Korean Journal of Gastrointestinal Endoscopy 2003;26(1): 8-14.
담즙 역류성 위염에서의 Helicobacter pylori 감염과
임종필·양종인·최기돈·김병관*·김주성·이국래*
서울시립보라매병원 *내과, †병리과, 서울대학교 의과대학 내과학교실
Helicobacter pylori Infection and Pathologic Findings in Bile Reflux Gastritis
Jong Pil Im, M.D., Jong In Yang, M.D., Kee Don Choi, M.D., Byeong Gwan Kim, M.D.*,
Departments of *Internal Medicine and †Pathology, Boramae Hospital; Department of Internal Medicine
Abstract
Backgroud/Aims: The role of Helicobacter pylori in bile reflux gastritis (BRG) is uncertain. We show the role of H. pylori and pathology in BRG. Methods: Thirty seven patients, including 5 patients who had undergone subtotal gastrectomy, were diagnosed with BRG by gastroscopic findings of bile-stained mucosa with hyperemia/ erosions. We measured total bile acid (TBA) concentration and compared the H. pylori positivity between BRG patients and 70 non-BRG patients. We showed how often we could see the pathologic findings of reactive gastritis in BRG and compared the grade of lymphoplasma cell and neutrophil infiltration between H. pylori positive and negative group in BRG. Results: TBA concentration of 10 patients was 7,376.7⁑5,482.6μmol/L. H. pylori positive rate of BRG was 45.9% and that of non-BRG was 70% (p=0.015). The gastric pit elongation and tortuosity were found only in 3 cases with gastric surgery. The grade of lymphoplasma cell and neutrophil infiltration was 2.41⁑0.51 and 1.88⁑0.86 in H. pylori positive BRG and 1.55⁑0.69 and 0.55⁑0.76 in H. pylori negative BRG, respectively (p＜0.001). Conclusions: H. pylori infection in BRG was lower than that in non-BRG. The gastric pit elongation and tortuosity of BRG were not seen often. The lymphoplasma cell and neutrophil infiltration were relatively sparse in H. pylori negative BRG. (Korean J Gastrointest Endosc 2003;26:814)
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