Although postpolypectomy fever (PPF) without colon perforation or hemorrhage is rare, its incidence and risk factors have not been investigated. The objective of this study was to analyze the incidence and risk factors for PPF among inpatients.
Seven patients with PPF were matched with 70 patients without PPF from a total of 3,444 patients who underwent colonoscopic polypectomy. The PPF incidence during index hospitalization after colonoscopy was calculated, and univariate and multivariate analyses were performed to calculate the adjusted odds ratios (ORs) for risk factors.
PPF without bleeding or perforation in the colon occurred in seven patients (0.2%). The median age was 58 years for cases and 61 years for controls. The median interval from polypectomy to occurrence of fever was 7 hours, and the median duration of fever was 9 hours. Polyp size >2 cm (adjusted OR, 1.08; 95% confidence interval [CI], 1.01 to 1.15;
Although the crude incidence of PPF is low, PPF may prolong hospitalization. Risk factors for PPF include hypertension and large polyps.
The detection and removal of colorectal polyps by colonoscopic polypectomy reduces the incidence of colorectal cancer.
The incidence of postpolypectomy electrocoagulation syndrome ranges from 0.07% to 1.0% in patients undergoing polypectomy. Less is known, however, about the risk factors and clinical course in postpolypectomy electrocoagulation syndrome, also called postpolypectomy syndrome, a condition characterized by the development of abdominal pain, fever, leukocytosis, and peritoneal inflammation without frank perforation of the colon.
In real-world practice, we have often encountered patients who, after colonoscopic polypectomy, experience new-onset fever without peritoneal signs or definitive fever foci. It remains unclear, however, whether this condition, named postpolypectomy fever (PPF), is the same as postpolypectomy syndrome, as there is no clear definition of PPF.
Although the rates of PPF are very low, it is difficult for clinicians to determine whether this fever represents a local or metastatic infection or is a transient event. This leads to an increase in the length of hospital stay and, consequently, in medical costs.
The purpose of the present study was to investigate the incidence of PPF and identify the risk factors associated with the development of PPF and its outcomes. This study is distinguished by the inclusion of a definitive documentation of fever (based on body temperature) after excluding other possible fever foci in patients who had undergone polypectomy.
The medical records of 5,411 patients who underwent colonoscopic polypectomy at Asan Medical Center, Seoul, Korea, between January 2005 and December 2011 were retrospectively reviewed. Of these, 1,967 patients underwent colonoscopic polypectomy in the outpatient clinic and were excluded owing to the lack of documentation of PPF. PPF was defined as follows: 1) no fever at admission; 2) no symptoms or signs of infection before polypectomy; 3) development of fever with a body temperature of >37.2℃ (98.9℉) after polypectomy during the index hospitalization period; and 4) no evidence of other explainable fever foci. Index hospitalization is defined as the first admission for polypectomy. Patients with colon perforation, hemorrhage, or symptoms or signs of infection associated with conditions other than colonoscopic polypectomy were also excluded. To identify risk factors for PPF, 10 patients without fever were randomly selected for each patient with PPF. Controls were matched according to the calendar day on which polypectomy was performed. The medical records for all cases and controls were reviewed. We decided to perform a nested case-control study because our aim was to identify the risk factors associated with PPF in the same cohort. Age or sex could be a risk factor, and the date of polypectomy was matched between the case group and the control group.
The study protocol was approved by the Institutional Review Board of the Asan Medical Center (IRB no. 2013-0172).
After written informed consent was acquired from the patients, all patients were prepared for colonoscopy by asking them to swallow a polyethylene glycol solution before the procedure. All colonoscopic polypectomies were performed by six attending physicians in the Department of Gastroenterology, using standard colonoscopes (CF 240L, or 260L; Olympus Optical Co., Ltd., Tokyo, Japan). Patients were placed under conscious sedation with intravenously administered meperidine and/or midazolam or propofol. Monitoring during colonoscopy and polypectomy included pulse oximetry. Resected material was retrieved using a basket or through simple aspiration into a connection cap, and placed in a numbered container. Each removed polyp was sent to a pathologist for histopathologic examination.
Patients were observed for at least 12 hours after the procedure to detect the occurrence of PPF. If there were no polypectomy-related adverse events such as hemorrhage, perforation, or fever, the patient was discharged the day after the procedure. Each patient was scheduled for a follow-up visit to the outpatient clinic within 2 weeks of the procedure. Those with adverse events underwent additional evaluation and therapeutic procedures.
Patient- and polyp-related factors were investigated to identify the risk factors associated with PPF. Patient-related risk factors included age, sex, comorbid disease (e.g., hypertension, diabetes mellitus, arrhythmia, history of stroke, liver cirrhosis, or a history of abdominal surgery), and medications (e.g., aspirin, clopidogrel, or warfarin). The date of discontinuation of each drug before colonoscopic polypectomy was carefully documented.
Polyp-related variables included the number, size, shape, and histopathology of the polyps. For patients with two or more removed polyps, the size of the largest polyp was recorded. Polyp location was defined as either the left colon (from the rectum to the splenic flexure) or the right colon (from the transverse colon to the cecum). Other polyp-associated variables included the total procedure time for colonoscopy, the method of polyp removal (snare vs. endoscopic mucosal resection [snare after submucosal injection]), experience of colonoscopists performing the polypectomy, and the state of bowel preparation, with the latter also evaluated as a potential risk factor for PPF.
Continuous variables were expressed as the median (interquartile range [IQR]) and categorical variables as the number (percentage). Because the number of patients with PPF was small, the Mann-Whitney
Of the 3,444 patients who underwent colonoscopic polypectomy during index hospitalization, 17 (0.49%) developed fever. Ten of these patients were excluded, including five because of postpolypectomy bleeding; two because of microperforation; and one each because of pneumonia, diverticulitis, and
Of the seven patients with PPF, six were treated with antibiotics. Fever subsided within 1 day in all seven cases. The median length of hospitalization was longer for patients with PPF than for those without PPF (3 days vs. 2 days;
A binary logistic regression model was used to assess the risk factors related to the development of PPF assessed through univariate and multivariate analyses (
To our knowledge, this is the first study to assess the incidence, risk factors, and outcomes in patients who developed PPF during index hospitalization. Hypertension and polyps >2 cm were associated with an increased risk of PPF. The length of hospital stay was longer for patients with PPF than for those without PPF.
Fever after colonoscopic polypectomy occurred in 17 of 3,444 (0.49%) inpatients. Although we did not intend to investigate the possible causes of fever after polypectomy, fever was associated with postpolypectomy bleeding in five patients, with microperforation in two patients, and infections associated with other conditions in three patients (one each with pneumonia, diverticulitis, or
Three of the four patients tested showed leukocytosis, but none showed elevated CRP levels. After the initial tissue injury, CRP levels increased up to several hundred-fold within 24 to 48 hours, peaking at 72 hours.
The median length of hospitalization was significantly longer for patients with PPF than for those without PPF (3 days vs. 2 days;
Interestingly, the two risk factors for PPF identified in this study, polyp size and hypertension, are the same as those identified in patients with postpolypectomy coagulation syndrome.
Our findings do not fully explain the possible mechanisms underlying PPF. However, PPF may be explained by three hypotheses. The first is that PPF is a manifestation of postpolypectomy syndrome, which occurs in 0.07% to 1% of patients who undergo polypectomy, and is thought to result from a transmural burn to the colon wall in the absence of actual perforation.
The second hypothesis is that, during colonoscopic procedures, bacteria translocate from the gut to the bloodstream through a mucosal break. The incidence of transient bacteremia is approximately 3.6% within 10 minutes after polypectomy.
The third hypothesis is that PPF may be caused by an inflammatory mechanism other than infection. Adenomatous polyps have an inflammatory stromal microenvironment, which is rich in macrophages, neutrophils, and T helper cells.
The mechanism by which hypertension promotes PPF is unclear. Patients with hypertension tend to have innate lowgrade inflammation.
Although PPF could be a mild form of postpolypectomy syndrome based on similar risk factors or similar mechanisms, other plausible mechanisms of sole fever after polypectomy should be considered, such as bacterial translocation and the proinflammatory microenvironment of adenomatous polyps. Thus, PPF would be more appropriate until the precise mechanism is made.
The strength of this study is that it is the first to investigate the incidence of documented PPF in a tertiary hospital. Although some laboratory tests were not performed in all patients, all the medical records were accurately and clearly maintained in the electronic medical records of our center; therefore, accurate chart reviews were available. The results suggest a favorable course of sole fever after colonoscopic polypectomy, and clinicians may need observation time without antibiotic treatment or excessive evaluation.
The limitations of this study include the small number of patients assessed. The number of patients with PPF was too small to identify the risk factors for this condition, as PPF itself is rare. Moreover, the distribution of patient characteristics varied widely. However, an increase in the number of patients may result in a decrease in the OR. Second, the crude incidence of patients with PPF may have been underestimated, as we only enrolled inpatients who developed fever during hospitalization after polypectomy. Thus, we may have missed those patients who experienced fever after discharge. Moreover, we did not include patients who underwent colonoscopic polypectomy in an outpatient clinic and therefore could not be monitored after the procedure. Finally, this study was performed at a single center and thus is not representative of the entire Korean population. However, six experienced attending physicians in our hospital performed these procedures, which might compensate for the limitations of a single-center study.
In previous studies, the rate of colonoscopy-associated bacteremia ranged from 0% to 25%, with a mean frequency of 4.4%.
In conclusion, hypertension and polyps >2 cm in size were risk factors for the development of PPF. Although use of prophylactic antibiotics is not warranted, owing to the favorable course of PPF, a greater understanding of the occurrence of PPF and its risk factors is needed for better patient management. To elucidate the mechanism of PPF development, it is necessary to measure the serum concentrations of several cytokines associated with the onset of fever.
The authors have no financial conflicts of interest.
Demographic and Clinical Variables of Patients with and without Postpolypectomy Fever after Polypectomy
Values are presented as median (range) or number (%).
a)Including atrial fibrillation; b)Aspirin, clopidogrel, and/or warfarin.
Polyp-Related Variables in Patients with and without Postpolypectomy Fever after Polypectomy
Values are presented as median (range), mean±SD or number (%).
LST, laterally spreading tumor.
Univariate and Multivariate Analyses of the Association between Patient- and Polyp-Related Variables and Postpolypectomy Fever
OR, odds ratio; CI, confidence interval; EMR, endoscopic mucosal resection.
a)Including atrial fibrillation; b)Aspirin, clopidogrel, and/or warfarin.