Korean J Gastrointest Endosc > Volume 17(3); 1997 > Article
Korean Journal of Gastrointestinal Endoscopy 1997;17(3): 346-350.
원저 : 식도 위장관 ; 대장내시경검사의 전처치로서 항콜린제 사용에 관한 연구 - 전향적 , 이중맹검법으로 - ( Original Articles : Esophagus , Stomach & Intestine ; A Clinical Usefulness of Premedication with Hyoscine-N- butyl bromide ( Buscopanⓡ ) in Colonoscopy - A Randomized , Double Blinded , Prospective Study - )
함준수, 박경남, 이민호, 최호순, 한동수, 전용철, 이오영, 손주현, 윤병철, 기춘석, 송승찬, 박준용, 이종희 (Joon Soo Hahm, Kyung Nam Park, Min Ho Lee, Ho Soon Choi, Dong Soo Han, Yong Cheol Jeon, Oh Young Lee, Joo Hyun Sohn, Bung Chul Yoon, Chun Suhk Khee, Seung Chan Song, June Yong Park and Jhong Hee Lee)
Abstract
Background: Use of antispasmodic medication prior to colonoscopy is controversial but someone believes antispasmodic may improve visualization of colonic mucosa and ease colonoscope insertion. So, we designed a study to assess the effect of premedication with the antispasmodic, hyoscine-N-butyl bromide(Buscopan') on the performance of colonoscopy.
Methods:
This study was prospective, double blinded, randomized, controlled study, One hundred three consecutive patients were randomized to receive intravenous buscopan lml(n=52) or placebo(n=51) combined with our standard initial medication(me- peridine 50 mg and midazolam 2 mg). Insertion of colonoscopy was timed, and 100 mm visual analogue scales (VAS) were used for asscssing difficulty of procedure, colonic motility, frequency of positional change, frequency of external compression, difficulty of assistance and degree of discomfort experienced by the patients.
Results:
There were no significant differences of intubation time between buscopan group(mean time, 7.23 min., range 2~15) and placebo group(7.07 min., range 3-25), (p=0.83) and withdrawal time between buscopan group (6.46 min., range 2-22) and placebo group(6.76 min., range 2 25), (p=0.69). Also, there was no significant differences in intubation time between males and females(buscopan; males 7.00 min., females 7.60 min., p=0.34, placebo; males 7.0~5 min., females 7.08 min., p 0.44). The VAS scores checked by endoscopist(p=0.29), assistant(p=0.32) and patient (p=0.15) were not significantly different in both groups. There were no significant differences in intubation time, VAS scores nf endoscopist, assistant, and patients.
Conclusion:
Premedication with intravenous bu.opan has no advantage on colonoscopy procedure. Use of antispasmodic medication prior to colonoscopy was not considered as recommendable agent, (Korean J Gastrointest Kndosc 17: 346-350, 1997)
Key Words: Colonoscopy , Antispasmodic , Premedication
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