Korean Journal of Gastrointestinal Endoscopy 1997;17(2): 119-124.
원저 : 식도 위장관 ; 식도정맥류 결찰술후 O-ring 탈락부위의 출혈에 대한 N-butyl-2-cyanoacrylate ( Histoacryl ) 의 지혈효과 ( Original Articles : Esophagus , Stomach & Intestine ; Hemostatic Effect of Histoacryl for Band - induced Esophageal Ulcer Bleeding )
김영수, 조성원, 함기백, 김진홍, 홍사준, 문영수, 이광재 (Young Soo Kim, Sung Won Cho, Ki Baik Hahm, Jin Hong Kim, Sa Joon Hong, Young Soo Moon and Kwang Jae Lee)
Abstract
Background/Amis: Endoscopic variceal ligation(EVL) is a method to manage esophageal varices bleeding and induces mechanical ligation and strangulation of varices by using elastic O-rings. The lower complication rate seen with EVL compared to sclerotherapy can be explained by the more limited degree of local tissue injury induced by EVL. Only the mucosal and submucosal layers are aspirated into cylinder attachment of the ligating devices, thus limiting injury to these layers. But, sometimes band induced ulcer shows massive bleeding. In these cases, endoscopic therapy is very difficult. This study was performed in order to find out the effectiveness of Histoacryl ingection for band-induced esophageal ulcer bleeding, Methods: We tried to control band-induced bleeding by injecting Histoacryl in 8 cases of band-induced ulcer bleeding. Results: This therapeutic trials show exellent control of bleeding in all cases without rebleeding. Conclusions: The cyanoacrylate tissue adhesive Histoacryl(N-butyl-2-cyanoacrylate) is a remarkable substance that transforms from its original liquid state into a solid state when mixed with a physiologic medium such as blood. Histoacryl undergoes an instantaneous polymerization reaction and hardens, thereby plugging the varix or bleeding vessel lumen. Rapid hemostasis of an active bleeding occurs and rebleeding of the treated lesion is prevented. We found out that Histoacryl injection is a safe and effective treatment for band-induced ulcer bleeding. (Korean J Gastrointest Endosc 17: 119-124, 1997)
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