Korean Journal of Gastrointestinal Endoscopy 1998;18(6): 847-852.
원저 : 식도 위장관 ; Helicobacter pylori 균주의 Metronidazole 내성이 균 박멸에 미치는 영향 ( Original Articles : Esophagus , Stomach $ Intestine ; Metronidazole Resistance and the Eradication of Helicobacter pylori )
문광호, 함준수, 류광현, 이오영, 한동수, 윤병철, 최호순, 이민호, 기춘석, 박경남, 강정옥 (Gwang Ho Mun, Joon Soo Hahm, Kwang Hyun Ryu, Oh Young Lee, Dong Soo Han, Byung Chul Yoon, Ho Soon Choi, Min Ho Lee, Choon Suhk Lee, Kyung Nam Park and Jung Ok Kang)
Abstract
Background/Aims: The success of Helicobacter pylori eradication is limited by antibiotic resistances, and the primary resistance to metranidazole seems to be high. In this study, the frequency af metronidazole resistance and the eradication rate in metronidazole-resistant H. pylori strain was evaluated. Methods: Sixty-eight patients were tested for metronidazole resistance using microdilution broth, the E test and disk diffusion method. Twenty-two patients were treated for 14 days with amoxicilline 2000 mg, metronidazole 750 mg, and tripotassium dicitrate bismuth 1200 mg. Results: Metronida-zole resistance was 46% (31/68). The eradication rates for H. pylori was 91.7% in patients with metronidazole-sensistive strains and 70% in patients with metronidazole-resistant strains. Conclusions: Metronidazole resistance was high (46%) in Korea, however, triple therapy was an efficient method of eradicating H. pylori in both metronidazole sensitive and resistant strains. (Korean J Gastrointest Endosc 18: 847-852, 1998)
PDF Links
Full text via DOI 
Download Citation 
