João Guilherme Ribeiro Jordão Sasso, Roberto Pa
World Journal of Gastrointestinal Endoscopy.2023; 15(8): 528. CrossRef - Prevalence, natural progression, and clinical practices of upper gastrointestinal subepithelial lesions in Korea: a multicenter study
Younghee Choe, Yu Kyung Cho, Gwang Ha Kim, Jun-Ho Choi, Eun Soo Kim, Ji Hyun Kim, Eun Kwang Choi, Tae Hyeon Kim, Seong-Hun Kim, Do Hoon Kim
Clinical Endoscopy.2023; 56(6): 744. CrossRef - Significance of Ultrasound Endoscopy in the Differential Diagnosis of Cardiac Leiomyomas and Gastrointestinal Stromal Tumors
燊 苏
Advances in Clinical Medicine.2023; 13(11): 17185. CrossRef - The Diagnosis of Small Gastrointestinal Subepithelial Lesions by Endoscopic Ultrasound-Guided Fine Needle Aspiration and Biopsy
Masanari Sekine, Takeharu Asano, Hirosato Mashima
Diagnostics.2022; 12(4): 810. CrossRef - Diagnostic accuracy of endoscopic ultrasound with artificial intelligence for gastrointestinal stromal tumors: A meta‐analysis
Xiao Hua Ye, Lin Lin Zhao, Lei Wang
Journal of Digestive Diseases.2022; 23(5-6): 253. CrossRef
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4,733
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Focused Review Series: Image-Enhanced Endoscopy: Update on Clinical Practice
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Application of Current Image-Enhanced Endoscopy in Gastric Diseases
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Wansik Lee
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Clin Endosc 2021;54(4):477-487. Published online July 28, 2021
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DOI: https://doi.org/10.5946/ce.2021.160
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- Image-enhanced endoscopy (IEE) plays an integral role in endoscopic diagnosis and treatment. IEE enables an early and accurate detection of cancer and characterization of lesions prior to therapeutic decisions. Ideal IEE can serve as an optical or digital chromoscopic endoscopy, as well as an optical biopsy that predicts exact histopathology. Several IEE modalities have recently been developed and are used in the clinical field. The stomach is a challenging organ for imaging because of its complex secretion function and status of Helicobacter pylori infection. Therefore, understanding the current IEE modalities for their clinical applicability in an evidence-based approach is warranted. Along with technology refinements, the new paradigm will be available for the diagnosis of gastric cancer or other conditions in the stomach in the near future.
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Citations
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- Correlation between White Globe Appearance and Clinicopathologic Characteristics in Early Gastric Cancer
Dae Jin Jung, Gwang Ha Kim, Kyungbin Kim, Hye Kyung Jeon, Dong Chan Joo, Moon Won Lee, Bong Eun Lee
Gut and Liver.2025; 19(1): 50. CrossRef - The Diagnostic Performance of Linked Color Imaging Compared to White Light Imaging in Endoscopic Diagnosis of Helicobacter pylori Infection: A Systematic Review and Meta-Analysis
Jae Gon Lee, In Kyung Yoo, Abdullah Ozgur Yeniova, Sang Pyo Lee
Gut and Liver.2024; 18(3): 444. CrossRef - Endoscopic appearances of gastric mucosa in different endoscopic models according to H. pylori infection status
Shinwari Abdullah Jan, Hashimi Sayed Zekria
JGH Open.2024;[Epub] CrossRef - Artificial Intelligence-Based Classification of Anatomical Sites in Esophagogastroduodenoscopy Images
Peng Yuan, Zhong-Hua Ma, Yan Yan, Shi-Jie Li, Jing Wang, Qi Wu
International Journal of General Medicine.2024; Volume 17: 6127. CrossRef - Magnifying Endoscopy with Narrow-Band Imaging for Duodenal Neuroendocrine Tumors
Gwang Ha Kim, Kiyoun Yi, Dong Chan Joo, Moon Won Lee, Hye Kyung Jeon, Bong Eun Lee
Journal of Clinical Medicine.2023; 12(9): 3106. CrossRef - Endoscopic Resection for Gastric Adenocarcinoma of the Fundic Gland Type: A Case Series
Hwa Jin Lee, Gwang Ha Kim, Dong Chan Joo, Moon Won Lee, Bong Eun Lee, Kyungbin Kim
The Korean Journal of Gastroenterology.2023; 81(6): 259. CrossRef - Detecting colorectal lesions with image-enhanced endoscopy: an updated review from clinical trials
Mizuki Nagai, Sho Suzuki, Yohei Minato, Fumiaki Ishibashi, Kentaro Mochida, Ken Ohata, Tetsuo Morishita
Clinical Endoscopy.2023; 56(5): 553. CrossRef - Role of linked color imaging for upper gastrointestinal disease: present and future
Sang Pyo Lee
Clinical Endoscopy.2023; 56(5): 546. CrossRef - Endoscopic submucosal dissection for early gastric cancer: It is time to consider the quality of its outcomes
Gwang Ha Kim
World Journal of Gastroenterology.2023; 29(43): 5800. CrossRef - Quality indicators in esophagogastroduodenoscopy
Sang Yoon Kim, Jae Myung Park
Clinical Endoscopy.2022; 55(3): 319. CrossRef - Endoscopic treatment for early gastric cancer
Ji Yong Ahn
Journal of the Korean Medical Association.2022; 65(5): 276. CrossRef - Endoscopic diagnosis of early gastric cancer
Dong Chan Joo, Gwang Ha Kim
Journal of the Korean Medical Association.2022; 65(5): 267. CrossRef - Risk factors for early gastric cancer: focus on Helicobacter pylori gastritis
Hee Seok Moon
Journal of the Korean Medical Association.2022; 65(5): 259. CrossRef - Current status of the gastric cancer screening program in Korea
Young-Il Kim, Il Ju Choi
Journal of the Korean Medical Association.2022; 65(5): 250. CrossRef - Paneth Cell Carcinoma of the Stomach
Jun Wan Kim, Gwang Ha Kim, Kyung Bin Kim
The Korean Journal of Gastroenterology.2022; 80(1): 34. CrossRef - Current Evidence for a Paradigm Shift in Gastric Cancer Prevention From Endoscopic Screening toHelicobacter pyloriEradication in Korea
Young-Il Kim, Il Ju Choi
Journal of Gastric Cancer.2022; 22(3): 169. CrossRef
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Case Report
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Successful Endoscopic Resection of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Unresponsive to Helicobacter pylori Eradication Therapy
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Jeongmin Choi
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Clin Endosc 2022;55(1):136-140. Published online November 16, 2020
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DOI: https://doi.org/10.5946/ce.2020.232
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- Eradication of Helicobacter pylori is the first-line treatment for gastric mucosa-associated lymphoid tissue (MALT) lymphomas; however, lesions may persist in 20% of patients after initial treatment, thereby necessitating the use of an additional therapeutic approach. Other treatment options include radiation therapy, chemotherapy, endoscopic resection, rituximab therapy, or watchful waiting. We present a case of localized gastric MALT lymphoma that did not respond to H. pylori eradication therapy. The patient waited for 12 months but the tumor showed no signs of regression endoscopically. Histologic examination revealed residual MALT lymphoma. The tumor was then successfully treated using endoscopic submucosal dissection and the patient remained disease-free for 4 years. To our knowledge, this is the first case in which a gastric MALT lymphoma was treated with endoscopic submucosal dissection. In conclusion, endoscopic resection may be recommended as second-line therapy for properly selected patients with gastric MALT lymphoma as it is effective and minimally invasive.
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Citations
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- A Common Symptom With an Uncommon Diagnosis: A Case of Primary Esophageal Diffuse Large B-cell Lymphoma
Shruthi Narasimha, Rasiq Zackria, Jonathan Hughes, Vijay Jayaraman
Cureus.2024;[Epub] CrossRef - A Case of Esophageal MALT Lymphoma Mimicking a Subepithelial Tumor
Ha Eun Lee, Gwang Ha Kim, Min Ji Kim, Kyung Bin Kim, Dong Chan Joo, Hye Kyung Jeon, Moon Won Lee, Bong Eun Lee
The Korean Journal of Gastroenterology.2024; 83(4): 157. CrossRef - Characteristics of Gastric Mucosa-associated Lymphoid Tissue Lymphoma in Korea
Tae-Woo Kim, Joon Sung Kim
The Korean Journal of Gastroenterology.2024; 84(6): 243. CrossRef - Clinical Management of Patients with Gastric MALT Lymphoma: A Gastroenterologist’s Point of View
Tamara Matysiak-Budnik, Kateryna Priadko, Céline Bossard, Nicolas Chapelle, Agnès Ruskoné-Fourmestraux
Cancers.2023; 15(15): 3811. CrossRef - Endoscopic Submucosal Dissection for Treatment of Localized Gastric Mucosa-associated Lymphoid Tissue Lymphoma: A Case Series
Jun-young Seo, Kee Don Choi, In Hye Song, Young Soo Park, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2023; 23(3): 188. CrossRef - Bacteria-Mediated Oncogenesis and the Underlying Molecular Intricacies: What We Know So Far
Shashanka K. Prasad, Smitha Bhat, Dharini Shashank, Akshatha C. R., Sindhu R., Pornchai Rachtanapun, Devananda Devegowda, Prasanna K. Santhekadur, Sarana Rose Sommano
Frontiers in Oncology.2022;[Epub] CrossRef - Primary Esophageal Lymphoma: Clinical Experience in Diagnosis and Treatment
Junchi Qu, Yanyan Zhuang, Dandan Zheng, Fengting Huang, Shineng Zhang
Cureus.2021;[Epub] CrossRef
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Original Articles
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Reduced Intravenous Fluorescein Dose for Upper and Lower Gastrointestinal Tract Probe-Based Confocal Laser Endomicroscopy
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Kazuya Inoki, Seiichiro Abe, Yusaku Tanaka, Koji Yamamoto, Daisuke Hihara, Ryoji Ichijima, Yukihiro Nakatani, HsinYu Chen, Hiroyuki Takamaru, Masau Sekiguchi, Masayoshi Yamada, Taku Sakamoto, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Ichiro Oda, Takahisa Matsuda, Yutaka Saito
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Clin Endosc 2021;54(3):363-370. Published online September 8, 2020
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DOI: https://doi.org/10.5946/ce.2020.058
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- Background
/Aims: Probe-based confocal laser endomicroscopy (pCLE) requires the administration of intravenous (IV) fluorescein. This study aimed to determine the optimal dose of IV fluorescein for both upper and lower gastrointestinal (GI) tract pCLE.
Methods
Patients 20 to 79 years old with gastric high-grade dysplasia (HGD) or colorectal neoplasms (CRNs) were enrolled in the study. The dose de-escalation method was employed with five levels. The primary endpoint of the study was the determination of the optimal dose of IV fluorescein for pCLE of the GI tract. The reduced dose was determined based on off-line reviews by three endoscopists. An insufficient dose of fluorescein was defined as the dose of fluorescein with which the pCLE images were not deemed to be visible. If all three endoscopists determined that the tissue structure was visible, the doses were de-escalated.
Results
A total of 12 patients with gastric HGD and 12 patients with CRNs were enrolled in the study. Doses were de-escalated to 0.5 mg/kg of fluorescein for both non-neoplastic duodenal and colorectal mucosa. All gastric HGD or CRNs were visible with pCLE with IV fluorescein at 0.5 mg/kg.
Conclusions
In the present study, pCLE with IV fluorescein 0.5 mg/kg was adequate to visualize the magnified structure of both the upper and lower GI tract.
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- Prospective assessment of probe‐based confocal laser endomicroscopy under direct cholangioscopic visualization for biliary strictures that could not be definitively diagnosed using endoscopic retrograde cholangiopancreatography (with video)
Yuki Tanisaka, Shomei Ryozawa, Masafumi Mizuide, Akashi Fujita, Ryuhei Jinushi, Ryuichi Watanabe, Ryo Sato, Tomoaki Tashima, Yumi Mashimo
DEN Open.2025;[Epub] CrossRef - Precision endoscopy in colorectal polyps' characterization and planning of endoscopic therapy
Francesco Vito Mandarino, Silvio Danese, Toshio Uraoka, Adolfo Parra‐Blanco, Yasuharu Maeda, Yutaka Saito, Shin‐Ei Kudo, Michael J. Bourke, Marietta Iacucci
Digestive Endoscopy.2024; 36(7): 761. CrossRef
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2
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2
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Efficacy of the Envelope Method in Applying Polyglycolic Acid Sheets to Post-Endoscopic Submucosal Dissection Ulcers in Living Pigs
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Hiroya Sakaguchi, Toshitatsu Takao, Yoshitaka Takegawa, Yuki Koga, Kazunori Yamanaka, Masataka Sagata, Shinwa Tanaka, Yoshinori Morita, Takashi Toyonaga, Yuzo Kodama
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Clin Endosc 2021;54(1):64-72. Published online July 16, 2020
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DOI: https://doi.org/10.5946/ce.2020.014
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Abstract
PDF
Supplementary Material
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- Background
/Aims: Application of polyglycolic acid (PGA) sheets using fibrin glue in post-endoscopic submucosal dissection (ESD) ulcers to prevent bleeding has been reported to be difficult with the conventional delivery method because of gravity. This study assessed the usefulness of the envelope-based delivery system with and against gravity in living pigs.
Methods
PGA sheets were applied on post-ESD ulcers with and against gravity six times each using the conventional and envelope methods, respectively. The PGA sheet delivery time and the endoscopic and histological findings of the treated ulcer floors were compared.
Results
With gravity, the median PGA sheet application time was 1.00 (0.68–1.30) min/cm2 and 0.32 (0.18–0.52) min/cm2 with the conventional and envelope techniques (p=0.002), respectively, and against gravity, it was 1.20 (1.13–1.63) min/cm2 and 0.50 (0.39–0.58) min/cm2 (p=0.002), respectively. Against gravity, the endoscopic and histological findings revealed that the conventional group had insufficient fixation of the PGA sheets, but the envelope groups had sufficient fixation. The results with gravity were similar between the groups.
Conclusions
The envelope method makes it possible to deliver PGA sheets to the stomach quickly and cover ulcers appropriately both with and against gravity in living pigs.
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- Endoscopic sealing hemostasis with polyglycolic acid sheet and fibrin glue as a novel endoscopic hemostatic technique: a report of three cases
Kai Korekawa, Atsushi Kunimitsu
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Congzhi Liu, Guochun Yan, Jie Gao, Haixin Guo, Qidong Hou
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Kei Matsumoto, Shinwa Tanaka, Takashi Toyonaga, Nobuaki Ikezawa, Mari Nishio, Masanao Uraoka, Tomoatsu Yoshihara, Hiroya Sakaguchi, Hirofumi Abe, Tetsuya Yoshizaki, Madoka Takao, Toshitatsu Takao, Yoshinori Morita, Hiroshi Yokozaki, Yuzo Kodama
Clinical Endoscopy.2022; 55(1): 86. CrossRef - The importance of pH adjustment for preventing fibrin glue dissolution in the stomach: an in vitro study
Yoshitaka Takegawa, Toshitatsu Takao, Hiroya Sakaguchi, Tatsuya Nakai, Kazuhiro Takeo, Yoshinori Morita, Takashi Toyonaga, Yuzo Kodama
Scientific Reports.2022;[Epub] CrossRef - A Novel Self-Assembled Gel for Gastric Endoscopic Submucosal Dissection-Induced Ulcer: A Preclinical Study in a Porcine Model
Meng Li, Haifeng Jin, Changpei Shi, Bin Lyu, Xiao Ying, Yuan Shi
Frontiers in Pharmacology.2021;[Epub] CrossRef
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Review
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Diagnosing Gastric Mesenchymal Tumors by Digital Endoscopic Ultrasonography Image Analysis
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Moon Won Lee, Gwang Ha Kim
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Clin Endosc 2021;54(3):324-328. Published online June 18, 2020
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DOI: https://doi.org/10.5946/ce.2020.061
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Abstract
PDF
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- Gastric mesenchymal tumors (GMTs) are incidentally discovered in national gastric screening programs in Korea. Endoscopic ultrasonography (EUS) is the most useful diagnostic modality for evaluating GMTs. The differentiation of gastrointestinal stromal tumors from benign mesenchymal tumors, such as schwannomas or leiomyomas, is important to ensure appropriate clinical management. However, this is difficult and operator dependent because of the subjective interpretation of EUS images. Digital image analysis computes the distribution and spatial variation of pixels using texture analysis to extract useful data, enabling the objective analysis of EUS images and decreasing interobserver and intraobserver agreement in EUS image interpretation. This review aimed to summarize the usefulness and future of digital EUS image analysis for GMTs based on published reports and our experience.
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Xian‐Da Zhang, Ling Zhang, Ting‐Ting Gong, Zhuo‐Ran Wang, Kang‐Li Guo, Jun Li, Yuan Chen, Jian‐Tao Zhang, Ben‐Gong Ye, Jin Ding, Jian‐Wei Zhu, Feng Liu, Duan‐Min Hu, JianGang Chen, Chun‐Hua Zhou, Duo‐Wu Zou
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Shotaro Okanoue, Masaya Iwamuro, Takehiro Tanaka, Takuya Satomi, Kenta Hamada, Hiroyuki Sakae, Makoto Abe, Yoshiyasu Kono, Hiromitsu Kanzaki, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada
Medicine.2021; 100(40): e27520. CrossRef
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Focused Review Series: Recent Update of Endoscopic Ultrasonography in Gastrointestinal Subepithelial Tumors
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Endoscopic Ultrasound-Guided Fine Needle Aspiration and Biopsy in Gastrointestinal Subepithelial Tumors
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Gyu Young Pih, Do Hoon Kim
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Clin Endosc 2019;52(4):314-320. Published online July 30, 2019
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DOI: https://doi.org/10.5946/ce.2019.100
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Abstract
PDF
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- The incidence of asymptomatic and incidentally found upper gastrointestinal subepithelial tumors (SETs) is increasing with the implementation of national cancer screening and the development of high-resolution endoscopy in Korea. However, endoscopy alone cannot be used to determine whether SETs are benign or malignant. Endoscopic ultrasound (EUS) is used to further characterize these lesions through the examination of their layered structure, internal echogenicity, size, and relationship to the extramural structure. These provide additional information on whether the lesion is benign or malignant. Nevertheless, the sensitivity and specificity of EUS alone in predicting malignancy is unsatisfactory. Recent guidelines have recommended deciding the timing of EUS-fine needle aspiration and biopsy (EUS-FNA/B) for SETs based on tumor size, malignant features on endoscopy, and high-risk features on EUS. The diagnostic accuracy of EUS-FNA/B is reportedly influenced by factors including needle size, number of needle passes, use of suction, use of a stylet in the needle assembly, fanning technique, availability of an on-site cytopathologist, and experience of the endosonographer. Therefore, according to the characteristics of the SETs, various subsequent methods and techniques should be appropriately employed to improve the diagnostic yield of EUS-FNA/B.
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Focused Review Series: Endoscopic Submucosal Dissection for Undifferentiated-Type Early Gastric Cancer
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Strategy for Curative Endoscopic Resection of Undifferentiated-Type Early Gastric Cancer
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Jie-Hyun Kim
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Clin Endosc 2019;52(1):9-14. Published online January 24, 2019
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DOI: https://doi.org/10.5946/ce.2018.199
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Abstract
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- Endoscopic resection (ER) of undifferentiated-type early gastric cancer (UD-EGC) has a lower curative resection (CR) rate than differentiated-type EGC. However, if UD-EGC is curatively resected using ER, long-term outcomes can be favorable. Thus, the strategy for CR by ER is important in UD-EGC. To achieve CR in UD-EGC, biological behaviors including tumor growth patterns must be considered. This review aims to describe what is important for curative ER of UD-EGC.
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Jie-Hyun Kim, Young-Il Kim, Ji Yong Ahn, Woon Geon Shin, Hyo-Joon Yang, Su Youn Nam, Byung-Hoon Min, Jae-Young Jang, Joo Hyun Lim, Wan Sik Lee, Bong Eun Lee, Moon Kyung Joo, Jae Myung Park, Hang Lak Lee, Tae-Geun Gweon, Moo In Park, Jeongmin Choi, Chung H
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Jie-Hyun Kim
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Raquel Ortigão, Diogo Libânio, Mário Dinis‐Ribeiro
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Eun Jeong Gong, Chang Seok Bang
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Chang Seok Bang, Ji Yong Ahn, Jie-Hyun Kim, Young-Il Kim, Il Ju Choi, Woon Geon Shin
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Si Hyung Lee, Min Cheol Kim, Seong Woo Jeon, Kang Nyeong Lee, Jong Jae Park, Su Jin Hong
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Original Article
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Magnified Endoscopic Findings of Multiple White Flat Lesions: A New Subtype of Gastric Hyperplastic Polyps in the Stomach
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Rino Hasegawa, Kenshi Yao, Shoutomi Ihara, Masaki Miyaoka, Takao Kanemitsu, Kenta Chuman, Go Ikezono, Akikazu Hirano, Toshiharu Ueki, Hiroshi Tanabe, Atsuko Ota, Seiji Haraoka, Akinori Iwashita
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Clin Endosc 2018;51(6):558-562. Published online November 21, 2018
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DOI: https://doi.org/10.5946/ce.2018.104
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Abstract
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- Background
/Aims: While the occurrence of multiple whitish flat elevated lesions (MWFL) was first reported in 2007, no studies on MWFL have been published to date. The present retrospective observational study aimed to clarify the endoscopic findings and clinicopathological features of MWFL.
Methods
Subjects were consecutive patients who underwent upper gastrointestinal endoscopy as part of routine screening between April 2014 and March 2015. The conventional white-light, non-magnifying and magnifying narrow-band images were reviewed. Clinical features were compared between patients with and without MWFL.
Results
The conventional endoscopic findings of MWFL include multiple whitish, flat, and slightly elevated lesions of various sizes, mainly located in the gastric body and fundus. Narrow-band imaging enhanced the contrast of MWFL and background mucosa, and magnifying narrow-band imaging depicted a uniformly long, narrow, and elliptical marginal crypt epithelium with an unclear microvascular pattern. Histopathological findings revealed hyperplastic changes of the foveolar epithelium, and parietal cell protrusions and oxyntic gland dilatations were observed in the fundic glands, without any intestinal metaplasia. The rate of acid-reducing drug use was significantly higher in patients with MWFL than in those without (100% [13/13] vs. 53.7% [88/164], p<0.001).
Conclusions
The present study indicated a relationship between the presence and endoscopic features of MWFL and history of acidreducing drug use.
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- Endoscopic findings and outcomes of gastric mucosal changes relating to potassium‐competitive acid blocker and proton pump inhibitor therapy
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Hiroto Noda, Mitsuru Kaise, Ryuichi Wada, Eriko Koizumi, Kumiko Kirita, Kazutoshi Higuchi, Jun Omori, Teppei Akimoto, Osamu Goto, Hiroshi Kawachi, Katsuhiko Iwakiri, Sanjiv Mahadeva
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Gwang Ha Kim
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Matthew Banks, David Graham, Marnix Jansen, Takuji Gotoda, Sergio Coda, Massimiliano di Pietro, Noriya Uedo, Pradeep Bhandari, D Mark Pritchard, Ernst J Kuipers, Manuel Rodriguez-Justo, Marco R Novelli, Krish Ragunath, Neil Shepherd, Mario Dinis-Ribeiro
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Focused Review Series: Current Status of Image-Enhanced Endoscopy (IEE)
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Usefulness of Narrow-Band Imaging in Endoscopic Submucosal Dissection of the Stomach
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Jung-Wook Kim
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Clin Endosc 2018;51(6):527-533. Published online November 19, 2018
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DOI: https://doi.org/10.5946/ce.2018.186
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Abstract
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- There have been many advances in endoscopic imaging technologies. Magnifying endoscopy with narrow-band imaging is an innovative optical technology that enables the precise discrimination of structural changes on the mucosal surface. Several studies have demonstrated its usefulness and superiority for tumor detection and differential diagnosis in the stomach as compared with conventional endoscopy. Furthermore, magnifying endoscopy with narrow-band imaging has the potential to predict the invasion depth and tumor margins during gastric endoscopic submucosal dissection. Classifications of the findings of magnifying endoscopy with narrow-band imaging based on microvascular and pit patterns have been proposed and have shown excellent correlations with invasion depth confirmed by microscopy. In terms of tumor margin prediction, magnifying endoscopy with narrow-band imaging offers superior delineation of gastric tumor margins compared with traditional chromoendoscopy with indigo carmine. The limitations of narrow-band imaging, such as the need for considerable training, long procedure time, and lack of studies about its usefulness in undifferentiated cancer, should be resolved to confirm its value as a complementary method to endoscopic submucosal dissection. However, the role of magnifying endoscopy with narrow-band imaging is expected to increase steadily with the increasing use of endoscopic submucosal dissection for the treatment of gastric tumors.
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World Journal of Gastrointestinal Endoscopy.2024; 16(3): 157. CrossRef - Effectiveness of serological markers of gastric mucosal atrophy in the gastric precancer screening and in cancer prevention
Sergey M Kotelevets, Sergey A Chekh, Sergey Z Chukov
World Journal of Gastrointestinal Endoscopy.2024; 16(8): 462. CrossRef - Identification of gastric cancer with convolutional neural networks: a systematic review
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Dong Chan Joo, Gwang Ha Kim
Journal of the Korean Medical Association.2022; 65(5): 267. CrossRef - NBI utility in oncologic surgery: An organ by organ review
Francesca Boscolo Nata, Giancarlo Tirelli, Vincenzo Capriotti, Alberto Vito Marcuzzo, Erica Sacchet, Azzurra Nicole Šuran-Brunelli, Nicolò de Manzini
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Andrew Canakis, Raymond Kim
Gastrointestinal Endoscopy Clinics of North America.2021; 31(3): 543. CrossRef - Recent advances in diagnostic upper endoscopy
Jun-Liang Teh, Asim Shabbir, Soon Yuen, Jimmy Bok-Yan So
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Jung‐Wook Kim, Yunho Jung, Jae‐Young Jang, Gwang Ha Kim, Byoung Wook Bang, Jun Chul Park, Hyuk Soon Choi, Jun‐Hyung Cho
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Focused Review Series: Updates on endoscopic bariatric and metabolic therapies
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Experimental Gastric Non-Balloon Devices
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Youn I Choi, Kyoung Oh Kim
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Clin Endosc 2018;51(5):420-424. Published online September 27, 2018
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DOI: https://doi.org/10.5946/ce.2018.150
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Abstract
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- Endoscopic bariatric therapies (EBTs) are promising alternatives to the conventional surgeries used to treat obesity and related metabolic conditions, targeting gastrointestinal anatomical and physiological processes. Many EBTs are at various stages of development and are aimed at promoting an early sense of satiety via anatomical and physiological mechanisms. In the present study, we focused on relevant clinical issues and future perspectives with regard to gastric non-balloon methods treating obesity.
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- Repeated photodynamic therapy using a chlorin e6‐embedded device to prolong the therapeutic effects on obesity
Jung‐Hoon Park, Ji Won Kim, Dae Sung Ryu, Hyeonseung Lee, Hee Kyong Na, Jin Hee Noh, Do Hoon Kim, Sanghee Lee, Kun Na, Hwoon‐Yong Jung
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Ji Won Kim, Sanghee Lee, Dae Sung Ryu, Jinhwan Park, Hyeonseung Lee, Hee Kyong Na, Jin Hee Noh, Do Hoon Kim, Jung-Hoon Park, Hwoon-Yong Jung, Kun Na
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Sanghee Lee, Ji Won Kim, Jinhwan Park, Hee Kyong Na, Do Hoon Kim, Jin Hee Noh, Dae Sung Ryu, Jae Myung Park, Jung-Hoon Park, Hwoon-Yong Jung, Kun Na
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Adrian Goldis, Ramona Goldis, Traian V. Chirila
Medicina.2019; 55(11): 734. CrossRef
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Focused Review Series: Updates on Capsule Endoscopy from Esophagus to Colon
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Evaluation of Gastric Disease with Capsule Endoscopy
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Seung-Joo Nam, Hyun Seok Lee, Yun Jeong Lim
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Clin Endosc 2018;51(4):323-328. Published online July 31, 2018
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DOI: https://doi.org/10.5946/ce.2018.092
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Abstract
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- The clinical indication for capsule endoscopy has expanded from small bowel evaluation to include esophagus or colon evaluation.Nevertheless, the role of capsule endoscopy in evaluation of the stomach is very limited because of the large volume and surface.However, efforts to develop an active locomotion system for capsule manipulation in detailed gastric evaluation are ongoing, becausethe technique is non-invasive, convenient, and safe, and requires no sedation. Studies have successfully reported gastric evaluation usinga magnetic-controlled capsule endoscopy system. Advances in technology suggest that capsule endoscopy will have a major role notonly in the evaluation of gastric disorders but also in the pathologic diagnosis, intervention, and treatment of any gastrointestinal tractdisorder.
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- Magnetic Navigation System Composed of Dual Permanent Magnets for Accurate Position and Posture Control of a Capsule Endoscope
Seunguk Kim, Suhong Bae, Wonseo Lee, Gunhee Jang
IEEE Transactions on Industrial Electronics.2024; 71(1): 739. CrossRef - Performance evaluation and future prospects of capsule robot localization technology
Yan Xu, Peng Zhang, Lei Wang, You Li, Bin Luo, Yue Yu, Ruizhi Chen
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Sophia V. Hoffmann, Joseph P. O'Shea, Paul Galvin, Vincent Jannin, Brendan T. Griffin
European Journal of Pharmaceutical Sciences.2024; 203: 106911. CrossRef - State of the Art on Advancements in Wireless Capsule Endoscopy Telemetry: A Systematic Approach
Sara Fontana, Simona D’Agostino, Alessandra Paffi, Paolo Marracino, Marco Balucani, Giancarlo Ruocco, Salvatore Maria Aglioti, Francesca Apollonio, Micaela Liberti
IEEE Open Journal of Antennas and Propagation.2024; 5(5): 1282. CrossRef - The role of the colonic capsule in the diagnosis of pathological changes in the small intestine and colon
E. V. Ivanova, O. V. Ivinskaya, E. D. Fedorov
Filin’s Clinical endoscopy.2024; 65(4): 25. CrossRef - Upper gastrointestinal video capsule endoscopy: The state of the art
Apostolis Papaefthymiou, Apostolos Koffas, Faidon-Marios Laskaratos, Owen Epstein
Clinics and Research in Hepatology and Gastroenterology.2022; 46(3): 101798. CrossRef - Computer-Aided Diagnosis of Gastrointestinal Protruded Lesions Using Wireless Capsule Endoscopy: A Systematic Review and Diagnostic Test Accuracy Meta-Analysis
Hye Jin Kim, Eun Jeong Gong, Chang Seok Bang, Jae Jun Lee, Ki Tae Suk, Gwang Ho Baik
Journal of Personalized Medicine.2022; 12(4): 644. CrossRef - First prospective European study for the feasibility and safety of magnetically controlled capsule endoscopy in gastric mucosal abnormalities
Milán Szalai, Krisztina Helle, Barbara Dorottya Lovász, Ádám Finta, András Rosztóczy, László Oczella, László Madácsy
World Journal of Gastroenterology.2022; 28(20): 2227. CrossRef - Proton pump inhibitor in the prevention of upper gastrointestinal mucosal injury associated with dual antiplatelet therapy after coronary artery bypass grafting (DACAB-GI-2): study protocol for a randomized controlled trial
Yunpeng Zhu, Xiaojin Wang, Yi Yang, Lei Liu, Qiang Zhao, Lifen Yu
Trials.2022;[Epub] CrossRef - 10.07uW Multi-Mode Baseband Transceiver for Encrypted Capsule Endoscopy
Jung Hyun Bae, Myung Hoon Sunwoo
Journal of Signal Processing Systems.2021; 93(1): 25. CrossRef - Novel Clinical Applications and Technical Developments in Video Capsule Endoscopy
Shahrad Hakimian, Mark Hanscom, David R. Cave
Gastrointestinal Endoscopy Clinics of North America.2021; 31(2): 399. CrossRef - Modular Capsules with Assembly and Separation Mechanism: Proof of Concept
Zhenyu Li, Manh Cuong Hoang, Chang-Sei Kim, Eunpyo Choi, Doyeon Bang, Jong-Oh Park, Byungjeon Kang
Actuators.2021; 10(7): 159. CrossRef - Examination of Entire Gastrointestinal Tract: A Perspective of Mouth to Anus (M2A) Capsule Endoscopy
Ji Hyung Nam, Kwang Hoon Lee, Yun Jeong Lim
Diagnostics.2021; 11(8): 1367. CrossRef - Capsule Endoscopy: Pitfalls and Approaches to Overcome
Seung Han Kim, Hoon Jai Chun
Diagnostics.2021; 11(10): 1765. CrossRef - Capsule Endoscopy for Gastric Evaluation
Ji-Hyun Kim, Seung-Joo Nam
Diagnostics.2021; 11(10): 1792. CrossRef - Gastric examination using a novel three-dimensional magnetically assisted capsule endoscope and a hand-held magnetic controller: A porcine model study
Dong Jun Oh, Ji Hyung Nam, Junseok Park, Youngbae Hwang, Yun Jeong Lim, Edoardo Sinibaldi
PLOS ONE.2021; 16(10): e0256519. CrossRef - Medical Microrobot — A Drug Delivery Capsule Endoscope with Active Locomotion and Drug Release Mechanism: Proof of Concept
Kim Tien Nguyen, Manh Cuong Hoang, Eunpyo Choi, Byungjeon Kang, Jong-Oh Park, Chang-Sei Kim
International Journal of Control, Automation and Systems.2020; 18(1): 65. CrossRef - A New Active Locomotion Capsule Endoscopy under Magnetic Control and Automated Reading Program
Dong Jun Oh, Kwang Seop Kim, Yun Jeong Lim
Clinical Endoscopy.2020; 53(4): 395. CrossRef - Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia
Marie E. Faughnan, Johannes J. Mager, Steven W. Hetts, Valerie A. Palda, Kelly Lang-Robertson, Elisabetta Buscarini, Erik Deslandres, Raj S. Kasthuri, Andrea Lausman, David Poetker, Felix Ratjen, Mark S. Chesnutt, Marianne Clancy, Kevin J. Whitehead, Hann
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Philip Daniel, Surinder Singh Rana
Journal of Digestive Endoscopy.2020; 11(03): 228. CrossRef - Fundamentals of the gut for capsule engineers
Lavinia Barducci, Joseph C Norton, Sunandita Sarker, Sayeed Mohammed, Ryan Jones, Pietro Valdastri, Benjamin S Terry
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Min-Cheol Kim, Eui-Sun Kim, Jong-Oh Park, Eunpyo Choi, Chang-Sei Kim
Sensors.2020; 20(20): 5728. CrossRef
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Case Reports
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Primary Gastric Small Cell Carcinoma: A Case Identified as a Large Subepithelial Tumor from Invisible State in 6 Months
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Yun Im Lee, Hong Kil Jeon, Jae Wook Im, Sang Yu Oh, Kyung Bin Kim, Byunggyu Kim
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Clin Endosc 2019;52(1):76-79. Published online July 6, 2018
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DOI: https://doi.org/10.5946/ce.2018.062
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- Primary gastric small cell carcinoma (GSCC) is one of the gastroenteropancreatic neuroendocrine tumors. It is a rare cancer with a very aggressive behavior and a poor prognosis because of the high rate of metastases. It is usually found in far advanced stage. We experienced a case of GSCC which had developed into a large subepithelial tumor (SET) from invisible state in a short period. A 65-year-old man consulted our hospital because of early gastric cancer. He underwent endoscopic submucosal dissection for the early gastric cancer at high body posterior wall. After 6 months, the follow-up endoscopy showed a large newly developed SET-like lesion with central ulceration at the gastric cardia. Endoscopic biopsy revealed GSCC. Total gastrectomy was performed. One out of the 26 perigastric lymph nodes had a metastasis. He received 6 cycles of adjuvant chemotherapy with etoposide and cisplatin. He is still in good health 12 months after operation.
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Citations
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- Metastatic Small Cell Carcinoma of the Stomach
Mirac Gunay, Celia Leone, Oksana Albayati, Abdalla Mohamed, Nnaemeka Anyadike
ACG Case Reports Journal.2024; 11(10): e01540. CrossRef - Lysyl oxidase and hypoxia-inducible factor 1α: biomarkers of gastric cancer
Ya-Lin Han, Li Chen, Rui Qin, Guan-Qing Wang, Xiao-Hua Lin, Guang-Hai Dai
World Journal of Gastroenterology.2019; 25(15): 1828. CrossRef
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5,440
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128
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2
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Gastric Ulceration and Bleeding with Hemodynamic Instability Caused by an Intragastric Balloon for Weight Loss
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Larrite Reed, Hawa Edriss, Kenneth Nugent
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Clin Endosc 2018;51(6):584-586. Published online June 1, 2018
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DOI: https://doi.org/10.5946/ce.2018.038
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Abstract
PDF
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- Obesity in the United States is a medical crisis with many people attempting to lose weight with caloric restriction. Some patients choose minimally invasive weight loss solutions, such as intragastric balloon systems. These balloon systems were approved by the Federal Drug Administration (FDA) in 2015–2016 and have been considered safe, with minimal side effects. We report a patient with a two-day history of melena, abdominal pain, hypotension, and syncope which developed five months after placement of an intragastric balloon. Esophagogastroduodenoscopy with balloon removal revealed a small 8-mm gastric ulcer in the incisura. This gastric ulcer probably developed secondary to mechanical compression of the stomach mucosa by the gastric balloon which contained 900 mL of saline. The FDA is now investigating five deaths since 2016 associated with these second-generation balloons. Clinicians should be aware of these complications when evaluating patients with gastrointestinal complications, such as bleeding.
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- Prediction Factors of Early Postoperative Bleeding after Bariatric Surgery
Mahdieh Golzarand, Karamollah Toolabi, Reza Parsaei
Obesity Surgery.2022; 32(7): 1. CrossRef - Clinical follow-up on weight loss, glycemic control, and safety aspects of 24 months of duodenal-jejunal bypass liner implantation
B. Betzel, M. I. Cooiman, E. O. Aarts, I. M. C. Janssen, P. J. Wahab, M. J. M. Groenen, J. P. H. Drenth, F. J. Berends
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Sindhura Kolli, Andrew Ofosu, Harini Gurram, Simcha Weissman, Paul Khoi Dang‐Ho, Tej I. Mehta, Hailie Gill, Krishna C. Gurram
Clinical Case Reports.2020; 8(11): 2116. CrossRef
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5,036
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3
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3
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Original Articles
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Factors Affecting Endoscopic Curative Resection of Gastric Cancer in the Population-Based Screening Era
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Yoon Gwon Mun, Myung-Gyu Choi, Chul-Hyun Lim, Han Hee Lee, Dong Hoon Kang, Jae Myung Park, Kyo Young Song
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Clin Endosc 2018;51(5):478-484. Published online June 1, 2018
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DOI: https://doi.org/10.5946/ce.2018.006
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Abstract
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- Background
/Aims: Since population-based screening for gastric cancer in Korea was implemented, endoscopic treatment of early gastric cancer has become increasingly popular. This study investigates factors affecting endoscopic curative resection of early gastric cancer in population-based screening for gastric cancer.
Methods
We retrospectively reviewed data of patients with newly diagnosed gastric cancer who underwent treatment at Seoul St. Mary’s Hospital. All patients completed questionnaires about clinical information, including interval between surveillance tests for gastric cancer.
Results
Of 469 gastric cancer patients, 147 (31.3%) had undergone curative endoscopic resection, 260 (55.4%) had undergone curative surgical resection, and 62 (13.3%) underwent non-curative resection or were in an inoperable state. Patients with curative endoscopic resection had fewer alarm symptoms/signs than other groups. In multivariate analysis, regular surveillance endoscopy was the only factor predicting curative endoscopic resection (odds ratio [OR], 6.099; 95% confidence interval [CI], 2.532–14.933). In addition, patients undergoing gastric cancer screening had a significantly higher rate of endoscopic curative resection compared with subjects who had never been screened. (1-year interval: OR, 49.969; 95% CI, 6.340–393.827, 2-year interval: OR, 15.283; 95% CI, 1.833–127.406, over 2-year interval: OR, 10.651; 95% CI, 1.248–90.871). Shorter screening test intervals were associated with higher rates of endoscopic curative resection.
Conclusions
Regular surveillance testing was the independent factor predicting curative endoscopic resection of gastric cancer.
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- A model established using marital status and other factors from the Surveillance, Epidemiology, and End Results database for early stage gastric cancer
Lixiang Zhang, Baichuan Zhou, Panquan Luo, Aman Xu, Wenxiu Han, Zhijian Wei
Journal of Investigative Medicine.2022; 70(6): 1373. CrossRef - Risk Factors and Clinical Outcomes of Non-Curative Resection in Patients with Early Gastric Cancer Treated with Endoscopic Submucosal Dissection: A Retrospective Multicenter Study in Korea
Si Hyung Lee, Min Cheol Kim, Seong Woo Jeon, Kang Nyeong Lee, Jong Jae Park, Su Jin Hong
Clinical Endoscopy.2020; 53(2): 196. CrossRef - The More, the Better: Is This True in Endoscopy for Gastric Cancer Screening?
Seong Woo Jeon
Clinical Endoscopy.2018; 51(5): 402. CrossRef
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Characteristics of Synchronous and Metachronous Multiple Gastric Tumors after Endoscopic Submucosal Dissection of Early Gastric Neoplasm
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Hyun Jik Lee, Yoo Jin Lee, Ju Yup Lee, Eun Soo Kim, Woo Jin Chung, Byoung Kuk Jang, Kyung Sik Park, Jae Seok Hwang, Kwang Bum Cho
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Clin Endosc 2018;51(3):266-273. Published online April 6, 2018
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DOI: https://doi.org/10.5946/ce.2017.109
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Abstract
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- Background
/Aims: Endoscopic submucosal dissection (ESD) has been widely accepted as a method of treatment of early gastric tumor. This study aimed to identify the incidence and characteristics of multiple gastric tumors after ESD.
Methods
Patients with early gastric tumors who were treated by ESD from January 2004 to June 2012 and followed up with endoscopic examination periodically for at least 1 year were enrolled. All multiple gastric lesions were subsequently treated with ESD and the medical records of the patients were retrospectively reviewed.
Results
In total, 643 patients were included. The mean duration of endoscopic follow-up was 45.27±27.59 (range, 12–148) months. Overall, 144 patients (22.4%) showed multiple gastric tumors during the follow-up period (44 synchronous [6.8%] and 100 metachronous [15.5%]). The cumulative incidence rate steadily increased during the follow-up period. More than 50% of the tumors that developed at the same longitudinal location of the stomach were of the same macroscopic and histological type as the primary lesions.
Conclusions
Because synchronous and/or metachronous gastric tumors are common, considerable attention should be paid to detect multiple gastric lesions after ESD of early gastric neoplasm.
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Yudai Chen, Chaoying Fang, Jianmin Huang, Hui Pan, Liping He, Chenlin Zhuang, Xiaoling Zheng
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Yudai Chen, Liping He, Xiaoling Zheng
Medicine.2023; 102(49): e36439. CrossRef - Risk factors for gastric metachronous lesions after endoscopic or surgical resection: a systematic review and meta-analysis
Raquel Ortigão, Gonçalo Figueirôa, Leonardo Frazzoni, Pedro Pimentel-Nunes, Cesare Hassan, Mário Dinis-Ribeiro, Lorenzo Fuccio, Diogo Libânio
Endoscopy.2022; 54(09): 892. CrossRef - Endoscopic diagnosis of early gastric cancer
Dong Chan Joo, Gwang Ha Kim
Journal of the Korean Medical Association.2022; 65(5): 267. CrossRef - Clinical outcomes of metachronous recurrence of gastric epithelial neoplasia based on Helicobacter pylori infection status and microsatellite stability
Yeon-Ji Kim, Jaeyoung Kim, Woo Chul Chung
The Korean Journal of Internal Medicine.2022; 37(4): 768. CrossRef - Diagnosis and clinical implication of collision gastric adenocarcinomas: a case report
Hiromitsu Imataki, Hideo Miyake, Hidemasa Nagai, Yuichiro Yoshioka, Norihiro Yuasa, Junichi Takamizawa, Ayami Kiriyama, Masahiko Fujino
Surgical Case Reports.2022;[Epub] CrossRef - Long-term outcomes and clinical safety of expanded indication early gastric cancer treated with endoscopic submucosal dissection versus surgical resection: a meta-analysis
Xing Xu, Guoliang Zheng, Na Gao, Zhichao Zheng
BMJ Open.2022; 12(12): e055406. CrossRef - Editors' Choice of Noteworthy Clinical Endoscopy Publications in the First Decade
Gwang Ha Kim, Kwang An Kwon, Do Hyun Park, Jimin Han
Clinical Endoscopy.2021; 54(5): 633. CrossRef - A predictive risk‐scoring model for multiple synchronous early gastric cancers or gastric dysplasia before initial endoscopic resection
Shan Shan Xu, Ning Li Chai, Xiao Wei Tang, En Qiang Linghu, Sha Sha Wang, Xiu Xue Feng, Bao Li
Journal of Digestive Diseases.2021; 22(11): 637. CrossRef - Characteristics of metachronous gastric neoplasms after curative endoscopic submucosal dissection for early gastric neoplasms
Shan-Shan Xu, Ning-Li Chai, Xiao-Wei Tang, En-Qiang Linghu, Sha-Sha Wang, Bao Li
Chinese Medical Journal.2021; 134(21): 2603. CrossRef - Long-term outcomes of patients with gastric adenoma in Korea
Tae Young Park, Su Jin Jeong, Tae Hyung Kim, Jin Lee, Jongha Park, Tae Oh Kim, Yong Eun Park
Medicine.2020; 99(12): e19553. CrossRef - Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer
Jue Lie Kim, Sang Gyun Kim, Jung Kim, Jae Yong Park, Hyo-Joon Yang, Hyun Ju Kim, Hyunsoo Chung
Gut and Liver.2020; 14(2): 190. CrossRef - Risk of multiple early gastric cancers in a patient with precursor lesions and endoscopic surveillance for 7 years
Hui Pan, Chaoying Fang, Liping He, Houqiang Li, Lanzai Liu, Chao Wang, Jiansu Chen
Medicine.2019; 98(22): e15686. CrossRef - Assessment of Endoscopic Gastric Atrophy according to the Kimura-Takemoto Classification and Its Potential Application in Daily Practice
Duc Trong Quach, Toru Hiyama
Clinical Endoscopy.2019; 52(4): 321. CrossRef - Common Locations of Gastric Cancer: Review of Research from the Endoscopic Submucosal Dissection Era
Su Jin Kim, Cheol Woong Choi
Journal of Korean Medical Science.2019;[Epub] CrossRef - Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of a Gastric Neoplasm
A Reum Choe, Ki-Nam Shim, Tae Oh Kim, Sang Yoon Kim, Jiyoung Lim, Chung Hyun Tae, Chang Mo Moon, Seong-Eun Kim, Hye-Kyung Jung, Sung-Ae Jung
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2019; 19(3): 184. CrossRef - Immunohistochemical Expression of Epithelial-Mesenchymal Transition Markers in Early Gastric Cancer: Cancer Tissue versus Noncancer Tissue
Hee Jae Jung, Su Jin Hong, Shin Hee Kim
Clinical Endoscopy.2019; 52(5): 464. CrossRef - Effectiveness of Autologous Platelet-Rich Plasma for the Healing of Ulcers after Endoscopic Submucosal Dissection
Eunju Jeong, In kyung Yoo, Ozlem Ozer Cakir, Hee Kyung Kim, Won Hee Kim, Sung Pyo Hong, Joo Young Cho
Clinical Endoscopy.2019; 52(5): 472. CrossRef - Clinical Implications of Synchronous and Metachronous Multiple Gastric Tumors after Endoscopic Resection of Gastric Neoplasms
Cheol Min Shin
Clinical Endoscopy.2018; 51(3): 209. CrossRef - Characteristics of overlooked synchronous gastric epithelial neoplasia after endoscopic submucosal dissection
Hyeong Seok Nam, Hyung Wook Kim, Cheol Woong Choi, Dae Hwan Kang, Su Bum Park, Su Jin Kim, Jung Sik Choi
Medicine.2018; 97(39): e12536. CrossRef
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Case Report
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Stomach Perforation Caused by Ingesting Liquid Nitrogen: A Case Report on the Effect of a Dangerous Snack
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Dong-Wook Kim
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Clin Endosc 2018;51(4):381-383. Published online March 5, 2018
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DOI: https://doi.org/10.5946/ce.2017.178
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Abstract
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- We report our experience with a case of stomach perforation after accidental ingestion of liquid nitrogen. A 13-year-old boy ate a snack at an amusement park and began to complain of sudden onset of severe abdominal pain with shortness of breath. It was determined that the snack he had ingested had been cooled with liquid nitrogen. A computed tomography scan of the abdomen and a chest X-ray showed a large volume of pneumoperitoneum. During surgery, a 4-cm perforation of the angularis incisura of the stomach was identified. Primary repair and omentopexy was performed. The patient was discharged without postoperative complications.
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Soma Nakaso, Shimpei Ono, Kevin C Chung, Rei Ogawa
Journal of Burn Care & Research.2024; 45(5): 1325. CrossRef - Gastric Perforation by Smoking Biscuits: Report of a Case
Abhishek Mishra, Ashirbad Panda, Laxminarayan Mohanty, Mohammad Ibrarullah
Indian Journal of Surgery.2023; 85(3): 630. CrossRef - Liquid Nitrogen Applied at Point of Sale
Victoria A. Pinilla Escobar, Caroline J. Granger, Anthony R. Hogan, Chad M. Thorson, Eduardo A. Perez, Juan E. Sola, Ann-Christina Brady
Pediatric Emergency Care.2022; 38(1): e85. CrossRef
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Original Articles
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Non-Exposure Endoscopic-Laparoscopic Cooperative Surgery for Stomach Tumors: First Experience from the Czech Republic
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Jan Hajer, Lukáš Havlůj, Adam Whitley, Robert Gürlich
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Clin Endosc 2018;51(2):167-173. Published online January 4, 2018
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DOI: https://doi.org/10.5946/ce.2017.076
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Abstract
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- Background
/Aims: The aim of this study was to investigate the use of non-exposure endoscopic wall-inversion surgery (NEWS) and the combination of laparoscopic and endoscopic approaches to neoplasia with non-exposure technique (CLEAN-NET) in gastric tumors.
Methods
We reviewed all cases of NEWS and CLEAN-NET performed in the department of surgery of the Royal Vinohrady Teaching Hospital.
Results
Our department performed 12 gastric tumor resections (NEWS, n=10 and CLEAN-NET, n=2) between March 2016 and February 2017. The cases chosen for these resections included predominantly submucosal tumors with no signs of dissemination or local invasion and early gastric carcinomas (T1SM1 and T1M), where tumor location made it impossible to use endoscopic submucosal dissection. R0 resection margins were confirmed in all the cases.
Conclusions
NEWS and CLEAN-NET allow en bloc non-exposed full-thickness gastric wall resection in a way that uses a “close first, cut later” approach to prevent seeding of the peritoneal cavity with tumor cells. These mini-invasive techniques combine laparoscopic and endoscopic techniques, and preserve the full function of the stomach.
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Citations
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- Pure endoscopic resection versus laparoscopic assisted procedure for upper gastrointestinal stromal tumors: Perspective from a surgical endoscopist
Hon Chi Yip, Jun Liang Teh, Anthony Y. B. Teoh, Philip Chiu
Digestive Endoscopy.2023; 35(2): 184. CrossRef - Advances of endoscopic and surgical management in gastrointestinal stromal tumors
Lei Yue, Yingchao Sun, Xinjie Wang, Weiling Hu
Frontiers in Surgery.2023;[Epub] CrossRef - Laparoscopic and endoscopic cooperative surgery for early gastric cancer: Perspective for actual practice
Peng-yue Zhao, Zhao-fu Ma, Ya-nan Jiao, Yang Yan, Song-yan Li, Xiao-hui Du
Frontiers in Oncology.2022;[Epub] CrossRef - The techniques of hybrid laparo-endoscopic resections for non-epithelial gastric tumors
S.V. Dzhantukhanova, Yu.G. Starkov, R.D. Zamolodchikov, A.A. Zvereva, P.K. Kontorshchikov
Endoskopicheskaya khirurgiya.2021; 27(4): 47. CrossRef - Editors' Choice of Noteworthy Clinical Endoscopy Publications in the First Decade
Gwang Ha Kim, Kwang An Kwon, Do Hyun Park, Jimin Han
Clinical Endoscopy.2021; 54(5): 633. CrossRef - CLEAN-NET: a modified laparoendoscopic wedge resection of the stomach to minimize the sacrifice of innocent gastric wall
Eiji Kanehira, Aya Kamei Kanehira, Takashi Tanida, Kodai Takahashi, Yuichi Obana, Kazunori Sasaki
Surgical Endoscopy.2020; 34(1): 290. CrossRef - Clinical outcomes of non-exposed endoscopic wall-inversion surgery for gastric submucosal tumors: long-term follow-up and functional results
Junya Aoyama, Osamu Goto, Hirofumi Kawakubo, Shuhei Mayanagi, Kazumasa Fukuda, Tomoyuki Irino, Rieko Nakamura, Norihito Wada, Hiroya Takeuchi, Naohisa Yahagi, Yuko Kitagawa
Gastric Cancer.2020; 23(1): 154. CrossRef - Application of NOTES combined with ESD for the treatment of an exogenous gastric stromal tumor: A case report and review of the literature
Xiao-Bo Liu, Zi-Ye Gao, Sandeep Pandey, Bao-Zhen Shan, Ping Liu, Chuan-Tao Sun, Sheng-Bao Li, Shu Jin
World Academy of Sciences Journal.2020;[Epub] CrossRef - Comparison of Nonexposed Endoscopic Wall-Inversion Surgery with Endoscopic-Navigated Laparoscopic Wedge Resection for Gastric Submucosal Tumours: Results of a Two-Centre Study
Jan Hajer, Lukáš Havlůj, Petr Kocián, Günther Klimbacher, Andreas Shamiyeh, Robert Gürlich, Adam Whitley
Gastroenterology Research and Practice.2019; 2019: 1. CrossRef - Clinical Overview of GIST and Its Latest Management by Endoscopic Resection in Upper GI: A Literature Review
Cicilia Marcella, Rui Hua Shi, Shakeel Sarwar
Gastroenterology Research and Practice.2018; 2018: 1. CrossRef
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Therapeutic Outcomes of Endoscopic Resection of Early Gastric Cancer with Undifferentiated-Type Histology: A Korean ESD Registry Database Analysis
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Chang Seok Bang, Jae Myung Park, Gwang Ho Baik, Jong Jae Park, Moon Kyung Joo, Jae Young Jang, Seong Woo Jeon, Suck Chei Choi, Jae Kyu Sung, Kwang Bum Cho
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Clin Endosc 2017;50(6):569-577. Published online July 25, 2017
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DOI: https://doi.org/10.5946/ce.2017.017
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Abstract
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- Background
/Aims: To assess the therapeutic outcomes of endoscopic resection (ER) of early gastric cancer (EGC) with undifferentiated-type histology.
Methods
Cases of ER of EGC with undifferentiated-type histology in the Korean endoscopic submucosal dissection (ESD) registry database were identified and reviewed. The immediate outcomes, including en bloc resection, complete resection, and curative resection rates, and long-term outcomes, including recurrence and survival rates, were extracted and analyzed.
Results
From 2006 to 2015, 275 EGCs with undifferentiated-type histology from 275 patients were identified. The immediate outcomes were as follows: en bloc resection rate: 92.4%; complete resection rate: 80%; and curative resection rate: 36.4%. Compared to patients with lesions that were beyond the expanded indication, those with expanded indication lesions showed better therapeutic outcomes. There was no difference in immediate outcomes between patients with poorly differentiated adenocarcinoma (PDC) and signet ring cell carcinoma (SRC). However, compared to ER of SRC, ER of PDC had a stronger association with submucosal invasion (41.9% vs. 23.6%, p=0.003). With regard to long-term outcomes, there was no difference between lesions with curative and non-curative resections in the recurrence and mortality rates. These rates also did not differ between PDC and SRC (median follow up: 3.96 years).
Conclusions
ER confined to expanded indication lesions can be considered for treatment of EGC with undifferentiated-type histology.
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Citations
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- A Rare Case of Primary Gastric Signet Ring Cell Carcinoma: a Review of Guidelines for the Management of Gastric Cancer
Ronald Mauricio Blanco Montecino, Mikhail Sukhorosl, Mayi Ann Francis, Neeraj Kancherla, Ogbonnaya Akuma, Nkiruka Lauretta Nwangene, Shreyas Nandyal, Rohan Raj, Chinaza Mercy Akuma, Tamer Zahdeh, Sharanya Kaushik, Adil M. Khan
Indian Journal of Surgical Oncology.2024; 15(1): 153. CrossRef - Update on Endoscopic Diagnosis and Treatment of Early Gastric Signet Ring Cell Carcinoma
鹏齐 陈
Advances in Clinical Medicine.2024; 14(03): 922. CrossRef - Advances in Endoscopic Detection and Therapeutic Strategies for Early Gastric Signet Ring Cell Carcinoma
Jiahui Xu, Fan Yin, Mengyu Cao, Linlin Ren, Shidong Wang, Congcong Min, Xiaoyu Li, Zibin Tian, Tao Mao
Nature Cell and Science.2024; 2(1): 10. CrossRef - An artificial intelligence system for comprehensive pathologic outcome prediction in early gastric cancer through endoscopic image analysis (with video)
Seunghan Lee, Jiwoon Jeon, Jinbae Park, Young Hoon Chang, Cheol Min Shin, Mi Jin Oh, Su Hyun Kim, Seungkyung Kang, Su Hee Park, Sang Gyun Kim, Hyuk-Joon Lee, Han-Kwang Yang, Hey Seung Lee, Soo-Jeong Cho
Gastric Cancer.2024; 27(5): 1088. CrossRef - Endoscopic Resection of Undifferentiated Early Gastric Cancer
Yuichiro Hirai, Seiichiro Abe, Mai Ego Makiguchi, Masau Sekiguchi, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Yutaka Saito
Journal of Gastric Cancer.2023; 23(1): 146. CrossRef - Update on diagnosis and treatment of early signet-ring cell gastric carcinoma: A literature review
Yun-He Tang, Lin-Lin Ren, Tao Mao
World Journal of Gastrointestinal Endoscopy.2023; 15(4): 240. CrossRef - Clinical Features of Gastric Signet Ring Cell Cancer: Results from a Systematic Review and Meta-Analysis
Mariagiulia Dal Cero, Maria Bencivenga, Drolaiz H. W. Liu, Michele Sacco, Mariella Alloggio, Kelly G. P. Kerckhoffs, Federica Filippini, Luca Saragoni, Mar Iglesias, Anna Tomezzoli, Fátima Carneiro, Heike I. Grabsch, Giuseppe Verlato, Lorena Torroni, Guil
Cancers.2023; 15(21): 5191. CrossRef - Long-term outcomes of endoscopic resection followed by additional surgery after non-curative resection in undifferentiated-type early gastric cancer: a nationwide multi-center study
Jie-Hyun Kim, Young-Il Kim, Ji Yong Ahn, Woon Geon Shin, Hyo-Joon Yang, Su Youn Nam, Byung-Hoon Min, Jae-Young Jang, Joo Hyun Lim, Wan Sik Lee, Bong Eun Lee, Moon Kyung Joo, Jae Myung Park, Hang Lak Lee, Tae-Geun Gweon, Moo In Park, Jeongmin Choi, Chung H
Surgical Endoscopy.2022; 36(3): 1847. CrossRef - Diffuse-type Gastric Cancer
Jie-Hyun Kim
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(1): 11. CrossRef - Endoscopic submucosal dissection for early signet ring cell gastric cancer: A systematic review and meta-analysis
Chun-Yan Weng, Shao-Peng Sun, Chang Cai, Jing-Li Xu, Bin Lv
World Journal of Clinical Cases.2022; 10(20): 6915. CrossRef - Clinico-pathologic determinants of non-e-curative outcome following en-bloc endoscopic submucosal dissection in patients with early gastric neoplasia
Kidane Siele Embaye, Chao Zhang, Matiwos Araya Ghebrehiwet, Zhihao Wang, Fengdi Zhang, Liwei Liu, Shenghui Qin, Lingzhi Qin, Jun Wang, Xi Wang
BMC Cancer.2021;[Epub] CrossRef - Factors associated with overall survival in early gastric cancer patients who underwent additional surgery after endoscopic submucosal dissection
Zhi Zheng, Fan-Di Bu, Hao Chen, Jie Yin, Rui Xu, Jun Cai, Jun Zhang, Hong-Wei Yao, Zhong-Tao Zhang
World Journal of Clinical Cases.2021; 9(10): 2192. CrossRef - Long-Term Outcomes of Endoscopic Submucosal Dissection of Undifferentiated-Type Early Gastric Cancer
Chang Seok Bang
Clinical Endoscopy.2021; 54(2): 143. CrossRef - Establishing Machine Learning Models to Predict Curative Resection in Early Gastric Cancer with Undifferentiated Histology: Development and Usability Study
Chang Seok Bang, Ji Yong Ahn, Jie-Hyun Kim, Young-Il Kim, Il Ju Choi, Woon Geon Shin
Journal of Medical Internet Research.2021; 23(4): e25053. CrossRef - Результаты проксимальной резекции желудка в зависимости от методов реконструкции желудочно-кишечного тракта
Виктория Эдуардовна Тишакова , Дмитрий Валерьевич Ручкин , Александр Анатольевич Грицкевич , Николай Алексеевич Ефименко
Естественные и Технические Науки.2021; (№11): 198. CrossRef - Protocol for expanded indications of endoscopic submucosal dissection for early gastric cancer in China: a multicenter, ambispective, observational, open-cohort study
Zhi Zheng, Jie Yin, Ziyu Li, Yingjiang Ye, Bo Wei, Xin Wang, Yantao Tian, Mengyi Li, Qian Zhang, Na Zeng, Rui Xu, Guangyong Chen, Jie Zhang, Peng Li, Jun Cai, Hongwei Yao, Jun Zhang, Zhongtao Zhang, Shutian Zhang
BMC Cancer.2020;[Epub] CrossRef - Regional Lymph Node Dissection as an Additional Treatment Option to Endoscopic Resection for Expanded Indications in Gastric Cancer: a Prospective Cohort Study
Ho Seok Seo, Han Mo Yoo, Yoon Ju Jung, Sung Hak Lee, Jae Myung Park, Kyo Young Song, Eun Sun Jung, Myung-Gyu Choi, Cho Hyun Park
Journal of Gastric Cancer.2020; 20(4): 442. CrossRef - Effect of ilaprazole on the healing of endoscopic submucosal dissection-induced gastric ulcer: randomized-controlled, multicenter study
Chang Seok Bang, Woon Geon Shin, Seung In Seo, Min Ho Choi, Hyun Joo Jang, Se Woo Park, Sea Hyub Kae, Young Joo Yang, Suk Pyo Shin, Gwang Ho Baik, Hak Yang Kim
Surgical Endoscopy.2019; 33(5): 1376. CrossRef - Effect of age on the clinical outcomes of patients with early gastric cancer with undifferentiated-type histology
Jeung Hui Pyo, Hyuk Lee, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Kyoung-Mee Kim, Heejin Yoo, Kyunga Kim, Yoon-Ho Choi, Jae J. Kim, Sung Kim
Surgery.2019; 165(4): 802. CrossRef - Long-term clinical outcomes of endoscopic vs. surgical resection for early gastric cancer with undifferentiated histology
Joo Hyun Lim, Jung Kim, Sang Gyun Kim, Hyunsoo Chung
Surgical Endoscopy.2019; 33(11): 3589. CrossRef - Pitfalls in the Interpretation of Publications about Endoscopic Submucosal Dissection of Early Gastric Cancer with Undifferentiated-Type Histology
Chang Seok Bang, Gwang Ho Baik
Clinical Endoscopy.2019; 52(1): 30. CrossRef - Strategy for Curative Endoscopic Resection of Undifferentiated-Type Early Gastric Cancer
Jie-Hyun Kim
Clinical Endoscopy.2019; 52(1): 9. CrossRef - Risk Factors for Lymph Node Metastasis in Undifferentiated-Type Gastric Carcinoma
Myeong-Cherl Kook
Clinical Endoscopy.2019; 52(1): 15. CrossRef - Is Radical Surgery Necessary for All Patients Diagnosed as Having Non-Curative Endoscopic Submucosal Dissection?
Si Hyung Lee, Byung Sam Park
Clinical Endoscopy.2019; 52(1): 21. CrossRef - Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
Jin Sung Koh, Moon Kyung Joo, Jong-Jae Park, Beom Jae Lee, Hoon Jai Chun, Sang Woo Lee, You-Jin Jang, Young-Jae Mok, Masaru Katoh
PLOS ONE.2019; 14(9): e0223284. CrossRef - Usefulness of histologic differences and perivascular infiltration for preoperative T staging of advanced gastric cancer using computed tomography
Ji Youn Kim, Woo-Suk Chung, Hyeun Jin Lee, Ji Hae An, Jang Shin Son
Japanese Journal of Radiology.2019; 37(12): 817. CrossRef - Mixed poorly differentiated adenocarcinoma in undifferentiated-type early gastric cancer predicts endoscopic noncurative resection
Yusuke Horiuchi, Junko Fujisaki, Noriko Yamamoto, Naoki Ishizuka, Masami Omae, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Yorimasa Yamamoto, Masatsugu Nagahama, Hiroshi Takahashi, Tomohiro Tsuchida
Gastric Cancer.2018; 21(4): 689. CrossRef - Self-expandable metal stents in patients with postoperative delayed gastric emptying after distal gastrectomy
Seung Han Kim, Bora Keum, Hyuk Soon Choi, Eun Sun Kim, Yeon Seok Seo, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Soon Ho Um, Chang Duck Kim, Sungsoo Park
World Journal of Gastroenterology.2018; 24(40): 4578. CrossRef - Endoscopic Resection of Early Gastric Cancer with Undifferentiated-Type Histology
Jie-Hyun Kim
Clinical Endoscopy.2017; 50(6): 511. CrossRef
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Case Report
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Gastric Adenocarcinoma with Systemic Metastasis Involving the Intraocular Choroid and Duodenum
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Soon Young Kim, Kee-Taek Jang, Jun Haeng Lee
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Clin Endosc 2018;51(1):95-98. Published online May 22, 2017
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DOI: https://doi.org/10.5946/ce.2017.049
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- Gastric cancer with double metastasis to the orbit and duodenum is extremely rare. We report the case of a patient with gastric adenocarcinoma who presented with synchronous orbital and duodenal metastases at the time of initial diagnosis. A 60-year-old man presented with a 1-month history of visual disorder and pain in his right eye. He underwent ophthalmological examinations. The biopsy results suggested intraocular metastatic carcinoma. We conducted a systemic evaluation to identify primary malignancy. Finally, a diagnosis of advanced gastric adenocarcinoma with multi-organ metastasis was made. He planned to be treated with systemic chemotherapy.
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- Bilateral exudative retinal detachment as the first manifestation of metastatic gastrointestinal cancer
S. Croitoru, C. Ducloux, K. Ouamrane, H. Merle
Journal Français d'Ophtalmologie.2024; 47(3): 104031. CrossRef - Choroidal metastasis from gastric cancer: A case report and review of the literature
Yan-Ying Huang, Li-Yan Zhu, Zhao-Dong Li
Journal of International Medical Research.2023;[Epub] CrossRef - Neuron-Specific Enolase and Hemoglobin as Risk Factors of Intraocular Metastasis in Patients with Renal Cell Carcinoma
Qiu-Yu Li, Ting Su, Wen-Qing Shi, Jian-Wen Fang, Meng-Yao Zhang, Qian-Hui Xu, Rong-Bin Liang, Qian-Min Ge, Biao Li, Yi Shao, Zhongqiu Xie
Disease Markers.2022; 2022: 1. CrossRef - Serum markers change for intraocular metastasis in renal cell carcinoma
Tie Sun, Jing Tang, Yi-Cong Pan, Chen-Yu Yu, Biao Li, Li-Juan Zhang, Hui-Ye Shu, Qian-Min Ge, Yi Shao
Bioscience Reports.2021;[Epub] CrossRef - Spontaneous rupture of the eyeball due to choroidal metastasis of gastric carcinoma
Shuang-Qing Wu, Qiu-Shi Li, Yu Zhang, Li-Wei Zhu
Medicine.2019; 98(40): e17441. CrossRef
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Original Article
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Can Endoscopic Ulcerations in Early Gastric Cancer Be Clearly Defined before Endoscopic Resection? A Survey among Endoscopists
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Sung Min Park, Byung-Wook Kim, Joon Sung Kim, Young Wook Kim, Gi Jun Kim, Seung Ji Ryu
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Clin Endosc 2017;50(5):473-478. Published online April 24, 2017
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DOI: https://doi.org/10.5946/ce.2016.143
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Abstract
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- Background
/Aims: Early gastric cancer (EGC) with ulcerations can be treated via endoscopic resection (ER) when it is differentiated pathologically, limited to the mucosa, and <3 cm in diameter. The presence of ulceration is a key factor in deciding treatment strategies and is usually diagnosed during endoscopic examination. The aim of this study was to evaluate whether ulcerations in EGC can be clearly defined among endoscopists and which factors are related to the differences.
Methods
A survey questionnaire, composed of demographic features and endoscopic images of seven patients with EGC, was presented to the endoscopists via e-mail. The endoscopists were asked whether such patients have ulcerations in the lesions.
Results
The questionnaires were e-mailed to 197 endoscopists, and 103 doctors replied. The presence of an endoscopic ulceration was defined differently among the endoscopists, depending on the duration of endoscopic practice and the experience of endoscopic submucosal dissection (ESD). The differences were especially high in the lesions without mucosal breaks and converging folds, which were expected to be viewed as non-ulcerative.
Conclusions
Before ER, endoscopic ulcerations in EGC must be reviewed by experienced endoscopists to reduce overestimations, and adequate educational programs for trainees should be established.
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Citations
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- A standardized pathology report for gastric cancer: 2nd edition
Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So-Young Jin, Joon Mee Kim, Yoon Jung Choi,
Journal of Pathology and Translational Medicine.2023; 57(1): 1. CrossRef - A Standardized Pathology Report for Gastric Cancer: 2nd Edition
Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So-Young Jin, Joon Mee Kim, Yoon Jung Choi,
Journal of Gastric Cancer.2023; 23(1): 107. CrossRef - Applicability of endoscopic submucosal dissection for patients with early gastric cancer beyond the expanded indication for endoscopic submucosal dissection
Jeong Ho Song, Sejin Lee, Sung Hyun Park, Anastasios Kottikias, Aleisa Abdulmohsen, Nasser Alrashidi, Minah Cho, Yoo Min Kim, Hyoung-Il Kim, Woo Jin Hyung
Surgical Endoscopy.2022; 36(11): 8349. CrossRef - Construction and analysis of an ulcer risk prediction model after endoscopic submucosal dissection for early gastric cancer
San-Dong Gong, Huan Li, Yi-Bin Xie, Xiao-Hui Wang
World Journal of Gastrointestinal Oncology.2022; 14(9): 1823. CrossRef - Discrepancy between endoscopic and pathological ulcerative findings in clinical intramucosal early gastric cancer
Yohei Yabuuchi, Kohei Takizawa, Naomi Kakushima, Noboru Kawata, Masao Yoshida, Yoichi Yamamoto, Yoshihiro Kishida, Sayo Ito, Kenichiro Imai, Hirotoshi Ishiwatari, Kinichi Hotta, Hiroyuki Matsubayashi, Etsuro Bando, Masanori Terashima, Takashi Sugino, Hiro
Gastric Cancer.2021; 24(3): 691. CrossRef - Predictive Model of Nonneoplastic Pathology after Endoscopic Resection of Gastric Epithelial Neoplasia
Tae-Geun Gweon, Byung-Wook Kim, Joon Sung Kim, Sung Min Park, Jeong Seon Ji, Bo In Lee
Gut and Liver.2020; 14(2): 199. CrossRef - Endoscopic Factors that Can Predict Histological Ulcerations in Early Gastric Cancers
Jaesin Lee, Byung-Wook Kim, Cheal Wung Huh, Joon Sung Kim, Lee-So Maeng
Clinical Endoscopy.2020; 53(3): 328. CrossRef - What is the Most Precise Endoscopic Finding for Predicting the Clinicopathological Behaviors in Ulcerative Early Gastric Cancer?
Youngdae Kim
Clinical Endoscopy.2020; 53(3): 249. CrossRef - Risk Factors for Lymph Node Metastasis in Undifferentiated-Type Gastric Carcinoma
Myeong-Cherl Kook
Clinical Endoscopy.2019; 52(1): 15. CrossRef - Identification of Ulceration in Early Gastric Cancer before Resection is Not Easy: Need for a New Guideline for Endoscopic Submucosal Dissection Indication Based on Endoscopic Image
Hang Lak Lee
Clinical Endoscopy.2017; 50(5): 410. CrossRef
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Case Report
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Acute Gastric Injury Caused by Undissolved Sodium Picosulfate/Magnesium Citrate Powder
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Eun Young Ze, Chang Hwan Choi, Jeong Wook Kim
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Clin Endosc 2017;50(1):87-90. Published online October 12, 2016
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DOI: https://doi.org/10.5946/ce.2016.081
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- Sodium picosulfate/magnesium citrate (SPMC) is a widely used oral bowel cleansing agent considered to be relatively safe. However, partially dissolved or undissolved SPMC powder may cause severe injuries of the esophagus and stomach. We report a very rare case of acute gastric injury without esophageal damage caused by the ingestion of undissolved SPMC powder. A 69-year-old man experienced epigastric pain after swallowing SPMC powder without dissolving it in water in preparation for a screening colonoscopy. He realized his mistake immediately and subsequently drank 2 L of water. The esophagogastroduodenoscopy conducted after 12 hours indicated an acute gastric ulceration without injury of the esophagus or duodenum. The endoscopy conducted after 6 weeks of oral proton pump inhibitor treatment showed healing of the gastric injury. This suggested that drinking large amounts of water after ingesting partially dissolved or undissolved SPMC powder can prevent serious esophageal injury, but offers no preventive benefit for acute gastric injury.
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- Riesgos, indicaciones y aspectos técnicos de la colonoscopia en pacientes de edad avanzada o con fragilidad. Documento de posicionamiento de la Societat Catalana de Digestologia, la Societat Catalana de Geriatria i Gerontologia i la Societat Catalana de M
Salvador Machlab, Esther Francia, Juanjo Mascort, Pilar García-Iglesias, Juan Manuel Mendive, Francesc Riba, Carles Guarner-Argente, Mònica Solanes, Jordi Ortiz, Xavier Calvet
Gastroenterología y Hepatología.2024; 47(1): 107. CrossRef - Risks, indications and technical aspects of colonoscopy in elderly or frail patients. Position paper of the Societat Catalana de Digestologia, the Societat Catalana de Geriatria i Gerontologia and the Societat Catalana de Medicina de Familia i Comunitaria
Salvador Machlab, Esther Francia, Juanjo Mascort, Pilar García-Iglesias, Juan Manuel Mendive, Francesc Riba, Carles Guarner-Argente, Mònica Solanes, Jordi Ortiz, Xavier Calvet
Gastroenterología y Hepatología (English Edition).2024; 47(1): 107. CrossRef - Acute Gastropathy Associated with Bowel Preparation According to Age: Oral Sulfate Tablets versus 1-L Polyethylene Glycol with Ascorbic Acid
Jin Young Yoon, Su Bee Park, Moon Hyung Lee, Min Seob Kwak, Jae Myung Cha
The Korean Journal of Gastroenterology.2024; 84(4): 177. CrossRef - Quality of bowel preparation in patients with inflammatory bowel disease undergoing colonoscopy: What factors to consider?
Antonietta Gerarda Gravina, Raffaele Pellegrino, Mario Romeo, Giovanna Palladino, Marina Cipullo, Giorgia Iadanza, Simone Olivieri, Giuseppe Zagaria, Nicola De Gennaro, Antonio Santonastaso, Marco Romano, Alessandro Federico
World Journal of Gastrointestinal Endoscopy.2023; 15(3): 133. CrossRef - Regulation of a delicate problem in patients with rectal diseases
V. V. Skvortsov, A. A. Eremenko, N. V. Eremenko
Ambulatornaya khirurgiya = Ambulatory Surgery (Russia).2022; 19(1): 81. CrossRef - Esophageal Stricture Caused by the Ingestion of Undissolved Picosulfate Powder
Daehyun Kim, Byungha Cho, Jong Wook Choi, Ki Bae Kim, Seon Mee Park
Clinical Endoscopy.2021; 54(1): 122. CrossRef - Optimal Laxatives for Oral Colonoscopy Bowel Preparation: from High-volume to Novel Low-volume Solutions
Soo-Young Na, Won Moon
The Korean Journal of Gastroenterology.2020; 75(2): 65. CrossRef - Unexpected caustic esophageal injury associated with the use of a bowel preparation agent
Yi-Ting Chou, Tien-Yu Huang, Chao-Feng Chang
Journal of Medical Sciences.2019; 39(5): 251. CrossRef - Acute Abdominal Pain after Ingestion of Bowel Cleansing Agent for Colonoscopy
Hwon Kim, Jong Seol Park, Yong Sung Kim
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2018; 18(4): 275. CrossRef
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Reviews
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Endoscopic Submucosal Dissection for Early Gastric Cancers with Uncommon Histology
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Gwang Ha Kim
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Clin Endosc 2016;49(5):434-437. Published online September 30, 2016
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DOI: https://doi.org/10.5946/ce.2016.127
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- Endoscopic submucosal dissection (ESD) enables en bloc curative resection of early gastric cancers (EGCs) with a negligible risk of lymph node metastasis (LNM). Although ESD for EGCs with absolute and expanded indications is safe, the results differ between EGCs with specialized and common histologies. EGC with papillary adenocarcinoma is a differentiated-type adenocarcinoma. At present, it is treated with ESD according to the same criteria as other differentiated-type adenocarcinomas. The LNM rate under the current indication criteria is high, and over half of the patients who undergo ESD as a primary treatment for EGC with papillary adenocarcinoma achieve an out-of-ESD result. Gastric carcinoma with lymphoid stroma in EGC has a low LNM rate and a favorable outcome, despite deep submucosal invasion. Patients with this gastric cancer subtype may be good candidates for ESD, even with deep submucosal invasion. Large-scale prospective multi-center studies with longer follow-up periods are needed to set proper ESD criteria for these tumors. Clinicians should be aware of these disease entities and ESD should be more carefully considered for EGCs with papillary adenocarcinoma and gastric carcinoma with lymphoid stroma.
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Citations
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- Gastric carcinoma with lymphoid stroma derived from hamartomatous inverted polyp with osteoclast-like giant cells: a case report
Shoko Yamashita, Masaaki Nishi, Kozo Yoshikawa, Toshihiro Nakao, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Yuma Wada, Toshiaki Yoshimoto, Yosuke Iwakawa, Takeshi Oya, Koichi Tsuneyama, Mitsuo Shimada
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Endoscopic Ultrasonography in the Diagnosis of Gastric Subepithelial Lesions
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Eun Jeong Gong, Do Hoon Kim
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Clin Endosc 2016;49(5):425-433. Published online September 5, 2016
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DOI: https://doi.org/10.5946/ce.2016.065
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Abstract
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- Subepithelial lesions occasionally found in the stomach of patients undergoing endoscopy may be either benign lesions or tumors with malignant potential. They may also appear due to extrinsic compression. Discrimination of gastric subepithelial lesions begins with meticulous endoscopic examination for size, shape, color, mobility, consistency, and appearance of the overlying mucosa. Accurate diagnosis can be achieved with endoscopic ultrasonography, which provides useful information on the exact size, layer-of-origin, and characteristic morphologic features to support a definitive diagnosis. Endoscopic ultrasonography also aids in the prediction of malignant potential, especially in gastrointestinal stromal tumors. Features of subepithelial lesions identified on endoscopic ultrasonography can be used to determine whether further diagnostic procedures such as endoscopic resection, fine needle aspiration, or core biopsy are required. Endoscopic ultrasonography is a valuable tool for diagnosis and clinical decision making during follow-up of gastric subepithelial lesions.
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Citations
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