Now colorectal cancer is the second most common cancer in males and the fourth most common cancer in females in Korea. Since most of colorectal cancers occur after the prolonged transformation of adenomas into carcinomas, early detection and removal of colorectal adenomas are one of the most effective methods to prevent colorectal cancer. Considering the increasing incidence of colorectal cancer and polyps in Korea, it is very important to establish Korean guideline for colorectal cancer screening and polyp detection. The guideline was developed by the Korean Multi-Society Take Force and we tried to establish the guideline by evidence-based methods. Parts of the statements were draw by systematic reviews and meta-analyses. Herein we discussed epidemiology of colorectal cancers and adenomas in Korea and optimal methods for screening of colorectal cancer and detection of adenomas including fecal occult blood tests, radiologic tests, and endoscopic examinations.
According to the statistical yearbook of the Ministry of Health and Welfare, crude colorectal cancer incidence rates in Korea in 2008 were 54.7 and 36.9 per 100,000 among males and females, respectively. Colorectal cancer is thus the second most common cancer in males and the fourth most common cancer in females.
Because most cases of colorectal cancer occur after the prolonged transformation of adenomas into carcinomas, early detection and removal of colorectal adenomas are effective methods of secondary prevention of colorectal cancer. Advanced adenomas are clearly precancerous lesions and serve as surrogate markers of colorectal cancer (the ultimate target of secondary prevention).
In this report, we discuss methods of preventing colorectal cancer by detecting advanced adenomas based on the concept of the adenoma-carcinoma sequence. The report will discuss the use of fecal occult blood testing (FOBT) for large-scale colorectal cancer screening and the use of endoscopic and radiologic tests to identify polyps and other structural changes in the colorectal mucosa that occur at the early stages of carcinogenesis.
The guidelines outlined in this report were established for asymptomatic, average-risk adults without a personal history of colorectal cancer, clinical signs and symptoms suspicious for colorectal cancer or a family history suggesting a high risk of colon cancer. Systematic reviews of existing colorectal cancer screening guidelines in Western countries and of the published domestic and foreign literature regarding colorectal cancer screening were performed. Meta-analyses were conducted in some cases to evaluate the timing, methods, benefits and limitations of the tests for colorectal cancer screening and polyp detection. The ultimate goal of this report is to aid practicing physicians. People with symptoms or signs suggestive of the presence of colorectal cancer or polyps do not fall within the scope of these guidelines; such individuals should undergo appropriate diagnostic testing. Although epidemiologic data have been obtained through Korean multi-center studies over the past decade, these studies alone were not felt to provide sufficient information for the establishment of colorectal cancer screening and polyp detection guidelines. To better reflect the reality of medical care in Korea, opinions of domestic experts and endoscopic specialists responsible for colorectal cancer screening were collected to evaluate the levels of evidence on the screening of colorectal cancer and detection of polyps.
The Korean literature on colorectal cancer screening and polyp detection is quite limited. Therefore, most of the evidence used in this report comes from Western guidelines and systematic reviews. Although the results of major studies performed since 2006 were reviewed, the quality of evidence (even among similar studies) based on the grade assessment method was quite low. This was generally due to heterogeneity among the different trials regarding important elements such as the risk of colorectal cancer, demographic differences among patients, qualitative and quantitative differences among screening tests and a lack of standardized test methods. To overcome these limitations and reflect the different approach to polyp care and the different health care environment in Korea, web-based questionnaire surveys were conducted. Furthermore, using the Delphi method, the extent of agreement regarding the guidelines was determined by asking a number of domestic experts to participate in a series of round-table discussion to formulate a consensus on policies regarding colorectal cancer screening and polyp detection.
In May 2010, a committee tasked with the development of clinical practice guidelines for colorectal cancer screening and polyp detection was organized. The committee consisted of nine practice committee members and two consultants from the three major Korean gastroenterology societies: the Korean Society of Gastroenterology (KSG), the Korean Society of Gastrointestinal Endoscopy (KSGE) and the Korean Association for the Study of Intestinal Diseases (KASID). The consultants were Professor Hyo Jong Kim (Kyung Hee University School of Medicine), representing the KSGE and the KASID, and Professor Suk-Kyun Yang (University of Ulsan College of Medicine), representing the KSG. At the first meeting in June 2010, the Development Committee appointed a chairman, Hyun-Soo Kim (Yonsei University Wonju College of Medicine), and a secretary, Dong-Hoon Yang (University of Ulsan College of Medicine). The committee was divided into three teams: one associated with colorectal cancer screening and colorectal polyp detection (Team leaders: Hyun-Soo Kim from Yonsei University Wonju College of Medicine; Bo In Lee from The Catholic University of Korea College of Medicine; Seong-Eun Kim from Ewha Womans University School of Medicine; and Sung Pil Hong from Yonsei University College of Medicine), one associated with surveillance (Team leaders: Young-Ho Kim from Sungkyunkwan University School of Medicine; Sung Noh Hong from Konkuk University School of Medicine; and Dong-Hoon Yang from University of Ulsan College of Medicine), and one associated with treatment (Team leaders: Dong Il Park from Sungkyunkwan University School of Medicine; Suck Ho Lee from Soonchunhyang University College of Medicine; and Sung Jae Shin from Ajou University School of Medicine). Between June and July 2010, during the first and second workshops, the committee members learned methodologies for guideline development from various experts, including Professor Hyeong-Sik Ahn, the chairman of the Korean Medical Guideline Advisory Committee of the Korean Academy of Medical Science. The committee members shared experiences in the process of clinical practice guideline development with Professor Joong-Wonk Park (Department of Internal Medicine, National Cancer Center), Professor Eun Sook Lee (Department of Surgery, National Cancer Center) and Professor Byong Duk Ye (Department of Gastroenterology, University of Ulsan College of Medicine). Thereafter, the methods, scope, schedule and direction of the clinical practice guideline development were discussed. It was decided to adapt evidence-based foreign guidelines for screening and surveillance to avoid unnecessary duplication of effort. Revisions were made to fit our practice situation, and some topics were subject to meta-analysis and systematic review using the newest data. Because there were no relevant foreign guidelines for endoscopic trea-tment for colorectal polyps, it was decided to develop new guidelines based on systematic literature reviews and meta-analyses. In September 2010, Professor Hyun Jung Kim (Department of Preventive Medicine, Korea University College of Medicine) was invited to share her opinions on guideline development methodologies, systematic literature review and meta-analysis.
Key questions were identified by the practice committee and were organized, to the extent possible, according to the Patient, Intervention, Comparison and Outcome format. Each question was investigated by performing a literature search, and evidence tables for each key question were made. The screening test team selected clinical practice guidelines or recommendations for adaptation. The team considered whet-her the guidelines had been written in English and took into account the American or European society who developed them. Evidence tables were included and evaluated with the Appraisal of Guidelines for Research & Evaluation II tool. From this analysis, 10 recommendations were extracted. In December 2010, Professor Se Hyung Kim (Department of Radiology, Seoul National University College of Medicine) and Professor Hae Jeong Jeon (Department of Radiology, Konkuk University School of Medicine), who are experts in computed tomography (CT) colonography and the use of double-contrast barium enemas (DCBEs) for colorectal cancer screening, joined the committee as a team member and a consultant representing the Korean Society of Abdominal Radiology, respectively. To investigate the screening, surveillance and endoscopic treatment of polyps in Korea, questionnaire surveys were conducted between January and February 2011 among 263 members of the KASID. The results of the questionnaire can be utilized as a comparative indicator of future adherence to the new guidelines. In April 2011, the results of the surveys were presented at the spring conference of the KASID. In addition, keypad voting was conducted in April 2011 during the spring symposium of the Korean Societies of Gastroenterology Association. The voting was performed before and after presenting evidences and foreign guidelines on various aspects of screening, surveillance, and endoscopic treatment to assess the influence of education on clinicians' decisions regarding the management of polyps. In July 2011, drafts of key phrases were completed with the help of external experts, and 45 experts gathered to determine the extent of agreement using the Delphi method. The expert panels consisted primarily of councilors and current members of the KSG, the KSGE and the KASID, as well as 11 members of the Korean Society of Abdominal Radiology. Final key phrases for the developed guidelines were chosen when over 50% agreement was obtained. The determination of 50% agreement was made when the sum of responses of 'completely agree,' 'mostly agree' and 'partially agree,' based on the five-level Likert scale, was greater than 50%. The draft of the report obtained official approval from the multiple societies involved in polyp management after a public hearing that was held in August 2010. The evidence bases of the key phrases were presented in a seminar of the KSGE. The final report was announced at the autumn conference of the KSG in November 2011. There was no conflict of interest among any of the committee members participating in the development process of these clinical practice guidelines.
The developed guidelines will be co-published in the journals of the KSG, the KSGE, the KASID and the journal of the Korean Society of Radiology. The guidelines will also be published through the websites of the relevant societies and in major medical newspapers. Additionally, the contents will be widely distributed through summary guidebooks to training hospitals.
After a certain amount of time has passed after the distribution and implementation of the guidelines, adherence to the guidelines in clinical practice will be assessed. Furthermore, the contents will be periodically revised to reflect the latest clinical knowledge.
To support the need for establishing Korean clinical practice guidelines, key questions regarding the epidemiology of colorectal cancer and polyps in Korea were chosen. Key questions also included whether FOBT, CT colonography, DCBE or colonoscopies are appropriate colorectal cancer screening and colorectal adenoma detection methods. Information regarding risk factors for colorectal cancer and polyps is contained in the
Literature regarding screening tests was sought using two search databases, Medline's PubMed and the National Guideline Clearinghouse (NGC), and one secondary literature search engine, Trip. Because NGC is a database where only guidelines have been collected, three key terms (colorectal cancer, screening and diagnosis) were searched together, and links that included all three search terms were investigated to review major guidelines, including those of the USA and the European Union. In PubMed, clinical trials published in English from January 2006 to June 2010 were searched using the following sets of key words: 1) "colon adenoma," "colon neoplasm," "colon polyp" or "colorectal cancer"; 2) "screening," "asymptomatic" or "average risk"; and 3) key words for each screening test method. The terms "colonoscopy" or "sigmoidoscopy" were searched separately to compare each screening method. Regarding epidemiology investigations, the key word, "Korean" was used; for FOBT tests, "fecal occult blood test," "FOBT," "FIT," and "fecal immunochemical test" were used; for CT colonography, "CT colonography," "CTC," "virtual colonoscopy," "VC," and "colonography, computed tomographic" were used; and for double-contrast barium enema (DCBE), "double contrast barium enema," "barium study," and "DCBE" were used. Limits based on the study design and the quality of each paper were excluded based on opinions collected from the practice committee.
A total of 6,304 papers from the world literature (1,409 on epidemiology, 833 on FOBT, 201 on CT colonography, 45 on DCBE, 2,743 on sigmoidoscopy and 1,073 on colonoscopy) were identified. Overlapping papers were excluded, and papers that did not meet the selection criteria were excluded by reviewing the paper titles or the full texts of abstracts. When necessary, the suitability of the materials was judged by reviewing the full texts of the papers. Finally, 148 papers (26 on epidemiology, 24 on FOBT, 32 on CT colonography, 18 on DCBE, 29 on sigmoidoscopy and 19 on colonoscopy) were chosen. Literature search methods by subtitle are shown in
Meta-analyses were conducted on FOBT and CT colonography. All studies included in the analyses were observational studies. To minimize clinical heterogeneity among the studies, studies with similar groups of enrolled subjects and test methods were selected.
The sensitivity and specificity of FOBT for colorectal cancer and advanced colorectal adenomas compared to colonoscopy were calculated. Meta-analyses were conducted to compare detection rates for colorectal cancer and polyps between the traditional guaiac FOBT and the FIT and between one-time and two-time FIT methods. To minimize heterogeneity am-ong studies, analyses were limited to studies that were similar in terms of the enrolled subjects, state of rehydration, sampling methods, number of tests and positive thresholds. For these meta-analyses, the odds ratios (OR) of polyp detection rates were calculated for the two test methods and for the number of tests conducted. For CT colonography, 9 papers published since 2,000 describing studies only among asymptomatic, average-risk patients were selected through literature searches, and meta-analyses were conducted on these papers. Details of the literature search methods, literature assessments and development of the evidence table are presented in the appendix (
The sensitivity and specificity of each test method were calculated from papers in which the true positive, false positive, true negative and false negative rates for polyp detection compared with colonoscopies could be calculated. Papers that did not present the individual values were excluded from the analyses. When the I2 value of the analysis was over 50% or when the results of Cochran's Q-test showed
Recommendations are presented based on a systematic review of the selected literature and meta-analyses. The quality of evidence, indicating the degree of scientific evidence that each recommendation has, and the strength of the recommendation were determined following the methodology proposed by the Grading of Recommendations Assessment, Development and Evaluation Working Group (
The quality of evidence was assessed to be "high" when the evidence consisted of randomized controlled trials and "low" when evidence included observational studies. However, in cases where studies used as evidence had limitations in the study design or execution, inconsistent results, indirect evidence, imprecise results or publication bias, the quality of evidence was adjusted downward. In cases of observational studies where large effects were observed, where reported effects might have been reduced due to confounding variables or where dose-response gradients existed, the quality of evidence was adjusted upward. The strength of each recommendation was assessed as "strong" or "weak" by considering the balance of desirable and undesirable consequences, the quality of the evidence, the confidence in the values and the references and the effective allocation of medical expenses and resources. That is, in cases where it was judged that following a specific recommendation would lead to significant health benefits or losses for most patients, the strength of the recommendation was classified as "strong." The strength of the recommendation was classified as "weak" in cases where it was judged that following the recommendation would lead to important benefits or loss in terms of the quality of the health of patients but where differences existed among patients, thus leading to the need to consider individual environments, preferences and values.
In Korea, the incidence rate of colorectal cancer is increasing.
Quality of evidence: low Level of agreement: completely agree (87%), generally agree (13%), partially agree (0%), generally disagree (0%), totally disagree (0%)
Colorectal cancer has historically been one of the most common cancers in Western countries. However, the incidence rate has recently been increasing in some Asian countries due to the Westernization of lifestyles and increases in the obese population. The prevalence rates of colorectal cancer are rapidly increasing in Korea, too. According to 2002 data, the age-standardized incidence rates of colorectal cancer had rapidly increased in Asian countries to 49.3 per 100,000 in Japan, 24.7 in Korea and 35.1 in Singapore. For comparison, colorectal cancer rates are 44.4 per 100,000 in North America and 42.9 in Europe. In East Asian countries, colorectal cancer was the third most common cancer among both males and females.
In Korea, the incidence rate of colorectal adenomas is increasing.
Quality of evidence: very low Level of agreement: completely agree (53%), generally agree (35%), partially agree (5%), generally disagree (5%), totally disagree (2%)
In Korea, the incidence rate of colorectal adenomas is also increasing in proportion to the rapid increase in colorectal cancers. According to a previous retrospective study, among 2,435 adults aged 50 or more who underwent a screening colonoscopy between 1998 and 2004, colorectal adenomas were found in 30.2% and advanced adenomas in 4.1% of patients. 13 Among males, adenomas and advanced adenomas were found in 35.9 and 5.1% of patients, respectively. Adenomas and advanced adenomas were found in 18.7 and 2.0% of female patients, respectively. The prevalence rates of colorectal adenomas were therefore higher among males. In a recent prospective multicenter study conducted among 2,307 adults aged 50 or more who underwent a screening colonoscopy during 2003 or 2004, colorectal adenomas and advanced adenomas were found in 40.5 and 2.5% of patients, respectively.
It is recommended to begin colorectal cancer screening test and colorectal adenoma detection test from the age of 50 in average-risk groups. However, those who have symptoms or signs that lead to the suspicion of colorectal cancers should receive appropriate diagnostic tests regardless of age.
Quality of evidence: low Strength of recommendation: strong recommendation Level of agreement: completely agree (42%), generally agree (50%), partially agree (5%), generally disagree (3%), totally disagree (0%)
The incidence rates of colorectal cancer and colorectal adenoma increase with age. According to the 2008 statistics of the Korea Central Cancer Registry, the incidence rates of colorectal cancers by age group were 28.8 per 100,000 in people aged 40 to 49, 82.5 in those aged 50 to 59, 174.5 in those aged 60 to 69 and 245.7 in those aged 70 or more. Thus, the incidence rates rapidly increased in people aged 50 or more.
The FOBT is a method of detecting blood in the stool, a finding that may suggest the presence of tumors in the large intestine. The advantage of FOBT is that it is relatively simple, cheap and non-invasive. Thus, this test has been adopted as an effective mass screening test for colorectal cancer in most foreign guidelines. Prior to the development of immunochemical methods in the 1970s and their commercialization in the 1980s,
In average-risk adults aged 50 and older, FOBT is recommended as a large-scale colorectal cancer screening test. This is based on the premise that any positive test should be followed up with colonoscopy.
Quality of evidence: moderate quality Strength of recommendation: strong recommendation Level of agreement: completely agree (50%), generally agree (33%), partially agree (11%), generally disagree (6%), totally disagree (0%)
The sensitivity for diagnosing colorectal cancer in asymptomatic, average-risk groups ranged from 12.9% to 37.1% for one-time testing with an unrehydrated Hemoccult II test, a traditional guaiac based FOBT (gFOBT), to 79.4% for Hemoccult SENSA testing, a high-sensitivity gFOBT.
The sensitivity can be increased by repeating the gFOBT. Based on the results of a meta-analysis of three observational studies on FITs, the diagnostic accuracy for colorectal advanced neoplasia, including colorectal cancer and advanced adenomas, was significantly higher in cases where the test was repeated two times than in cases where the test was perfor-med only once (OR, 1.46; 95% CI, 1.34 to 1.60;
Despite the fact that the sensitivity and specificity of the gFOBT for colorectal cancer are low compared to those of colonoscopy, the gFOBT is a useful population screening test for colorectal cancer. According to studies in which patients were followed for 8 to 13 years, the gFOBT reduced colorectal cancer mortality by 15% to 30%.
The sensitivity of FOBT for colorectal adenomas is very low compared to that of colonoscopies. In asymptomatic average-risk groups, the sensitivity for advanced adenomas was 44% (35.5% to 52.0%)
In average-risk adults aged 50 and older, FIT is recommended as a colorectal cancer screening test prior to traditional gFOBT.
Quality of evidence: low Strength of recommendation: strong recommendation Level of agreement: completely agree (46%), generally agree (49%), partially agree (3%), generally disagree (2%), totally disagree (0%)
To judge whether FIT is superior to traditional gFOBT as a colorectal cancer screening test in average-risk groups, the diagnostic sensitivity, convenience and patient compliance associated with the tests should be examined. Although many studies have been conducted to determine the relative accuracy of different tests for colorectal cancer, there are difficulties in comparing these studies because most of them are observational, and subject characteristics and test methods are heterogeneous. In a meta-analysis that compared detection rates between traditional gFOBT and FIT in asymptomatic average-risk groups, the diagnostic accuracy for colorectal cancer was higher for FIT (OR, 1.88; 95% CI, 1.04 to 3.40;
The issue of which FOBT test method is the most useful should also be considered in terms of test convenience and compliance. Guaiac tests measure blood peroxidase in stool and the results are influenced by diet, drugs taken and rehydration of stool specimens. To increase diagnostic accuracy, the test should be repeated 2 to 3 times. In guaiac tests, false positive results may be produced if aspirin or non-steroidal anti-inflammatory drugs have been taken within 7 days before testing and if meat or fish has been ingested within 3 days before testing. False-negative results may be produced if vitamin C has been taken because vitamin C interrupts peroxidase reactions. Thus, vitamin C preparations of 250 mg or more, fruits and juices should be avoided for three days before the test. Rehydration consists of adding a drop of water to the slide containing the stool sample before the test. Although rehydration increases sensitivity, it is generally not recommended because it can raise the number of false-positive results and lead to unnecessary additional tests.
FITs measure antibodies specific to the globin moiety of human hemoglobin, and results are not affected by diet or drug ingestion. Furthermore, because globin is degraded by digestive enzymes in the upper gastrointestinal tract, FITs are more specific for lower gastrointestinal hemorrhage, thereby enhancing the accuracy of the test for colorectal cancer.
CT colonography, also known as "virtual colonoscopy," has rapidly evolved along with significant advances in CT imaging technologies. The fundamental elements of CT colonography include fecal and fluid tagging, bowel preparation, colonic distention, CT scanning, interpretation and reporting. The aforementioned elements are important for successful CT colonography. Before the CT colonography examination, the patient should take laxatives for proper cleansing of the colon, and radioopaque contrast media should be given to label the residual fluid and fecal material. The importance of proper colonic distention during CT colonography cannot be overstated. Both supine and prone scans should be routinely obtained. The CT colonography usually takes approximately 10 minutes at the CT scanner. No sedation is required, and patients have the capability to return to work the same day. Recently, research has been performed regarding non-cathartic approaches to minimize the inconvenience of bowel preparation, but these techniques are not yet sufficiently validated.
In average-risk groups aged 50 and older, CT colonography is recommended as one of the colorectal cancer screening and polyp detection methods.
Quality of evidence: low Strength of recommendation: strong recommendation Level of agreement: completely agree (27%), generally agree (34%), partially agree (26%), generally disagree (13%), totally disagree (0%)
For the detection of colon cancer and advanced adenoma, which is the primary goal of screening for colorectal cancer, recent data suggest that CT colonography is comparable to colonoscopy when state-of-the-art techniques are applied.
According to the results of a meta-analysis of data from nine studies conducted only in asymptomatic average-risk groups after 2000,
Furthermore, because the risk for colonic perforation or bleeding is extremely low, CT colonography is also a safe and noninvasive method.
Because CT colonography produces CT images not only of the colon but also of the upper and lower abdomen, there is a chance that incidental extracolonic findings will be detected. The results of 11 CT colonography studies, where lesions outside the colon were mentioned,
CT-related radiation exposure may be one of the limitations of CT colonography. According to a recent report issued by the Health Physics Society in the USA, the health effects of low-dose radiation exposure (defined as below 50 to 100 mSv) were considered to be "either too small to be observed or are nonexistent."
As mentioned above, due to its good diagnostic performance and safety profile, CT colonography was suggested as a screening test for colorectal cancer and polyps in the 2008 revised colorectal screening guidelines jointly published by the American Cancer Society (ACS), the US Multi-Society Task Force on Colorectal Cancer (USMSTF), and the ACR.
In the case that a polyp 6 mm or larger is found in CT colonography, a colonoscopy is recommended.
Quality of evidence: very low Strength of recommendation: strong recommendation Level of agreement: completely agree (78%), generally agree (22%), partially agree (0%), generally disagree (0%), totally disagree (0%)
There is consensus that all patients with one or more polyps larger than 1 cm or with three or more 6 to 9-mm lesions identified on CT colonography should be referred for colonoscopy.
There are limited studies on surveillance periods in patients with negative CT colonography results. Furthermore, the optimal management of patients with 5 mm or smaller polyps detected on CT colonography is controversial, and experts have thus recommended different policies.
DCBE is an imaging technique that evaluates the entire colon by coating the mucosal surface with high-density barium and distending the colon with air introduced through a thin, flexible catheter that is inserted into the rectum. Multiple radiographic images are obtained from various positions during direct fluoroscopic evaluation. The test takes approximately 10 to 20 minutes. Although patients may experience discomfort during or after the examination, sedation is not necessary, and the patient can return to daily life immediately after the examination.
In average-risk groups aged 50 and older, DCBE is recommended as one of the colorectal cancer screening tests.
Quality of evidence: low Strength of recommendation: weak recommendation Level of agreement: completely agree (19%), generally agree (6%), partially agree (33%), generally disagree (36%), totally disagree (6%)
Much of the literature describing the diagnostic performance of DCBEs is limited by a retrospective study design and lack of results from an asymptomatic, average-risk group.
Colorectal perforation related to DCBE is very rare. Out of 1,987 patients who underwent DCBE, no cases of colorectal perforation occurred.
DCBE was adopted as a colorectal cancer screening test method in 1997 by the ACS based on its high sensitivity for colorectal cancer, accessibility and non-invasiveness.
In cases where a 6 mm or larger polyp has been found in DCBE a colonoscopy is recommended.
Quality of evidence: very low Strength of recommendation: strong recommendation Level of agreement: completely agree (79%), generally agree (21%), partially agree (0%), generally disagree (0%), totally disagree (0%)
Studies regarding the management of colorectal lesions detected by DCBE are limited. According to the 2008 revised colorectal screening guidelines jointly published by the ACS, the USMSTF and the ACR, in cases where one or more 6 mm or larger polyps are found by DCBE, an additional colonoscopy is recommended.4 Furthermore, no direct evidence exists (except with respect to the use of stool guaiac tests) regarding surveillance periods for colorectal cancer and polyp screening in such patients.
Screening colonoscopy is advantageous because it allows the entire colon to be examined at once, and adenomas or early cancers found during the examination can be removed. Screening colonoscopy also requires bowel preparation, and the quality of preparation significantly affects the quality of the examination. During colonoscopy, conscious sedation is usually performed to minimize pain and discomfort. Perforation may occur during colonoscopy at a frequency of approximately 0.09%,
Although it is clear that colonoscopy can detect colorectal polyps effectively and even remove polyps, it cannot be said to be a perfect test. According to reports, colonoscopy can miss between 6 and 12% of 1 cm or larger adenomas
Colonoscopic withdrawal times should average at least 6 minutes in cases where no biopsy or polypectomy is performed.
However, because the length, angulations, and degree of bowel preparation can vary by patients and adenoma detection abilities differ by endoscopist, colonoscopic withdrawal time cannot be the only way to assess the quality of a colonoscopy. The most important quality metric is the adenoma detection rate of each endoscopist. In fact, the adenoma detection rate among endoscopists was inversely related with the risk of interval colorectal cancer.
In average-risk patients aged 50 and older, colonoscopy is recommended with priority for colorectal cancer screening and polyp detection.
Quality of evidence: low Strength of recommendation: strong recommendation Level of agreement: completely agree (74%), generally agree (20%), partially agree (6%), generally disagree (0%), totally disagree (0%)
Unlike the case of screening sigmoidoscopy, there has been no randomized controlled trial to assess whether screening colonoscopy can reduce colorectal cancer incidence and its related mortality. However, FOBTs and sigmoidoscopy decrease colorectal cancer incidence and its related mortality by removing precancerous lesions or early cancers with colonoscopic. Thus, it can be indirectly assumed that colonoscopy and polypectomy will reduce colorectal cancer incidence and its related mortality.
According to the National Polyp Study of the United States, the colorectal cancer incidence decreased by 76% to 90% in a cohort that underwent colonoscopy and polypectomy compared to three other reference populations.
However, this effect may be lower in the right colon than in the left colon. The reasons for the decreased rates of colorectal cancer prevention by colonoscopy in the right colon include biological differences between right-sided and left-sided colorectal cancers,
In average-risk patients aged 50 and older, if no colorectal cancer or colorectal adenoma is found at the time of the qualified index colonoscopy, follow-up colonoscopy is recommended five years later. However, in patients with alarming symptoms or with a high risk of interval cancer, surveillance may be performed earlier than 5 years.
Quality of evidence: very low Strength of recommendation: weak recommendation Level of agreement: completely agree (20%), generally agree (65%), partially agree (9%), generally disagree (6%), totally disagree (0%)
Studies regarding the appropriate interval of the follow-up colonoscopy in cases where index colonoscopy is negative are still insufficient. Some of the recommendations are based on indirect evidence from sigmoidoscopy studies.
In many cohort studies and case-control studies, when the index colonoscopy was negative, the incidence of colorectal cancer or advanced adenomas remained low for at least 5 years.
There is still no evidence regarding the appropriate follow-up after screening colonoscopy with suboptimal bowel preparation. Most gastroenterologists tend to advance follow-up rather than to repeat the examination.
Sigmoidoscopy is fundamentally similar to colonoscopy but examines less of the colon. It is necessary to inform subjects who are undergoing screening sigmoidoscopy that bowel preparation is required, a certain degree of discomfort can occur during the examination, cancer prevention effects may be limited to the extent of the examination, and positive findings on sigmoidoscopy usually result in a referral for colonoscopy.
According to currently available study results,
Standard methods for bowel preparation in screening sigmoidoscopy have not yet been determined. Although oral lavage solutions are more effective than enemas,
If any adenomas are identified by sigmoidoscopy, it is necessary to recommend colonoscopy regardless of the adenoma size because the possibility of proximal tumors increases even if the adenoma is small. However, because 2% to 5% of patients may have advanced neoplasms in the proximal colon even without a distal adenoma, colonoscopic examination only in patients with positive sigmoidoscopies may miss advanced neoplasms in the proximal colon.
In cases where screening sigmoidoscopy is negative in average-risk patients aged 50 and older, it is not essential to perform follow-up sigmoidoscopy within 5 years.
In conclusion, because screening sigmoidoscopy has long-term colorectal cancer-preventing effects,
Epidemiology of colorectal cancer and colorectal adenomas in Korea
(1) In Korea, the incidence rate of colorectal cancer is increasing.
(2) In Korea, the incidence rate of colorectal adenomas is increasing.
Colorectal cancer screening and polyp detection test guidelines
(1) It is recommended to begin colorectal cancer screening test and colorectal adenoma detection test from the age of 50 in average-risk groups. However, those who have symptoms or signs that lead to the suspicion of colorectal cancers should receive appropriate diagnostic tests regardless of age.
(1) In average-risk adults aged 50 and older, FOBT is recommended as a large-scale colorectal cancer screening test. This is based on the premise that any positive test should be followed up with colonoscopy.
(2) In average-risk adults aged 50 and older, FIT is recommended as a colorectal cancer screening test prior to traditional gFOBT.
(1) In average-risk groups aged 50 and older, CT colonography is recommended as one of the colorectal cancer screening and polyp detection methods.
(2) In the case that a polyp 6 mm or larger is found in CT colonography, a colonoscopy is recommended.
(1) In average-risk groups aged 50 and older, double-contrast barium enema is recommended as one of the colorectal cancer screening tests.
(2) In cases where a 6 mm or larger polyp has been found in double-contrast barium enema, a colonoscopy is recommended.
(1) In average-risk patients aged 50 and older, colonoscopy is recommended with priority for colorectal cancer screening and polyp detection.
(2) In average-risk patients aged 50 and older, if no colorectal cancer or colorectal adenoma is found at the time of the qualified index colonoscopy, follow-up colonoscopy is recommended in five years or later. However, in patients with alarming symptoms or with a high risk of interval cancer, surveillance may be performed earlier than 5 years.
We extend profound thanks to Professor Hwang Choi (Department of Internal Medicine, The Catholic University of Korea College of Medicine), Professor Sung-Ae Jung (Department of Internal Medicine, Ewha Womans University School of Medicine) and Professor Seon-Ja Park (Department of Internal Medicine, Kosin University College of Medicine), who gave unsparing advice regarding the development of this guideline for colorectal cancer screening and polyp detection. We express our deep appreciation to Professor So Yeon Kim (Department of Radiology, University of Ulsan College of Medicine) for her great devotion to the completion of this guideline.
We also give great thanks to the Korean Association of Internal Medicine and Korean Physicians Association for their agreement with final version of this guideline.
This study was initiated with the support of the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, and the Korean Association for the Study of Intestinal Disease. This study was supported by a grant for the Korean Health Technology R&D Project with the Ministry for Health and Welfare of the Republic of Korea (A102065-23).
These guidelines are being co-published in the Korean Journal of Gastroenterology, the Intestinal Research, the Korean Journal of Radiology, and the Clinical Endoscopy for the facilitated distribution.
The authors have no financial conflicts of interest.
Study selection. DCBE, double-contrast barium enema; CTC, computed tomography colonography; FSG, flexible sigmoidoscopy; CS, colonoscopy; RCT, randomized controlled trial.
Meta-analysis of the detection rate of fecal immunochemical test (FIT) for advanced colorectal neoplasms according to the number of samples (1 test vs. 2 tests). CI, confidence interval.
Meta-analysis comparing guaiac based fecal occult blood testing and fecal immunochemical test in the detection of colorectal cancer in average-risk groups. gFOBT, guaiac based fecal occult blood testing; CI, confidence interval.
Meta-analysis of reported sensitivity and specificity in the included studies by polyp size. (A) Per-patient sensitivity for computed tomography (CT) colonography. (B) Per-patient specificity for CT colonography. (C) Per-polyp sensitivity for CT colonography. CI, confidence interval.
Quality of Evidence and Strength of Recommendations