Korean Journal of Gastrointestinal Endoscopy 2001;22(6): 406-410.
활동성 크론병에서 초기 스테로이드 치료 반응에 따른 임상적 , 생화학적 , 병리학적 인자들에 관한 연구 ( Analysis of Clinical , Biochemical and Pathologic Factors According to the Response to Initial steroid Therapy in Active Crohn`s Disease )
현재근(Jae Geun Hyun),김재준(Jae J . Kim),김영호(Young Ho Kim),안병훈(Byeong Hoon Ahn),도재혁(Jae Hyuk Do),류민규(Min Kyu Ryu),장재권(Jae Kwon Jang),김지은(Jee Eun Kim),박동일(Dong Il Park),이풍렬(Poong Lyul Rhee),고광철(Kwang Cheol Koh),백승운(Seung Woon Paik),이종철(Jong Chul Rhee),최규완(Kyoo Wan Choi)
Abstract
Background/Aims: The predictory factors of the response to initial steroid therapy in active Crohn's disease has been controversial in numerous literature reviews. We evaluated any predictory faetor of the response to initial steroid therapy in active Crohn`s disease patients, Methods: The medical records of 32 patients with active Crohn`s disease who clinically responded to oral steroid therapy were retrospectively reviewed. The steroid responsive group was defined as the one showing maintenance of response for more than one month from steroid withdrawal and the steroid dependent group as the one showing relapse or exacerbation during steroid tapering or within 30 days from steroid withdrawal. The clinical, biochemical, and pathologic factors were evaluated. Results: There were 22 male and 10 female patients. The mean age was 28.9 years. The number of steroid responsive and dependent group was 22 (68,8%) and 10 (31.2%), respectively. There were no significant differences between these two groups in age, sex, time to diagnosis, perianal lesion, extent of disease, extraintestinal manifestations, presence of granuloma, presenting features, hemoglobin, ESR, and CRP, except serum albumin level. Conclusions: Serum albumin level was significantly lower in steroid dependent group than steroid responsive group, reflecting severe inflammation in steroid dependent group, (Korean J Gastrointest Endosc 2001;22:406-410)
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